Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells.

abstract：:A previous study reported the decreased expression of long non-coding RNA mortal obligate RNA transcript (lncRNA MORT) in 16 types of cancer, while the functionality of lncRNA MORT in cancer biology remains unknown. Therefore, the present study was conducted to characterize the functionality of lncRNA MORT in prostate...

journal_title：Oncology letters

authors： Shi Z,Guo F,Jia D,Huang J,Chen J,Sun M,Qi F,Liang C

更新日期：2019-10-01 00:00:00

abstract：:Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable p...

journal_title：Oncology letters

authors： Fusco P,Esposito MR,Tonini GP

更新日期：2018-12-01 00:00:00

abstract：:Fluoro-edenite is a natural mineral species initially isolated in Biancavilla, Sicily. The fibres are similar in size and morphology to certain amphibolic asbestos fibres, the inhalation of which may cause chronic inflammation and cancer. Occupational asbestos exposure is known to be associated with pleural and lung d...

journal_title：Oncology letters

authors： Rapisarda V,Ledda C,Ricceri V,Arena F,Musumeci A,Marconi A,Fago L,Bracci M,Santarelli L,Ferrante M

更新日期：2015-05-01 00:00:00

abstract：:Primary Ewing's sarcoma (ES) is rare, especially when it occurs in the spinal canal during middle or old age. The rarity of Ewing's sarcoma breakpoint region 1 fusion-negative ES has been reported in the literature. The present case report describes a 60-year-old Chinese patient who was diagnosed with ES originating f...

journal_title：Oncology letters

authors： Yan D,Zhang J,Zhong D

更新日期：2019-12-01 00:00:00

abstract：:The aim of the present study was to compare intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in irradiation of lung cancer. Plans of 14 patients were compared. The results demonstrated that in peripheral lung cancer, V5 (%) of the lung in partial-arc (PA)-VMAT was decreased comp...

journal_title：Oncology letters

authors： Li Y,Wang J,Tan L,Hui B,Ma X,Yan Y,Xue C,Shi X,Drokow EK,Ren J

更新日期：2018-03-01 00:00:00

abstract：:The aim of the current study was to investigate the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) expression and cell proliferation in the human osteosarcoma cell line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 and 40 μmol/l) for various times (24, 48 and 72...

journal_title：Oncology letters

authors： Liu Z,Li Y,Yang R

更新日期：2012-10-01 00:00:00

abstract：:Ovarian cancer (OC) is the most common and lethal gynecologic malignancy. The pathophysiology of OC tumor development is complex and involves numerous biological pathways. Previous studies suggest that circular (circ)RNAs serve important roles in OC tumor pathology. In the present study, a re-annotation strategy was p...

journal_title：Oncology letters

authors： Guo Q,He Y,Sun L,Kong C,Cheng Y,Zhang G

更新日期：2019-04-01 00:00:00

abstract：:The major aim of the present study was to develop an integrin receptor-targeted liposomal paclitaxel (PTX) to enhance the targeting specificity and therapeutic effect of PTX on hepatocellular carcinoma (HCC) cells. The specific Arg-Gly-Asp (RGD) ligand was conjugated to 1,2-distearoylphosphatidylethanolamine-polyethyl...

journal_title：Oncology letters

authors： Chen L,Liu Y,Wang W,Liu K

更新日期：2015-07-01 00:00:00

abstract：:The aim of the current study was to investigate the antineoplastic activities of 5-aza-2'-deoxycytidine (also known as decitabine; DAC) and all-trans retinoic acid (ATRA), administered alone or in combination, in K562 cells in vitro, as well as the effects on the expression of the tumor suppressor genes, p16INK4a (p16...

journal_title：Oncology letters

authors： Xiang L,Dong W,Wang R,Wei J,Qiu G,Cen J,Chen Z,Zheng X,Hu S,Xie X,Cao X,Gu W

更新日期：2014-07-01 00:00:00

abstract：:Gallbladder cancer (GBC) is a rare but highly aggressive cancer for which no well-accepted prognostic biomarkers have been identified. Thymus cell antigen 1 (Thy1), also known as cluster of differentiation (CD)90, and integrin α6 (ITGA6), also known as CD49f, are important molecules in cancer and putative markers of v...

journal_title：Oncology letters

authors： Zhang DH,Yang ZL,Zhou EX,Miao XY,Zou Q,Li JH,Liang LF,Zeng GX,Chen SL

更新日期：2016-12-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a major subtype of non-small cell lung cancer. Despite significant progress in its diagnosis and treatment, the mortality and morbidity rate of LUAD remains high worldwide. The aim of the present study was to perform a systematic investigation of the tumor microenvironment (TME) and ident...

journal_title：Oncology letters

authors： Yuan J,Yuan B,Zeng L,Liu B,Chen Y,Meng X,Sun R,Lv X,Wang W,Yang S

更新日期：2020-08-01 00:00:00

abstract：:The present study investigated the potential anticancer activity of the bark of Mangifera zeylanica, an endemic plant in Sri Lanka that has been traditionally used for cancer therapy. Cytotoxic and apoptotic effects were investigated in vitro using sulphorodamine assay, acridine orange and ethidium bromide staining, c...

journal_title：Oncology letters

authors： Ediriweera MK,Tennekoon KH,Samarakoon SR,Thabrew I,Dilip DE Silva E

更新日期：2016-02-01 00:00:00

abstract：:Although bulk high-throughput genomic profiling studies have led to a significant increase in the understanding of cancer biology, there is increasing awareness that bulk profiling approaches do not completely elucidate tumor heterogeneity. Single-cell genomic profiling enables the distinction of tumor heterogeneity, ...

journal_title：Oncology letters

authors： Yan B,Hu Y,Ban KHK,Tiang Z,Ng C,Lee J,Tan W,Chiu L,Tan TW,Seah E,Ng CH,Chng WJ,Foo R

更新日期：2017-03-01 00:00:00

abstract：:The present study aimed to examine whether monoclonal immunoglobulin heavy chain (IGH) or T-cell receptor (TCR) gene rearrangement in cell-free DNA (cfDNA) may be used for minimal residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML). Monoclonal IGH and TCR rearrangement in cfDNA were monitor...

journal_title：Oncology letters

authors： Zhong L,Chen J,Huang X,Li Y,Jiang T

更新日期：2018-08-01 00:00:00

abstract：:Angioleiomyoma of the nasal cavity is extremely rare. There are only a small number of studies in the literature that demonstrate that the estrogen receptor (ER) and progesterone receptor (PR) are expressed in angioleiomyoma, and the results from these studies are inconsistent. The present study identified 6 patients ...

journal_title：Oncology letters

authors： Zhu G,Xiao D,Sun P

更新日期：2016-04-01 00:00:00

abstract：:Lung cancer causes over 1.6 million mortalities worldwide annually. MicroRNAs (miRs) are involved in various types of cancer-associated processes. The present study investigated the possible mechanism of miR-107 in the development of lung cancer in order to identify novel targets for clinical treatment. The expression...

journal_title：Oncology letters

authors： Cai P,Li J,Chen G,Peng B,Yu L,Zhao B,Yu Y

更新日期：2020-03-01 00:00:00

abstract：:No evidence currently exists to demonstrate the prognostic value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with unresectable colorectal cancer liver metastases (CRLM). Therefore, we retrospectively investigated the correlation between serum CEA and CA19-9 levels and ove...

journal_title：Oncology letters

authors： Mitsuyama Y,Shiba H,Haruki K,Fujiwara Y,Furukawa K,Iida T,Hayashi T,Ogawa M,Ishida Y,Misawa T,Kashiwagi H,Yanaga K

更新日期：2012-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) metastases in the mediastinum are rare, particularly under the arch of the aorta. The present study describes the case of a 30-year-old male patient who presented with back pain and hoarseness for 2 months due to lymph node metastasis of HCC. The patient had undergone right hepatic lobec...

journal_title：Oncology letters

authors： Xu L,Xue F,Wang B,Yan D,Ding W,Yin J,Yi C,Wang W

更新日期：2016-08-01 00:00:00

abstract：:The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...

journal_title：Oncology letters

authors： Takuwa H,Tsuji W,Yamamoto Y,Shintaku M,Yotsumoto F

更新日期：2018-05-01 00:00:00

abstract：:The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain rea...

journal_title：Oncology letters

authors： Hu Y,Tang Z,Jiang B,Chen J,Fu Z

更新日期：2017-03-01 00:00:00

abstract：:The geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) is known to induce internalisation and degradation of the otherwise internalisation-resistant human epidermal growth factor receptor 2 (HER2) receptor. In the present study, 17-AAG was used to increase internalisation of the HER2-specific Affi...

journal_title：Oncology letters

authors： Göstring L,Lindegren S,Gedda L

更新日期：2016-10-01 00:00:00

abstract：:Vasculogenic mimicry (VM) formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma (GAC). The present study aimed to investigate the association between signal transducer and activator of transcription-3 (STAT3), phosphor-STAT3 (p-STAT3), hypoxia-inducible factor-1α (HIF-1α) and VM f...

journal_title：Oncology letters

authors： Song YY,Sun LD,Liu ML,Liu ZL,Chen F,Zhang YZ,Zheng Y,Zhang JP

更新日期：2014-07-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effects of corosolic acid (CA) in the human lung adenocarcinoma A549 cell line. A549 cells were treated with increasing concentrations of CA, prior to assessing cell viability, migration rate, vascular endothelial growth factor receptor 2 (VEGFR2) kinase activity a...

journal_title：Oncology letters

authors： Li B,Li Y,Wang Q,Li F,Li F

更新日期：2019-06-01 00:00:00

abstract：:A 20-year-old male presented to hospital with blood in the mucus, which had occurred for 6 months, and was diagnosed with nasopharyngeal carcinoma (NPC). Due to passive smoking, the patient developed a constant and violent cough, pain behind the right ear and swelling of the retropharynx. The results of a computed tom...

journal_title：Oncology letters

authors： Liu LH,Yang XF

更新日期：2016-06-01 00:00:00

abstract：:An alteration in the mitochondrial DNA (mtDNA) copy number has been detected in numerous human cancers. However, certain changes in the mtDNA copy number that occur during the initiation and progression of gastric cancer remain undetected. In the present study, using quantitative PCR analysis, the quantitative changes...

journal_title：Oncology letters

authors： Wen SL,Zhang F,Feng S

更新日期：2013-10-01 00:00:00

abstract：:Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...

journal_title：Oncology letters

authors： He J,Li Y,Wang Y,Zhang H,Ge S,Fan X

更新日期：2018-05-01 00:00:00

abstract：:LIM domain containing 2 (LIMD2) is a small LIM-only protein that has been demonstrated to promote tumor progression; however, the expression and function of LIMD2 in non-small cell lung cancer (NSCLC) has not previously been reported. In the present study, reverse transcription-quantitative PCR and western blot analys...

journal_title：Oncology letters

authors： Zhang F,Qin S,Xiao X,Tan Y,Hao P,Xu Y

更新日期：2019-08-01 00:00:00

abstract：:Hypoxia occurs in a wide range of solid tumors, and is strongly associated with radio-resistance of malignant tumors. The aim of the present study was to investigate the effect of endostatin combined with ionizing radiation (IR) on hypoxic conditions. A total of 24 mice bearing SKOV3 ovarian carcinoma were divided int...

journal_title：Oncology letters

authors： Zhang YC,Li XM,Yu Z,Shi XL,Li Y,Wang WL

更新日期：2017-03-01 00:00:00

abstract：:We experienced a rare case of primary intracranial choriocarcinoma treated successfully with synchronous chemotherapy and radiotherapy followed by three consecutive courses of chemotherapy without surgery. A 19-year-old male patient presented with a two-week history of diplopia, headache, nausea and vomiting. Neurolog...

journal_title：Oncology letters

authors： Kim M,Yun J,Hur SM,Moon JJ,Nam JH,Kim SH,Kim HJ,Kim CK,Park SK,Hong DS

更新日期：2012-12-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is an abundant non-histone nuclear protein that functions as a structural protein of chromatin, regulating genome replication and recombination, mRNA transcription and DNA repair. HMGB1 has been implicated in the tumorigenesis of various cancer types, and the upregulation of HMGB1 has...

journal_title：Oncology letters

authors： Jia L,Song H,Fan W,Song Y,Wang G,Li X,He Y,Yao A

更新日期：2020-01-01 00:00:00