High-level C-X-C chemokine receptor type 4 expression correlates with brain-specific metastasis following complete resection of non-small cell lung cancer.

abstract：:The present study aimed to identify the regulatory mechanisms associated with the metastasis of prostate cancer (PC). The microRNA (miRNA/miR) microarray dataset GSE21036 and gene transcript dataset GSE21034 were downloaded from the Gene Expression Omnibus database. Following pre-processing, differentially expressed m...

journal_title：Oncology letters

authors： Guo K,Liang Z,Li F,Wang H

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effects of corosolic acid (CA) in the human lung adenocarcinoma A549 cell line. A549 cells were treated with increasing concentrations of CA, prior to assessing cell viability, migration rate, vascular endothelial growth factor receptor 2 (VEGFR2) kinase activity a...

journal_title：Oncology letters

authors： Li B,Li Y,Wang Q,Li F,Li F

更新日期：2019-06-01 00:00:00

abstract：:Expression level of miR-181c in neuroblastoma children and its effect on proliferation of neuroblastoma M17 cells were investigated. Fifty-seven neuroblastoma patients admitted to Weifang People's Hospital from January 2013 to December 2017 were selected and their cancer tissues and normal adjacent tissues were obtain...

journal_title：Oncology letters

authors： Xu X,Wu J,Ren G,Hu Q

更新日期：2019-09-01 00:00:00

abstract：:Long non-coding (lnc)RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1), an lncRNA antisense transcript adjacent to the heart and neural crest derivatives expressed 2 protein (HAND2), inhibits the development of several types of cancer; however, its role in melanoma is currently unknown. In...

journal_title：Oncology letters

authors： Liu P,Du R,Yu X

更新日期：2019-08-01 00:00:00

abstract：:A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human pap...

journal_title：Oncology letters

authors： Gao H,Huang Z,Shi C,Li H

更新日期：2015-02-01 00:00:00

abstract：:K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...

journal_title：Oncology letters

authors： Peng N,Zhao X

更新日期：2014-08-01 00:00:00

abstract：:Ulcerative colitis (UC) is thought to be associated with precancerous lesions that can ultimately lead to colon cancer. Therefore, diagnostic markers for colorectal dysplasia and cancer are urgently needed for patients with UC. Stathmin 1 (STMN1) is a novel cancer biomarker that is also a novel target for treatment in...

journal_title：Oncology letters

authors： Osone K,Yokobori T,Katayama C,Takahashi R,Kato R,Tatsuski H,Takada T,Yajima R,Motegi Y,Ogawa H,Fujii T,Ojima H,Nakamura J,Yao T,Shirabe K,Kuwano H

更新日期：2019-11-01 00:00:00

abstract：:Aquaporin 1 (AQP1), which functions as a water transporter, is associated with cancer cell proliferation, invasion, metastasis and angiogenesis in numerous types of solid cancer, including colorectal cancer (CRC). The focus of the present study was to address the potential clinical use of AQP1 expression in CRC as a p...

journal_title：Oncology letters

authors： Imaizumi H,Ishibashi K,Takenoshita S,Ishida H

更新日期：2018-05-01 00:00:00

abstract：:Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase ch...

journal_title：Oncology letters

authors： Togashi Y,Masago K,Ito Y,Sakamori Y,Okuda C,Fukuhara A,Nagai H,Kim YH,Mishima M

更新日期：2013-02-01 00:00:00

abstract：:Pancreatic cancer is a deadly disease that is frequently associated with mortality at the time of diagnosis due to rapid metastasis, which makes it unsuitable for operative surgery, and resistant to chemotherapy and radiation therapy. Isochorismatase domain-containing protein 1 (ISOC1) has putative isochorismatase act...

journal_title：Oncology letters

authors： Cheng L,Zhao Y,Tang M,Luo Z,Wang X

更新日期：2019-05-01 00:00:00

abstract：:Interleukin-8 (IL-8), an important inflammatory factor, is induced by Helicobacter pylori infection and is clearly associated with gastric cancer. IL-8 levels have been revealed to correlate significantly with the adhesion, migration and invasion of gastric cancer cells. However, whether IL-8 influences cell prolifera...

journal_title：Oncology letters

authors： Shi J,Wei PK

更新日期：2014-12-01 00:00:00

abstract：:A standard treatment for patients with early-stage non-small cell lung cancer (NSCLC) who undergo surgery, and subsequently develop local failure or intrathoracic oligo-recurrence, has not yet been established. The present study aimed to assess the feasibility of stereotactic body radiotherapy (SBRT) for this subgroup...

journal_title：Oncology letters

authors： Aoki S,Yamashita H,Takahashi W,Nawa K,Ota T,Imae T,Ozaki S,Nozawa Y,Nakajima J,Sato M,Anraku M,Nitadori J,Karasaki T,Abe O,Nakagawa K

更新日期：2020-04-01 00:00:00

abstract：:Diagnostic value of magnetic resonance imaging (MRI) and multi-slice spiral CT (MSCT) for different pathological stages of prostate cancer was compared. A total of 112 patients with prostate cancer who underwent surgical pathology in The Affiliated Yantai Yuhuangding Hospital of Qingdao University from February 2014 t...

journal_title：Oncology letters

authors： Sui Y,Li J,Zou Z,Shi Y,Hao C

更新日期：2019-06-01 00:00:00

abstract：:Ovarian cancer (OVAC) remains the most lethal gynecological malignancy; it is ranked fifth among the most common types of cancer that affect women worldwide. Several aspects of the disease, including molecular pathogenesis, epidemiology, histological subtypes, poor prognosis at early stages due to the absence of speci...

journal_title：Oncology letters

authors： Sun W,Fu S

更新日期：2019-09-01 00:00:00

abstract：:Previous studies have demonstrated that nicotinamide N-methyltransferase (NNMT) is aberrantly expressed in a number of tumors. In the present study, it was demonstrated that the gene and protein levels of NNMT were significantly increased in gastric cancer cells. Furthermore, upregulation of NNMT significantly increas...

journal_title：Oncology letters

authors： Liang L,Zeng M,Pan H,Liu H,He Y

更新日期：2018-04-01 00:00:00

abstract：:Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by a genome-wide search for differentially expressed genes in human colon cancer tissues, metastases and normal tissues. MACC1 exerts an important role in colon cancer metastasis through upregulation of the c-Met proto-oncogene. T...

journal_title：Oncology letters

authors： Li H,Zhang H,Zhao S,Shi Y,Yao J,Zhang Y,Guo H,Liu X

更新日期：2015-05-01 00:00:00

abstract：:Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 0...

journal_title：Oncology letters

authors： Li X,Rui B,Cao Y,Gong X,Li H

更新日期：2020-03-01 00:00:00

abstract：:Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-co...

journal_title：Oncology letters

authors： Kochi T,Shimizu M,Ohno T,Baba A,Sumi T,Kubota M,Shirakami Y,Tsurumi H,Tanaka T,Moriwaki H

更新日期：2014-07-01 00:00:00

abstract：:Chemotherapy drugs, including 5-fluorouracil (5-FU), oxaliplatin and docetaxel, are commonly used in the treatment of gastric cancer (GC). Apoptosis-relevant genes may be associated with drug resistance. In the present study, the messenger RNA (mRNA) expression levels of B-cell lymphoma 2 interacting mediator of cell ...

journal_title：Oncology letters

authors： Wu N,Huang Y,Zou Z,Gimenez-Capitan A,Yu L,Hu W,Zhu L,Sun X,Sanchez JJ,Guan W,Liu B,Rosell R,Wei J

更新日期：2017-03-01 00:00:00

abstract：:Phospholipase C (PLC) is a membrane-associated enzyme that regulates several cellular behaviors including cell motility, growth, transformation and differentiation. PLC is involved in cancer migration, invasion and drug resistance. However, the expression status and prognostic role of PLCB4 in acute myeloid leukemia (...

journal_title：Oncology letters

authors： Wu S,Zhang W,Shen D,Lu J,Zhao L

更新日期：2019-12-01 00:00:00

abstract：:Actinomycosis is a chronic disease characterized by slow progression, abscess formation, tissue fibrosis and draining sinuses. Occurrence originating from the nasopharynx is extremely low. The present study described the case of a 46-year-old otherwise healthy female, with no remarkable history of mucosal injury or te...

journal_title：Oncology letters

authors： Lin YH,Hu C,Chuang HW,Lin MY

更新日期：2015-07-01 00:00:00

abstract：:Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients was studied. Colon cancer cases (n=176) admitted to Xiangya Hospital Central South University were selected into the study. They were divided into group A (n=92) and group B (...

journal_title：Oncology letters

authors： Zhao L,Li Y

更新日期：2020-08-01 00:00:00

abstract：:The objective of the present study was to investigate the association between zinc finger protein (ZNF) 689 expression and the clinicopathological features and prognosis of hepatocellular carcinoma (HCC). A total of 102 paired HCC and paired non-cancerous tissues, and 16 normal liver tissues were collected. ZNF689 exp...

journal_title：Oncology letters

authors： Yi PS,Wu B,Deng DW,Zhang GN,Li JS

更新日期：2018-10-01 00:00:00

abstract：:Human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV oncogenesis. These E6 and E7 gene products play a central role in the induction of malignant transformation by interacting with several cellular regulatory proteins such as p16(INK4a), p53 and nuclear factor κB (NF-κB). In the present stud...

journal_title：Oncology letters

authors： Senba M,Mori N,Fujita S,Jutavijittum P,Yousukh A,Toriyama K,Wada A

更新日期：2010-07-01 00:00:00

abstract：:The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). The viability of T24 cells was estimated using a sulforhodamine B assay. Cell morphological changes were examin...

journal_title：Oncology letters

authors： Si L,Yang X,Yan X,Wang Y,Zheng Q

更新日期：2017-07-01 00:00:00

abstract：:Human lactoferrin (hLF) is a multifunctional glycoprotein that inhibits cancer growth. However, the inhibitory effect of this glycoprotein in cervical cancer remains inconclusive. This study investigated the efficacy of hLF on the inhibition of U14 cervical cancer in vivo. Recombinant adenovirus carrying hLF (Ad-hLF) ...

journal_title：Oncology letters

authors： Shi H,Li W

更新日期：2014-03-01 00:00:00

abstract：:Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying mechanisms by whic...

journal_title：Oncology letters

authors： Yang L,Huang M,Tan J,Hou J,He J,Wang F,Cui H,Yi L

更新日期：2017-06-01 00:00:00

abstract：:The aim of this study was to evaluate potential predictive factors in the treatment of limited-disease small cell lung cancer (LD-SCLC). A total of 33 patients with LD-SCLC who underwent definitive chemoradiotherapy at our institute between April 1996 and May 2007 were enrolled in our retrospective study. The relation...

journal_title：Oncology letters

authors： Komatsu T,Oizumi Y,Kunieda E,Tamai Y,Akiba T,Kogawa A

更新日期：2011-09-01 00:00:00

abstract：:Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples w...

journal_title：Oncology letters

authors： Yu B,Liu X,Cao X,Zhang M,Chang H

更新日期：2017-04-01 00:00:00

abstract：:The present study aimed to investigate the imaging characteristics of primary malignant bone tumors in children. The imaging results of 34 children with primary malignant bone tumors confirmed by histopathological diagnosis between March 2008 and January 2014 were retrospectively analyzed. In total, 25 patients had os...

journal_title：Oncology letters

authors： Sun Y,Liu X,Pan S,Deng C,Li X,Guo Q

更新日期：2017-11-01 00:00:00