Identification and functional characterization of long non-coding RNAs in human gastric cancer.

abstract：:microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains li...

journal_title：Oncology letters

authors： Nian W,Ao X,Wu Y,Huang Y,Shao J,Wang Y,Chen Z,Chen F,Wang D

更新日期：2013-08-01 00:00:00

abstract：:We previously reported that the dissected pancreatic tissue margin (DPM) and the preoperative serum level of carbohydrate antigen 19-9 (preCA19-9) were independent prognostic factors in pancreatic ductal adenocarcinoma (PDAC). In the current study, the prognostic relevance of these factors, including their molecular a...

journal_title：Oncology letters

authors： Nishizawa N,Kumamoto Y,Katoh H,Ushiku H,Yokoi K,Tanaka T,Ishii S,Igarashi K,Tajima H,Kaizu T,Yoshida T,Saegusa M,Watanabe M,Yamashita K

更新日期：2019-02-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical utility of plasma chromogranin A (CgA) in patients diagnosed with early-stage pancreatic neuroendocrine tumors (PNETs) in terms of diagnostic value and treatment response. A total of 35 patients with PNETs were prospectively enrolled from August 2010 to April 2...

journal_title：Oncology letters

authors： Tseng CM,Cheng TY,Chen TB,Tien YW,Chen CC,Lin JT,Wang HP

更新日期：2018-06-01 00:00:00

abstract：:Phospholipase C (PLC) is a membrane-associated enzyme that regulates several cellular behaviors including cell motility, growth, transformation and differentiation. PLC is involved in cancer migration, invasion and drug resistance. However, the expression status and prognostic role of PLCB4 in acute myeloid leukemia (...

journal_title：Oncology letters

authors： Wu S,Zhang W,Shen D,Lu J,Zhao L

更新日期：2019-12-01 00:00:00

abstract：:Thyroid cancer is the most common malignant endocrine tumor, with significant morbidity and mortality. Bovine myeloid antimicrobial peptide 28 (BMAP-28) is a cathelicidin that is found in bovine neutrophils. In the present study, the effect and relative mechanism of BMAP-28 on the human thyroid cancer TT cell line in ...

journal_title：Oncology letters

authors： Zhang D,Wan L,Zhang J,Liu C,Sun H

更新日期：2015-10-01 00:00:00

abstract：:Pro-angiogenic factors [vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)] and anti-angiogenic factors (endostatin) play important roles in the progression of pancreatic cancer. The purpose of the present study was to investigate the knockdown effect by either VEGF or bFGF siRNA on th...

journal_title：Oncology letters

authors： Yan C,Wang C,Dong M,Liu S,Qi C,Zhao Y

更新日期：2013-03-01 00:00:00

abstract：:The aim of the present study was to assess the expression of microRNA-146a (miR-146a) in human lung adenocarcinoma cells, its effect on cellular behaviors, and the underlying molecular mechanisms. Reverse transcription-quantitative PCR (RT-qPCR) was used to measure miR-146a expression in the human normal lung epitheli...

journal_title：Oncology letters

authors： Yuan F,Zhang S,Xie W,Yang S,Lin T,Chen X

更新日期：2020-06-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the best of our knowle...

journal_title：Oncology letters

authors： Wei YB,Gao YL,Wu HT,Ou-Yang SF,Xu T,Mao DF,Yang JR

更新日期：2015-01-01 00:00:00

abstract：:Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus ...

journal_title：Oncology letters

authors： Mendoza-Almanza G,Ortíz-Sánchez E,Rocha-Zavaleta L,Rivas-Santiago C,Esparza-Ibarra E,Olmos J

更新日期：2019-10-01 00:00:00

abstract：:Activation of brown adipose tissue (BAT) is an effective strategy for treating obesity. Hepatocellular carcinoma (HCC) is a life-threatening hepatic malignancy with a high mortality rate. Considering that obesity is a risk factor for HCC, the aim of the present study was to investigate the association between HCC and ...

journal_title：Oncology letters

authors： Liu D,Li Y,Shang Y,Wang W,Chen SZ

更新日期：2019-03-01 00:00:00

abstract：:It has been reported that zerumbone (ZER) has marked effects on the regulation of cell proliferation and migration in multiple types of cancer, and has anti-cancer effects on various types of malignant cell. However, the effects and underlying molecular mechanisms of treatment with ZER on melanoma cells remain unclear...

journal_title：Oncology letters

authors： Yan H,Ren MY,Wang ZX,Feng SJ,Li S,Cheng Y,Hu CX,Gao SQ,Zhang GQ

更新日期：2017-04-01 00:00:00

abstract：:Spontaneous remission (SR) in acute lymphoblastic leukemia (ALL) is a rare phenomenon, but the disease course and its underlying processes are of basic and clinical interest. Herein is reported the case of a pregnant, 31-year-old patient who developed ALL, followed by septic shock and SR of ALL. Information is summari...

journal_title：Oncology letters

authors： Höres T,Wendelin K,Schaefer-Eckart K

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of peroxisome proliferator-activated receptor (PPAR)-γ in inflammatory bowel disease (IBD), and to also identify the association between PPAR-γ and the clinical features of patients with IBD. An azoxymethane (AOM)/dextran sodium sulfate (DSS) animal model of ...

journal_title：Oncology letters

authors： Dou X,Xiao J,Jin Z,Zheng P

更新日期：2015-09-01 00:00:00

abstract：:The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected fro...

journal_title：Oncology letters

authors： Chang H,Ma M,Ma R,Zhang C,Zeng W,Xing LQ

更新日期：2016-12-01 00:00:00

abstract：:Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...

journal_title：Oncology letters

authors： Liu H,Li Y,Li J,Liu Y,Cui B

更新日期：2018-08-01 00:00:00

abstract：:Telomeres are located at the ends of chromosomes and protect them from degradation. Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining short telomeres is a protective mechanism against cancer in humans. In most human somatic cells, the expression of telomerase reverse transcriptase...

journal_title：Oncology letters

authors： Trybek T,Kowalik A,Góźdź S,Kowalska A

更新日期：2020-08-01 00:00:00

abstract：:Ovarian cancer (OVAC) remains the most lethal gynecological malignancy; it is ranked fifth among the most common types of cancer that affect women worldwide. Several aspects of the disease, including molecular pathogenesis, epidemiology, histological subtypes, poor prognosis at early stages due to the absence of speci...

journal_title：Oncology letters

authors： Sun W,Fu S

更新日期：2019-09-01 00:00:00

abstract：:The aim of the present study was to investigate the relationship between the expression of transcription factor forkhead box C2 (FOXC2) and the clinical features of cervical cancer. A total of 66 patients with cervical cancer, 42 patients with cervical intraepithelial neoplasia (CIN) and 25 patients with cervical infl...

journal_title：Oncology letters

authors： Wang J,Yue X

更新日期：2017-12-01 00:00:00

abstract：:Effect of microRNA-27b (miR-27b) on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma (OSCC) was investigated to provide a reference for clinical prevention of OSCC cell resistance. The clinical tissues of 34 patients with OSCC-resistant cancer and 28 patients with cisplatin-sensitive OSCC in Nanjing ...

journal_title：Oncology letters

authors： Liu B,Cao G,Dong Z,Guo T

更新日期：2019-07-01 00:00:00

abstract：:Breast cancer 1 (BRCA1) and insulin-like growth factor 1 receptor (IGF1R) are critical in ovarian cancer progression. However, the crosstalk between the BRCA1 and IGF1R signaling pathways in ovarian cancer remains largely unknown. The effects of BRCA1 on IGF1R were assessed in 121 serous ovarian cancer patients (BRCA1...

journal_title：Oncology letters

authors： Liu B,Li D,Guan YF

更新日期：2014-05-01 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a type of heterogeneous disease derived from haematopoietic stem cells. Cytogenetic characterisation is essential for diagnosis and prognosis stratification. Here, we present the case of a 43-year-old female diagnosed with leukaemia, who demonstrated a rare chromosomal change of t(11; ...

journal_title：Oncology letters

authors： Hu J,Hong X,Li Z,Lu Q

更新日期：2015-10-01 00:00:00

abstract：:Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...

journal_title：Oncology letters

authors： Ieni A,Giuffrè G,Lanzafame S,Nuciforo G,Curduman M,Villari L,Roz E,Certo G,Cabibi D,Salomone E,Labate A,Messina D,Franco V,Adamo V,Tuccari G

更新日期：2012-01-01 00:00:00

abstract：:Invasive breast carcinoma (BRCA) is a serious disease that threatens the survival time of those affected. Alternative splicing (AS) involved in BRCA pathogenesis may be a potential therapeutic target. However, to the best of our knowledge, a systematic analysis of survival-related alternative splicing events (SREs) ha...

journal_title：Oncology letters

authors： Jia K,Wu Y,Huang J,Chen J,Wei H,Wu H

更新日期：2020-08-01 00:00:00

abstract：:The basic helix-loop-helix transcription factor AP4 (TFAP4) gene serves an important function in the genesis and progression of tumors. However, few studies to date have defined the role of this gene in colorectal cancer (CRC). The aim of the present study was to assess the expression of TFAP4 in CRC and its impact on...

journal_title：Oncology letters

authors： Yang J,Ma JP,Xiao S,Zhang XH,Xu JB,Chen CQ,Cai SR,He YL

更新日期：2018-05-01 00:00:00

abstract：:Extra-adrenal pheochromocytomas are rare tumors that originate from the chromaffin tissue of the sympathetic nervous system. Ovarian extra-adrenal pheochromocytoma is even more rare. The present study reports a rare case of an extra-adrenal pheochromocytoma that was localized to the right ovary, but was gynecologicall...

journal_title：Oncology letters

authors： Liu H,Li WZ,Wang XY,Pei YG,Long XY,Chen CY,Hu YB

更新日期：2015-02-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) has been implicated in various types of human cancer. However, the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in gastric cancer remains unclear. In the present study, MALAT1 expression was significantly upregulated in gastric tumors compared with adjacen...

journal_title：Oncology letters

authors： Zhu K,Ren Q,Zhao Y

更新日期：2019-06-01 00:00:00

abstract：:Primary pulmonary leiomyosarcoma (PPL) is an extremely rare malignant tumor. It has been revealed that PPL may originate from the smooth muscle of the pulmonary parenchyma, pulmonary arteries and bronchi. Patients with PPL may be asymptomatic or present with symptoms similar to those observed in other primary lung tum...

journal_title：Oncology letters

authors： Xie X,Chen Y,Ding C,Yu X,Zou L,Xu B,Wang L,Huang X

更新日期：2016-03-01 00:00:00

abstract：:Epithelioid angiosarcoma (EA) is an extremely rare subtype of angiosarcoma, which is characterized by large cells with an epithelioid morphology. EA typically arises in deep soft tissues, including the adrenal gland, skin and thyroid, however, EA rarely arises in the spine. The current study presents a case of osteoly...

journal_title：Oncology letters

authors： Lang J,Chen L,Chen B,Chen K,Liu A,Li J,Wang J

更新日期：2014-06-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is the leading cause of cancer-associated mortality in the world. In previous years, almost no significant advancements have been made towards the molecular characterization of NSCLC, which highlights the requirement for novel target genes. Hypoxia inducibl...

journal_title：Oncology letters

authors： Qian J,Bai H,Gao Z,Dong YU,Pei J,Ma M,Han B

更新日期：2016-03-01 00:00:00

abstract：:Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel thera...

journal_title：Oncology letters

authors： Yong M,Yu T,Tian S,Liu S,Xu J,Hu J,Hu L

更新日期：2017-12-01 00:00:00