Corosolic acid impairs human lung adenocarcinoma A549 cells proliferation by inhibiting cell migration.

abstract：:Endostar, a modified recombinant human endostatin, inhibits the growth of a variety of tumors by suppressing neovascularization. Vascular endothelial growth factor (VEGF) has an important role in malignant ascites formation. In order to determine whether Endostar can suppress the formation of ascites and prolong survi...

journal_title：Oncology letters

authors： Wei H,Qin S,Yin X,Chen Y,Hua H,Wang L,Yang N,Chen Y,Liu X

更新日期：2015-06-01 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the most common female malignancies, and there is an urgent requirement to explore new therapeutic strategies. In the present study, Ishikawa H cells were treated with Momordica charantia protein (MCP30). The cell morphology, growth inhibition rate, cell cycle distribution, and exp...

journal_title：Oncology letters

authors： Gu HZ,Lin RR,Wang HC,Zhu XJ,Hu Y,Zheng FY

更新日期：2017-05-01 00:00:00

abstract：:The present case study reported of amelanotic malignant melanoma of the esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of th...

journal_title：Oncology letters

authors： Kobayashi J,Fujimoto D,Murakami M,Hirono Y,Goi T

更新日期：2018-06-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) promotes invasive and migratory activities by upregulating Forkhead box protein M1 (FoxM1) expression. The present study investigated whether modulation of MnSOD and FoxM1 expression was responsible for the antitumor effects of genistein on cancer stem-like cells (CSLCs) derived ...

journal_title：Oncology letters

authors： Fu Z,Cao X,Liu L,Cao X,Cui Y,Li X,Quan M,Ren K,Chen A,Xu C,Qiu Y,Chen X,Wang Z,Cao J

更新日期：2020-09-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 expression is positively correlated with malignant features in canine mammary carcinomas. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX activity and may therefore possess anticancer effects. Meloxicam is an NSAID that is widely used in human and veterinary medicine. High concentrati...

journal_title：Oncology letters

authors： Iturriaga MP,Paredes R,Arias JI,Torres CG

更新日期：2017-08-01 00:00:00

abstract：:The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve thi...

journal_title：Oncology letters

authors： Weng W,Zhang P,Ruan J,Zhang Y,Ba D,Tang Y

更新日期：2020-01-01 00:00:00

abstract：:Hypoxia is a critical aspect of tumor biology and has been associated with poor prognosis and resistance to traditional therapy. In the present study, differentially expressed genes and microRNAs (miRNAs/miRs) were screened for in the hepatocellular carcinoma (HCC) cell line Huh7 under hypoxic conditions. On the basis...

journal_title：Oncology letters

authors： Hu B,Tang WG,Fan J,Xu Y,Sun HX

更新日期：2018-01-01 00:00:00

abstract：:Diffusion weighted imaging (DWI) has been found to increase the sensitivity in the diagnosis of small hepatocellular carcinoma (HCC), although additional studies are required to confirm its value. The aim of the present study was to explore the diagnostic performance of DWI combined with contrast-enhanced magnetic res...

journal_title：Oncology letters

authors： Lan H,Lin G,Zhong W

更新日期：2020-09-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) has a high incidence and mortality rate, particularly in Southern China. Apogossypolone (ApoG2) is a novel derivative of gossypol with antitumor activity and less toxicity. The human NPC CNE-2 cell line was studied in the in vitro model; whilst 4 week-old male nude mice (BALB/c-nu) were ...

journal_title：Oncology letters

authors： Zheng R,Chen K,Zhang Y,Huang J,Shi F,Wu G,Wang S

更新日期：2017-07-01 00:00:00

abstract：:Bladder cancer (BC) is one of the most common urogenital malignancies. However, present studies of its multiple gene interaction and cellular pathways remain unable to accurately verify the genesis and the development of BC. The aim of the present study was to investigate the genetic signatures of BC and identify its ...

journal_title：Oncology letters

authors： Yan M,Jing X,Liu Y,Cui X

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to investigate the ability of Nimotuzumab to increase radiosensitivity at different delivery times in the mixed cancer cell line Eca109, to determine the optimal delivery time. Cultured Eca109 cells were classified into five groups: Control with no treatment (O group); irradiation with...

journal_title：Oncology letters

authors： Li J,Wang L,Qiu Z,Su Y

更新日期：2019-03-01 00:00:00

abstract：:Hypoxia occurs in a wide range of solid tumors, and is strongly associated with radio-resistance of malignant tumors. The aim of the present study was to investigate the effect of endostatin combined with ionizing radiation (IR) on hypoxic conditions. A total of 24 mice bearing SKOV3 ovarian carcinoma were divided int...

journal_title：Oncology letters

authors： Zhang YC,Li XM,Yu Z,Shi XL,Li Y,Wang WL

更新日期：2017-03-01 00:00:00

abstract：:KG-1 and its less differentiated subline KG-1a are leukemia cell lines used in research in a number of laboratories. The karyotypes of the two lines were initially identical. In the following years, further analysis revealed that the cell lines had acquired additional karyotypical abnormalities and differed in the pre...

journal_title：Oncology letters

authors： Pelliccia F,Ubertini V,Bosco N

更新日期：2012-08-01 00:00:00

abstract：:The aim of the present study was to develop a procedure for the isolation of circulating tumor cells (CTCs), and to evaluate its application in the detection of epidermal growth factor receptor (EGFR) mutations, and potential heterogeneity in patients with non-small-cell lung cancer (NSCLC). Peripheral blood samples w...

journal_title：Oncology letters

authors： Zhang Q,Nong J,Wang J,Yan Z,Yi L,Gao X,Liu Z,Zhang H,Zhang S

更新日期：2019-04-01 00:00:00

abstract：:The present study investigated the value of combinations of five specific tumor biomarkers for the diagnosis of colorectal cancer (CRC): Neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), cancer antigen (CA)19-9, CA125 and CA242. Associations between these markers and clinicopathological characteristics (i...

journal_title：Oncology letters

authors： Luo H,Shen K,Li B,Li R,Wang Z,Xie Z

更新日期：2020-07-01 00:00:00

abstract：:Endotracheal intubation (ETI) and laryngeal mask airway (LMA) in terms of hemodynamics and reaction were compared. A total of 54 general anesthesia patients were randomized into two groups with 27 cases in each group. Acceleration index (ACI), cardiac index (CI), cardiac output (CO), left cardiac work (LCW), systemic ...

journal_title：Oncology letters

authors： Song Z,Tan J,Fang J,Bian Q,Gu L

更新日期：2019-02-01 00:00:00

abstract：:The use of bronchoscopy is central to the diagnosis of lung cancer. However, the sensitivity of bronchoscopy is low. In addition, bronchial washing cytology, which is a routine adjunctive test, does not significantly improve the performance of bronchoscopy owing to its low sensitivity. To enhance the diagnostic perfor...

journal_title：Oncology letters

authors： Jeong IB,Yoon YS,Park SY,Cha EJ,Na MJ,Kwon SJ,Kim JH,Oh TJ,An S,Park CR,Kim YJ,Park DH,Son JW

更新日期：2018-07-01 00:00:00

abstract：:To determine the radiosensitizing effect of apatinib on esophageal cancer cells, and to preliminarily investigate the underlying mechanism, KYSE-150 cells were treated with apatinib, x-ray or apatinib combined with x-ray, and compared with a blank control. It was observed that apatinib significantly inhibited vascular...

journal_title：Oncology letters

authors： Hu L,Sun F,Sun Z,Ni X,Wang J,Wang J,Zhou M,Feng Y,Kong Z,Hua Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：:The aim of the present study was to investigate whether ultrasound combined with microbubbles was able to enhance liposome-mediated transfection of genes into human prostate cancer cells, and to examine the association between autophagy and tumor protein P53 (P53). An MTT assay was used to evaluate cell viability, whi...

journal_title：Oncology letters

authors： Wang YU,Chen YN,Zhang W,Yang YU,Bai WK,Shen E,Hu B

更新日期：2016-01-01 00:00:00

abstract：:Choristoma is a mass of tissue that is histologically normal for the organ or part of the body from which it originates, but is located at an abnormal site. Choristoma of the nervous system involves the occurrence of residual dysplastic tissues outside the nervous system and exhibits a low incidence. Thus far, there h...

journal_title：Oncology letters

authors： Chang PF,Qu LM,Li M,Qi B

更新日期：2017-08-01 00:00:00

abstract：:Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduce...

journal_title：Oncology letters

authors： Delgado-Ramirez Y,Colly V,Gonzalez GV,Leon-Cabrera S

更新日期：2020-07-01 00:00:00

abstract：:Epidemiological data has demonstrated that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 µm (PM2.5) is associated with cancer incidence. However, the precise mechanisms underlying PM2.5-mediated hepatocellular carcinoma cancer (HCC) migration and invasion remain unclear. The aim of the present study was t...

journal_title：Oncology letters

authors： Zhang Q,Luo Q,Yuan X,Chai L,Li D,Liu J,Lv Z

更新日期：2017-05-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a treatment modality that has clinical applications in both non-neoplastic and neoplastic diseases. PDT involves a light-sensitive compound (photosensitizer), light and molecular oxygen. This procedure may lead to several different cellular responses, including cell death. Alterations in ...

journal_title：Oncology letters

authors： Pacheco-Soares C,Maftou-Costa M,DA Cunha Menezes Costa CG,DE Siqueira Silva AC,Moraes KC

更新日期：2014-08-01 00:00:00

abstract：:The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...

journal_title：Oncology letters

authors： Yan W,Chen S,Zhao Y,Ye X

更新日期：2018-06-01 00:00:00

abstract：:Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-co...

journal_title：Oncology letters

authors： Kochi T,Shimizu M,Ohno T,Baba A,Sumi T,Kubota M,Shirakami Y,Tsurumi H,Tanaka T,Moriwaki H

更新日期：2014-07-01 00:00:00

abstract：:The causes of lung cancer in never-smokers remain unclear. The potential contribution of human papillomavirus (HPV) to the carcinogenesis of non-small cell lung cancer (NSCLC) has been reported. In 2008, a prospective registry of never-smokers with NSCLC was established at the Kinki-Chuo Chest Medical Center, Sakai, O...

journal_title：Oncology letters

authors： Isa SI,Kurahara Y,Yamamoto S,Tamiya A,Omachi N,Asami K,Okishio K,Utsumi T,Ito N,Yoon HE,Matsumura A,Atagi S,Kawaguchi T

更新日期：2015-02-01 00:00:00

abstract：:It is crucial to classify cervical lesions into high-grade squamous intraepithelial lesions (HSILs) and low-grade SILs (LSILs), as LSILs are conservatively treated by observation, based on an expectation of natural regression, whereas HSILs usually require electrosurgical excision. In the present study, peripheral blo...

journal_title：Oncology letters

authors： Zou C,Lyu Y,Jiang J,Cao Y,Wang M,Sang C,Zhang R,Li H,Liew CC,Cheng C,Zhao S

更新日期：2020-09-01 00:00:00

abstract：:Breast cancer is the most prevalent cancer among women, and diagnosis and treatment represent a substantial challenge due to the lack of adequate molecular targets. It has been shown that long noncoding RNAs (lncRNAs) serve pivotal roles in regulating gene expression in tumors. The roles of long intervening noncoding ...

journal_title：Oncology letters

authors： Zhu Q,Li Y,Dong X,Yang Y,Wang H,Guo S

更新日期：2020-01-01 00:00:00

abstract：:Osteosarcoma (OS) is identified as the most commonly diagnosed malignant cancer of bone, and has approximately three million new cases annually. miR-26a plays an important role in the development of various types of cancer. We investigated whether miR-26a can regulate the migration and invasion of OS by targeting high...

journal_title：Oncology letters

authors： Liu J,Mi B,Wang Y,Shi C,Mi X,Lu Y,Yu P

更新日期：2018-06-01 00:00:00

abstract：:ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the ATAD3 gene cluster contains ATAD3A, ATAD3B and ATAD3C. The association between ATAD3 ge...

journal_title：Oncology letters

authors： Liu X,Li G,Ai L,Ye Q,Yu T,Yang B

更新日期：2019-08-01 00:00:00