Abstract:
:Taxol is the first-line chemotherapeutic agent for patients with castration-resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosphatase and tensin homolog (PTEN)-positive 22Rv1 cells than PTEN-negative LNCaP cells. Knockdown of PTEN in 22Rv1 cells resulted in increased resistance to paclitaxel and impaired the induction of maspin expression by paclitaxel. Overexpression of PTEN sensitized LNCaP cells to paclitaxel treatment and increased maspin induction by paclitaxel. Furthermore, knocking down maspin abrogated PTEN-induced paclitaxel sensitivity in LNCaP cells. PTEN/maspin signaling may be important for regulating the susceptibility to paclitaxel in prostate cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Gan Y,Chen Q,Lei Ydoi
10.3892/ol.2017.6793subject
Has Abstractpub_date
2017-10-01 00:00:00pages
4977-4982issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-6793journal_volume
14pub_type
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