The importance of molecular cytogenetic analysis prior to using cell lines in research: The case of the KG-1a leukemia cell line.

abstract：:Trefoil factor 2 (TFF2) plays a protective role in gastric mucosa and may be involved in the progression of gastric cancer, but the detailed functions and underlying molecular mechanisms are not clear. The present study used a combination of clinical observations and molecular methods to investigate the correlation be...

journal_title：Oncology letters

authors： Jiang P,Yu G,Zhang Y,Xiang Y,Zhu Z,Feng W,Lee W,Zhang Y

更新日期：2014-05-01 00:00:00

abstract：:Numerous studies concerning hepatic arterial infusion chemotherapy (HAIC) have been conducted by adopting regimens containing 5-fluorouracil (FU), with a favourable efficacy compared with conventional transcatheter arterial chemoembolisation (TACE) treatment; however, the detailed mechanism of HAIC remains unclear. Th...

journal_title：Oncology letters

authors： Gao J,Zhen R,Liao H,Zhuang W,Guo W

更新日期：2018-05-01 00:00:00

abstract：:Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and as a potential target for cancer therapy. In this study, F§FJ-5, a characterized naphthoquinone modifier of mollugin, was synthesized in order to investigate its anticancer activity and the potential mechanisms. It was observed...

journal_title：Oncology letters

authors： Wei X,Li M,Ma M,Jia H,Zhang Y,Kang W,Wang T,Shi X

更新日期：2017-02-01 00:00:00

abstract：:Natural products are a promising source for the development of novel cancer therapies, due to their potential effectiveness and low toxicity profiles. As a main component of Herba oxytropis, 2',4'-dihydroxychalcone (TFC) is known to demonstrate anti-tumor activity in vitro. In the present study, TFC was found to potent...

journal_title：Oncology letters

authors： Sheng Y,Zou M,Wang Y,Li Q

更新日期：2015-12-01 00:00:00

abstract：:Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...

journal_title：Oncology letters

authors： Xie C,Yang Z,Hu Y,Cao X,Chen J,Zhu Y,Lu N

更新日期：2017-11-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the best of our knowle...

journal_title：Oncology letters

authors： Wei YB,Gao YL,Wu HT,Ou-Yang SF,Xu T,Mao DF,Yang JR

更新日期：2015-01-01 00:00:00

abstract：:The response of triple-negative breast cancer (TNBC) to chemotherapy is heterogeneous; particular subtype classifications based on mRNA gene expression analysis have been demonstrated to be associated with a pathological complete response (pCR). The aim of the present study was to investigate additional clinical and p...

journal_title：Oncology letters

authors： Nakashoji A,Matsui A,Nagayama A,Iwata Y,Sasahara M,Murata Y

更新日期：2017-10-01 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a type of heterogeneous disease derived from haematopoietic stem cells. Cytogenetic characterisation is essential for diagnosis and prognosis stratification. Here, we present the case of a 43-year-old female diagnosed with leukaemia, who demonstrated a rare chromosomal change of t(11; ...

journal_title：Oncology letters

authors： Hu J,Hong X,Li Z,Lu Q

更新日期：2015-10-01 00:00:00

abstract：:The present study reports a case of a 59-year-old male suffering from oligodendroglioma that metastasized to the bone marrow (BM). The metastasis was detected 5 years after craniotomy was performed for the resection of the primary tumor; however, it manifested as multiple myeloma (MM)-like bone lesions, a small M comp...

journal_title：Oncology letters

authors： Jian Y,Gao W,Wu Y,Li Y,Zhang Y,Yang G,Chen W

更新日期：2016-07-01 00:00:00

abstract：:Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...

journal_title：Oncology letters

authors： Wang L,Xu ML,Wang C,Dong QQ,Miao Z,Chen XY,Wang N,He HP,Zhang TC,Luo XG

更新日期：2020-05-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-298 has been reported to be downregulated and to modify the expression of the polycomb protein enhancer of zeste 2 (EZH2) in recurrent epithelial ovarian cancer (EOC). To date, no functional evidence of a miR-298-EZH2 axis in EOC has been documented. The present study aimed to investigate the a...

journal_title：Oncology letters

authors： Zhou F,Chen J,Wang H

更新日期：2016-11-01 00:00:00

abstract：:Primary Ewing's sarcoma (ES) is rare, especially when it occurs in the spinal canal during middle or old age. The rarity of Ewing's sarcoma breakpoint region 1 fusion-negative ES has been reported in the literature. The present case report describes a 60-year-old Chinese patient who was diagnosed with ES originating f...

journal_title：Oncology letters

authors： Yan D,Zhang J,Zhong D

更新日期：2019-12-01 00:00:00

abstract：:The seven-amino acid truncated (7ND) protein is an N-terminal deletion mutant of monocyte chemoattractant protein-1 (MCP-1) and it functions as a dominant-negative inhibitor. 7ND and wild-type MCP-1 form a heterodimer, which binds to MCP-1 receptors and inhibits monocyte chemotaxis. In the present study, the 7ND prote...

journal_title：Oncology letters

authors： Luo S,Zhou C,Zhang J,Chen M,Li H,Zheng S,Quan J

更新日期：2018-05-01 00:00:00

abstract：:The alteration of microRNA (miR)-130b expression has been associated with promoting or suppressing numerous types of human cancer. A previous study evaluated the expression level of miR-130b in osteosarcoma tissues, and subsequently investigated the effects of miR-130b on the regulation of osteosarcoma cells malignant...

journal_title：Oncology letters

authors： Wu Y,Sun W,Kong Y,Liu B,Zeng M,Wang W

更新日期：2018-07-01 00:00:00

abstract：:The CyberKnife® is expected to be a novel local treatment for hepatocellular carcinoma (HCC), however, a long-term follow-up using dynamic computed tomography and magnetic resonance imaging is required to determine the effect of treatment in a number of the affected patients. Therefore, there is a requirement to evalu...

journal_title：Oncology letters

authors： Shiozawa K,Watanabe M,Ikehara T,Kobayashi K,Ochi Y,Suzuki Y,Fuchinoue K,Yoneda M,Kenmochi T,Okubo Y,Mori T,Makino H,Tsukamoto N,Igarashi Y,Sumino Y

更新日期：2016-01-01 00:00:00

abstract：:Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferat...

journal_title：Oncology letters

authors： Li Z,Wu J,Wu C,Jiang J,Zheng X,Xu B,Li M

更新日期：2012-10-01 00:00:00

abstract：:The clinical efficiency of bone transport distraction osteogenesis in the reconstruction of large tibial defects following resection of osteosarcoma remains unclear. The current study presents two cases of large tibial defects treated with bone transport distraction using an Orthofix external fixator. Case 1 was a 29-...

journal_title：Oncology letters

authors： Yang Z,Jin L,Tao H,Yang D

更新日期：2016-08-01 00:00:00

abstract：:The aim of the present study was to develop a water-soluble biomarker for the detection of breast cancer using quantum dots (QDs) conjugated to Ki-67, a nuclear protein associated with the cell cycle. Ki-67 is also a marker of cell proliferation, with expression levels categorizing good and poor prognosis in invasive ...

journal_title：Oncology letters

authors： Sun G,Xing W,Xing R,Cong L,Tong S,Yu S

更新日期：2018-02-01 00:00:00

abstract：:Extranodal natural killer/T-cell lymphoma (ENKL) is marked by a profound cellular immune deficiency that may influence the capacity of T cells to extract an efficient antitumor immune response. It has been confirmed that the B7-CD28 pathway may promote tumor immune evasion by providing a negative regulatory signal. Th...

journal_title：Oncology letters

authors： Han L,Liu F,Li R,Li Z,Chen X,Zhou Z,Zhang X,Hu T,Zhang Y,Young K,Sun S,Wen J,Zhang M

更新日期：2014-10-01 00:00:00

abstract：:An alteration in the mitochondrial DNA (mtDNA) copy number has been detected in numerous human cancers. However, certain changes in the mtDNA copy number that occur during the initiation and progression of gastric cancer remain undetected. In the present study, using quantitative PCR analysis, the quantitative changes...

journal_title：Oncology letters

authors： Wen SL,Zhang F,Feng S

更新日期：2013-10-01 00:00:00

abstract：:Colorectal carcinoma (CRC) is a common tumor of the digestive system with poor prognosis. Studies have shown that aberrant microRNA (miRNA) expression can affect CRC progression by regulating target genes. In the present study, we investigated the functional roles and potential mechanisms of miR-331-3p in CRC. The exp...

journal_title：Oncology letters

authors： Zhang H,Wang R,Wang M

更新日期：2019-12-01 00:00:00

abstract：:N6-methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m6A during B-cell development and B-cell tumorigenesis remains poorly understood. By analy...

journal_title：Oncology letters

authors： Zhang W,He X,Hu J,Yang P,Liu C,Wang J,An R,Zhen J,Pang M,Hu K,Ke X,Zhang X,Jing H

更新日期：2019-10-01 00:00:00

abstract：:Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...

journal_title：Oncology letters

authors： Lu X,Cui J,Fu M,Wang W

更新日期：2016-07-01 00:00:00

abstract：:The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-assoc...

journal_title：Oncology letters

authors： Cui L,Song J,Wu L,Cheng L,Chen A,Wang Y,Huang Y,Huang L

更新日期：2017-01-01 00:00:00

abstract：:The molecular profile of low-grade mucoepidermoid carcinomas remains to be clarified. In the present study, matrix metalloproteinase (MMP) expression was compared in low-grade mucoepidermoid carcinoma (MEC) and typical lung cancer. The expression of MMP-2, MMP-7 and MMP-9 was detected by immunohistochemistry in a coho...

journal_title：Oncology letters

authors： Fan J,Wu FY,Wang L,Jiang GN,Gao W

更新日期：2011-11-01 00:00:00

abstract：:Serine/threonine kinase 39 (STK39) is associated with hypertension, autism, Parkinson's disease and various types of cancer in recent years. This study investigated STK39 expression and possible roles in osteosarcoma using qPCR and western blot analysis. Compared to normal bone tissues, the mRNA and protein expression...

journal_title：Oncology letters

authors： Huang T,Zhou Y,Cao Y,Tao J,Zhou ZH,Hang DH

更新日期：2017-10-01 00:00:00

abstract：:Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS-TICs) were isolated and enriched from the osteosarcoma U2OS and MG-63 cell lines using sphere formation ass...

journal_title：Oncology letters

authors： Lee YH,Yang HW,Yang LC,Lu MY,Tsai LL,Yang SF,Huang YF,Chou MY,Yu CC,Hu FW

更新日期：2017-07-01 00:00:00

abstract：:Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocytes. Data regarding the association between genetic defects and the de...

journal_title：Oncology letters

authors： Chen X,Zhang Y,Wang F,Wang M,Teng W,Lin Y,Han X,Jin F,Xu Y,Cao P,Fang J,Zhu P,Tong C,Liu H

更新日期：2017-11-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-associated mortality worldwide and its prognosis is poor. Few effective biomarkers for non-small cell lung cancer (NSCLC) have been translated into the clinical practice aiming to assist in the treatment plan design and prognosis evaluation. The aim of the present study was t...

journal_title：Oncology letters

authors： Hao L,Du B,Xi X

更新日期：2017-08-01 00:00:00

abstract：:Cardiac toxicity has been the major concern when using doxorubicin (DOX) in cancer therapy. Thrombopoietin (TPO) protects cardiac cells from DOX-induced cell damage; however, its molecular mechanism remains exclusive. The anti-autophagic and anti-apoptotic effects of TPO upon DOX treatment were studied in the cardiac ...

journal_title：Oncology letters

authors： Wang H,Wang H,Liang EY,Zhou LX,Dong ZL,Liang P,Weng QF,Yang M

更新日期：2018-01-01 00:00:00