Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis.

Abstract:

:Pancreatic cancer has a low survival rate globally. Anillin (ANLN) is involved in the pathogenesis of pancreatic cancer (PC). The present study used databases and reverse transcription-quantitative PCR to investigate the association between ANLN expression, clinical variables and the survival rate of patients with pancreatic cancer. Gene expression of ANLN in normal and cancer tissues was analyzed using data from The Cancer Genome Atlas, Oncomine and Gene Expression database of Normal and Tumor tissues 2 and ANOVA, and the association between ANLN mRNA expression and ANLN genovariation was analyzed using cBioPortal. The association between ANLN expression and the survival, clinical, pathological and prognostic characteristics of PC was analyzed using Kaplan-Meier (K-M) survival analysis, Kruskal Wallis and Mann Whitney-U tests, and logistic and Cox regression models. Gene Set Enrichment Analysis (GSEA) revealed the molecular pathways underpinning ANLN function in PC. Overexpression of ANLN was observed in PC cells (normal vs. tumor, P<0.01) and tissues (normal vs. tumor, P=0.008). Enhanced ANLN expression was associated with high tumor grade (grade 1 vs. grade 3, odds ratio: 5.662, P<0.001). However, ANLN expression was not associated with other clinical features (all P>0.05). K-M analysis suggested that increased ANLN expression was associated with poor survival (P=0.002). Univariate and multivariate analysis revealed the ANLN is an independent prognostic factor for PC (P<0.001). GSEA demonstrated the p53, cell cycle, DNA replication, mismatch repair, nucleotide excision repair and PC pathways were associated with low expression of ANLN. Overall, ANLN is more highly expressed in PC compared with in normal tissue, and is associated with poor differentiation. The expression of ANLN may be a novel prognostic marker of poor survival. Finally, ANLN exert its functions in PC through the p53, cell cycle, DNA replication, mismatch repair and nucleotide excision repair and pathways.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Nie Y,Zhao Z,Chen M,Ma F,Fan Y,Kang Y,Kang B,Wang C

doi

10.3892/ol.2020.12368

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

107

issue

2

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-12368

journal_volume

21

pub_type

杂志文章
  • Prognostic significance of S-phase fractions in peritumoral invading zone analyzed by laser scanning cytometry in patients with high-grade glioma: A preliminary study.

    abstract::The predominant characteristic of malignant glioma is the presence of invading tumor cells in the peritumoral zone. Distinguishing between tumor cells and normal cells in a peritumoral lesion is challenging. Therefore, the aim of the present study was to investigate the cell-cycle phase measurements of fixed paraffin-...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4205

    authors: Nakajima S,Morii K,Takahashi H,Fujii Y,Yamanaka R

    更新日期:2016-03-01 00:00:00

  • Aryl hydrocarbon receptor nuclear translocator promotes the proliferation and invasion of clear cell renal cell carcinoma cells potentially by affecting the glycolytic pathway.

    abstract::Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in regulating glycolysis, angiogenesis and apoptosis. Recently, ARNT has been reported to a play role in pancreatic-islet function in type 2 diabetes. However, the role of ARNT in kidney cancer h...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11917

    authors: Zhao Y,Han F,Zhang X,Zhou C,Huang D

    更新日期:2020-10-01 00:00:00

  • IMRT dose verification considering passing rate and respiratory motion.

    abstract::The aim of the present study was to investigate the association between the dynamic intensity-modulated radiation therapy planned γ analysis passing rate and respiratory amplitude (A) and period (T) for different tumor volumes. A total of 30 patients with malignant lung tumors were divided into three groups: A; B; and...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8724

    authors: Xie K,Sun H,Lin T,Gao L,Sui J,Ni X

    更新日期:2018-07-01 00:00:00

  • Effect of hypoxia on hypoxia inducible factor-1α, insulin-like growth factor I and vascular endothelial growth factor expression in hepatocellular carcinoma HepG2 cells.

    abstract::Hypoxic microenvironments and angiogenesis have been a focus of tumor research in previous years. The aim of the the present study was to create a hypoxic model and observe the effect of hypoxia on the expression of hypoxia inducible factor-1α (HIF-1α), insulin-like growth factor I (IGF-1) and vascular endothelial gro...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.2879

    authors: Liu Q,Xu Z,Mao S,Chen W,Zeng R,Zhou S,Liu J

    更新日期:2015-03-01 00:00:00

  • Surgical wound management made easier and more cost-effective.

    abstract::Evidence-based guidelines for the prevention of surgical site infection (SSI) have been published by the U.S. Centers for Disease Control and Prevention (CDC). According to these guidelines, a wound should usually be covered with a sterile dressing for 24 to 48 h when a surgical incision is closed primarily. However, ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.687

    authors: Akagi I,Furukawa K,Miyashita M,Kiyama T,Matsuda A,Nomura T,Makino H,Hagiwara N,Takahashi K,Uchida E

    更新日期:2012-07-01 00:00:00

  • Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer.

    abstract::Abnormal glucose metabolism is critical in colorectal cancer (CRC) development. Expression of the pyruvate kinase (PK) M2 isoform, rather than the PKM1 isoform, serves important functions in reprogramming the glucose metabolism of cancer cells. Preferential expression of PKM2 is primarily driven by alternative splicin...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.7085

    authors: Sun Y,Luo M,Chang G,Ren W,Wu K,Li X,Shen J,Zhao X,Hu Y

    更新日期:2017-12-01 00:00:00

  • BRAF-activated long non-coding RNA contributes to colorectal cancer migration by inducing epithelial-mesenchymal transition.

    abstract::Long non-coding RNAs (lncRNAs) are recently identified regulators in tumorigenesis and tumour progression. BRAF-activated lncRNA (BANCR) is overexpressed in melanoma and has a potential functional role in melanoma cell migration. However, little is known concerning the role of BANCR in the development of colorectal ca...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2154

    authors: Guo Q,Zhao Y,Chen J,Hu J,Wang S,Zhang D,Sun Y

    更新日期:2014-08-01 00:00:00

  • Penile mucinous carcinoma: A case report.

    abstract::Penile cancer is an extremely rare form of urological cancer that usually originates in the epithelium of the inner preputium or glans. Major etiological factors include phimosis, poor penile hygiene and smoking. Nearly 95% of penile cancers are squamous cell carcinomas and usually occur in the sixth decade of life. T...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2839

    authors: Öztürk H

    更新日期:2015-03-01 00:00:00

  • Rate of detecting CIN3+ among patients with ASC-US using digital colposcopy and dynamic spectral imaging.

    abstract::The present study compared two methods for the detection of severe cervical dysplasia in women with atypical squamous cells of underdetermined significance (ASC-US) cytology; digital colposcopy with adjunctive dynamic spectral imaging (DSI) and conventional colposcopy. IMPROVE-COLPO was a two-arm cross-sectional study...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11878

    authors: Harris KE,Lavin PT,Akin MD,Papagiannakis E,Denardis S

    更新日期:2020-10-01 00:00:00

  • Leiomyosarcoma of the thyroid gland: A case report and literature review.

    abstract::Primary smooth muscle tumors of the thyroid gland are extremely rare neoplasms. Due to their rarity, clinical case studies concerning management are lacking. According to a literature review, only 19 cases of primary thyroid leiomyosarcomas (TLs) have been reported. In the majority of patients, the prognosis is poor s...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1853

    authors: Conzo G,Candela G,Tartaglia E,Gambardella C,Mauriello C,Pettinato G,Bellastella G,Esposito K,Santini L

    更新日期:2014-04-01 00:00:00

  • The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway.

    abstract::The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA fro...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6038

    authors: Liu Y,Wang R,Zhang L,Li J,Lou K,Shi B

    更新日期:2017-06-01 00:00:00

  • PLCB4 upregulation is associated with unfavorable prognosis in pediatric acute myeloid leukemia.

    abstract::Phospholipase C (PLC) is a membrane-associated enzyme that regulates several cellular behaviors including cell motility, growth, transformation and differentiation. PLC is involved in cancer migration, invasion and drug resistance. However, the expression status and prognostic role of PLCB4 in acute myeloid leukemia (...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10921

    authors: Wu S,Zhang W,Shen D,Lu J,Zhao L

    更新日期:2019-12-01 00:00:00

  • Clinicopathologic features and treatment of breast metastasis from nasopharyngeal carcinoma: A report of two cases and literature review.

    abstract::Breast metastasis is a rare pattern of distant metastasis from nasopharyngeal carcinoma (NPC) following curative treatment. The present study reported two patients with breast metastasis from NPC and reviewed four such patients reported in the literature, including the analysis of clinical profiles, pathological diagn...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3818

    authors: Xiao W,He Z,Xing C,Zhen W,Wang S,Lin H

    更新日期:2015-12-01 00:00:00

  • Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels.

    abstract::Hyperbaric oxygenation (HBO) on postoperative rehabilitation of brain tumors and effects on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were explored. A retrospective analysis of 132 patients with brain tumors treated in the People's Hospital of Rizhao from October 2014 to October 2017 was performe...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10000

    authors: Hou S,Wu G,Liang J,Cheng H,Chen C

    更新日期:2019-03-01 00:00:00

  • Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2.

    abstract::[This retracts the article DOI: 10.3892/ol.2016.4607.]. ...

    journal_title:Oncology letters

    pub_type: 杂志文章,撤回出版物

    doi:10.3892/ol.2019.10108

    authors: Li L,Mao X,Qin X,Zhou M,Xing H,Dong F,Jiang X,Zhuang W

    更新日期:2019-05-01 00:00:00

  • Distinct expression and prognostic value of OTU domain-containing proteins in non-small-cell lung cancer.

    abstract::The ubiquitin-proteasome pathway is an important protein degradation regulatory system in cells. This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. Ovarian tumor-associated proteases domain-containing...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10883

    authors: Deng J,Hou G,Fang Z,Liu J,Lv XD

    更新日期:2019-11-01 00:00:00

  • Interferon-α suppresses invasion and enhances cisplatin-mediated apoptosis and autophagy in human osteosarcoma cells.

    abstract::Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1762

    authors: Zhao J,Wang M,Li Z,Chen J,Yin Z,Chang J,Gao D,Wang S

    更新日期:2014-03-01 00:00:00

  • Transforming growth factor-β decreases side population cells in hepatocellular carcinoma in vitro.

    abstract::Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-β (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effec...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8441

    authors: Kim JB,Lee S,Kim HR,Park SY,Lee M,Yoon JH,Kim YJ

    更新日期:2018-06-01 00:00:00

  • Screening specific polypeptides of breast cancer stem cells from a phage display random peptide library.

    abstract::The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5248

    authors: Liu F,Qi CL,Kong M,Liu TT,Li L,Li BJ

    更新日期:2016-12-01 00:00:00

  • Casticin inhibits epithelial-mesenchymal transition of liver cancer stem cells of the SMMC-7721 cell line through downregulating Twist.

    abstract::The existence of cancer stem cells (CSCs) is central to the pathogenesis and therapeutic target of human hepatocellular carcinoma. The aim of this study was to investigate the effects of casticin on epithelial-mesenchymal transition (EMT) of liver cancer stem cells (LCSCs) derived from the SMMC-7721 cell line. Our res...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1899

    authors: He M,Cao XC,He GC,Sheng XF,Ai XH,Wu YH

    更新日期:2014-05-01 00:00:00

  • Synergy of Taxol and rhein lysinate associated with the downregulation of ERK activation in lung carcinoma cells.

    abstract::In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer. The present study aimed to investigate the effects of RHL on H460 and A549 non-sma...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1398

    authors: Zhen YZ,Hu G,Zhao YF,Yan F,Li R,Gao JL,Lin YJ

    更新日期:2013-08-01 00:00:00

  • Downregulation of PDCD4 by miR-21 suppresses tumor transformation and proliferation in a nude mouse renal cancer model.

    abstract::Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6605

    authors: Yuan H,Xin S,Huang Y,Bao Y,Jiang H,Zhou L,Ren X,Li L,Wang Q,Zhang J

    更新日期:2017-09-01 00:00:00

  • Integrated analysis of lncRNA CTD-2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma.

    abstract::Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new stra...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10920

    authors: Zou B,Guan X,Zhang W,Wang D,Xu K,Yuan DY,Meng Z,Zhang B

    更新日期:2019-12-01 00:00:00

  • Clinicopathological findings in a case series of abdominopelvic solitary fibrous tumors.

    abstract::Solitary fibrous tumors (SFTs) represent a rare type of soft tissue tumor. Extrathoracic SFTs (ESFTs) in the soft tissues of the abdominopelvic cavity are extremely rare. Between January 2002 and January 2013, 10 patients were identified with abdominopelvic SFTs at the Northern Jiangsu People's Hospital. The clinicopa...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1872

    authors: Wang H,Chen P,Zhao W,Shi L,Gu X,Xu Q

    更新日期:2014-04-01 00:00:00

  • Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer.

    abstract::Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fr...

    journal_title:Oncology letters

    pub_type: 杂志文章,评审

    doi:10.3892/ol.2019.10349

    authors: Ahmed K,Zaidi SF,Cui ZG,Zhou D,Saeed SA,Inadera H

    更新日期:2019-07-01 00:00:00

  • Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer.

    abstract::The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The result...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.527

    authors: Zhao X,Wang N,Zhang M,Xue S,Shi K,Chen Z

    更新日期:2012-03-01 00:00:00

  • Antitumor effect of FP3 in a patient-derived tumor tissue xenograft model of gastric carcinoma through an antiangiogenic mechanism.

    abstract::FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effe...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.603

    authors: Jin K,Lan H,Cao F,Xu Z,Han N,Li G,He K,Teng L

    更新日期:2012-05-01 00:00:00

  • Melatonin treatment induces apoptosis through regulating the nuclear factor-κB and mitogen-activated protein kinase signaling pathways in human gastric cancer SGC7901 cells.

    abstract::Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.5785

    authors: Li W,Wang Z,Chen Y,Wang K,Lu T,Ying F,Fan M,Li Z,Wu J

    更新日期:2017-04-01 00:00:00

  • Selection of a malignant subpopulation from a colorectal cancer cell line.

    abstract::Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide; therefore, there is an emerging need for novel experimental models that allow for the identification and validation of biomarkers for CRC-specific progression. In the present study, a repeated sphere-forming assay was used as a strate...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11829

    authors: Lai PL,Chen TC,Feng CY,Lin H,Ng CH,Chen Y,Hsiao M,Lu J,Huang HC

    更新日期:2020-09-01 00:00:00

  • miR-101 sensitizes A549 NSCLC cell line to CDDP by activating caspase 3-dependent apoptosis.

    abstract::MicroRNA-101 (miR-101) is evidently downregulated in several types of cancer, including non-small cell lung cancer (NSCLC), and is crucial in sensitizing cells to chemotherapy drugs. The aim of the present study was to investigate the correlation between miR-101 and chemosensitivity in the A549 NSCLC cell line. Here, ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1725

    authors: Yin J,Wang M,Jin C,Qi Q

    更新日期:2014-02-01 00:00:00