Hsp27 regulates epithelial mesenchymal transition, metastasis and proliferation in colorectal carcinoma.

abstract：:Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3',5'-monophosphate- determined signaling pathway intercessors, which are associated with the pathogenesis of neurological disorders and numerous human diseases. To the best of our knowledge, the role of EPAC2 signaling via matrix metall...

journal_title：Oncology letters

authors： Jiang M,Zhuang Y,Zu WC,Jiao L,Richard SA,Zhang S

更新日期：2019-06-01 00:00:00

abstract：:Research on the immunosuppression of cancer cells has attracted much attention in recent years. The present study sought to provide a new strategy for tumor immunotherapy targeting mast cells by studying the mechanisms underlying mast cell function in cancer immunosuppression. Between January 2015 and December 2017, t...

journal_title：Oncology letters

authors： Zhao YB,Yang SH,Shen J,Deng K,Li Q,Wang Y,Cui W,Ye H

更新日期：2020-12-01 00:00:00

abstract：:Cancer stem cell (CSC) properties have been recently proposed to explain tumor carcinogenesis and multidrug resistance in several human cancers, including non-small cell lung cancer (NSCLC). The present study examined the protein expression of three CSC-associated markers, namely ATP binding cassette subfamily B membe...

journal_title：Oncology letters

authors： Zou F,Seike M,Noro R,Kunugi S,Kubota K,Gemma A

更新日期：2017-07-01 00:00:00

abstract：:The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) are currently not well documented, and as the prevalence of SC/ASC is uncommon in gallbladder cancers, a prognostic marker has not yet been found. In the present study, the expression of tumor susceptibility gene (TSG) 101 and pa...

journal_title：Oncology letters

authors： Liu Z,Yang Z,Liu D,Li D,Zou Q,Yuan Y,Li J,Liang L,Chen M,Chen S

更新日期：2014-04-01 00:00:00

abstract：:Gastric cancer is one of the most common malignancies with high cancer-associated mortality rate globally. Hepcidin is the peptide hormone, which is critically important in the regulation of systemic iron homeostasis. Cumulating evidence has reported that the disturbed local expression of hepcidin may serve as a predi...

journal_title：Oncology letters

authors： Zuo E,Lu Y,Yan M,Pan X,Cheng X

更新日期：2018-02-01 00:00:00

abstract：:Extraskeletal myxoid chondrosarcoma (EMC) is a relatively rare but well-defined neoplasm. This report describes two patients, one with EMC of the buttock and one with EMC of the knee. The two cases presented with large lobed masses and long T1 and T2 signaling identified by magnetic resonance imaging (MRI). An enhance...

journal_title：Oncology letters

authors： Zhang GW,Wang AJ,Zhang GH,Zhao SN,Qu JL

更新日期：2014-04-01 00:00:00

abstract：:Cancer is a histologically and genetically heterogeneous population of tumor cells that exhibits distinct molecular profiles determined by epigenetic alterations. P-element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) have been previously demonstrated to be involved in epigenetic r...

journal_title：Oncology letters

authors： Litwin M,Szczepańska-Buda A,Piotrowska A,Dzięgiel P,Witkiewicz W

更新日期：2017-05-01 00:00:00

abstract：:In order to assess the metastatic potential of residual hepatocellular carcinoma (HCC) following insufficient radiofrequency ablation (RFA) and to improve the current animal model, an insufficient RFA orthotopic nude mouse model of HCC was developed in the present study. A human HCC orthotopic nude mouse model was est...

journal_title：Oncology letters

authors： Zhang N,Zhu H,Dong YH,Wang L

更新日期：2019-09-01 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4 (TLR4) are involved in numerous mechanisms of cancer biology, including cell proliferation and survival; however the interaction of the two factors under hypoxic conditions remains unclear. The present study investigated the in vitro mechanism that results ...

journal_title：Oncology letters

authors： Zhang X,Li S,Li M,Huang H,Li J,Zhou C

更新日期：2016-08-01 00:00:00

abstract：:The ATP-binding cassette subfamily B member 1 (ABCB1) is a transporter that mediates multidrug resistance (MDR) against chemotherapy, which leads to decreased patient survival. To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) P...

journal_title：Oncology letters

authors： Wei S,Chen W,Hu L,Pan J,Wang X

更新日期：2018-11-01 00:00:00

abstract：:The aim of the present study was to investigate the underlying molecular mechanisms of the potent cell cycle inhibition and apoptotic effect of luteolin on LoVo human colon cancer cells. In the present study, Cell Counting kit-8 assay revealed that luteolin exerted notable cytotoxicity on LoVo cells in a dose- and tim...

journal_title：Oncology letters

authors： Chen Z,Zhang B,Gao F,Shi R

更新日期：2018-02-01 00:00:00

abstract：:Giant cell tumor (GCT) of the bone is a relatively common primary bone tumor. Treatment with simple curettage often results in a high local recurrence rate. Tumor resection and reconstruction with prosthesis or an allograft has a low rate of local recurrence; however, the patient's native joint function becomes signif...

journal_title：Oncology letters

authors： Yu X,Xu M,Xu S,Su Q

更新日期：2013-02-01 00:00:00

abstract：:Rare types of cancer are often not effectively treated by approaches such as chemotherapy and radio-therapy, although their side-effects persist. Immunotherapy has been gaining attention worldwide with growing examples of its anticancer activity demonstrated in vivo. This case report describes a 35-year-old male who s...

journal_title：Oncology letters

authors： Ratnavelu K,Subramani B,Pullai CR,Krishnan K,Sugadan SD,Rao MS,Veerakumarasivam A,Deng X,Hiroshi T

更新日期：2013-05-01 00:00:00

abstract：:The aim of the present study was to use imaging to retrospectively analyze the recurrent sites and patterns of spread of early cervical cancer following radical surgery. A total of 86 patients with cervical cancer (stage IB or IIA) showed postoperative pelvic recurrences and distant metastases. Based on positron emiss...

journal_title：Oncology letters

authors： Cheng S,Li Y,Zhang M,Tong T

更新日期：2018-09-01 00:00:00

abstract：:Increasing evidence has suggested that microRNAs (miRNAs; miRs) are extensively involved in the progression of chondrosarcoma (CHS). However, few studies have investigated the functional role of miR-525 in CHS tissues and cells. In the present study, it was discovered that miR-525 levels were decreased in CHS tissues ...

journal_title：Oncology letters

authors： Liu B,Song X,Yan Z,Yang H,Shi Y,Wu J

更新日期：2019-01-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) exhibits the highest mortality among all urological malignancies. The investigation of the potential disease progression markers can improve ccRCC diagnosis and treatment. Gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) is involved in carcinogenesis and c...

journal_title：Oncology letters

authors： Yan N,Feng X,Jiang S,Sun W,Sun MZ,Liu S

更新日期：2020-06-01 00:00:00

abstract：:Morphological response is considered an improved surrogate to the Response Evaluation Criteria in Solid Tumors (RECIST) model with regard to predicting the prognosis for patients with colorectal liver metastases. However, its use as a decision-making tool for surgical intervention has not been examined. The present st...

journal_title：Oncology letters

authors： Suzuki K,Muto Y,Ichida K,Fukui T,Takayama Y,Kakizawa N,Kato T,Hasegawa F,Watanabe F,Kaneda Y,Kikukawa R,Saito M,Tsujinaka S,Futsuhara K,Takata O,Noda H,Miyakura Y,Kiyozaki H,Konishi F,Rikiyama T

更新日期：2017-08-01 00:00:00

abstract：:Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrupted and cell cycle ...

journal_title：Oncology letters

authors： Nakamura Y,Ishigaki Y

更新日期：2014-12-01 00:00:00

abstract：:Brain-specific metastasis is one of the primary causes of recurrence following complete resection of non-small cell lung cancer (NSCLC) and the underlying mechanism remains unclear. The present study was designed to investigate the correlation between C-X-C chemokine receptor type 4 (CXCR4) expression and brain-specif...

journal_title：Oncology letters

authors： Wang L,Wang Z,Liu X,Liu F

更新日期：2014-06-01 00:00:00

abstract：:The histological subtype of non-small-cell lung cancer (NSCLC) is a significant factor when selecting treatment strategies. However, cases are occasionally encountered that are diagnosed as 'not otherwise specified' (NOS) prior to surgery, due to an uncertain histological subtype. The present study investigated the pr...

journal_title：Oncology letters

authors： Tane S,Nishio W,Ogawa H,Hokka D,Tane K,Tanaka Y,Tauchi S,Uchino K,Sakai Y,Ohbayashi C,Yoshimura M,Maniwa Y

更新日期：2014-09-01 00:00:00

abstract：:Differences in inflammatory factors IL-6 and miR-1271 expression levels between elderly and young gastric cancer patients were investigated. A retrospective analysis of 146 cases of gastric cancer tissue and normal fresh tissue specimens diagnosed in The First Hospital of Lanzhou University from January 2013 to Januar...

journal_title：Oncology letters

authors： Liu S,Zhou Y,Zhao L,Wang J,Ji R,Wang Y,Wu J,Yan X

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to investigate the expression and roles of deleted in pancreatic carcinoma locus 4 (DPC4) and vascular endothelial growth factor (VEGF) in the development of cervical carcinoma. A total of 115 patients aged between 25 and 60 years were involved, including 19 cervical inflammation, 35 cervical i...

journal_title：Oncology letters

authors： A Y,Li Y,Zhao S

更新日期：2018-02-01 00:00:00

abstract：:The present study aimed to assess the feasibility, safety and efficiency of ultrasound-guided percutaneous microwave ablation (MWA) on liver metastases from colon or rectal cancer. Patients who received MWA therapy for liver metastases from colon or rectal cancer between June 2009 and May 2012 were enrolled in the stu...

journal_title：Oncology letters

authors： Wang J,Liang P,Yu J,Yu MA,Liu F,Cheng Z,Yu X

更新日期：2014-07-01 00:00:00

abstract：:Resistance to apoptosis is an characteristic of cancer cells that serves a critical function in tumor development and represents a target for antitumor therapy. Isoimperatorin (ISOIM), a coumarin compound, exhibits antitumor functions in multiple types of tumor cells. However, its antitumor effects and molecular mecha...

journal_title：Oncology letters

authors： Yang HB,Gao HR,Ren YJ,Fang FX,Tian HT,Gao ZJ,Song W,Huang SM,Zhao AF

更新日期：2018-05-01 00:00:00

abstract：:The aim of the present study was to develop a water-soluble biomarker for the detection of breast cancer using quantum dots (QDs) conjugated to Ki-67, a nuclear protein associated with the cell cycle. Ki-67 is also a marker of cell proliferation, with expression levels categorizing good and poor prognosis in invasive ...

journal_title：Oncology letters

authors： Sun G,Xing W,Xing R,Cong L,Tong S,Yu S

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to examine the effects of compound Radix Sophorae Flavescentis on the proliferation of esophageal carcinoma TE-8 cells and to elucidate the mechanisms involved. For this purpose, we incubated TE-8 cells in medium containing various concentrations (0, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4 and 0.8...

journal_title：Oncology letters

authors： Yang X,Cai W,Yang Q,Lu Z,Li J,Yu J

更新日期：2015-10-01 00:00:00

abstract：:Carbohydrate sulfotransferase 15 (CHST15) synthesizes matrix proteoglycan that regulates various pathogenic mediators and contributes to tissue remodeling and fibrosis during injury. CHST15 has been reported to promote tumor growth and invasion in various types of cancer. Our previous study reported the safety and eff...

journal_title：Oncology letters

authors： Matsuda Y,Fujii Y,Matsukawa M,Ishiwata T,Nishimura M,Arai T

更新日期：2019-10-01 00:00:00

abstract：:The aims of this study were to determine the methylation and expression status of secreted Frizzled-related protein 1 (SFRP1) in bladder cancer, to explore the mechanisms involved and to study the role of SFRP1 in the pathogenesis of bladder cancer. SFRP1 mRNA was detected by reverse transcription PCR (RT-PCR). The DN...

journal_title：Oncology letters

authors： Wang X,Wang H,Bu R,Fei X,Zhao C,Song Y

更新日期：2012-08-01 00:00:00

abstract：:Glucagonoma is an extremely rare pancreatic α-islet cell tumor and is often accompanied by certain clinical symptoms including necrotizing migratory erythema (NME), diabetes, weight loss and anemia. The objectives of the current review were to discern the clinical features, diagnosis, treatment and prognosis of glucag...

journal_title：Oncology letters

authors： Song X,Zheng S,Yang G,Xiong G,Cao Z,Feng M,Zhang T,Zhao Y

更新日期：2018-03-01 00:00:00

abstract：:Cervical cancer is the third most common malignancy worldwide, accounting for 250,000 mortalities annually. Notch1, an important regulator of cell-fate decisions and differentiation, has been found to be overexpressed in certain types of cancer. However, the role of Notch1 in cervical carcinogenesis remains unclear. I...

journal_title：Oncology letters

authors： Sun Y,Zhang R,Zhou S,Ji Y

更新日期：2015-06-01 00:00:00