Rotundic acid induces Cas3-MCF-7 cell apoptosis through the p53 pathway.

abstract：:The mechanisms underlying the pathogenesis of papillary thyroid carcinoma (PTC) have not yet been elucidated. The aim of the current study was to identify potential pathogenic biomarkers in PTC by comprehensively analyzing gene expression and methylation profiles, and to increase the understanding of PTC pathogenesis....

journal_title：Oncology letters

authors： Wei S,Yun X,Ruan X,Wei X,Zheng X,Gao M

更新日期：2019-12-01 00:00:00

abstract：:Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is...

journal_title：Oncology letters

authors： Chaudhary S,Krishna BM,Mishra SK

更新日期：2017-08-01 00:00:00

abstract：:The development of drug resistance to chemotherapeutic agents has consistently presented a challenge in terms of the treatment of patients with triple-negative breast cancer (TNBC). In the present study, gemcitabine (dFdC)-resistant TNBC cells were established, and the effects of lentivirus-deoxyribonucleoside kinase ...

journal_title：Oncology letters

authors： Zhao Y,Jiang H,Gu M,Zu C,Zheng X

更新日期：2020-11-01 00:00:00

abstract：:This study aims to comparatively analyze the impact of laparoscopic myomectomy (LM) and transcervical resection of myoma (TCRM) on ovarian function, immune function and quality of sexual life of patients with hysteromyoma. Two hundred and forty patients with hysteromyoma admitted into the Second Affiliated Hospital of...

journal_title：Oncology letters

authors： Zhang Y,Gu X,Meng Y,Guo H,Du J,Xing W

更新日期：2018-03-01 00:00:00

abstract：:The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical N status who receiv...

journal_title：Oncology letters

authors： Hamada M,Ebihara Y,Nagata K,Yano M,Kogashiwa Y,Nakahira M,Sugasawa M,Nagatsuka H,Yasuda M

更新日期：2020-04-01 00:00:00

abstract：:Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully under...

journal_title：Oncology letters

authors： Chen J,Wang F,Lu Y,Yang S,Chen X,Huang Y,Lin X

更新日期：2020-12-01 00:00:00

abstract：:The ubiquitin-proteasome pathway is an important protein degradation regulatory system in cells. This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. Ovarian tumor-associated proteases domain-containing...

journal_title：Oncology letters

authors： Deng J,Hou G,Fang Z,Liu J,Lv XD

更新日期：2019-11-01 00:00:00

abstract：:Carbonyl reductase 1 (CBR1) is theorized to participate in various cellular processes, such as signal transduction, apoptosis, carcinogenesis and drug resistance, and is highly expressed in certain malignancies, including lung tumors. Several studies have provided evidence that gene polymorphisms may affect susceptibi...

journal_title：Oncology letters

authors： Guo Y,Shen Y,Xia Y,Gu J

更新日期：2017-11-01 00:00:00

abstract：:The LIM domain only protein 2 (LMO2) is a key regulator of hematopoietic stem cell development. Expression of LMO2 has been evaluated in B-cell lymphoma, T-cell acute lymphoblastic leukemia and acute myeloid leukemia; however, information concerning its role in breakpoint cluster region/Abelson murine leukemia viral o...

journal_title：Oncology letters

authors： Aly RM,Taalab MM,Abdsalam EM,Elyamany OH,Hasan OE

更新日期：2016-03-01 00:00:00

abstract：:Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor, which may affect various organs. The preferential site for IMT in the genitourinary system is the urinary bladder, while the presence of IMT in the kidney, and particularly in the renal pelvis, is rare. In the present report, the case of a 4...

journal_title：Oncology letters

authors： Wu S,Xu R,Zhao H,Zhu X,Zhang L,Zhao X

更新日期：2015-12-01 00:00:00

abstract：:The present study reports a case of pancreatic vasoactive intestinal peptide-secreting tumor (VIPoma), of 2.2 cm in diameter, arising from the region of the uncus of the pancreas with liver metastases in a 50-year-old patient, which demonstrated unusual multiple-phase spiral computed tomography (MPSCT) results. The pa...

journal_title：Oncology letters

authors： Chen Y,Shi D,Dong F,Han SG,Qian ZH,Yang LI,Wang Y,Yu RS,Li QH,Fu YB

更新日期：2015-10-01 00:00:00

abstract：:Metastasis negatively affects the prognosis of hepatocellular carcinoma (HCC). In the present study, niclosamide, which is known to suppress the proliferation of HCC cells, was investigated for possible suppressant effects on the migration of HCC cells. HLF and PLC/PRF/5 HCC cells were cultured in the presence of nicl...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Ishige N

更新日期：2015-12-01 00:00:00

abstract：:Based on our previous analysis of neutral glycolipids in the human endometrium, the present authors already reported that the concentrations of glucosylceramide, lactosylceramide and globotriaosylceramide (Gb3Cer), in which both fatty acids and sphingosines in the ceramides are hydroxylated, exhibit a marked increase ...

journal_title：Oncology letters

authors： Tajima T,Miyazawa M,Hayashi M,Asai S,Ikeda M,Shida M,Hirasawa T,Iwamori M,Mikami M

更新日期：2017-01-01 00:00:00

abstract：:The correlation between the expression levels of p65 and TNF-α in patients with acute myelocytic leukemia (AML) and AML cell lines were investigated. The bone marrow samples of 30 AML patients and 10 non-leukemia controls were studied. The mRNA expression levels of p65 and TNF-α were detected by reverse transcription-...

journal_title：Oncology letters

authors： Dong QM,Ling C,Zhu JF,Chen X,Tang Y,Zhao LI

更新日期：2015-11-01 00:00:00

abstract：:Ovarian metastasis from non-small cell lung cancer (NSCLC) is a rare condition. The current study presents the cases of 2 female patients aged 38 and 47 years old, respectively, who were initially diagnosed with NSCLC adenocarcinoma on histology. Both patients initially presented with chest pain and a cough, and subse...

journal_title：Oncology letters

authors： Mushi RT,Yang Y,Cai Q,Zhang R,Wu G,Dong X

更新日期：2016-12-01 00:00:00

abstract：:To investigate the prospective roles and the clinicopathological application of microRNA-21-5p (miR-21-5p) in hepatocellular carcinoma (HCC), the present review is based on 24 studies and bioinformatics investigation. Firstly, HCC-associated miR-21-5p data were aggregated from literature databases and two public genom...

journal_title：Oncology letters

authors： Zhong XZ,Deng Y,Chen G,Yang H

更新日期：2019-01-01 00:00:00

abstract：:The present study was performed to determine the molecular mechanism of calcium gluconate (CG) in alleviating the toxic effect of hydrofluoric (HF) acid on human dermal fibroblasts (HDFs). HDF morphology was observed by optical microscopy and the vimentin immunofluorescence assay. Cell viability and apoptosis were eva...

journal_title：Oncology letters

authors： Peng J,Liu R,Peng L,Jia H

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to identify the underlying molecular mechanisms associated with spinal metastases. Gene expression profiles in cancellous bone samples from the spines of five patients with spinal metastases, with different primary cancers, and three normal control patients were measured using microarray analys...

journal_title：Oncology letters

authors： Liu W,Liang Y,Bian C,Jiang L,Zheng G,Dong J

更新日期：2018-01-01 00:00:00

abstract：:Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...

journal_title：Oncology letters

authors： Liu B,Li LJ,Gong X,Zhang W,Zhang H,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:Our previous study demonstrated that the 2-benzyloxybenzaldehyde analog CCY-1a-E2 is a potent compound against HL-60 human leukemia cell lines. To investigate the potential therapeutic application of CCY-1a-E2 for leukemia, we analyzed the antileukemic effects and safety of CCY-1a-E2 in the BALB/c mouse WEHI-3 allogra...

journal_title：Oncology letters

authors： Lin C,Yang JS,Tsai SC,Lin CF,Lee MR

更新日期：2013-03-01 00:00:00

abstract：:microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...

journal_title：Oncology letters

authors： Chen X,Wang A,Yue X

更新日期：2018-07-01 00:00:00

abstract：:Glycocholic acid (GCA) is a novel identified biomarker for hepatocellular carcinoma (HCC). However, clinical pathological study of GCA has not been extensive due to the limited availability of anti-GCA monoclonal antibodies (mAbs) and restricted detection methods. In the present study, using human GCA conjugated with ...

journal_title：Oncology letters

authors： Wu M,Zhai S,Gao J,Wei D,Xue J,Zhou Y,Li N,Hu L

更新日期：2019-03-01 00:00:00

abstract：:Taxol is the first-line chemotherapeutic agent for patients with castration-resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosp...

journal_title：Oncology letters

authors： Gan Y,Chen Q,Lei Y

更新日期：2017-10-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) accounts for 30% of all pediatric cancers. Currently available treatments exhibit toxicity and certain patients may develop resistance. Thus, less toxic and chemoresistance-reversal agents are required. In the present study, the potential effect of curcumin, a component of Curcuma lo...

journal_title：Oncology letters

authors： Pimentel-Gutiérrez HJ,Bobadilla-Morales L,Barba-Barba CC,Ortega-De-La-Torre C,Sánchez-Zubieta FA,Corona-Rivera JR,González-Quezada BA,Armendáriz-Borunda JS,Silva-Cruz R,Corona-Rivera A

更新日期：2016-11-01 00:00:00

abstract：:Primary smooth muscle tumors of the thyroid gland are extremely rare neoplasms. Due to their rarity, clinical case studies concerning management are lacking. According to a literature review, only 19 cases of primary thyroid leiomyosarcomas (TLs) have been reported. In the majority of patients, the prognosis is poor s...

journal_title：Oncology letters

authors： Conzo G,Candela G,Tartaglia E,Gambardella C,Mauriello C,Pettinato G,Bellastella G,Esposito K,Santini L

更新日期：2014-04-01 00:00:00

abstract：:The aim of the present study was to identify and characterize side population (SP) cells in primary cervical cancer. A primary culture was successfully established, and the SP cells were isolated via fluorescence-activated cell sorting. Subsequently, in vitro analysis of clonogenic capacity by soft agar assay and in v...

journal_title：Oncology letters

authors： Wei ZT,Yu XW,He JX,Liu Y,Zhang SL

更新日期：2017-09-01 00:00:00

abstract：:Stromal cell-derived factor 1α (SDF1α) and its receptor C-X-C chemokine receptor type 4 (CXCR4) have been reported to form an important chemokine signaling pathway. Our previous study reported that SDF1α from tumor stromal cells may stimulate the proliferation of gastric cancer (GC) cells through the CXCR4 axis in a h...

journal_title：Oncology letters

authors： Yashiro M,Kinoshita H,Tsujio G,Fukuoka T,Yamamoto Y,Sera T,Sugimoto A,Nishimura S,Kushiyama S,Togano S,Kuroda K,Toyokawa T,Ohira M

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study was to determine the usefulness of the positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) in the detection of recurrence or metastasization of differentiated thyroid carcinoma (DTC) in patients with abnormal thyroglobulin levels and negative finding...

journal_title：Oncology letters

authors： Lu CZ,Cao SS,Wang W,Liu J,Fu N,Lu F

更新日期：2016-04-01 00:00:00

abstract：:Induction of apoptosis in human cancer cells by Sasa quelpaertensis Nakai has been considered to be a potential therapeutic target for cancer treatment; however, the underlying mechanisms of action are not well understood. The present study investigated the role of nitric oxide (NO•) and inhibitors of apoptosis (IAPs)...

journal_title：Oncology letters

authors： Kim MY

更新日期：2020-04-01 00:00:00

abstract：:The CDw75 epitope is an α(2,6) sialylated antigen overexpressed in colorectal cancer (CRC), where its expression correlates with the progression of the disease. The CDw75 epitope is located mainly in N-glycoproteins, whose identity remains unknown. The aim of the present study was to identify proteins with the CDw75 e...

journal_title：Oncology letters

authors： Mariño-Crespo Ó,Fernández-Briera A,Gil-Martín E

更新日期：2018-01-01 00:00:00