Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells.


:The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.


Oncol Lett


Oncology letters


Cui L,Song J,Wu L,Cheng L,Chen A,Wang Y,Huang Y,Huang L




Has Abstract


2017-01-01 00:00:00














  • Pyridine analogues of curcumin exhibit high activity for inhibiting CWR-22Rv1 human prostate cancer cell growth and androgen receptor activation.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhou DY,Zhao SQ,DU ZY,Zheng XI,Zhang K

    更新日期:2016-06-01 00:00:00

  • Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yan F,Ma Y,Sun J,Zhu P

    更新日期:2015-03-01 00:00:00

  • Clinical significance of BRCA1 and BRCA2 mRNA and protein expression in patients with sporadic gastric cancer.

    abstract::The purpose of the present study was to investigate the clinical significance of BRCA1/BRCA2 DNA repair associated (BRCA1/BRCA2) gene expression in patients with sporadic gastric cancer (GC) who had received postoperative adjuvant chemotherapy. Breast cancer type 1 and 2 susceptibility protein (BRCA1 and BRCA2) expres...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Kim HS,Hwang IG,Min HY,Bang YJ,Kim WH

    更新日期:2019-05-01 00:00:00

  • Characterization of topoisomerase II α and minichromosome maintenance protein 2 expression in anal carcinoma.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Scapulatempo-Neto C,Veo C,Fregnani JHTG,Lorenzi A,Mafra A,Melani AGF,Loaiza EAA,Rosa LAR,de Oliveira CM,Levi JE,Longatto-Filho A

    更新日期:2017-03-01 00:00:00

  • Giant cell tumor of the tendon sheath extending around the patellar tendon and invading the knee joint and tibia: A case report.

    abstract::The current report presents the case of a 41-year-old male exhibiting a giant cell tumor of the tendon sheath (GCT-TS) arising from the patellar tendon sheath. Plain radiography and magnetic resonance imaging revealed a well-localized mass that wrapped around the patellar tendon, and extended from the subcutis into th...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Akahane T,Mori N,Yoshida K

    更新日期:2014-12-01 00:00:00

  • Basic fibroblast growth factor as a potential biomarker for diagnosing malignant tumor metastasis in women.

    abstract::Previous studies have reported that basic fibroblast growth factor (bFGF) is associated with tumor genesis, growth and prognosis. The present study was conducted to detect the levels of bFGF expression in women with non-small cell lung cancer (NSCLC), colon cancer, breast cancer and melanoma, and analyze its associati...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Liu M,Xing LQ

    更新日期:2017-08-01 00:00:00

  • High serum Ephrin-B2 levels predict poor prognosis for patients with gastric cancer.

    abstract::Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yue WJ,Liu YP,Li M,Liu CX,Mou SJ,Li QK,Chen ZP

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  • Downregulation of GSK3β by miR-544a to maintain self-renewal ability of lung caner stem cells.

    abstract::In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Mo XM,Li HH,Liu M,Li YT

    更新日期:2014-10-01 00:00:00

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhen YZ,Hu G,Zhao YF,Yan F,Li R,Gao JL,Lin YJ

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  • The heterogenic tumor microenvironment of hepatocellular carcinoma and prognostic analysis based on tumor neo-vessels, macrophages and α-SMA.

    abstract::The present study was performed to quantify tumor neo-vessels, macrophages and fibroblasts in the tumor microenvironment of hepatocellular carcinoma (HCC) and explore the prognostic factors of HCC. The distribution of tumor neo-vessels, macrophages and fibroblasts was quantified by immunohistochemistry and inverted mi...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Fang M,Yuan J,Chen M,Sun Z,Liu L,Cheng G,Ying H,Yang S,Chen M

    更新日期:2018-04-01 00:00:00

  • Fisetin inhibits the proliferation of gastric cancer cells and induces apoptosis through suppression of ERK 1/2 activation.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yan W,Chen S,Zhao Y,Ye X

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  • Application values of 3.0T magnetic resonance diffusion weighted imaging for distinguishing liver malignant tumors and benign lesions.

    abstract::The aim of the present study was to investigate the significance and values of 3.0T diffusion weighted imaging (DWI) to differentially diagnose benign and malignant space-occupying liver lesions. A total of 91 patients with liver space-occupying lesions (145 lesions) were admitted into Zhongnan Hospital of Wuhan Unive...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Li R,Wu G,Wang R

    更新日期:2018-02-01 00:00:00

  • Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and comparison in chronic hepatitis B, liver cirrhosis and liver cancer.

    abstract::Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and its expression in chronic hepatitis B, liver cirrhosis and liver cancer were investigated to evaluated the significance of APOBEC3G. Fifty-eight patients with chronic hepatitis B were selected, including 20 cases of...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Ni L,Li C,Li Y

    更新日期:2020-03-01 00:00:00

  • Neuroendocrine tumors of the gallbladder.

    abstract::A gallbladder neuroendocrine neoplasm (GB-NEN) is a unique heterogeneous neoplasm, originating from neuroendocrine cells and able to secrete peptides as its neurotransmitter. Among all the neuroendocrine tumors (NETs), the GB-NEN prevalence is 0.5%, which accounts for ~2.1% of all gallbladder tumors. The current study...

    journal_title:Oncology letters

    pub_type: 杂志文章,评审


    authors: Niu C,Wang S,Guan Q,Ren X,Ji B,Liu Y

    更新日期:2020-05-01 00:00:00

  • Analysis of imaging characteristics of primary malignant bone tumors in children.

    abstract::The present study aimed to investigate the imaging characteristics of primary malignant bone tumors in children. The imaging results of 34 children with primary malignant bone tumors confirmed by histopathological diagnosis between March 2008 and January 2014 were retrospectively analyzed. In total, 25 patients had os...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Sun Y,Liu X,Pan S,Deng C,Li X,Guo Q

    更新日期:2017-11-01 00:00:00

  • THBS2, a microRNA-744-5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors.

    abstract::The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET) development have not yet been clearly identified. The present study revealed that thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression of THBS2 inhibited the proliferation and migration of pNET cells in vit...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Jiao H,Zeng L,Zhang J,Yang S,Lou W

    更新日期:2020-03-01 00:00:00

  • Effects of HPV16E6 transfection on the biological behavior of Eca109 and Eca9706 cells.

    abstract::The aim of the present study was to investigate the effect of HPV16E6 gene integration on the biological behavior of Eca109 and Eca9706 cells. This was evaluated through positive liposome transfection of HPV16E6 into Eca109 cells and Eca9706 cells. The transfection efficiency was evaluated by calculating the ratio of ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Kang XD,Zheng Y,Chen WG,Cheng M,Zhang D

    更新日期:2018-02-01 00:00:00

  • Thermal ablation in cancer.

    abstract::Radiofrequency ablation (RFA) and cryoablation are alternative forms of therapy used widely in various pathological states, including treatment of carcinogenesis. The reason is that ablation techniques have ability of modulating the immune system. Furthermore, recent studies have applied this form of therapy on tumor ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Liu Y,Cao CS,Yu Y,Si YM

    更新日期:2016-10-01 00:00:00

  • Resveratrol-induced autophagy in human U373 glioma cells.

    abstract::Autophagy is an intracellular protein transport process leading to the degradation of organelles and long-lived proteins in eukaryotes. The down-regulation of autophagy observed in cancer cells has been associated with tumor progression. This study investigated autophagy induced by resveratrol, a natural compound, in ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yamamoto M,Suzuki SO,Himeno M

    更新日期:2010-05-01 00:00:00

  • Signal transducer and activator of transcription 6 as a target in colon cancer therapy.

    abstract::Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduce...

    journal_title:Oncology letters

    pub_type: 杂志文章,评审


    authors: Delgado-Ramirez Y,Colly V,Gonzalez GV,Leon-Cabrera S

    更新日期:2020-07-01 00:00:00

  • Comparison of K-ras mutations in lung, colorectal and gastric cancer.

    abstract::K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Peng N,Zhao X

    更新日期:2014-08-01 00:00:00

  • microRNA-497 overexpression decreases proliferation, migration and invasion of human retinoblastoma cells via targeting vascular endothelial growth factor A.

    abstract::The expression level and roles of microRNA-497 (miR-497) have been frequently reported in previous studies on cancer. However, its expression, function and associated molecular mechanisms in retinoblastoma remain unknown. In the present study, miR-497 expression levels in human retinoblastoma tissues, normal retinal t...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Li J,Zhang Y,Wang X,Zhao R

    更新日期:2017-06-01 00:00:00

  • Serum secreted frizzled-related protein 5 levels differentially decrease in patients with hepatitis B virus-associated chronic infection and hepatocellular carcinoma.

    abstract::The aim of this study was to investigate the characteristics of serum secreted frizzled-related protein 5 (SFRP5), an inhibitor of Wnt signaling, in hepatitis B virus (HBV)-associated infections and hepatocellular carcinoma (HCC) patients. Serum SFRP5 levels were detected in 147 patients with HBV-associated chronic in...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Peng C,Xiao X,Kang B,He S,Li J

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  • BRCA1 regulates insulin-like growth factor 1 receptor levels in ovarian cancer.

    abstract::Breast cancer 1 (BRCA1) and insulin-like growth factor 1 receptor (IGF1R) are critical in ovarian cancer progression. However, the crosstalk between the BRCA1 and IGF1R signaling pathways in ovarian cancer remains largely unknown. The effects of BRCA1 on IGF1R were assessed in 121 serous ovarian cancer patients (BRCA1...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Liu B,Li D,Guan YF

    更新日期:2014-05-01 00:00:00

  • RNA interference-mediated silencing of VEGF and bFGF suppresses endostatin secretion in pancreatic carcinoma cells.

    abstract::Pro-angiogenic factors [vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)] and anti-angiogenic factors (endostatin) play important roles in the progression of pancreatic cancer. The purpose of the present study was to investigate the knockdown effect by either VEGF or bFGF siRNA on th...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yan C,Wang C,Dong M,Liu S,Qi C,Zhao Y

    更新日期:2013-03-01 00:00:00

  • Morphological response contributes to patient selection for rescue liver resection in chemotherapy patients with initially un-resectable colorectal liver metastasis.

    abstract::Morphological response is considered an improved surrogate to the Response Evaluation Criteria in Solid Tumors (RECIST) model with regard to predicting the prognosis for patients with colorectal liver metastases. However, its use as a decision-making tool for surgical intervention has not been examined. The present st...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Suzuki K,Muto Y,Ichida K,Fukui T,Takayama Y,Kakizawa N,Kato T,Hasegawa F,Watanabe F,Kaneda Y,Kikukawa R,Saito M,Tsujinaka S,Futsuhara K,Takata O,Noda H,Miyakura Y,Kiyozaki H,Konishi F,Rikiyama T

    更新日期:2017-08-01 00:00:00

  • Significance of clearing differentiated thyroid carcinoma lymph node by high-frequency color Doppler ultrasonography.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Liu B,Qin H,Zhang B,Shi T,Li C,Liu Y,Song M

    更新日期:2017-01-01 00:00:00

  • Melanotic neuroectodermal tumor of infancy: A case report and review of the surgical treatment.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Cui Y,Mao Z,Liao C

    更新日期:2015-01-01 00:00:00

  • CD133 and Ki-67 expression is associated with gastrointestinal stromal tumor prognosis.

    abstract::CD133+ tumor cells have a greater potential ability for tumorigenesis, proliferation, invasion and metastasis compared with CD133- tumor cells. Ki-67 is associated with cell proliferation in various tumors and has a markedly positive correlation with the prognosis of patients. However, there are a limited number of st...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Lu C,Liu L,Wu X,Xu W

    更新日期:2013-11-01 00:00:00

  • Partial response of liver metastases treated with abiraterone in castration-resistant prostate cancer: A case report.

    abstract::Docetaxel is the current first-line treatment for castration-resistant prostate cancer (CRPC), following failure to respond to maximal androgen blockade (MAB). Patients who fail to respond to docetaxel may receive cabazitaxel or abiraterone; however, there are no recommendations on which of these two agents should be ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Marech I,Vacca A,Sivestris N,Gnoni A,Lorusso V

    更新日期:2013-06-01 00:00:00