Abstract:
:Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients was studied. Colon cancer cases (n=176) admitted to Xiangya Hospital Central South University were selected into the study. They were divided into group A (n=92) and group B (n=84). In group A, patients underwent surgery anesthesia with dexmedetomidine combined with sufentanil. In group B, patients underwent surgery anesthesia only with sufentanil. The anesthesia induced intubation, operation time and incidence of postoperative adverse reaction of patients were compared between the two groups. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were observed and recorded before induction, before intubation and after intubation. Blood coagulation analyzer was used to detect four items of coagulation before and after operation. FACSCalibur flow cytometry was used to detect T lymphocyte subsets in peripheral blood of patients in the two groups. The pain scores (VAS) of patients in the two groups were measured and recorded after surgery at 4, 24 and 48 h. There was a difference in anesthesia induced intubation and operation time of patients in both groups (P<0.05). There were differences in HR, SBP and DBP of patients in both groups after intubation (P<0.05), in postoperative coagulation function (P<0.05), and in postoperative immune function of patients in both groups (P<0.05). The VAS scores of patients in both groups were different at different time-points after operation (P<0.05). There were differences in postoperative adverse reactions of patients in both groups (P<0.05). Dexmedetomidine combined with sufentanil is a viable anesthetic regimen for colon cancer resection. The coagulation function and immune function have certain improvement effect for patients.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhao L,Li Ydoi
10.3892/ol.2020.11643subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1288-1294issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-11643journal_volume
20pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease and atherosclerosis. Pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7259
更新日期:2017-12-01 00:00:00
abstract::In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells, leaving only the nuclear localization signal (NLS)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5706
更新日期:2017-04-01 00:00:00
abstract::Persistent infection with Helicobacter pylori may contribute to the carcinogenesis of gastric cancer through modulating local prostaglandin E2 (PGE2) levels. Cyclooxygenase-2 (COX-2) and 15-hydroxy prostaglandin dehydrogenase (15-PGDH) are two key enzymes that regulate PGE2 synthesis and inactivation, respectively. Th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6843
更新日期:2017-11-01 00:00:00
abstract::Discovering the underlying signalling pathways that control cancer cells is crucial for understanding their biology and to develop therapeutic regimens. Thus, the aim of the present study was to determine the effect of Cripto-1 on pathways controlling glioblastoma (GBM) cell function. To this end, changes in protein p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10626
更新日期:2019-09-01 00:00:00
abstract::The role of laparoscopic resection for large gastric gastrointestinal stromal tumors (GISTs), particularly those >5 cm, remains under debate due the possibility of intraoperative tumor rupture. To determine the feasibility and safety of the laparoscopic approach in the treatment of large gastric GISTs, a prospective s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3547
更新日期:2015-10-01 00:00:00
abstract::The aberrant expression of microRNAs (miRs) has a significant impact on the biological characteristics of lymphocytes, and is important in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). It has been demonstrated, using miR profiling and detecting distinct miR signatures, that certain miRs may accurately dis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4064
更新日期:2016-02-01 00:00:00
abstract::Urothelial cancer is the most frequently diagnosed type of malignant tumor in the bladder, of which primary adenocarcinoma accounts for a small percentage. Secondary malignancies, in particular metastatic adenocarcinoma from the lung, are exceedingly rare, with only six cases previously reported in the literature. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3445
更新日期:2015-09-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC). Covalently closed circular DNA (cccDNA) is an intermediate in the life cycle of HBV. HBV-encoded X protein (HBx), a key viral oncoprotein, can be specifically ubiquitylated by male specific lethal 2 (MSL2), which causes upregulatio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10833
更新日期:2019-11-01 00:00:00
abstract::Lung cancer is one of the leading causes of cancer-associated mortality. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as general parameters for systemic inflammatory response (SIR). Fu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9858
更新日期:2019-02-01 00:00:00
abstract::Aldo-keto reductases, known as AKR1C1-AKR1C4 enzymes, are pivotal to NADPH-dependent reduction, and their expression is highly associated with the progression of malignant cancers. However, the expression and distinct prognostic value of the AKR1C family members in liver cancer are not well established. In the current...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10802
更新日期:2019-11-01 00:00:00
abstract::Regulatory ability of micro-ribose nucleic acid-130a (miRNA-130a) in the proliferation and invasive growth of human brain glioma cells and its mechanism were investigated. RT-qPCR was used to analyze expression of miRNA-130a in U-87MG glioma specimens; lipidosome was used to mediate miRNA-130a mimic transfecting gliom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8878
更新日期:2018-08-01 00:00:00
abstract::[-2]pro-prostate-specific antigen (2pPSA), a proform of PSA, is a new marker in patients at risk of prostate cancer. We explored the potential role of 2pPSA in the identification of patients with metastatic progression following radical prostatectomy for prostate cancer. Seventy-six patients with biochemical (PSA) rec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.570
更新日期:2012-04-01 00:00:00
abstract::Skin cancer is the deadliest type of malignant disease and causes primary mortality worldwide. Dioscin, which exists in medicinal plants, has potent anticancer effects. However, its effects on skin cancer remain unknown. In the present study, the activity and mechanism of dioscin on the human skin cancer A431 cell lin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12321
更新日期:2021-01-01 00:00:00
abstract::Activating mutations in the cytosolic serine/threonine kinase, BRAF, have been reported in a variety of neoplasms. BRAF activation may contribute to tumor growth via activation of the MAP/ERK kinase pathway, and BRAF represents a possible therapeutic target. Activating BRAF mutations were recently reported in approxim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000127
更新日期:2010-07-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common malignancy of the head and neck. The aim of the present study was to conduct an integrated bioinformatics analysis of differentially expressed genes (DEGs) and to explore the molecular mechanisms of NPC. Two profiling datasets, GSE12452 and GSE34573, were downloaded from the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10382
更新日期:2019-07-01 00:00:00
abstract::Sunitinib based adjuvant chemotherapy combined with chloroquine (CQ) for the treatment of renal cell carcinoma (RCC) is in clinical trials; however, its anti-RCC effect and the mechanism remain unclear. In the present study, the anti-RCC effect of sunitinib with CQ and the underlying mechanism was investigated. An MTT...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7635
更新日期:2018-03-01 00:00:00
abstract::Angiomatoid fibrous histiocytoma (AFH) is a rare, low-grade malignant potential soft tissue tumor which occurs most commonly in children and young adults. Only a few case reports have been described that typically occur in the extremities of the deep dermis and subcutaneous tissue, followed by the trunk, as well as th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1273
更新日期:2013-06-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as a global chromatin organizer to regulate gene expression. Recent studies have suggested an oncogenic role of SATB1 in breast cancer. However, the role of SATB1 in gastric cancer, especially in regulating the malignant phenotypes, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.681
更新日期:2012-07-01 00:00:00
abstract::Pancreatic cancer has a low survival rate globally. Anillin (ANLN) is involved in the pathogenesis of pancreatic cancer (PC). The present study used databases and reverse transcription-quantitative PCR to investigate the association between ANLN expression, clinical variables and the survival rate of patients with pan...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12368
更新日期:2021-02-01 00:00:00
abstract::Poor nutritional status is common in ovarian cancer. It is well known that the nutritional status of a patient with malignant disease is associated with survival, and that it can be assessed by serum levels of rapid turnover proteins (RTPs), such as retinol binding protein, prealbumin and transferrin. Systemic inflamm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1735
更新日期:2014-02-01 00:00:00
abstract::A significant factor that affects the value of the Ki-67 proliferation index (IK) is the interpretation and implementation approach. This method is based on visual or automated methods to count tumor nuclei labeled with Ki-67 antigen, and is prone to errors. Detection of Ki-67 is a useful tool in breast cancer and con...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1654
更新日期:2014-01-01 00:00:00
abstract::Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and potential therapeutic target for the treatment of cancer. In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madder) was used in orde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5761
更新日期:2017-04-01 00:00:00
abstract::Gastric cancer is one of the most common malignancies with high cancer-associated mortality rate globally. Hepcidin is the peptide hormone, which is critically important in the regulation of systemic iron homeostasis. Cumulating evidence has reported that the disturbed local expression of hepcidin may serve as a predi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7574
更新日期:2018-02-01 00:00:00
abstract::Low-grade cribriform cystadenocarcinoma (LGCCC) is a malignant salivary gland tumor. LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56-year-old female ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3528
更新日期:2015-10-01 00:00:00
abstract::S100A11, a member of S100 calcium-binding protein family, is associated with the numerous processes of tumorigenesis and metastasis. In the present study, the role of S100A11, and its possible underlying mechanisms in cell proliferation, apoptosis and cell cycle distribution in human pancreatic cancer were explored. I...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7295
更新日期:2018-01-01 00:00:00
abstract::The clinical effect of interventional therapy on gastric cancer after chemotherapy and effect on inflammatory factors in peripheral blood serum of patients were investigated. A retrospective analysis of 429 patients with gastric cancer treated in Xiangyang No. 1 People's Hospital, Hubei University of Medicine from Jul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10505
更新日期:2019-08-01 00:00:00
abstract::The CDw75 epitope is an α(2,6) sialylated antigen overexpressed in colorectal cancer (CRC), where its expression correlates with the progression of the disease. The CDw75 epitope is located mainly in N-glycoproteins, whose identity remains unknown. The aim of the present study was to identify proteins with the CDw75 e...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7336
更新日期:2018-01-01 00:00:00
abstract::The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12077
更新日期:2020-11-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-β (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8441
更新日期:2018-06-01 00:00:00
abstract::microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains li...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1375
更新日期:2013-08-01 00:00:00