Cardamonin as a potential treatment for melanoma induces human melanoma cell apoptosis.

abstract：:Telomeres are located at the ends of chromosomes and protect them from degradation. Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining short telomeres is a protective mechanism against cancer in humans. In most human somatic cells, the expression of telomerase reverse transcriptase...

journal_title：Oncology letters

authors： Trybek T,Kowalik A,Góźdź S,Kowalska A

更新日期：2020-08-01 00:00:00

abstract：:The aim of the current study was to investigate the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) expression and cell proliferation in the human osteosarcoma cell line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 and 40 μmol/l) for various times (24, 48 and 72...

journal_title：Oncology letters

authors： Liu Z,Li Y,Yang R

更新日期：2012-10-01 00:00:00

abstract：:Diagnostic value of magnetic resonance imaging (MRI) and multi-slice spiral CT (MSCT) for different pathological stages of prostate cancer was compared. A total of 112 patients with prostate cancer who underwent surgical pathology in The Affiliated Yantai Yuhuangding Hospital of Qingdao University from February 2014 t...

journal_title：Oncology letters

authors： Sui Y,Li J,Zou Z,Shi Y,Hao C

更新日期：2019-06-01 00:00:00

abstract：:The Mantle Cell Lymphoma International Prognostic Index (MIPI) combines four factors to differentiate low-, intermediate- and high-risk prognostic groups in advanced mantle cell lymphoma using data from patients treated in clinical trials. To evaluate its use in routine practice, we applied the simplified index retros...

journal_title：Oncology letters

authors： Lim SY,Horsman JM,Hancock BW

更新日期：2010-01-01 00:00:00

abstract：:The aim of the present study was to investigate the significance and values of 3.0T diffusion weighted imaging (DWI) to differentially diagnose benign and malignant space-occupying liver lesions. A total of 91 patients with liver space-occupying lesions (145 lesions) were admitted into Zhongnan Hospital of Wuhan Unive...

journal_title：Oncology letters

authors： Li R,Wu G,Wang R

更新日期：2018-02-01 00:00:00

abstract：:Metaplastic carcinoma of the breast (MBC) is a rare and heterogeneous type of neoplasm. Knowledge about its clinical characteristics, prognostic significance and optimal treatment modalities is fragmentary and controversial. The present retrospective study aimed to investigate the prognostic value of the clinicopathol...

journal_title：Oncology letters

authors： Xiao M,Yang Z,Tang X,Mu L,Cao X,Wang X

更新日期：2017-08-01 00:00:00

abstract：:A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human pap...

journal_title：Oncology letters

authors： Gao H,Huang Z,Shi C,Li H

更新日期：2015-02-01 00:00:00

abstract：:The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...

journal_title：Oncology letters

authors： Dong S,Zhang P,Liang S,Wang S,Sun P,Wang Y

更新日期：2013-12-01 00:00:00

abstract：:Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully under...

journal_title：Oncology letters

authors： Chen J,Wang F,Lu Y,Yang S,Chen X,Huang Y,Lin X

更新日期：2020-12-01 00:00:00

abstract：:Ecto-5'-nucleotidase [cluster of differentiation (CD)73] has important functions in several types of cancer, however, its expression in squamous cell carcinoma (SCC) remains unknown. The present study was designed to investigate CD73 expression in SCC. CD73 expression was assessed by immunohistochemistry in 113 patien...

journal_title：Oncology letters

authors： Ren ZH,Yuan YX,Ji T,Zhang CP

更新日期：2016-07-01 00:00:00

abstract：:microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...

journal_title：Oncology letters

authors： Chen X,Wang A,Yue X

更新日期：2018-07-01 00:00:00

abstract：:An elevated neutrophil to lymphocyte ratio (NLR) has been reported to be associated with the pathological response to neoadjuvant therapies in numerous types of cancer. The aim of the current study was to clarify the association between pre-treatment NLR and the pathological response to preoperative chemoradiotherapy ...

journal_title：Oncology letters

authors： Hasegawa S,Eguchi H,Tomokuni A,Tomimaru Y,Asaoka T,Wada H,Hama N,Kawamoto K,Kobayashi S,Marubashi S,Konnno M,Ishii H,Mori M,Doki Y,Nagano H

更新日期：2016-02-01 00:00:00

abstract：:Previous studies have demonstrated that microRNAs (miRs) are involved in the carcinogenesis of colorectal cancer (CRC). To the best of our knowledge, the function and regulatory role of miR-532-5p in human CRC remains unknown. The aim of the present study was to determine the role and regulation of miR-532-5p in CRC. ...

journal_title：Oncology letters

authors： Zhang J,Zhou W,Liu Y,Liu T,Li C,Wang L

更新日期：2018-05-01 00:00:00

abstract：:The role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is a disease with not only a genetic, but also an immunological basis. Additionally, immune cell infiltration is an important feature of oral cancer. C-X-C motif chemokine ligand 12 (CXCL12) serves an important role in immune suppression in the tum...

journal_title：Oncology letters

authors： Zhang B,Wu C,Zhang Z,Yan K,Li C,Li Y,Li L

更新日期：2019-08-01 00:00:00

abstract：:Bladder cancer (BC) is one of the most common urogenital malignancies. However, present studies of its multiple gene interaction and cellular pathways remain unable to accurately verify the genesis and the development of BC. The aim of the present study was to investigate the genetic signatures of BC and identify its ...

journal_title：Oncology letters

authors： Yan M,Jing X,Liu Y,Cui X

更新日期：2018-09-01 00:00:00

abstract：:The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-assoc...

journal_title：Oncology letters

authors： Cui L,Song J,Wu L,Cheng L,Chen A,Wang Y,Huang Y,Huang L

更新日期：2017-01-01 00:00:00

abstract：:Evaluation of carcinogenic substances from the environment is a challenge for scientists. Recently, a novel approach based on 10 key characteristics of human carcinogens classified by the International Agency for Research on Cancer (IARC) has emerged. Carcinogenesis depends on different mechanisms and factors, includi...

journal_title：Oncology letters

authors： Calaf GM,Ponce-Cusi R,Aguayo F,Muñoz JP,Bleak TC

更新日期：2020-07-01 00:00:00

abstract：:The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...

journal_title：Oncology letters

authors： Li J,Xie Y,Wang X,Jiang C,Yuan X,Zhang A,Yang L,Liu C,Zou H,Li F,Hu J

更新日期：2020-11-01 00:00:00

abstract：:The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. P...

journal_title：Oncology letters

authors： Fen X,Qin W,Bao W,Jiang F,Li B,Hu F,Chen X

更新日期：2013-08-01 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4 (TLR4) are involved in numerous mechanisms of cancer biology, including cell proliferation and survival; however the interaction of the two factors under hypoxic conditions remains unclear. The present study investigated the in vitro mechanism that results ...

journal_title：Oncology letters

authors： Zhang X,Li S,Li M,Huang H,Li J,Zhou C

更新日期：2016-08-01 00:00:00

abstract：:The present study reported three rare cases of multicystic vestibular schwannoma with fluid-fluid levels. These three tumors exhibited apparent fluid-fluid levels that demonstrated a radiological appearance of two fluid levels in the cystic area. Two cases had an acute history, whereas one case presented with a chroni...

journal_title：Oncology letters

authors： Li P,Bi Z,Hao S,Zhang J

更新日期：2015-07-01 00:00:00

abstract：:The current study aimed to explore whether the efficiency of the standard International Prognostic Index (S-IPI), revised-IPI (R-IPI) and enhanced-IPI (NCCN-IPI) in evaluating the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) may be improved by interim 18F-FDG PET/CT. A total of 185 patients with ne...

journal_title：Oncology letters

authors： Jiang M,Chen P,Ruan X,Ye X,Pan Y,Zhang J,Huang Q,Zhou W,Wu H,Wang Q

更新日期：2017-12-01 00:00:00

abstract：:Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts i...

journal_title：Oncology letters

authors： Zheng LH,Cai FF,Ge I,Biskup E,Cheng ZP

更新日期：2014-08-01 00:00:00

abstract：:Although tumor thrombus (TT) infringement of the inferior vena cava (IVC) and right atrium (RA) is rarely observed in hepatocellular carcinoma (HCC), the prognosis for this condition is extremely poor, with a median survival time of several months, given that the condition is often diagnosed at an advanced tumor stage...

journal_title：Oncology letters

authors： Xia Y,Zhang J,Ni X

更新日期：2020-10-01 00:00:00

abstract：:Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...

journal_title：Oncology letters

authors： Li M,Zhao Y,Liu X,Zhang S,Jiang Y,Yang Z

更新日期：2020-04-01 00:00:00

abstract：:The phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway is a cellular pathway involved in cell growth, tumorigenesis and cell invasion which is frequently activated in various types of cancer. The downstream effector of the pathway is mTOR which is important in cellular growth and homeost...

journal_title：Oncology letters

authors： Li M,Sun H,Song L,Gao X,Chang W,Qin X

更新日期：2012-12-01 00:00:00

abstract：:The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The pote...

journal_title：Oncology letters

authors： Kim W,Kang J,Lee S,Youn B

更新日期：2017-06-01 00:00:00

abstract：:Abnormal regulation of long non-coding RNAs (lncRNAs) appears to be a primary feature of numerous types of human cancer. However, the association between the dysregulation of lncRNAs and functional alterations in gastric cancer (GC) remains unclear. In previous studies, we applied microarray and bioinformatics analyse...

journal_title：Oncology letters

authors： Li CY,Liang GY,Yao WZ,Sui J,Shen X,Zhang YQ,Ma SM,Ye YC,Zhang ZY,Zhang WH,Yin LH,Pu YP

更新日期：2018-06-01 00:00:00

abstract：:The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single...

journal_title：Oncology letters

authors： Ma C,Liu C,Huang P,Kaku H,Chen J,Guo K,Ueki H,Sakai A,Nasu Y,Kumon H,Shimizu K,Watanabe M

更新日期：2014-08-01 00:00:00

abstract：:Esophageal cancer staging is important for the treatment of esophageal cancer. Endoscopic ultrasonography (EUS) is a common diagnostic tool for esophageal cancer prior to surgery. However, EUS is unable to accurately discriminate the N-staging of lymph nodes. In order to distinguish an optimized standard for malignant...

journal_title：Oncology letters

authors： Zhang Y,He S,Dou L,Liu Y,Ke Y,Yu X,Wang Z,Wang G

更新日期：2019-01-01 00:00:00