Abstract:
:Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-β (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effect of TGF-β on the HCC Huh-7 and Huh-Bat cell lines was evaluated. To study the effect of TGF-β, Huh-7 and Huh-Bat cells were treated with TGF-β and a TGF-β receptor inhibitor (SB431542). Cell survival, cell cycle, numbers of side population (SP) cells and expression of the cancer stem cell marker cluster of differentiation (CD)133, epithelial-mesenchymal transition markers (E-cadherin, α-smooth muscle actin and vimentin) and TGF-β-regulated proteins [phospho-c-Jun N-terminal kinase (p-JNK), p-c-Jun and p-smad2] were investigated. TGF-β treatment resulted in decreased cell survival with a targeted effect on SP cells. Expression of CD133 and vimentin was upregulated by treatment with the TGF-β receptor antagonist SB431542, but not with TGF-β. By contrast, TGF-β induced accumulation of cells at G0/G1, and upregulated expression of p-JNK, p-c-Jun and p-smad2. However, these effects were blocked when cells were treated with TGF-β plus SB431542, indicating the specificity of the TGF-β effect. The present results indicated that TGF-β has anticancer effects mediated by survival inhibition of cancer stem cells, which may be developed as a novel therapy for HCC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Kim JB,Lee S,Kim HR,Park SY,Lee M,Yoon JH,Kim YJdoi
10.3892/ol.2018.8441subject
Has Abstractpub_date
2018-06-01 00:00:00pages
8723-8728issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-8441journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::An individual with a twin who has developed leukemia or non-Hodgkin lymphoma (NHL) has an increased risk of developing the same disease, particularly with monozygotic twins. The few reported pairs of twins who developed NHL had similar primary sites and pathological subtypes. Here, we present the first reported cases ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9723
更新日期:2019-01-01 00:00:00
abstract::Exosomes have gained increased research focus due to their key roles as messengers. The components of exosomes include proteins and RNAs that may be horizontally transferred between adjacent or distant cells. Hepatocellular carcinoma (HCC) is among the most malignant types of cancer worldwide, with exosomes implicated...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7257
更新日期:2017-12-01 00:00:00
abstract::Decoy receptor 3 (DcR3) is a tumor necrosis factor receptor, which may inhibit apoptosis. The aim of the present study was to investigate the clinical significance of DcR3 upregulation in patients with chronic hepatitis B (CHB) and hepatic fibrosis. A total of 128 patients with a clinical diagnosis of CHB who underwen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8762
更新日期:2018-07-01 00:00:00
abstract::The present study aimed to investigate the association between excision repair cross-complementation group 1 (ERCC1) expression and clinical resistance to platinum-based chemotherapy or clinical characteristics, including survival time, in patients with epithelial ovarian cancer (EOC). ERCC1 expression was determined ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4732
更新日期:2016-08-01 00:00:00
abstract::The aim of this study was to investigate the characteristics of serum secreted frizzled-related protein 5 (SFRP5), an inhibitor of Wnt signaling, in hepatitis B virus (HBV)-associated infections and hepatocellular carcinoma (HCC) patients. Serum SFRP5 levels were detected in 147 patients with HBV-associated chronic in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2256
更新日期:2014-09-01 00:00:00
abstract::The histological boundary between benign and malignant vascular tumors is not clear. Thus, the discrepancies between clinical judgement and pathological diagnosis often lead to a difficult clinical decision, and may result in misdiagnosis. In order to develop more effective treatment methods, the clinical and patholog...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1025
更新日期:2013-02-01 00:00:00
abstract::The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clini...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.249
更新日期:2011-03-01 00:00:00
abstract::Stromal cell-derived factor 1α (SDF1α) and its receptor C-X-C chemokine receptor type 4 (CXCR4) have been reported to form an important chemokine signaling pathway. Our previous study reported that SDF1α from tumor stromal cells may stimulate the proliferation of gastric cancer (GC) cells through the CXCR4 axis in a h...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12299
更新日期:2021-01-01 00:00:00
abstract::The present study aimed to identify the underlying molecular mechanisms associated with spinal metastases. Gene expression profiles in cancellous bone samples from the spines of five patients with spinal metastases, with different primary cancers, and three normal control patients were measured using microarray analys...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7267
更新日期:2018-01-01 00:00:00
abstract::Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11897
更新日期:2020-10-01 00:00:00
abstract::Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cyc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9111
更新日期:2018-09-01 00:00:00
abstract::Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6329
更新日期:2017-08-01 00:00:00
abstract::DNA hypermethylation plays a major role in the regulation of gene expression in differentiation, development and diseases. The DNA mismatch repair system, which includes Mut-S-Homologon-2 (MSH2) protein, is essential to maintain the stability of the genome during repeated duplication. This study aimed to investigate t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2482
更新日期:2014-11-01 00:00:00
abstract::The recent successful use of the immune checkpoint inhibitors (CPIs) anti-programmed death receptor-1 (PD-1)/PD-1 ligand 1 in clinical trials indicates their crucial role in obtaining an effective cancer immune therapy. These CPIs have been identified to have an effective therapeutic response, particularly in tumors w...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10166
更新日期:2019-06-01 00:00:00
abstract::The evaluation of minimal residual disease (MRD) in acute leukemia (AL) is currently recognized as a potential critical tool to assess the response and relapse rate of treatments. The present study investigated serum peptides from patients with AL to identify biomarkers that would be useful in providing clinical evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1574
更新日期:2013-11-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common and malignant type of glioma, with a poor prognosis for patients. The survival time of patients varies greatly due to the complexity of the human genome, which harbors diverse oncogenic drivers. In order to identify the specific driving factors, 325 glioma samples from ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10296
更新日期:2019-07-01 00:00:00
abstract::Intramuscular myxoma (IM) is a benign intramuscular neoplasm composed of fibroblasts and abundant myxoid stroma. IMs most commonly affect larger skeletal muscles, while those affecting the oral and maxillofacial regions are rare, with a small number of documented cases in the available literature. The aim of the prese...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1955
更新日期:2014-05-01 00:00:00
abstract::The aim of the study was to determine whether interleukin-8 (IL-8) affects human SKOV3 ovarian cancer cell migration and invasion by targeting silencing of IL-8 expression. Silencing small-interfering RNA (siRNA) targeting IL-8 gene was constructed to infect SKOV3 cells by lentiviral vector. The expression of IL-8 and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5511
更新日期:2017-02-01 00:00:00
abstract::In previous studies, we observed that STAT1 and Survivin correlated negatively with gastric cancer tissues, and that the functions of the IFN-γ-STAT1 pathway and Survivin in gastric cancer are the same as those reported for other types of cancer. In this study, the SGC7901 gastric cancer cell line and 83 gastric cance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.423
更新日期:2012-01-01 00:00:00
abstract::5-fluorouracil (5-FU) is one of the standard chemoradiotherapy regimens for hepatocellular carcinoma (HCC) treatment. B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) has been demonstrated to regulate proliferation. Additionally, Bmi-1 overexpression has been identified in HCC cell lines and corr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.805
更新日期:2012-10-01 00:00:00
abstract::Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10499
更新日期:2019-08-01 00:00:00
abstract::MicroRNAs (miRNAs/miRs) are small, noncoding RNA molecules that are closely associated with the occurrence and development of tumors. miR-20b is overexpressed in hepatocellular carcinoma cell lines and tissues. However, it is not clear whether miR-20b can promote the proliferation of hepatocellular carcinoma cells. In...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9925
更新日期:2019-03-01 00:00:00
abstract::MicroRNAs (miRs) can function as tumor suppressors or oncogenes in different types of human malignancy, and may provide an effective therapy for cancer. The expression and functions of miR-592 have previously been studied in relation to cancer. However, the expression and potential functions of miR-592 in hepatocellul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5902
更新日期:2017-05-01 00:00:00
abstract::The aberrant expression of microRNAs (miRs) has a significant impact on the biological characteristics of lymphocytes, and is important in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). It has been demonstrated, using miR profiling and detecting distinct miR signatures, that certain miRs may accurately dis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4064
更新日期:2016-02-01 00:00:00
abstract::In order to assess the metastatic potential of residual hepatocellular carcinoma (HCC) following insufficient radiofrequency ablation (RFA) and to improve the current animal model, an insufficient RFA orthotopic nude mouse model of HCC was developed in the present study. A human HCC orthotopic nude mouse model was est...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10552
更新日期:2019-09-01 00:00:00
abstract::Retroperitoneal primary mucinous adenocarcinoma (RPMA) is extremely rare and the histogenesis of this tumor remains unclear. There is no consensus on the appropriate treatment for RPMA. Surgical resection is standard for the treatment of RPMA, whereas the benefits of chemotherapy with regard to this tumor remain to be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.319
更新日期:2011-07-01 00:00:00
abstract::The present study reports the case of a 20-year-old female who was identified to have a left renal angiomyolipoma (AML) with hemorrhage. Following temporary conservative observation, the patient received continuous ultrasonic follow-up. Due to the rapid growth of the lesion, further examinations were performed. Comput...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3718
更新日期:2015-11-01 00:00:00
abstract::The chemokine CXCL10 and its receptor CXCR3 have been demonstrated to be implicated in cancer cell proliferation and metastasis. CXCR3 has three splice variants: CXCR3A, CXCR3B and CXCR3-alt. CXCR3A and B serve multiple roles in the growth and invasiveness of a number of cancer types. However, the roles of CXCR3 isofo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11326
更新日期:2020-03-01 00:00:00
abstract::Human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV oncogenesis. These E6 and E7 gene products play a central role in the induction of malignant transformation by interacting with several cellular regulatory proteins such as p16(INK4a), p53 and nuclear factor κB (NF-κB). In the present stud...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000106
更新日期:2010-07-01 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for patients with advanced cancer. The aim of the present study was to investigate the prognostic value of somatic mutations in mismatch repair (MMR) genes in metastatic cancers after ICI treatment, as well as their assoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11888
更新日期:2020-10-01 00:00:00