Abstract:
:Exosomes have gained increased research focus due to their key roles as messengers. The components of exosomes include proteins and RNAs that may be horizontally transferred between adjacent or distant cells. Hepatocellular carcinoma (HCC) is among the most malignant types of cancer worldwide, with exosomes implicated to play a crucial role in its regulation; however, the possible function of exosomes in modulating the motile ability of tumor cells and key molecules in HCC remain largely unknown. To investigate the regulatory effect of exosomes on the motile ability of HCC cells, exosomes from the culture medium of different HCC origins (high metastatic MHCC97-H and low metastatic MHCC97-L cells) were isolated for in vitro migration and invasion assays. The results indicated that the motile ability of MHCC97-L cells was significantly increased by pretreatment with MHCC97-H-derived exosomes when compared with MHCC97-L-exosome pretreatment (P<0.05). To further characterize the function of exosomes at the molecular level, protein profiling of exosomes from different cell origins was performed, which identified 129 proteins. Among these, adenylyl cyclase-associated protein 1, a protein implicated in HCC metastasis, was significantly enriched in exosomes from cells with high motile ability (P<0.05). The results of the present study validated the regulatory effect of exosomes on the motile ability of HCC cells. Furthermore, systematic analysis of the protein profiles of exosomes from different origins identified potential factors correlated with HCC metastasis, which may provide a basis for future functional analysis of exosomes regarding their involvement in cancer metastasis and recurrence.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wang S,Chen G,Lin X,Xing X,Cai Z,Liu X,Liu Jdoi
10.3892/ol.2017.7257subject
Has Abstractpub_date
2017-12-01 00:00:00pages
8122-8131issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-7257journal_volume
14pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Long non-coding RNAs (lncRNAs) govern gene expression by competitively binding to microRNA response elements (MREs). Although they were initially considered as transcriptional noise, lncRNAs have attracted increased attention in oncology. Dysregulation of lncRNAs occurs in various types of human tumor, including esoph...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10808
更新日期:2019-11-01 00:00:00
abstract::Acute myeloid leukaemia (AML) is a type of heterogeneous disease derived from haematopoietic stem cells. Cytogenetic characterisation is essential for diagnosis and prognosis stratification. Here, we present the case of a 43-year-old female diagnosed with leukaemia, who demonstrated a rare chromosomal change of t(11; ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3511
更新日期:2015-10-01 00:00:00
abstract::5-lipoxygenase (5-LO) catalyzes the first step of arachidonic acid metabolism to inflammatory mediator leukotrienes. The present study assessed 5-LO expression in esophageal squamous cell carcinoma (ESCC) tissue specimens for associations with clinicopathological and survival data from patients, then explored 5-LO act...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8527
更新日期:2018-06-01 00:00:00
abstract::microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8609
更新日期:2018-07-01 00:00:00
abstract::The chemokine CXCL10 and its receptor CXCR3 have been demonstrated to be implicated in cancer cell proliferation and metastasis. CXCR3 has three splice variants: CXCR3A, CXCR3B and CXCR3-alt. CXCR3A and B serve multiple roles in the growth and invasiveness of a number of cancer types. However, the roles of CXCR3 isofo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11326
更新日期:2020-03-01 00:00:00
abstract::The role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is a disease with not only a genetic, but also an immunological basis. Additionally, immune cell infiltration is an important feature of oral cancer. C-X-C motif chemokine ligand 12 (CXCL12) serves an important role in immune suppression in the tum...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10415
更新日期:2019-08-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new stra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10920
更新日期:2019-12-01 00:00:00
abstract::Oncostatin M (OSM) induces the differentiation of liver cancer stem cells (LCSCs) and increases sensitivity to the chemotherapeutic agent 5-fluorouracil, whereas salinomycin (Sal) induces apoptosis in cancer stem cells and inhibits the proliferation of liver cancer cells. However, there have been no studies investigat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9796
更新日期:2019-02-01 00:00:00
abstract::Taxol is the first-line chemotherapeutic agent for patients with castration-resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6793
更新日期:2017-10-01 00:00:00
abstract::MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8557
更新日期:2018-06-01 00:00:00
abstract::Extra-abdominal desmoid tumour is a rare type of tumour which is conventionally treated with wide local excision. However, wide local excision usually causes irreparable damage to the limbs. Nevertheless, few patients have been subjected to wide local excision and reconstructive surgery in a single procedure. A 52-yea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.766
更新日期:2012-09-01 00:00:00
abstract::The present study aimed to investigate the effects of silencing RIP1 by small interfering RNA (siRNA) on the biological behavior of the LoVo human colorectal carcinoma cell line and to provide evidence for the feasibility of colorectal cancer gene therapy. LoVo cells were divided into the RIP1 siRNA group, the blank c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2040
更新日期:2014-06-01 00:00:00
abstract::Circulating tumor cells (CTCs), isolated as a 'liquid biopsy', may provide important diagnostic and prognostic information. Therefore, rapid, reliable and unbiased detection of CTCs are required for routine clinical analyses. It was demonstrated that negative enrichment, an epithelial marker-independent technique for ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6046
更新日期:2017-06-01 00:00:00
abstract::There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcriptio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8997
更新日期:2018-09-01 00:00:00
abstract::Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5449
更新日期:2017-01-01 00:00:00
abstract::Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, che...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6685
更新日期:2017-10-01 00:00:00
abstract::The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reco...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8084
更新日期:2018-04-01 00:00:00
abstract::Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6049
更新日期:2017-06-01 00:00:00
abstract::Factor that binds to the inducer of short transcripts of the human immunodeficiency virus-1 (FBI-1) represents as a crucial gene regulator in colorectal cancer; however, the correlation between FBI-1 and preoperative radiotherapy (RT) in rectal cancer (RC) has not yet been reported. The aim was to detect FBI-1 express...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10890
更新日期:2019-11-01 00:00:00
abstract::DNA topoisomerase II-α (Topo II-α) is essential for numerous cell processes, including DNA replication, transcription, recombination, and chromosome separation and condensation. Altered Topo II-α expression may lead to carcinogenesis and cancer progression. The aim of the present study was to investigate the associati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2367
更新日期:2014-10-01 00:00:00
abstract::Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, fast-growing, benign tumor originating from the neural crest. The tumor most often occurs during the first year of life. The predilection site of MNTI is the anterior maxilla, whereas lesions of the mandible are uncommon and account for only 6% of all cases....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2665
更新日期:2015-01-01 00:00:00
abstract::Ovarian cancer is the most malignant gynecologic neoplasm in women and has the worst prognosis of all cancer types in women based on the 5-year survival rates. A previous study indicated that mangiferin exerts an anti-neoplastic effect on human ovarian cancer cells by targeting Notch3. Additionally, it has been demons...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9708
更新日期:2019-01-01 00:00:00
abstract::The association between inflammation and cancer has been established in certain forms of human malignancies; however, its role in prostate cancer remains unclear. The present study investigates a possible association between chronic inflammation and the development of epithelial neoplasia in the prostate. Needle biops...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6668
更新日期:2017-10-01 00:00:00
abstract::The optimal administration of 5-fluorouracil (5-FU)/leucovorin (LV) for colorectal cancer (CRC) has yet to be fully defined although evidence of the combination has already been established. In a multicentre phase II study, pharmacokinetic modulating chemotherapy (PMC), which is based on the concept that continuous in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000014
更新日期:2010-01-01 00:00:00
abstract::Delisheng is a widely used antineoplastic agent in China. Although previous studies revealed that Delisheng exhibits numerous pharmacological effects including the inhibition of cancer cell differentiation and enhancement of immune function with the lowest toxicity, the precise anticancer mechanisms of Delisheng in hu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7074
更新日期:2017-12-01 00:00:00
abstract::Segmental ureterectomy (SU) represents a promising alternative for the treatment of upper tract urothelial carcinomas (UTUCs) as it is a less invasive procedure and guarantees the preservation of renal units. The present study evaluated oncological outcomes and renal functions following SU when compared with radical n...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9463
更新日期:2018-11-01 00:00:00
abstract::We previously reported the case of a 56-year-old male who underwent surgical treatment for gastric hepatoid adenocarcinoma and splenic metastasis. The present study reports the case of the same patient who underwent successful ex vivo hepatectomy and partial liver autotransplantation. Computed tomography scans demonst...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3041
更新日期:2015-05-01 00:00:00
abstract::The detection of epidermal growth factor receptor (EGFR) mutations is necessary for the selection of suitable patients with non-small cell lung cancer (NSCLC) for treatment with EGFR tyrosine kinase inhibitors. Cytology specimens are known to be suitable for EGFR mutation detection, although tissue specimens should be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7464
更新日期:2018-02-01 00:00:00
abstract::Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43-year-old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3422
更新日期:2015-09-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2012.934.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.11421
更新日期:2020-04-01 00:00:00