Abstract:
:K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to compare K-ras mutation in different types of cancer. Nested and COLD-PCR were used to detect K-ras mutations. The Chi-squared test was used for statistical analysis. In this study, the total K-ras mutation frequency was found to be 9.09, 18.61 and 6.67% in lung, colorectal and gastric cancer, respectively. Similar K-ras mutation frequencies were detected among sample types and genders for lung and gastric cancer, with the exception of colorectal cancer. However, age had no impact on the K-ras mutation rates.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Peng N,Zhao Xdoi
10.3892/ol.2014.2205subject
Has Abstractpub_date
2014-08-01 00:00:00pages
561-565issue
2eissn
1792-1074issn
1792-1082pii
ol-08-02-0561journal_volume
8pub_type
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