Abstract:
:Long non-coding RNA (lncRNA) has been implicated in various types of human cancer. However, the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in gastric cancer remains unclear. In the present study, MALAT1 expression was significantly upregulated in gastric tumors compared with adjacent healthy tissue in patients with gastric cancer. Furthermore, MALAT1 plasma expression was higher in patients with gastric cancer compared with healthy controls and was found to have prognostic and diagnostic value independent of patients' lifestyle choices. Cell proliferation assay and Transwell migration and invasion results indicated that the overexpression of MALAT1 resulted in increased proliferation, migration and invasion of gastric cancer cells in vitro, possibly through activation of the phosphoinositide 3-kinase/protein kinase B pathway.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhu K,Ren Q,Zhao Ydoi
10.3892/ol.2019.10253subject
Has Abstractpub_date
2019-06-01 00:00:00pages
5335-5342issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-10253journal_volume
17pub_type
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