Abstract:
:Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B-cell non-Hodgkin lymphoma has been less satisfactory compared with patients with B-cell acute lymphoblastic leukemia. The present study described a case of refractory follicular lymphoma. A high expression of programmed cell death 1 (PD-1) was measured on CD3+ T cells (80.90%) in peripheral blood samples obtained from the patient enrolled in this study, indicating that treatment with autologous CAR-T 19 cell therapy may not be successful. Therefore, a therapy regimen consisting of CAR-T 19 cells in combination with a reduced dose of nivolumab (1.5 mg/kg) for PD-1 blockade was used. A low dose of PD-1 blockade therapy was used to reduce the adverse effects associated with the combination of a PD-1 inhibitor and CAR-T 19 cells. This salvage therapy resulted in remission that lasted for >10 months.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wang J,Deng Q,Jiang YY,Zhang R,Zhu HB,Meng JX,Li YMdoi
10.3892/ol.2019.10783subject
Has Abstractpub_date
2019-11-01 00:00:00pages
4415-4420issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-10783journal_volume
18pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::This study aimed to investigate the correlation between the expression of CD24 and B7-H3 in breast cancer tissues and the clinical significance. Expression of CD24 and B7-H3 in breast cancer and adjacent tissues were detected by immunohistochemistry. Quantitative PCR was used to detect the expression of CD24 and B7-H3...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7142
更新日期:2017-12-01 00:00:00
abstract::Enhancement of antibody-dependent cellular cytotoxicity (ADCC) with some modalities may be a promising approach to enhance the efficacy of therapeutic monoclonal antibodies (mAbs). It has previously been demonstrated that the removal of fucose from antibody oligosaccharides (defucosylation) leads to augmentation of AD...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7556
更新日期:2018-02-01 00:00:00
abstract::The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2419
更新日期:2014-10-01 00:00:00
abstract::The clinical efficiency of bone transport distraction osteogenesis in the reconstruction of large tibial defects following resection of osteosarcoma remains unclear. The current study presents two cases of large tibial defects treated with bone transport distraction using an Orthofix external fixator. Case 1 was a 29-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4777
更新日期:2016-08-01 00:00:00
abstract::The aim of the present study was to compare intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in irradiation of lung cancer. Plans of 14 patients were compared. The results demonstrated that in peripheral lung cancer, V5 (%) of the lung in partial-arc (PA)-VMAT was decreased comp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7732
更新日期:2018-03-01 00:00:00
abstract::The present study aimed to examine the effectiveness of immunostaining of cytological specimens in discerning squamous from non-squamous cell carcinoma. Various combinations of six antibodies were examined in order to determine the optimal combination for use in differential diagnosis. Immunostaining was performed usi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3045
更新日期:2015-05-01 00:00:00
abstract::Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Breast imagi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6337
更新日期:2017-08-01 00:00:00
abstract::Dermatofibrosarcoma protuberans (DFSP) is a relatively rare low-grade sarcoma that occasionally exhibits melanin-containing spindle cells within the tumor. Fibrosarcomatous DFSP (FS-DFSP) is a variant that is characterized by areas which are histopathologically indistinguishable from fibrosarcoma. In the present study...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.765
更新日期:2012-09-01 00:00:00
abstract::The issue of delayed neurological damage as a result of treatment is becoming increasingly important now that an increased number of children survive treatment for acute lymphoblastic leukemia (ALL). Following modification of the treatment protocols, severe symptomatic late effects are rare, and most adverse effects a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1072
更新日期:2013-02-01 00:00:00
abstract::The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3082
更新日期:2015-06-01 00:00:00
abstract::Esophageal cancer is one of the most common types of malignant tumors located within the digestive system, with >50% of esophageal cancer cases worldwide occurring in China. Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are frequently dysregulated in cancer; however, few lncRNAs have been charac...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7968
更新日期:2018-04-01 00:00:00
abstract::Carbohydrate sulfotransferase 15 (CHST15) synthesizes matrix proteoglycan that regulates various pathogenic mediators and contributes to tissue remodeling and fibrosis during injury. CHST15 has been reported to promote tumor growth and invasion in various types of cancer. Our previous study reported the safety and eff...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10764
更新日期:2019-10-01 00:00:00
abstract::MicroRNAs (miRs) are an emerging class of non-coding, endogenous and small RNA molecules that serve important functions in tumorigenesis and development. The present study investigated the expression, functions and molecular mechanism underlying miR-205 in hepatocellular carcinoma. miR-205 was downregulated in hepatoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8933
更新日期:2018-08-01 00:00:00
abstract::The primary factor associated with poor survival rate in patients with colorectal carcinoma (CRC) is the presence of metastasis. The underlying molecular mechanisms of CRC metastasis are yet to be fully elucidated. The present study investigated the function of heat shock protein 27 (Hsp27) on the invasion and prolife...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9286
更新日期:2018-10-01 00:00:00
abstract::Salidroside is one of the most potent compounds extracted from the plant Rhodiola rosea, and its cardiovascular protective effects have been studied extensively. However, the role of salidroside in human ovarian carcinoma remains unknown. The aim of the current study was to investigate the effects of salidroside on th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8090
更新日期:2018-05-01 00:00:00
abstract::The aim of the present study was to investigate the expression and role of microRNA-26a (miR-26a) in lung cancer, and to verify whether differentially expressed in adenocarcinoma of the lung (DAL-1) is the target protein of miR-26a. mRNA expression levels of miR-26a and DAL-1 were detected using reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8048
更新日期:2018-04-01 00:00:00
abstract::Leptomeningeal metastasis (LM) is increasingly common in patients with non-small cell lung cancer (NSCLC) due to improved treatment, and ultimately, prolonged patient survival. The current study is a pooled analysis that evaluated intrathecal chemotherapy (ITC) as a treatment for NSCLC patients with LM. The PUBMED, OV...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4783
更新日期:2016-08-01 00:00:00
abstract::The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic activity of a novel G. lucidum polysaccharide peptide (GL-PP) i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7823
更新日期:2018-04-01 00:00:00
abstract::HRas proto-oncogene (HRAS) is one of the most commonly mutated genes in thyroid cancer, with mutations frequently occurring in the follicular and Hurthle cell subtypes. However, the contribution of mutations in HRAS to papillary thyroid carcinoma (PTC) progression and the tall-cell variant (TCV) is poorly understood. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7818
更新日期:2018-04-01 00:00:00
abstract::V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative immune checkpoint that belongs to the B7 family. VISTA is primarily expressed on hematopoietic cells and inhibits T cell proliferation and cytokine production. The blockade of VISTA has demonstrated promising results in certain murine ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9059
更新日期:2018-09-01 00:00:00
abstract::Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia. Colorectal cancer (CRC) is the third most common type ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10528
更新日期:2019-09-01 00:00:00
abstract::Exosomes derived from tumor cells are essential for processes involved in tumor progression, including angiogenesis, tumor cell proliferation and immunoregulation. In addition, exosome secretion may contribute to the mechanisms of hypoxia-induced angiogenesis and metastasis of tumors. In the present study, as it is on...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3841
更新日期:2016-01-01 00:00:00
abstract::In order to examine the role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression for the prognostic evaluation of non-small cell lung carcinoma (NSCLC), a total of 186 breast cancer patients, with adjacent non-tumor lung tissues, were selected for immunohistochemical staining of IMP3 protein. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2910
更新日期:2015-04-01 00:00:00
abstract::The aim of the present study was to use imaging to retrospectively analyze the recurrent sites and patterns of spread of early cervical cancer following radical surgery. A total of 86 patients with cervical cancer (stage IB or IIA) showed postoperative pelvic recurrences and distant metastases. Based on positron emiss...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9070
更新日期:2018-09-01 00:00:00
abstract::The correlation between expression and prognosis of thyroid transcription factor-1 (TTF-1) and CD44v6 in undifferentiated lung carcinoma was investigated. There were 116 cases with large cell undifferentiated carcinoma in group A, 120 cases with small cell undifferentiated carcinoma in group B and 80 normal individual...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10689
更新日期:2019-10-01 00:00:00
abstract::Ovarian remnant syndrome (ORS) is a rare, but well-known gynecological complication, most often induced by difficult bilateral salpingo-oophorectomy (BSO) procedures that leave residual ovarian tissue on the pelvic wall. The most common preexisting conditions for this complication include endometriosis, pelvic inflamm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2089
更新日期:2014-07-01 00:00:00
abstract::A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4760
更新日期:2016-08-01 00:00:00
abstract::The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5744
更新日期:2017-04-01 00:00:00
abstract::The present study aimed to investigate the expression and roles of deleted in pancreatic carcinoma locus 4 (DPC4) and vascular endothelial growth factor (VEGF) in the development of cervical carcinoma. A total of 115 patients aged between 25 and 60 years were involved, including 19 cervical inflammation, 35 cervical i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7580
更新日期:2018-02-01 00:00:00
abstract::Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.425
更新日期:2012-01-01 00:00:00