Abstract:
:Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully understood. The present study investigated the association between SOX2 and chloride voltage-gated channel 3 (CLC-3) in prostate cancer. Flow cytometry demonstrated that the inactivation of CLC-3 or SOX2 arrested cell cycle progression in the G0/G1 phase. Furthermore, CLC-3 was observed to bind to SOX2, and vice versa, by co-immunoprecipitation. SOX2 appears to initiate and maintain prostate cancer tumorigenesis, in part, by modulating the cell cycle. These findings indicate the potential of SOX2 and CLC-3 as targets for the development of multi-targeted therapeutics.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Chen J,Wang F,Lu Y,Yang S,Chen X,Huang Y,Lin Xdoi
10.3892/ol.2020.12235subject
Has Abstractpub_date
2020-12-01 00:00:00pages
372issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-12235journal_volume
20pub_type
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