Adefovir dipivoxil-induced Fanconi syndrome and its predictive factors: A study of 28 cases.


:The aim of the present study was to identify monitoring and prevention measures as well as predictive factors for early detection of renal toxicity associated with long-term administration of adefovir dipivoxil in order to avoid progression to Fanconi syndrome. Clinical data of 28 patients with Fanconi syndrome caused by long-term administration of adefovir dipivoxil for the treatment of chronic hepatitis B virus (HBV) infection were collected pre-and post-administration for analysis. Patients presented with fatigue, progressive systemic pain in multiple bones and joints, as well as difficulty in walking and pathological fractures in a number of severe cases. Laboratory examinations revealed hypophosphatemia, elevated serum cystatin C (Cys-C), elevated serum creatinine (SCr), reduced glomerular filtration rate (GFR), positive urinary protein, erythrocytes and glucose, as well as osteoporosis. In consequence, adefovir dipivoxil administration was stopped, and patients received concentrated divitamins, sodium phosphate syrup and calcitriol. Symptoms and abnormalities in laboratory examinations were significantly improved in all patients after 2-6 months. Therefore, serum phosphate, SCr, routine urine parameters, Cys-C and GFR should be monitored regularly in chronic HBV patients treated with adefovir dipivoxil. The following factors were identified as predictive of kidney damage and Fanconi syndrome: Age ≥40 years, living in rural areas, previous renal toxicity, estimated GFR (eGFR) <90 ml/min/1.73 m2, hypertension, diabetes, cirrhosis and duration of adefovir dipivoxil treatment exceeding 24 months. The present results indicate that timely termination of adefovir dipivoxil treatment and replacement with other antiviral agents is critical once renal impairment appears, and that it is necessary to change to other antiviral agents and prolong the interval of administration according to the eGFR level.


Oncol Lett


Oncology letters


Lin Y,Pan F,Wang Y,Chen Z,Lin C,Yao L,Zhang X,Zhou R,Pan C




Has Abstract


2017-01-01 00:00:00














  • Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy.

    abstract::The present study evaluated the use of saliva surface-enhanced Raman spectroscopy (SERS) for the detection of non-invasive nasopharyngeal carcinoma (NPC). SERS measurements were taken from 62 saliva samples, of which 32 were from NPC patients and 30 from healthy volunteers. Notable biochemical Raman bands in the SERS ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Qiu S,Xu Y,Huang L,Zheng W,Huang C,Huang S,Lin J,Lin D,Feng S,Chen R,Pan J

    更新日期:2016-01-01 00:00:00

  • MicroRNA-125a-3p downregulation correlates with tumorigenesis and poor prognosis in patients with non-small cell lung cancer.

    abstract::MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Hou L,Luo P,Ma Y,Jia C,Yu F,Lv Z,Wu C,Fu D

    更新日期:2017-10-01 00:00:00

  • BRAF V600E mutation and BRAF VE1 immunoexpression profiles in different types of glioblastoma.

    abstract::Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct vari...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Tosuner Z,Geçer MÖ,Hatiboğlu MA,Abdallah A,Turna S

    更新日期:2018-08-01 00:00:00

  • Expression of KIAA1456 in lung cancer tissue and its effects on proliferation, migration and invasion of lung cancer cells.

    abstract::The expression of human transfer ribonucleic acid (tRNA) methyltransferase 9-like (KIAA1456) protein in lung cancer tissue and its effects on certain genes involved in the proliferation, migration and invasion of lung cancer cells were investigated. Immunohistochemistry was applied to stain lung cancer tissue and adja...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Wang S,Liu X,Huang J,Zhang Y,Sang C,Li T,Yuan J

    更新日期:2018-09-01 00:00:00

  • Snail mediates invasion through uPA/uPAR and the MAPK signaling pathway in prostate cancer cells.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Randle DD,Clarke S,Henderson V,Odero-Marah VA

    更新日期:2013-12-01 00:00:00

  • Primary paratesticular osteosarcoma: A case report.

    abstract::Extraosseous osteosarcoma originating from paratesticular soft tissue is an extremely rare type of malignant tumor. With the exception of the present study, only one other case of osteosarcoma originating from paratesticular soft tissue has previously been reported. A 52-year-old man presented with a painless scrotal ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Hong R,Lee G,Kim H,Kim CS,Kee KH

    更新日期:2012-03-01 00:00:00

  • Effect of overexpression of HOX genes on its invasive tendency in cerebral glioma.

    abstract::Transcription factors encoded by HOX genes are vital in the determination of cell fate and identity during embryonic development. In certain malignancies, HOX genes also behave as oncogenes. The present study demonstrated suppression of the invasive tendency of glioblastoma multiforme U-118 and U-138 cells by the intr...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Guo YB,Shao YM,Chen J,Xu SB,Zhang XD,Wang MR,Liu HY

    更新日期:2016-01-01 00:00:00

  • Expression of the epigenetic H3K27me3 modifier genes KDM6A and EZH2 in patients with upper tract urothelial carcinoma.

    abstract::The development of upper tract urothelial carcinoma (UTUC) has been associated with the ingestion of aristolochic acid (AA) in Chinese herbs. The tumors are more malignant and patients have a worse prognosis in China compared with that in Western countries. Recently, whole-genome and exome sequencing of AA-associated ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Wang Y,Zhang JX,Wang SF,Zhang Y,He HY

    更新日期:2020-12-01 00:00:00

  • Effects and mechanism of the bile acid (farnesoid X) receptor on the Wnt/β-catenin signaling pathway in colon cancer.

    abstract::The downregulation of farnesoid X receptor (FXR; gene name, nuclear receptor subfamily 1 group h member 4), an enteric nuclear bile acid receptor, has been reported in colorectal carcinoma (CRC), and FXR expression has been inversely correlated with CRC stage and clinical outcome. FXR knockdown in chronic colitis mous...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Mao J,Chen X,Wang C,Li W,Li J

    更新日期:2020-07-01 00:00:00

  • PCDHGA12 methylation biomarker in bronchial washing specimens as an adjunctive diagnostic tool to bronchoscopy in lung cancer.

    abstract::The use of bronchoscopy is central to the diagnosis of lung cancer. However, the sensitivity of bronchoscopy is low. In addition, bronchial washing cytology, which is a routine adjunctive test, does not significantly improve the performance of bronchoscopy owing to its low sensitivity. To enhance the diagnostic perfor...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Jeong IB,Yoon YS,Park SY,Cha EJ,Na MJ,Kwon SJ,Kim JH,Oh TJ,An S,Park CR,Kim YJ,Park DH,Son JW

    更新日期:2018-07-01 00:00:00

  • A subpopulation of cancer stem cells identifies radiographic characteristics in glioblastoma.

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    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Kim JE,Kim SK,Shin J,Se YB,Choi SH,Park SH,Choi SA,Lee JY,Phi JH,Wang KC,Park CK,Kim SK

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  • Effect of cytokine-induced killer cells combined with dendritic cells on the survival rate and expression of 14-3-3ζ and p-Bad proteins in Lewis lung cancer cell lines.

    abstract::In the present study, the function and mechanism of cytokine-induced killer cells (CIK) combined with dendritic cells (DC-CIK) were examined in Lewis lung cancer (LLC) cells. Co-culture of CIK dendritic cells (DC) in vitro was used to investigate their proliferation and the antitumor effects on LLC cells. DC and CIK c...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Hou Y,Zang D,Li X,Li F

    更新日期:2018-08-01 00:00:00

  • Clinical significance of gefitinib antitumor activity in patients with lung adenocarcinoma.

    abstract::Non-small cell lung cancer is a subtype of adenocarcinoma, which has previously shown positive responses to gefitinib. The aim of the current study was to determine a clinical profile of gefitinib-induced disease controls for patients with lung adenocarcinoma. Retrospective evaluation of the clinical characteristics o...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Wang Z,Han QB,Gu JL,Yu XM,Sun XJ,Lin QR,Fang J,Wang YZ,Xu YP,Mao WM

    更新日期:2015-01-01 00:00:00

  • Surgical treatment of a retroperitoneal benign tumor surrounding important blood vessels by fractionated resection: A case report and review of the literature.

    abstract::Retroperitoneal tumors are lesions with diverse pathological subtypes that originate from the retroperitoneal space; ~40% of these tumors are benign. Due to such lesions often surrounding and associating with vital abdominal blood vessels, a complete surgical resection is difficult. The current study presents a novel ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Wan Z,Yin T,Chen H,Li D

    更新日期:2016-05-01 00:00:00

  • The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway.

    abstract::The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA fro...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Liu Y,Wang R,Zhang L,Li J,Lou K,Shi B

    更新日期:2017-06-01 00:00:00

  • Expression of C-X-C chemokine receptor types 1/2 in patients with gastric carcinoma: Clinicopathological correlations and significance.

    abstract::C-X-C chemokine receptor types 1/2 (CXCR1/2) may play multiple roles in the development and progression of a number of types of tumor. The abnormal expression of CXCR1/2 in various types of malignant tumors has been reported, but less is known with regard to gastric carcinoma. The present study was preliminarily condu...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Wang JP,Hu WM,Wang KS,Yu J,Luo BH,Wu C,Chen ZH,Luo GQ,Liu YW,Liu QL,Xiao Y,Zhou HY,Yang XJ,Jiang HY,Li JH,Wen JF

    更新日期:2013-02-01 00:00:00

  • Oncogenic role of microRNA-532-5p in human colorectal cancer via targeting of the 5'UTR of RUNX3.

    abstract::Previous studies have demonstrated that microRNAs (miRs) are involved in the carcinogenesis of colorectal cancer (CRC). To the best of our knowledge, the function and regulatory role of miR-532-5p in human CRC remains unknown. The aim of the present study was to determine the role and regulation of miR-532-5p in CRC. ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhang J,Zhou W,Liu Y,Liu T,Li C,Wang L

    更新日期:2018-05-01 00:00:00

  • Glucagonoma and the glucagonoma syndrome.

    abstract::Glucagonoma is an extremely rare pancreatic α-islet cell tumor and is often accompanied by certain clinical symptoms including necrotizing migratory erythema (NME), diabetes, weight loss and anemia. The objectives of the current review were to discern the clinical features, diagnosis, treatment and prognosis of glucag...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Song X,Zheng S,Yang G,Xiong G,Cao Z,Feng M,Zhang T,Zhao Y

    更新日期:2018-03-01 00:00:00

  • Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway.

    abstract::Gefitinib is a selective inhibitor of the tyrosine kinase epidermal growth factor receptor, which inhibits tumor pathogenesis, metastasis and angiogenesis, as well as promoting apoptosis. Therefore, gefitinib presents an effective drug for the targeted therapy of lung cancer. However, the underlying mechanisms by whic...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhao ZQ,Yu ZY,Li J,Ouyang XN

    更新日期:2016-07-01 00:00:00

  • Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells.

    abstract::Macrophages are a heterogeneous group of phagocytes that play critical roles in inflammation, infection and tumor growth. Macrophages respond to different environmental factors and are thereby polarized into specialized functional subsets. Although hypoxia is an important environmental factor, its impact on human macr...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Ke X,Chen C,Song Y,Cai Q,Li J,Tang Y,Han X,Qu W,Chen A,Wang H,Xu G,Liu D

    更新日期:2019-12-01 00:00:00

  • Short hairpin RNA of frizzled-2 suppresses the proliferation of hepatocellular carcinoma cells.

    abstract::In the present study, Frizzled-2 (Fz2), a receptor of the Wnt ligand, was investigated as a potential target of molecular therapy for hepatocellular carcinoma (HCC). Quantitative polymerase chain reaction (PCR) was performed to determine the expression levels of Fz2. A surgical specimen of HCC was immunostained with a...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Sueishi M

    更新日期:2014-10-01 00:00:00

  • Rate of detecting CIN3+ among patients with ASC-US using digital colposcopy and dynamic spectral imaging.

    abstract::The present study compared two methods for the detection of severe cervical dysplasia in women with atypical squamous cells of underdetermined significance (ASC-US) cytology; digital colposcopy with adjunctive dynamic spectral imaging (DSI) and conventional colposcopy. IMPROVE-COLPO was a two-arm cross-sectional study...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Harris KE,Lavin PT,Akin MD,Papagiannakis E,Denardis S

    更新日期:2020-10-01 00:00:00

  • Piper betle extracts exhibit antitumor activity by augmenting antioxidant potential.

    abstract::The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells i...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Alam B,Majumder R,Akter S,Lee SH

    更新日期:2015-02-01 00:00:00

  • Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway.

    abstract::Chronic myelogenous leukemia (CML) is a common hematological malignancy. Some patients progressing to the blast phase develop chemotherapeutic drug resistance. In the authors' previous study, it was found that the mammalian target of rapamycin (mTOR) pathway was activated in CML and that rapamycin inhibited the prolif...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Li J,Liu W,Hao H,Wang Q,Xue L

    更新日期:2019-09-01 00:00:00

  • N-myc downstream-regulated gene 1 inhibits the proliferation and invasion of hepatocellular carcinoma cells via the regulation of integrin β3.

    abstract::N-myc downstream-regulated gene 1 (NDRG1) is a multifunctional protein associated with carcinogenesis and tumor progression. The function of NDRG1 in hepatocellular carcinoma (HCC) cells remains controversial. The present study investigated the role of NDRG1 in HCC as well as its molecular mechanism using a range of t...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Song Y,Wu G,Zhang M,Kong Q,Du J,Zheng Y,Yue L,Cao L

    更新日期:2017-05-01 00:00:00

  • Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma.

    abstract::Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying mechanisms by whic...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yang L,Huang M,Tan J,Hou J,He J,Wang F,Cui H,Yi L

    更新日期:2017-06-01 00:00:00

  • Microglia immunophenotyping in gliomas.

    abstract::Microglia, once assimilated to peripheral macrophages, in gliomas has long been discussed and currently it is hypothesized to play a pro-tumor role in tumor progression. Uncertain between M1 and M2 polarization, it exchanges signals with glioma cells to create an immunosuppressive microenvironment and stimulates cell ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Annovazzi L,Mellai M,Bovio E,Mazzetti S,Pollo B,Schiffer D

    更新日期:2018-01-01 00:00:00

  • Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions.

    abstract::It has been reported that zerumbone (ZER) has marked effects on the regulation of cell proliferation and migration in multiple types of cancer, and has anti-cancer effects on various types of malignant cell. However, the effects and underlying molecular mechanisms of treatment with ZER on melanoma cells remain unclear...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yan H,Ren MY,Wang ZX,Feng SJ,Li S,Cheng Y,Hu CX,Gao SQ,Zhang GQ

    更新日期:2017-04-01 00:00:00

  • De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland: A case report.

    abstract::Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also uncommon, representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases ar...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Panelli Santos KCP,Matsuzaki H,Unetsubo T,Tsuyoshi S,Nagatsuka H,Asaumi JI

    更新日期:2017-04-01 00:00:00

  • Yi-qi-yang-yin-tang increases the sensitivity of KG1a leukemia stem cells to daunorubicin by promoting cell cycle progression and regulating the expression of PTEN, TOPOII and mTOR.

    abstract::The present study aimed to investigate the effects of serum containing a combination of yi-qi-yang-yin-tang (YQYYT) and daunorubicin (DNR) on multidrug resistance in KG1a leukemia stem cells (LSCs). The effects of YQYYT and DNR on proliferation, cell cycle progression and the expression of phosphatase and tensin homol...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Shi ZX,Li HY,Yang XD,Gao H,Li DG,Yang WH,Yao F,Yan LX

    更新日期:2017-12-01 00:00:00