Association of plasma VEGF-A, soluble VEGFR-1 and VEGFR-2 levels and clinical response and survival in advanced colorectal cancer patients receiving bevacizumab with modified FOLFOX6.

abstract：:Osteosarcoma (OS) is the third most frequent type of cancer in adolescents and represents >56% of all bone tumors. In addition, metastatic OS frequently demonstrates resistance to conventional chemotherapy; thus, the development of novel therapeutic agents for the treatment of patients with metastatic OS is warranted....

journal_title：Oncology letters

authors： Li X,Yan ML,Yu Q

更新日期：2017-06-01 00:00:00

abstract：:Fluoro-edenite is a natural mineral species initially isolated in Biancavilla, Sicily. The fibres are similar in size and morphology to certain amphibolic asbestos fibres, the inhalation of which may cause chronic inflammation and cancer. Occupational asbestos exposure is known to be associated with pleural and lung d...

journal_title：Oncology letters

authors： Rapisarda V,Ledda C,Ricceri V,Arena F,Musumeci A,Marconi A,Fago L,Bracci M,Santarelli L,Ferrante M

更新日期：2015-05-01 00:00:00

abstract：:Retroperitoneal tumors are lesions with diverse pathological subtypes that originate from the retroperitoneal space; ~40% of these tumors are benign. Due to such lesions often surrounding and associating with vital abdominal blood vessels, a complete surgical resection is difficult. The current study presents a novel ...

journal_title：Oncology letters

authors： Wan Z,Yin T,Chen H,Li D

更新日期：2016-05-01 00:00:00

abstract：:Plumbagin, a naphthoquinone constituent of Plumbago zeylanica L. (Plumbaginaceae) is widely used in traditional Chinese medicine as an antifungal, antibacterial and anti-inflammatory agent. Plumbagin is known to exhibit proapoptotic, antiangiogenic and antimetastatic effects in cancer cells. The transcriptional co-fac...

journal_title：Oncology letters

authors： Xue YL,Meng XQ,Ma LJ,Yuan Z

更新日期：2016-08-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is an abundant non-histone nuclear protein that functions as a structural protein of chromatin, regulating genome replication and recombination, mRNA transcription and DNA repair. HMGB1 has been implicated in the tumorigenesis of various cancer types, and the upregulation of HMGB1 has...

journal_title：Oncology letters

authors： Jia L,Song H,Fan W,Song Y,Wang G,Li X,He Y,Yao A

更新日期：2020-01-01 00:00:00

abstract：:Change in mitochondrial DNA (mtDNA) copy number has been reported in esophageal squamous cell carcinoma (ESCC). However, its prognostic implication in ESCC remains largely unknown. Using reverse transcription-quantitative PCR assay, the mtDNA copy number was assessed in a cohort of patients with ESCC (n=141) and norma...

journal_title：Oncology letters

authors： Li H,Tian Z,Zhang Y,Yang Q,Shi B,Hou P,Ji M

更新日期：2018-01-01 00:00:00

abstract：:In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer. The present study aimed to investigate the effects of RHL on H460 and A549 non-sma...

journal_title：Oncology letters

authors： Zhen YZ,Hu G,Zhao YF,Yan F,Li R,Gao JL,Lin YJ

更新日期：2013-08-01 00:00:00

abstract：:While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...

journal_title：Oncology letters

authors： Svaton M,Fiala O,Krakorova G,Blazek J,Hurdalkova K,Barinova M,Mukensnabl P,Pesek M

更新日期：2020-08-01 00:00:00

abstract：:Cross-talk between competing endogenous RNAs (ceRNAs) play key roles in tumor development. In this study, we performed exon-level expression profiling on 26 glioblastomas (GBMs) and 6 controls to identify long non-coding RNAs (lncRNAs) of GBM initiation and progression using lncRNA-mediated ceRNA network (LMCN). The m...

journal_title：Oncology letters

authors： Zan XY,Li L

更新日期：2019-05-01 00:00:00

abstract：:Bone metastasis resulting from breast cancer in pregnancy is rare. In the literature there are few reports regarding osteolytic lesions in pregnancy and no data on the treatment of such femoral fractures. The present study reports a case of a 29-week primigravida presenting with severe lumbosciatica in the left side, ...

journal_title：Oncology letters

authors： Ciavattini A,Mancioli F,Paci E,Politano R

更新日期：2016-01-01 00:00:00

abstract：:Primary hemangioendotheliomas (HEs) of the spleen are rare, low-grade borderline-malignant vascular tumors. To date, only a few splenic HE cases have been reported in adults. In infants, one 9-year-old male patient has previously been reported, and the patient succumbed to the disease shortly following surgery. Curren...

journal_title：Oncology letters

authors： Wang Z,Zhang L,Zhang B,Mu D,Cui K,Li S

更新日期：2015-01-01 00:00:00

abstract：:Follicular lymphoma (FL) occurs primarily in the gastrointestinal tract, with the stomach being one of the rarest sites. According to the literature, <20 cases of primary gastric FL have been reported, with the number of cases with detailed pathological descriptions being even less. The aim of the present study was to...

journal_title：Oncology letters

authors： Na HY,Kim YA,Lee C,Choe JY,Shin SA,Shim JW,Min SK,Kim HJ,Han JH,Kim JE

更新日期：2018-07-01 00:00:00

abstract：:Scalp angiosarcoma is a rare, extremely aggressive cutaneous malignancy with poor patient prognosis. The present study reviewed the cases of 42 patients who presented scalp angiosarcoma and were treated at the Zhongshan Hospital of Fudan University between January 2002 and December 2013. The clinical characteristics, ...

journal_title：Oncology letters

authors： Zhang Y,Yan Y,Zhu M,Chen C,Lu N,Qi F,Liu J

更新日期：2019-11-01 00:00:00

abstract：:The expression of T-box transcription factor 5 (TBX5) has previously been observed in human cancer. The aim of the present study was to investigate TBX5 expression and its potential clinical significance in gastric cancer (GC). Using reverse transcription-quantitative polymerase chain reaction, the TBX5 mRNA expressio...

journal_title：Oncology letters

authors： Zheng Y,Li YF,Wang W,Chen YM,Wang DD,Zhao JJ,Pan QZ,Jiang SS,Zhang XF,Yuan SQ,Qiu HB,Huang CY,Zhao BW,Zhou ZW,Xia JC

更新日期：2015-10-01 00:00:00

abstract：:The present study aimed to elucidate the role of cluster of differentiation (CD)8+, CD4+, natural killer (NK), and myeloid (CD11b+) cells in the course of the growth and rejection of experimental major histocompatibility complex (MHC) class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice. Stable mouse lines...

journal_title：Oncology letters

authors： Indrová M,Rossowska J,Pajtasz-Piasecka E,Mikyšková R,Richter J,Rosina J,Sedlacek R,Fišerová A

更新日期：2018-03-01 00:00:00

abstract：:The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...

journal_title：Oncology letters

authors： Dong S,Zhang P,Liang S,Wang S,Sun P,Wang Y

更新日期：2013-12-01 00:00:00

abstract：:The present study was performed to quantify tumor neo-vessels, macrophages and fibroblasts in the tumor microenvironment of hepatocellular carcinoma (HCC) and explore the prognostic factors of HCC. The distribution of tumor neo-vessels, macrophages and fibroblasts was quantified by immunohistochemistry and inverted mi...

journal_title：Oncology letters

authors： Fang M,Yuan J,Chen M,Sun Z,Liu L,Cheng G,Ying H,Yang S,Chen M

更新日期：2018-04-01 00:00:00

abstract：:The transcription factor forkhead box O1 (FOXO1) can be inactivated via its phosphorylation, resulting in suppression of apoptosis. Using immunohistochemistry, the expression of a phosphorylated form of FOXO1 was assessed in upper urinary tract urothelial carcinoma (UUTUC) specimens. Overall, phospho-FOXO1 (p-FOXO1) w...

journal_title：Oncology letters

authors： Ide H,Jiang G,Mizushima T,Fujita K,Inoue S,Yamaguchi S,Fushimi H,Nonomura N,Miyamoto H

更新日期：2019-01-01 00:00:00

abstract：:The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distingu...

journal_title：Oncology letters

authors： Chen D,Mei L,Zhou Y,Shen C,Xu H,Niu Z,Che G

更新日期：2015-03-01 00:00:00

abstract：:The aim of the present study was to investigate the significance and values of 3.0T diffusion weighted imaging (DWI) to differentially diagnose benign and malignant space-occupying liver lesions. A total of 91 patients with liver space-occupying lesions (145 lesions) were admitted into Zhongnan Hospital of Wuhan Unive...

journal_title：Oncology letters

authors： Li R,Wu G,Wang R

更新日期：2018-02-01 00:00:00

abstract：:The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The searc...

journal_title：Oncology letters

authors： Higashiura Y,Kajihara H,Shigetomi H,Kobayashi H

更新日期：2012-07-01 00:00:00

abstract：:Keratocystic odontogenic tumors (KCOTs) and ameloblastomas are benign odontogenic tumors that primarily occur in the molar region of the mandible. However, it is uncommon for these tumors to arise simultaneously in a patient's jaw. The present study reported the diagnostic process and features of a rare case of the si...

journal_title：Oncology letters

authors： Gamoh S,Akiyama H,Tominaga K,Nakajima M,Kakudo K,Tanaka A,Shimizutani K

更新日期：2015-08-01 00:00:00

abstract：:Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the dia...

journal_title：Oncology letters

authors： Jaœkiewicz K,Iżycka-Œwieszewska E,Janiak M,Lysiak-Szydłowska W,Adrych K,Reinartz J,Jankun J,Skrzypczak-Jankun E

更新日期：2010-09-01 00:00:00

abstract：:Although bulk high-throughput genomic profiling studies have led to a significant increase in the understanding of cancer biology, there is increasing awareness that bulk profiling approaches do not completely elucidate tumor heterogeneity. Single-cell genomic profiling enables the distinction of tumor heterogeneity, ...

journal_title：Oncology letters

authors： Yan B,Hu Y,Ban KHK,Tiang Z,Ng C,Lee J,Tan W,Chiu L,Tan TW,Seah E,Ng CH,Chng WJ,Foo R

更新日期：2017-03-01 00:00:00

abstract：:The aim of the present study was to investigate the underlying molecular mechanisms of the potent cell cycle inhibition and apoptotic effect of luteolin on LoVo human colon cancer cells. In the present study, Cell Counting kit-8 assay revealed that luteolin exerted notable cytotoxicity on LoVo cells in a dose- and tim...

journal_title：Oncology letters

authors： Chen Z,Zhang B,Gao F,Shi R

更新日期：2018-02-01 00:00:00

abstract：:Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thy...

journal_title：Oncology letters

authors： Ditsch N,Mayr D,Lenhard M,Strauss C,Vodermaier A,Gallwas J,Stoeckl D,Graeser M,Weissenbacher T,Friese K,Jeschke U

更新日期：2012-10-01 00:00:00

abstract：:Human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV oncogenesis. These E6 and E7 gene products play a central role in the induction of malignant transformation by interacting with several cellular regulatory proteins such as p16(INK4a), p53 and nuclear factor κB (NF-κB). In the present stud...

journal_title：Oncology letters

authors： Senba M,Mori N,Fujita S,Jutavijittum P,Yousukh A,Toriyama K,Wada A

更新日期：2010-07-01 00:00:00

abstract：:Lung cancer is one of the most common cancers, which is the leading cause of cancer-related death among various cancers worldwide. Flavokawain A (FKA), a chalcone found in the kava plant, exerts potent anticancer activity. However, the activity and mechanisms of FKA in inhibiting the viability of paclitaxel (PTX)-resi...

journal_title：Oncology letters

authors： Li J,Zheng L,Yan M,Wu J,Liu Y,Tian X,Jiang W,Zhang L,Wang R

更新日期：2020-01-01 00:00:00

abstract：:MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...

journal_title：Oncology letters

authors： Hou L,Luo P,Ma Y,Jia C,Yu F,Lv Z,Wu C,Fu D

更新日期：2017-10-01 00:00:00

abstract：:Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS-TICs) were isolated and enriched from the osteosarcoma U2OS and MG-63 cell lines using sphere formation ass...

journal_title：Oncology letters

authors： Lee YH,Yang HW,Yang LC,Lu MY,Tsai LL,Yang SF,Huang YF,Chou MY,Yu CC,Hu FW

更新日期：2017-07-01 00:00:00