Safety and efficacy of radiation and chemoradiation in patients over 70 years old with inoperable esophageal squamous cell carcinoma.

abstract：:Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and its expression in chronic hepatitis B, liver cirrhosis and liver cancer were investigated to evaluated the significance of APOBEC3G. Fifty-eight patients with chronic hepatitis B were selected, including 20 cases of...

journal_title：Oncology letters

authors： Ni L,Li C,Li Y

更新日期：2020-03-01 00:00:00

abstract：:The aim of the current study was to investigate the potential role of microRNA-183-5p (miR-183-5p) in the proliferation, invasion and metastasis of pancreatic cancer, and to identify promising target genes of oncogenic miR-183-5p. Western blotting and quantitative polymerase chain reaction (qPCR) were used to investig...

journal_title：Oncology letters

authors： Miao F,Zhu J,Chen Y,Tang N,Wang X,Li X

更新日期：2016-01-01 00:00:00

abstract：:Aberrant expression of Ras homolog enriched in brain (RHEB) has been observed in a variety of cancer tissues and is closely associated with clinicopathological features. However, the expression profile of RHEB in patients with hepatocellular carcinoma (HCC) and its clinical signature with underlying mechanisms have no...

journal_title：Oncology letters

authors： Liu F,Pan Z,Zhang J,Ni J,Wang C,Wang Z,Gu F,Dong W,Zhou W,Liu H

更新日期：2018-03-01 00:00:00

abstract：:The expression levels of cyclooxygenase (COX)-2 and the prostaglandin E2 (PGE2) content have been associated with poor prognosis in patients with colorectal cancer (CRC). There is a strong correlation between COX-2 expression and PGE2 production in tissues from CRC patients, suggesting an important role for COX-2 on t...

journal_title：Oncology letters

authors： Cervantes-Madrid DL,Nagi S,Asting Gustafsson A

更新日期：2017-03-01 00:00:00

abstract：:Myelolipoma is a rare, benign neoplasm composed of mature adipocytes and hematopoietic tissue, mainly occurring in the adrenal glands. The majority of extra-adrenal myelolipomas have been identified in the presacral region and primary mediastinal myelolipoma is very rare. Computed tomography (CT) and magnetic resonanc...

journal_title：Oncology letters

authors： Geng C,Liu N,Yang G,Qi M,Chen W

更新日期：2013-03-01 00:00:00

abstract：:Choroidal melanoma is a rare ocular tumor. The present study reports the case of a 66-year-old male who presented with chronic headache and progressive visual loss. Physical eye examination and combined A- and B-mode ultrasonography detected choroidal melanoma. Due to tumor characteristics the eye was enucleated resto...

journal_title：Oncology letters

authors： Terzidou C,Trivli A,Dalianis G,Apessou D,Spandidos DA,Goulielmos GN

更新日期：2018-07-01 00:00:00

abstract：:In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...

journal_title：Oncology letters

authors： Mo XM,Li HH,Liu M,Li YT

更新日期：2014-10-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) has been implicated in various types of human cancer. However, the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in gastric cancer remains unclear. In the present study, MALAT1 expression was significantly upregulated in gastric tumors compared with adjacen...

journal_title：Oncology letters

authors： Zhu K,Ren Q,Zhao Y

更新日期：2019-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading digestive malignancies, with a high metastasis and recurrence. The development and rapid progression of HCC involves numerous complex molecular and cellular events. Therefore, developing effective methods for the prevention and treatment of HCC requires an improved ...

journal_title：Oncology letters

authors： Xiao W,Zhao W,Li L,Wu Q,Zhu L,Zhang Q,Dai W,Wang Y,Zhang B

更新日期：2017-08-01 00:00:00

abstract：:The epidemiology and clinical outcome of gastrointestinal mucinous adenocarcinoma (MA) are not well illustrated. The present study aimed to explore the evolving epidemiology and prognostic factors that affect the survival of patients with MA in the gastrointestinal tract. A retrospective and population-based study was...

journal_title：Oncology letters

authors： Zong Z,Luo Y,Ying H,Wang A,Li H,Yi C

更新日期：2018-11-01 00:00:00

abstract：:Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresect...

journal_title：Oncology letters

authors： Sun H,Hu P,Du J,Wang X

更新日期：2018-03-01 00:00:00

abstract：:Preeclampsia (PE) is characterized by gestational hypertension and proteinuria, and is a leading cause of maternal death and perinatal morbidity globally. Although the exact cause of PE remains unclear, several studies have suggested a role for abnormal expression of multiple genes. The aim of the present study was to...

journal_title：Oncology letters

authors： Xu Z,Wu C,Liu Y,Wang N,Gao S,Qiu S,Wang Z,Ding J,Zhang L,Wang H,Wu W,Wan B,Yu J,Fang J,Yang P,Shao Q

更新日期：2020-08-01 00:00:00

abstract：:Poly(ADP-Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma and prostate cancer. The expression and function of PARP9 in human breast cancer remains unknown. In the present study, it was demonstrated that PARP9 is frequently overexpressed in human br...

journal_title：Oncology letters

authors： Tang X,Zhang H,Long Y,Hua H,Jiang Y,Jing J

更新日期：2018-09-01 00:00:00

abstract：:Transcription factors encoded by HOX genes are vital in the determination of cell fate and identity during embryonic development. In certain malignancies, HOX genes also behave as oncogenes. The present study demonstrated suppression of the invasive tendency of glioblastoma multiforme U-118 and U-138 cells by the intr...

journal_title：Oncology letters

authors： Guo YB,Shao YM,Chen J,Xu SB,Zhang XD,Wang MR,Liu HY

更新日期：2016-01-01 00:00:00

abstract：:Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a nove...

journal_title：Oncology letters

authors： Ma R,Zhang G,Wang H,Lv H,Fang F,Kang X

更新日期：2012-12-01 00:00:00

abstract：:The clinical resistance of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has been linked to EGFR T790M resistance mutations or MET amplifications. Additional mechanisms underlying EGFR-TKI drug resistance remain unclear. The present study demonstrated t...

journal_title：Oncology letters

authors： Zhai Y,Zhang Y,Nan K,Liang X

更新日期：2017-05-01 00:00:00

abstract：:Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by a genome-wide search for differentially expressed genes in human colon cancer tissues, metastases and normal tissues. MACC1 exerts an important role in colon cancer metastasis through upregulation of the c-Met proto-oncogene. T...

journal_title：Oncology letters

authors： Li H,Zhang H,Zhao S,Shi Y,Yao J,Zhang Y,Guo H,Liu X

更新日期：2015-05-01 00:00:00

abstract：:Hypoxic microenvironments and angiogenesis have been a focus of tumor research in previous years. The aim of the the present study was to create a hypoxic model and observe the effect of hypoxia on the expression of hypoxia inducible factor-1α (HIF-1α), insulin-like growth factor I (IGF-1) and vascular endothelial gro...

journal_title：Oncology letters

authors： Liu Q,Xu Z,Mao S,Chen W,Zeng R,Zhou S,Liu J

更新日期：2015-03-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the major causes of cancer-associated mortality worldwide. Wnt family member 10A (Wnt10a) is an oncogene associated with the carcinogenesis and progression of renal cell carcinoma, and is strongly expressed in the CRC cell line SW480. However, the role of Wnt10a in CRC has been rarely...

journal_title：Oncology letters

authors： Li J,Zhang Z,Wang L,Zhang Y

更新日期：2019-04-01 00:00:00

abstract：:The autosomal dominant hereditary disorder von Hippel-Lindau (VHL) disease is caused by a germline mutation in the VHL gene. The symptoms of VHL include hemangioblastoma of the central nervous system, retinal angiomas, visceral tumors and multiple visceral cysts. However, advanced renal cell carcinoma (RCC) occurs in ...

journal_title：Oncology letters

authors： Zhang L,Xu B,Wang Y,Liu C,Lu K,Huang Y,Liu N,Zhang X,Chen S,Chen M

更新日期：2015-08-01 00:00:00

abstract：:The recent successful use of the immune checkpoint inhibitors (CPIs) anti-programmed death receptor-1 (PD-1)/PD-1 ligand 1 in clinical trials indicates their crucial role in obtaining an effective cancer immune therapy. These CPIs have been identified to have an effective therapeutic response, particularly in tumors w...

journal_title：Oncology letters

authors： Cai LL,Wang J

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...

journal_title：Oncology letters

authors： Wan S,Zhao H

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to investigate the relationship between the expression of transcription factor forkhead box C2 (FOXC2) and the clinical features of cervical cancer. A total of 66 patients with cervical cancer, 42 patients with cervical intraepithelial neoplasia (CIN) and 25 patients with cervical infl...

journal_title：Oncology letters

authors： Wang J,Yue X

更新日期：2017-12-01 00:00:00

abstract：:The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcription factor 1 (RUNX...

journal_title：Oncology letters

authors： Tanaka K,Oshikawa G,Akiyama H,Ishida S,Nagao T,Yamamoto M,Miura O

更新日期：2017-07-01 00:00:00

abstract：:The majority of giant cell tumors (GCTs) occur in the ends of the long bones. The presence of more than one GCT in the axial skeleton is rare. A GCT is capable of remaining clinically latent following treatment and becoming active a number of years later. We report an extremely rare case of GCT occurring in the axial ...

journal_title：Oncology letters

authors： Park YS,Lee JK,Baek SW,Park CK

更新日期：2011-11-01 00:00:00

abstract：:Recently, there has been progress in the treatment of chronic myeloid leukemia (CML). However, novel therapeutic strategies are required in order to address the emerging problem of imatinib resistance. Histone deacetylase inhibitors (HDACi) and proteasome inhibitors are promising alternatives, and may be amenable to i...

journal_title：Oncology letters

authors： Zhou W,Zhu W,Ma L,Xiao F,Qian W

更新日期：2015-11-01 00:00:00

abstract：:Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...

journal_title：Oncology letters

authors： Liu B,Li LJ,Gong X,Zhang W,Zhang H,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distingu...

journal_title：Oncology letters

authors： Chen D,Mei L,Zhou Y,Shen C,Xu H,Niu Z,Che G

更新日期：2015-03-01 00:00:00

abstract：:The current case-control study was conducted to assess the value of activated fibroblasts with high α-smooth muscle actin (α-SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Cent...

journal_title：Oncology letters

authors： Parikh JG,Kulkarni A,Johns C

更新日期：2014-02-01 00:00:00

abstract：:Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43-year-old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a...

journal_title：Oncology letters

authors： Gong LI,Zhang WD,Mu XR,Han XJ,Yao LI,Zhu SJ,Zhang FQ,Li YH,Zhang W

更新日期：2015-09-01 00:00:00