Prognostic significance of the tumor suppressor protein p53 gene in childhood acute lymphoblastic leukemia.

Abstract:

:The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve this, TP53 mRNA levels of 146 children with ALL and 23 child donors with idiopathic thrombocytopenic purpura were determined by reverse transcription-quantitative PCR. Relapse-free survival (RFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. The results demonstrated that TP53 mRNA level in patients with ALL was higher compared with that in the ITP donors (P=0.019). Patients with highly-expressed TP53 exhibited lower percentages of peripheral blood blast, higher platelet counts and inferior complete remission rates compared with patients with low expression of TP53. Survival analyses revealed that high TP53 expression was associated with poor OS and RFS in childhood ALL (P=0.018 and P=0.028, respectively) and was an independent prognostic factor in multivariate analysis for poor RFS (P<0.001) and OS (P<0.001). In conclusion, high TP53 expression is associated with poor outcomes and may be used as a molecular prognostic marker to be incorporated into an improved risk classification system for childhood ALL.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Weng W,Zhang P,Ruan J,Zhang Y,Ba D,Tang Y

doi

10.3892/ol.2019.11064

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

549-556

issue

1

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-11064

journal_volume

19

pub_type

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