Multicentre phase II study of leucovorin plus pharmacokinetic modulating chemotherapy for metastatic colorectal cancer.

Abstract:

:The optimal administration of 5-fluorouracil (5-FU)/leucovorin (LV) for colorectal cancer (CRC) has yet to be fully defined although evidence of the combination has already been established. In a multicentre phase II study, pharmacokinetic modulating chemotherapy (PMC), which is based on the concept that continuous intravenous 5-FU infusion can be enhanced by low-dose oral uracil/tegafur, was combined with LV and administered. Thirty-seven patients were enrolled. The objective response rate was 31.4% and the tumour stabilization rate was 85.7%. The most common toxic effects were neutropenia and hand-foot skin reactions although no life-threatening grade 3-4 toxicities were noted. Grade 3 toxicities such as neutropenia, nausea, diarrhoea and oesophagitis occurred in one patient each. We identified the usefulness of a new type of infusional 5-FU combined with LV for the treatment of CRC. The combination of PMC and LV is active with an acceptable rate of toxicity as a first-line treatment of advanced CRC.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Inoue Y,Tanaka K,Hiro J,Toiyama Y,Miki C,Kusunoki M

doi

10.3892/ol_00000014

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

81-85

issue

1

eissn

1792-1074

issn

1792-1082

pii

ol-01-01-0081

journal_volume

1

pub_type

杂志文章
  • In vitro evaluation of anti-epidermoid cancer activity of Acanthus ebracteatus protein hydrolysate and their effects on apoptosis and cellular proteins.

    abstract::Acanthus ebracteatus Vahl. is commonly consumed with the aim of curing cancer, inflammatory conditions and skin diseases in traditional Thai medicine. It is known to contain various phytochemicals; however, very little is known about the effects of A. ebracteatus protein hydrolysate on cancer cells, including its mole...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10647

    authors: Khamwut A,Jevapatarakul D,Reamtong O,T-Thienprasert NP

    更新日期:2019-09-01 00:00:00

  • Adefovir dipivoxil-induced Fanconi syndrome and its predictive factors: A study of 28 cases.

    abstract::The aim of the present study was to identify monitoring and prevention measures as well as predictive factors for early detection of renal toxicity associated with long-term administration of adefovir dipivoxil in order to avoid progression to Fanconi syndrome. Clinical data of 28 patients with Fanconi syndrome caused...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5393

    authors: Lin Y,Pan F,Wang Y,Chen Z,Lin C,Yao L,Zhang X,Zhou R,Pan C

    更新日期:2017-01-01 00:00:00

  • Multiple regulatory mechanisms of hepatocyte growth factor expression in malignant cells with a short poly(dA) sequence in the HGF gene promoter.

    abstract::Hepatocyte growth factor (HGF) expression is a poor prognostic factor in various types of cancer. Expression levels of HGF have been reported to be regulated by shorter poly(dA) sequences in the promoter region. In the present study, the poly(dA) mononucleotide tract in various types of human cancer cell lines was exa...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2702

    authors: Sakai K,Takeda M,Okamoto I,Nakagawa K,Nishio K

    更新日期:2015-01-01 00:00:00

  • The antagonistic effect between STAT1 and Survivin and its clinical significance in gastric cancer.

    abstract::In previous studies, we observed that STAT1 and Survivin correlated negatively with gastric cancer tissues, and that the functions of the IFN-γ-STAT1 pathway and Survivin in gastric cancer are the same as those reported for other types of cancer. In this study, the SGC7901 gastric cancer cell line and 83 gastric cance...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.423

    authors: Deng H,Zhen H,Fu Z,Huang X,Zhou H,Liu L

    更新日期:2012-01-01 00:00:00

  • Expression of WNT1 in ameloblastoma and its significance.

    abstract::The present study aimed to measure the expression of WNT1 in ameloblastoma (AB). Immunohistochemistry was used to observe changes in WNT1 expression in 80 AB samples, 10 keratocystic odontogenic tumor (KCOT) samples and 10 normal oral mucosa (NOM) samples. Western blotting and reverse transcription-quantitative polyme...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8820

    authors: Wang GN,Zhong M,Chen Y,Ji J,Gao XQ,Wang TF

    更新日期:2018-08-01 00:00:00

  • Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma.

    abstract::Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal uterus tissue and uter...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.428

    authors: Wang Y,Ikeda JI,Rahadiani N,Mamat S,Ueda Y,Tian T,Enomoto T,Kimura T,Aozasa K,Morii E

    更新日期:2012-01-01 00:00:00

  • Gene and miRNA expression profiles of mouse Lewis lung carcinoma LLC1 cells following single or fractionated dose irradiation.

    abstract::In clinical practice ionizing radiation (IR) is primarily applied to cancer treatment in the form of fractionated dose (FD) irradiation. Despite this fact, a substantially higher amount of current knowledge in the field of radiobiology comes from in vitro studies based on the cellular response to single dose (SD) irra...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.5877

    authors: Stankevicius V,Kuodyte K,Schveigert D,Bulotiene D,Paulauskas T,Daniunaite K,Suziedelis K

    更新日期:2017-06-01 00:00:00

  • Integrated analysis revealing genome-wide chromosomal copy number variation in supraglottic laryngeal squamous cell carcinoma.

    abstract::Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribut...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11653

    authors: Li D,Wang X,Lu S,Wang P,Wang X,Yin W,Zhu W,Li S

    更新日期:2020-08-01 00:00:00

  • Analysis of soluble urokinase plasminogen activator receptor in multiple myeloma for predicting prognosis.

    abstract::Multiple myeloma is a type of malignancy, which affects the plasma cells of the bone marrow. Recent studies have found that malignant plasma cells may express urokinase plasminogen activator (uPA) and uPA receptor (uPAR), and that initiation of proteolytic events by this system contributes to the process of invasion a...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3613

    authors: Shen J,Wang Q,Wang J,Su GH,Wang J,Guo SH,Liu YA,Wu Z,Liu RF,Li X,Guo XJ,Cao J,Zhang YH,Wang ZY

    更新日期:2015-10-01 00:00:00

  • Berberine regulates the microRNA-21-ITGΒ4-PDCD4 axis and inhibits colon cancer viability.

    abstract::Berberine is sourced from multiple medicinal herb resources and is easy to extract. With the advantages of low price, safety and convenience, berberine may have potential for wide clinical use. The present study aimed to investigate whether berberine inhibited the viability of colon cancer and whether it regulated the...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7997

    authors: Lü Y,Han B,Yu H,Cui Z,Li Z,Wang J

    更新日期:2018-04-01 00:00:00

  • A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells.

    abstract::Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expr...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.11008

    authors: Schcolnik-Cabrera A,Dominguez-Gómez G,Chávez-Blanco A,Ramírez-Yautentzi M,Morales-Bárcenas R,Chávez-Díaz J,Taja-Chayeb L,Dueáas-González A

    更新日期:2019-12-01 00:00:00

  • TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis.

    abstract::Lung cancer is the leading cause of cancer-associated mortality worldwide and its prognosis is poor. Few effective biomarkers for non-small cell lung cancer (NSCLC) have been translated into the clinical practice aiming to assist in the treatment plan design and prognosis evaluation. The aim of the present study was t...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6467

    authors: Hao L,Du B,Xi X

    更新日期:2017-08-01 00:00:00

  • Characterization of uncommon portosystemic collateral circulations in patients with hepatic cirrhosis.

    abstract::The purpose of the present study was to characterize uncommon portosystemic collateral circulation in hepatic cirrhosis. Portosystemic uncommon collateral circulation (UCC) was detected, characterized and evaluated by a combination of spiral computed tomography angiography, three-dimensional imaging angiography and el...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2626

    authors: Wu Q,Shen L,Chu J,Ma X,Jin B,Meng F,Chen J,Wang Y,Wu L,Han J,Zhang W,Ma W,Wang H,Li H

    更新日期:2015-01-01 00:00:00

  • Low accuracy of chromogranin A for diagnosing early-stage pancreatic neuroendocrine tumors.

    abstract::The aim of the present study was to evaluate the clinical utility of plasma chromogranin A (CgA) in patients diagnosed with early-stage pancreatic neuroendocrine tumors (PNETs) in terms of diagnostic value and treatment response. A total of 35 patients with PNETs were prospectively enrolled from August 2010 to April 2...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8472

    authors: Tseng CM,Cheng TY,Chen TB,Tien YW,Chen CC,Lin JT,Wang HP

    更新日期:2018-06-01 00:00:00

  • The importance of molecular cytogenetic analysis prior to using cell lines in research: The case of the KG-1a leukemia cell line.

    abstract::KG-1 and its less differentiated subline KG-1a are leukemia cell lines used in research in a number of laboratories. The karyotypes of the two lines were initially identical. In the following years, further analysis revealed that the cell lines had acquired additional karyotypical abnormalities and differed in the pre...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.709

    authors: Pelliccia F,Ubertini V,Bosco N

    更新日期:2012-08-01 00:00:00

  • Expression of Toll-like receptor-9 is associated with poor progression-free survival in prostate cancer.

    abstract::Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1204

    authors: Väisänen MR,Jukkola-Vuorinen A,Vuopala KS,Selander KS,Vaarala MH

    更新日期:2013-05-01 00:00:00

  • Exophytic gastrointestinal stromal tumor with cystic changes: A case report.

    abstract::Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male pre...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1954

    authors: Zhu CC,Liu Y,Zhao G

    更新日期:2014-05-01 00:00:00

  • Clinicopathological characteristics of pulmonary epithelioid hemangioendothelioma: A report of four cases and review of the literature.

    abstract::This study aimed to investigate the clinicopathological characteristics, differential diagnosis and prognosis of pulmonary epithelioid hemangioendothelioma (PEH). PEH is a rare low-grade malignant vascular tumor. The cause of PEH remains unclear. Patient prognosis is unpredictable, with life expectancy ranging from 1 ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2566

    authors: Shao J,Zhang J

    更新日期:2014-12-01 00:00:00

  • Semi-automated evaluation of Ki-67 index in invasive ductal carcinoma of the breast.

    abstract::A significant factor that affects the value of the Ki-67 proliferation index (IK) is the interpretation and implementation approach. This method is based on visual or automated methods to count tumor nuclei labeled with Ki-67 antigen, and is prone to errors. Detection of Ki-67 is a useful tool in breast cancer and con...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1654

    authors: Suciu C,Muresan A,Cornea R,Suciu O,Dema A,Raica M

    更新日期:2014-01-01 00:00:00

  • Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer.

    abstract::Cell adhesion molecule (CADM) genes encode immunoglobulin superfamily molecules, which are involved in cell-cell adhesion in a number of human epithelia. Through the maintenance of epithelia, CADM genes protect against malignant conversion and metastasis. Whilst numerous in vitro studies have investigated the molecula...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.7536

    authors: Saito M,Goto A,Abe N,Saito K,Maeda D,Ohtake T,Murakami Y,Takenoshita S

    更新日期:2018-02-01 00:00:00

  • Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study.

    abstract::The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clini...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.249

    authors: Xu L,Zeng Z,Chen B,Wu X,Yu J,Xue L,Tian L,Wang Y,Chen M,Sung JJ,Hu P

    更新日期:2011-03-01 00:00:00

  • Investigation of the clinical significance and molecular mechanism of miR-21-5p in hepatocellular carcinoma: A systematic review based on 24 studies and bioinformatics investigation.

    abstract::To investigate the prospective roles and the clinicopathological application of microRNA-21-5p (miR-21-5p) in hepatocellular carcinoma (HCC), the present review is based on 24 studies and bioinformatics investigation. Firstly, HCC-associated miR-21-5p data were aggregated from literature databases and two public genom...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9627

    authors: Zhong XZ,Deng Y,Chen G,Yang H

    更新日期:2019-01-01 00:00:00

  • miR-202 acts as a potential tumor suppressor in breast cancer.

    abstract::Breast cancer affects ~10% of women worldwide and is responsible for ~12% of all cancer-associated mortalities. Breast cancer is more prone to metastasis compared with other types of cancer. Up to 5% of patients with breast cancer present with incurable metastasis and an additional 10-15% of patients develop metastase...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8726

    authors: Gao S,Cao C,Dai Q,Chen J,Tu J

    更新日期:2018-07-01 00:00:00

  • Influence of gap junction intercellular communication composed of connexin 43 on the antineoplastic effect of adriamycin in breast cancer cells.

    abstract::Gap junctions (GJs) serve the principal role in the antineoplastic (cytotoxicity and induced apoptosis) effect of chemical drugs. The aim of the present study was to determine the effect of GJ intercellular communication (GJIC) composed of connexin 43 (Cx43) on adriamycin cytotoxicity in breast cancer cells. Four cell...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5471

    authors: Jiang G,Dong S,Yu M,Han X,Zheng C,Zhu X,Tong X

    更新日期:2017-02-01 00:00:00

  • Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance.

    abstract::The aim of the present study was to investigate the expression of transactivation response RNA-binding protein (TARBP)1 and its clinical significance in human non-small-cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) i...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8202

    authors: Ye J,Wang J,Zhang N,Liu Y,Tan L,Xu L

    更新日期:2018-05-01 00:00:00

  • Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration.

    abstract::Regenerating islet-derived family, member 4 (REG4, which encodes Reg IV) is a marker for cancer and inflammatory bowel disease. This study aimed to investigate the diagnostic utility of Reg IV measurement in sera from esophageal cancer patients. Reg IV expression was examined in 269 esophageal cancer samples by immuno...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.239

    authors: Oue N,Noguchi T,Anami K,Sentani K,Sakamoto N,Uraoka N,Wakamatsu Y,Sasaki H,Yasui W

    更新日期:2011-03-01 00:00:00

  • Impact of molecular subtypes on metastatic behavior and overall survival in patients with metastatic breast cancer: A single-center study combined with a large cohort study based on the Surveillance, Epidemiology and End Results database.

    abstract::Breast cancer is a highly heterogeneous disease at the molecular level and >90% of mortalities are due to metastasis and its associated complications. The present study determined the impact of molecular subtypes on metastatic behavior and overall survival (OS) of patients with metastatic breast cancer. The influence ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11948

    authors: Yang H,Wang R,Zeng F,Zhao J,Peng S,Ma Y,Chen S,Ding S,Zhong L,Guo W,Wang W

    更新日期:2020-10-01 00:00:00

  • miR-204-5p and miR-3065-5p exert antitumor effects on melanoma cells.

    abstract::MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8443

    authors: Palkina N,Komina A,Aksenenko M,Moshev A,Savchenko A,Ruksha T

    更新日期:2018-06-01 00:00:00

  • Establishment of an insufficient radiofrequency ablation orthotopic nude mouse model of hepatocellular carcinoma to study the invasiveness and metastatic potential of residual cancer.

    abstract::In order to assess the metastatic potential of residual hepatocellular carcinoma (HCC) following insufficient radiofrequency ablation (RFA) and to improve the current animal model, an insufficient RFA orthotopic nude mouse model of HCC was developed in the present study. A human HCC orthotopic nude mouse model was est...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10552

    authors: Zhang N,Zhu H,Dong YH,Wang L

    更新日期:2019-09-01 00:00:00

  • Effects of melatonin on HIF-1α and VEGF expression and on the invasive properties of hepatocarcinoma cells.

    abstract::Liver cancer is the sixth most commonly occurring cancer globally, and the main histological type is hepatocellular carcinoma. This type of neoplasia has a poor prognosis due to a high rate of recurrence and intrahepatic metastasis, which are closely are closely associated with the angiogenic process. Vascular endothe...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4605

    authors: Colombo J,Maciel JM,Ferreira LC,DA Silva RF,Zuccari DA

    更新日期:2016-07-01 00:00:00