Long non-coding RNA LINC00152 acts as a sponge of miRNA-193b-3p to promote tongue squamous cell carcinoma progression.

abstract：:The major aim of the present study was to develop an integrin receptor-targeted liposomal paclitaxel (PTX) to enhance the targeting specificity and therapeutic effect of PTX on hepatocellular carcinoma (HCC) cells. The specific Arg-Gly-Asp (RGD) ligand was conjugated to 1,2-distearoylphosphatidylethanolamine-polyethyl...

journal_title：Oncology letters

authors： Chen L,Liu Y,Wang W,Liu K

更新日期：2015-07-01 00:00:00

abstract：:Effect of microRNA-27b (miR-27b) on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma (OSCC) was investigated to provide a reference for clinical prevention of OSCC cell resistance. The clinical tissues of 34 patients with OSCC-resistant cancer and 28 patients with cisplatin-sensitive OSCC in Nanjing ...

journal_title：Oncology letters

authors： Liu B,Cao G,Dong Z,Guo T

更新日期：2019-07-01 00:00:00

abstract：:The periostin protein, encoded by the POSTN gene, is a component of the extracellular matrix, which is expressed by fibroblasts and has been observed in a variety of human malignancies. The present study aimed to detect the expression of periostin in the tissues of non-small cell lung cancer (NSCLC) patients and benig...

journal_title：Oncology letters

authors： Hong LZ,Wei XW,Chen JF,Shi Y

更新日期：2013-12-01 00:00:00

abstract：:Liver cancer, which is the second leading cause of tumor-associated mortality, is of great concern worldwide due to its resistance to chemotherapeutic drugs. Transcatheter arterial chemoembolization (TACE) has previously been used as a treatment for unresectable liver tumors in China; however, the response to TACE tre...

journal_title：Oncology letters

authors： Liu DX,Li PP,Guo JP,Li LL,Guo B,Jiao HB,Wu JH,Chen JM

更新日期：2019-01-01 00:00:00

abstract：:The present study aimed to investigate the feasibility of using ecto-mesenchymal stem cell (EMSC)-derived dendritic cells (DCs) for glioma immunotherapy following infection by a recombinant adenovirus containing the melanoma-associated antigen D4a (MAGE-D4a) gene. The ex vivo cultured EMSCs were infected by the adenov...

journal_title：Oncology letters

authors： Hu S,Li B,Shen X,Zhang R,Gao D,Guo Q,Jin Y,Fei Z

更新日期：2016-04-01 00:00:00

abstract：:Patients with the luminal B subtype of breast cancer exhibit a poor prognosis, high metastatic risk and high incidence of chemotherapy resistance. Luminal B breast cancer is sub-classified into B1 and B2. The pathophysiological mechanism of luminal B2 breast cancer (LB2BC) progression has yet to be characterized. Ther...

journal_title：Oncology letters

authors： Wang J,Du Q,Li C

更新日期：2017-12-01 00:00:00

abstract：:Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential therapeutic tools for solid tumors. However, there are numerous inconsistent results regarding the effects of hUCMSCs on tumors, and the mechanisms underlying this remain poorly understood. The present study further examined this controv...

journal_title：Oncology letters

authors： Yuan Y,Zhou C,Chen X,Tao C,Cheng H,Lu X

更新日期：2018-06-01 00:00:00

abstract：:Cutaneous melanoma (CM) is the most aggressive form of skin cancer, exhibits an increasing incidence worldwide and has a high potential to develop metastasis. The current study aimed to identify a set of parameters that may aid in predicting the probability and timing of the onset of CM metastasis. A retrospective ana...

journal_title：Oncology letters

authors： Pjanova D,Ruklisa D,Kregere E,Azarjana K,Ozola A,Cema I

更新日期：2020-10-01 00:00:00

abstract：:A 54-year-old female presented with a large pancreatic tumor of the tail during a regular physical examination. The patient underwent surgical intervention and the surgeon identified that the tumor originated from the retroperitoneal region. Markedly severe hemodynamic fluctuations occurred during the manipulation of ...

journal_title：Oncology letters

authors： Huang YH,Liaw WJ,Kuo CP,Wu ZF,Cherng CH,Yu JC,Horng HC,Huang ST

更新日期：2013-09-01 00:00:00

abstract：:2',4'-dihydroxy-6'-methoxychalcone (cardamonin) is a natural compound with anti-proliferative effects on several cancer types including nasopharyngeal carcinoma. The effects of cardamonin on melanoma cells are unknown. The present study investigated the anti-proliferative effect of cardamonin on human melanoma cell li...

journal_title：Oncology letters

authors： Yue Y,Liu L,Liu P,Li Y,Lu H,Li Y,Zhang G,Duan X

更新日期：2020-02-01 00:00:00

abstract：:The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...

journal_title：Oncology letters

authors： Li Z,Gu X,Fang Y,Xiang J,Chen Z

更新日期：2012-02-01 00:00:00

abstract：:This study aimed to determine the relationship between human papillomavirus (HPV) and nuclear factor-κB (NF-κB) in cervical cancer using 62 tissues of cervical cancer, and to compare the findings to penile cancer. HPV-DNA integration is a crucial factor for malignant transformation in cervical cancer and can be identi...

journal_title：Oncology letters

authors： Senba M,Buziba N,Mori N,Fujita S,Morimoto K,Wada A,Toriyama K

更新日期：2011-01-01 00:00:00

abstract：:Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples f...

journal_title：Oncology letters

authors： Cheng L,Shi G,Fang C,Li G,Zheng Y,Chen W

更新日期：2019-03-01 00:00:00

abstract：:Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. In the present study, the clinicopathological significance of Ku80 in esophageal squamous cell carcinoma (ESCC) was investigated. The expression level...

journal_title：Oncology letters

authors： Wang S,Wang Z,Yang YU,Shi MO,Sun Z

更新日期：2015-11-01 00:00:00

abstract：:The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the ...

journal_title：Oncology letters

authors： Scapulatempo-Neto C,Veo C,Fregnani JHTG,Lorenzi A,Mafra A,Melani AGF,Loaiza EAA,Rosa LAR,de Oliveira CM,Levi JE,Longatto-Filho A

更新日期：2017-03-01 00:00:00

abstract：:DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...

journal_title：Oncology letters

authors： Lee H,Choi SK,Ro JY

更新日期：2012-03-01 00:00:00

abstract：:Low-grade cribriform cystadenocarcinoma (LGCCC) is a malignant salivary gland tumor. LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56-year-old female ...

journal_title：Oncology letters

authors： Kokabu S,Nojima J,Kayano H,Yoda T

更新日期：2015-10-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a major subtype of non-small cell lung cancer. Despite significant progress in its diagnosis and treatment, the mortality and morbidity rate of LUAD remains high worldwide. The aim of the present study was to perform a systematic investigation of the tumor microenvironment (TME) and ident...

journal_title：Oncology letters

authors： Yuan J,Yuan B,Zeng L,Liu B,Chen Y,Meng X,Sun R,Lv X,Wang W,Yang S

更新日期：2020-08-01 00:00:00

abstract：:A nitroxide radical, Tempol (Tempol, TPL), is usually used as an antioxidative agent clinically, whereas the mechanism underlying its pro-oxidative effect has not been thoroughly investigated. The present study investigated the pro-oxidative effect of TPL on the inhibition of cellular proliferation and its role in enh...

journal_title：Oncology letters

authors： Wang M,Li K,Zou Z,Li L,Zhu L,Wang Q,Gao W,Wang Y,Huang W,Liu R,Yao K,Liu Q

更新日期：2018-10-01 00:00:00

abstract：:Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameter...

journal_title：Oncology letters

authors： Jin S,Xu C,Wang L,Wei J,Wang S

更新日期：2021-02-01 00:00:00

abstract：:Integrin signaling may modulate several different functions involved in cell migration, invasion, proliferation and motility, and is a potential candidate biomarker for oral cancer. In the present study, a total of four integrin genes were evaluated as potential biomarkers of oral squamous cell carcinoma (OSCC). Gene ...

journal_title：Oncology letters

authors： Chang HW,Yen CY,Chen CH,Tsai JH,Tang JY,Chang YT,Kao YH,Wang YY,Yuan SF,Lee SY

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to analyze the characteristics of polyethylene glycol (PEG)ylated carboplatin liposomes (PL-CBPs), including size, stability, their release, entrapping and loading efficiencies, and their antitumor and antimetastatic effects on the lymph nodes. The PL-CBPs were prepared using PEG-2000 with the ...

journal_title：Oncology letters

authors： Zhang J,Huang C,Huang H

更新日期：2014-11-01 00:00:00

abstract：:The aims of this study were to determine the methylation and expression status of secreted Frizzled-related protein 1 (SFRP1) in bladder cancer, to explore the mechanisms involved and to study the role of SFRP1 in the pathogenesis of bladder cancer. SFRP1 mRNA was detected by reverse transcription PCR (RT-PCR). The DN...

journal_title：Oncology letters

authors： Wang X,Wang H,Bu R,Fei X,Zhao C,Song Y

更新日期：2012-08-01 00:00:00

abstract：:Cytokine-induced killer (CIK) cells are a group of heterogeneous immune cells which can be isolated from human peripheral blood mononuclear cells and have demonstrated therapeutic benefit both in hematologic malignancies and solid tumors, including colorectal cancer. However, poor tumor-targeted migration has limited ...

journal_title：Oncology letters

authors： Zou Y,Liang J,Li D,Fang J,Wang L,Wang J,Zhang J,Guo Q,Yan X,Tang H

更新日期：2020-07-01 00:00:00

abstract：:Dermatofibrosarcoma protuberans (DFSP) is a relatively rare low-grade sarcoma that occasionally exhibits melanin-containing spindle cells within the tumor. Fibrosarcomatous DFSP (FS-DFSP) is a variant that is characterized by areas which are histopathologically indistinguishable from fibrosarcoma. In the present study...

journal_title：Oncology letters

authors： Ishida M,Okabe H

更新日期：2012-09-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is rare in the adult population and even rarer with jaw involvement. The current study presents the case of a 39-year-old male who complained of recurrent pain, swelling of the gingiva and an occasional pus-like discharge in the right mandible for one year. The patient was previousl...

journal_title：Oncology letters

authors： Shi S,Liu Y,Fu T,Li X,Zhao S

更新日期：2014-09-01 00:00:00

abstract：:The histological subtype of non-small-cell lung cancer (NSCLC) is a significant factor when selecting treatment strategies. However, cases are occasionally encountered that are diagnosed as 'not otherwise specified' (NOS) prior to surgery, due to an uncertain histological subtype. The present study investigated the pr...

journal_title：Oncology letters

authors： Tane S,Nishio W,Ogawa H,Hokka D,Tane K,Tanaka Y,Tauchi S,Uchino K,Sakai Y,Ohbayashi C,Yoshimura M,Maniwa Y

更新日期：2014-09-01 00:00:00

abstract：:The present case report describes the infrequent coexistence of squamous cell transformation and the epidermal growth factor receptor (EGFR) T790M mutation as resistance mechanisms to first line treatment with tyrosine kinase inhibitors. The patient was a 44-year-old female, diagnosed with a primitive advanced lung ad...

journal_title：Oncology letters

authors： Bruno R,Proietti A,Alì G,Puppo G,Ribechini A,Chella A,Fontanini G

更新日期：2017-11-01 00:00:00

abstract：:Human lactoferrin (hLF) is a multifunctional glycoprotein that inhibits cancer growth. However, the inhibitory effect of this glycoprotein in cervical cancer remains inconclusive. This study investigated the efficacy of hLF on the inhibition of U14 cervical cancer in vivo. Recombinant adenovirus carrying hLF (Ad-hLF) ...

journal_title：Oncology letters

authors： Shi H,Li W

更新日期：2014-03-01 00:00:00

abstract：:The aim of the present study was to identify monitoring and prevention measures as well as predictive factors for early detection of renal toxicity associated with long-term administration of adefovir dipivoxil in order to avoid progression to Fanconi syndrome. Clinical data of 28 patients with Fanconi syndrome caused...

journal_title：Oncology letters

authors： Lin Y,Pan F,Wang Y,Chen Z,Lin C,Yao L,Zhang X,Zhou R,Pan C

更新日期：2017-01-01 00:00:00