High BIM mRNA levels are associated with longer survival in advanced gastric cancer.

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in different types of cancer, including gastric cancer. Although altered lncRNAs profiles have been observed in or around gastric cancer tissues, the diagnostic value of circulating lncRNAs in gastric cancer remains unclear. In the present study, a n...

journal_title：Oncology letters

authors： Xian HP,Zhuo ZL,Sun YJ,Liang B,Zhao XT

更新日期：2018-10-01 00:00:00

abstract：:Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non-small cell lung cancer (NSCLC), but its involvement in tumor growth has not fully been elucidated. The present study explored the associations between CD44 expression and clinicopathologi...

journal_title：Oncology letters

authors： Hu B,Ma Y,Yang Y,Zhang L,Han H,Chen J

更新日期：2018-04-01 00:00:00

abstract：:Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27-year-old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient receiv...

journal_title：Oncology letters

authors： Cao J,Zhou Y,Zou F,Ma JA,Hu C

更新日期：2017-03-01 00:00:00

abstract：:The present study aimed to analyze the characteristics of polyethylene glycol (PEG)ylated carboplatin liposomes (PL-CBPs), including size, stability, their release, entrapping and loading efficiencies, and their antitumor and antimetastatic effects on the lymph nodes. The PL-CBPs were prepared using PEG-2000 with the ...

journal_title：Oncology letters

authors： Zhang J,Huang C,Huang H

更新日期：2014-11-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in Western patients, however comprehensive genomic features of CCA in Chinese patients have not been well understood. To explore the specific genom...

journal_title：Oncology letters

authors： Tian W,Hu W,Shi X,Liu P,Ma X,Zhao W,Qu L,Zhang S,Shi W,Liu A,Cao J

更新日期：2020-04-01 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is an autosomal dominant disease involving multiple organs, but there are a limited number of reports on family TSC. In the present report, a case of a 52-year-old female with a familial genetic TSC, associated with bilateral giant renal angiomyolipoma, was described. The mother, secon...

journal_title：Oncology letters

authors： Wang L,Ni D,Zhong L,Wang J

更新日期：2017-12-01 00:00:00

abstract：:Cerebroma, a nervous system tumor located in the cranial cavity, seriously affects health and may even become life-threatening. The aim of the study was to investigate and discuss the expression levels of cluster of differentiation 44 (CD44) and Golgi protein 73 (GP73) in different types of cerebroma tissues and to st...

journal_title：Oncology letters

authors： Yuan Y,Shi L,Wang S

更新日期：2018-04-01 00:00:00

abstract：:TACC3, a member of the transforming acidic coiled-coil protein (TACC) family, is a multifunctional protein that is involved in various biological functions, including proliferation and differentiation of tumor cells, cancer progression and metastasis. The aims of the present study were to examine whether TACC3 express...

journal_title：Oncology letters

authors： Zhao C,He X,Li H,Zhou J,Han X,Wang D,Tian G,Sui F

更新日期：2018-05-01 00:00:00

abstract：:Current endocrine therapies for females with estrogen receptor-positive breast cancer have facilitated substantial improvements in outcomes. The effectiveness of endocrine therapy is limited by either initial de novo resistance or acquired endocrine resistance. Multiple mechanisms responsible for endocrine resistance ...

journal_title：Oncology letters

authors： Zhou J,Teng R,Wang Q,Xu C,Guo J,Yuan C,Shen J,Hu W,Wang L,Xie S

更新日期：2013-08-01 00:00:00

abstract：:Numerous studies have shown that marital status may be a prognostic factor in various malignancies, but little is known about its effect on duodenal adenocarcinoma. The aim of the present study was to determine the association between marital status and survival in patients with duodenal adenocarcinoma. The Surveillan...

journal_title：Oncology letters

authors： Wang N,Bu Q,Liu Q,Yang J,He H,Liu J,Ren X,Lyu J

更新日期：2019-08-01 00:00:00

abstract：:Patients with the luminal B subtype of breast cancer exhibit a poor prognosis, high metastatic risk and high incidence of chemotherapy resistance. Luminal B breast cancer is sub-classified into B1 and B2. The pathophysiological mechanism of luminal B2 breast cancer (LB2BC) progression has yet to be characterized. Ther...

journal_title：Oncology letters

authors： Wang J,Du Q,Li C

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effects of corosolic acid (CA) in the human lung adenocarcinoma A549 cell line. A549 cells were treated with increasing concentrations of CA, prior to assessing cell viability, migration rate, vascular endothelial growth factor receptor 2 (VEGFR2) kinase activity a...

journal_title：Oncology letters

authors： Li B,Li Y,Wang Q,Li F,Li F

更新日期：2019-06-01 00:00:00

abstract：:Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target...

journal_title：Oncology letters

authors： Pan X,Yang X,Zang J,Zhang S,Huang N,Guan X,Zhang J,Wang Z,Li X,Lei X

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, th...

journal_title：Oncology letters

authors： Shan XY,Xu TT,Liu ZL,Hu XF,Zhang YD,Guo SZ,Wang B

更新日期：2017-08-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is the leading cause of cancer-associated mortality in the world. In previous years, almost no significant advancements have been made towards the molecular characterization of NSCLC, which highlights the requirement for novel target genes. Hypoxia inducibl...

journal_title：Oncology letters

authors： Qian J,Bai H,Gao Z,Dong YU,Pei J,Ma M,Han B

更新日期：2016-03-01 00:00:00

abstract：:The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve thi...

journal_title：Oncology letters

authors： Weng W,Zhang P,Ruan J,Zhang Y,Ba D,Tang Y

更新日期：2020-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and remains the third leading cause of cancer-associated mortality. The present study aimed to fully elucidate the pathogenesis of CRC and identify associated genes in tumor development. Microarray GSE44076, GSE41328 and GSE44861 datasets were...

journal_title：Oncology letters

authors： Shen X,Yue M,Meng F,Zhu J,Zhu X,Jiang Y

更新日期：2016-11-01 00:00:00

abstract：:Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B-cell non-Hodgkin lymphoma has been less satisfactory compared with patients with B-cell acute lymphob...

journal_title：Oncology letters

authors： Wang J,Deng Q,Jiang YY,Zhang R,Zhu HB,Meng JX,Li YM

更新日期：2019-11-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cause of cancer-associated mortality worldwide. Currently, 5-fluorouracil (5-FU) remains a widely used chemotherapeutic drug in the treatment of CRC; however, 5-FU resistance during treatment has become a common problem. Livin, a member of the inhibitor of apoptosis pro...

journal_title：Oncology letters

authors： Liu S,Li X,Li Q,Liu H,Shi Y,Zhuo H,Li C,Zhu H

更新日期：2018-05-01 00:00:00

abstract：:In the present study, a low molecular weight polysaccharide, ABP-AW1, isolated from Agaricus blazei Murill was assessed for its potential adjuvant activity. ABP-AW1 is considered to create a 'depot' of antigen at a subcutaneous injection site. ICR mice were immunized with 100 μg ovalbumin (OVA) alone or with 100 μg OV...

journal_title：Oncology letters

authors： Cui L,Sun Y,Xu H,Xu H,Cong H,Liu J

更新日期：2013-10-01 00:00:00

abstract：:Aquaporin 5 (AQP5), a water channel protein, is highly expressed in non-small cell lung cancer (NSCLC) tissues compared with adjacent normal tissues. AQP5 expression in lung cancer tissues is associated with a poor prognosis. The present study aimed to analyze the expression of AQP5 and investigate its role in primary...

journal_title：Oncology letters

authors： Song T,Yang H,Ho JC,Tang SC,Sze SC,Lao L,Wang Y,Zhang KY

更新日期：2015-06-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistoch...

journal_title：Oncology letters

authors： Huang JX,Shen SL,Lin M,Xiao W,Chen WC,Lin MS,Yu H,Chen P,Qian RY

更新日期：2012-10-01 00:00:00

abstract：:Cutaneous melanoma (CM) is the most aggressive form of skin cancer, exhibits an increasing incidence worldwide and has a high potential to develop metastasis. The current study aimed to identify a set of parameters that may aid in predicting the probability and timing of the onset of CM metastasis. A retrospective ana...

journal_title：Oncology letters

authors： Pjanova D,Ruklisa D,Kregere E,Azarjana K,Ozola A,Cema I

更新日期：2020-10-01 00:00:00

abstract：:Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...

journal_title：Oncology letters

authors： Wang YD,Chen SX,Ren LQ

更新日期：2016-05-01 00:00:00

abstract：:The poor outcome of patients with recurrent ovarian cancer constitutes a continuous challenge for decision-making in clinical practice. In this setting, molecular targets have recently been identified, and novel compounds are now available. Bevacizumab has been introduced for the treatment of patients with ovarian can...

journal_title：Oncology letters

authors： Selle F,Emile G,Pautier P,Asmane I,Soares DG,Khalil A,Alexandre J,Lhommé C,Ray-Coquard I,Lotz JP,Goldwasser F,Tazi Y,Heudel P,Pujade-Lauraine E,Gouy S,Tredan O,Barbaza MO,Ady-Vago N,Dubot C

更新日期：2016-03-01 00:00:00

abstract：:N6-methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m6A during B-cell development and B-cell tumorigenesis remains poorly understood. By analy...

journal_title：Oncology letters

authors： Zhang W,He X,Hu J,Yang P,Liu C,Wang J,An R,Zhen J,Pang M,Hu K,Ke X,Zhang X,Jing H

更新日期：2019-10-01 00:00:00

abstract：:The aim of the present study was to determine the efficacy of microsurgery treatment for parasagittal meningioma in the central gyrus region. A microsurgical technique was used to treat 26 patients with large parasagittal meningioma in the central gyrus region. The Rolandic and draining veins and the peritumoral norma...

journal_title：Oncology letters

authors： Bi N,Xu RX,Liu RY,Wu CM,Wang J,Chen WD,Liu J,Xu YS,Wei ZQ,Li T,Zhang J,Bai JY,Dong B,Fan SJ,Xu YH

更新日期：2013-09-01 00:00:00

abstract：:The transcription factor forkhead box O1 (FOXO1) can be inactivated via its phosphorylation, resulting in suppression of apoptosis. Using immunohistochemistry, the expression of a phosphorylated form of FOXO1 was assessed in upper urinary tract urothelial carcinoma (UUTUC) specimens. Overall, phospho-FOXO1 (p-FOXO1) w...

journal_title：Oncology letters

authors： Ide H,Jiang G,Mizushima T,Fujita K,Inoue S,Yamaguchi S,Fushimi H,Nonomura N,Miyamoto H

更新日期：2019-01-01 00:00:00

abstract：:The risk factors for the development of hepatocellular carcinoma (HCC) in patients who have achieved a long-term sustained viral response (SVR) to interferon (IFN) are not fully understood. This study aimed to investigate the characteristics of patients who developed HCC after 10 years of achieving SVR. We retrospecti...

journal_title：Oncology letters

authors： Nojiri K,Sugimoto K,Shiraki K,Kusagawa S,Tanaka J,Beppu T,Yamamoto N,Takei Y,Hashimoto A,Shimizu A,Omori S,Tameda M,Takase K

更新日期：2010-05-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is associated with a history of heavy, long-term exposure to asbestos. However, MPM may also be associated with simian virus 40 (SV40), a polyomavirus. The association between SV40 and MPM remains unclear. The present study was conducted in order to investigate the proportion of SV...

journal_title：Oncology letters

authors： Thanh TD,Tho NV,Lam NS,Dung NH,Tabata C,Nakano Y

更新日期：2016-03-01 00:00:00