Overexpression of RHEB is associated with metastasis and poor prognosis in hepatocellular carcinoma.

abstract：:The present study aimed to evaluate the expression of p53, Ki-67, epidermal growth factor receptor (EGFR) and O6-methylguanine-DNA methyltransferase (MGMT), and to analyze the correlation between their expression and the histological grade of the tumors in 152 patients with gliomas. The tumors were classified accordin...

journal_title：Oncology letters

authors： Hu X,Miao W,Zou Y,Zhang W,Zhang Y,Liu H

更新日期：2013-07-01 00:00:00

abstract：:The development of drug resistance to chemotherapeutic agents has consistently presented a challenge in terms of the treatment of patients with triple-negative breast cancer (TNBC). In the present study, gemcitabine (dFdC)-resistant TNBC cells were established, and the effects of lentivirus-deoxyribonucleoside kinase ...

journal_title：Oncology letters

authors： Zhao Y,Jiang H,Gu M,Zu C,Zheng X

更新日期：2020-11-01 00:00:00

abstract：:Hypoxia occurs in a wide range of solid tumors, and is strongly associated with radio-resistance of malignant tumors. The aim of the present study was to investigate the effect of endostatin combined with ionizing radiation (IR) on hypoxic conditions. A total of 24 mice bearing SKOV3 ovarian carcinoma were divided int...

journal_title：Oncology letters

authors： Zhang YC,Li XM,Yu Z,Shi XL,Li Y,Wang WL

更新日期：2017-03-01 00:00:00

abstract：:Follicular lymphoma (FL) occurs primarily in the gastrointestinal tract, with the stomach being one of the rarest sites. According to the literature, <20 cases of primary gastric FL have been reported, with the number of cases with detailed pathological descriptions being even less. The aim of the present study was to...

journal_title：Oncology letters

authors： Na HY,Kim YA,Lee C,Choe JY,Shin SA,Shim JW,Min SK,Kim HJ,Han JH,Kim JE

更新日期：2018-07-01 00:00:00

abstract：:Gastrinoma is a gastrin-secreting tumor that is associated with Zollinger-Ellison syndrome. The majority of cases occur in the pancreas, followed by the duodenum. Early diagnosis is difficult due to the relative rarity of the tumor and the lack of specific symptoms. In the current study, a 68-year-old female patient p...

journal_title：Oncology letters

authors： Zhang WD,Liu DR,Wang P,Zhao JG,Wang ZF,Chen LI

更新日期：2016-05-01 00:00:00

abstract：:Previous studies have reported that basic fibroblast growth factor (bFGF) is associated with tumor genesis, growth and prognosis. The present study was conducted to detect the levels of bFGF expression in women with non-small cell lung cancer (NSCLC), colon cancer, breast cancer and melanoma, and analyze its associati...

journal_title：Oncology letters

authors： Liu M,Xing LQ

更新日期：2017-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third leading cause of cancer-associated mortalities. Long non-coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different ty...

journal_title：Oncology letters

authors： Zhang L,Zheng C,Sun Z,Wang H,Wang F

更新日期：2019-10-01 00:00:00

abstract：:Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel thera...

journal_title：Oncology letters

authors： Yong M,Yu T,Tian S,Liu S,Xu J,Hu J,Hu L

更新日期：2017-12-01 00:00:00

abstract：:Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...

journal_title：Oncology letters

authors： Zhao J,Wang M,Li Z,Chen J,Yin Z,Chang J,Gao D,Wang S

更新日期：2014-03-01 00:00:00

abstract：:Cancer and embryo expression protein 65 (CEP65) is a centrosomal protein that is expressed at relatively high levels in embryonic tissue and different cancerous tissues, but its role in tumorigenesis remains unknown. In the present study, CEP65 was stably expressed in AGS gastric cancer cells. CEP65 was found to promo...

journal_title：Oncology letters

authors： Jin G,Peng L,Zhang J,Qu L,Shou C

更新日期：2015-04-01 00:00:00

abstract：:The purpose of the present study was to evaluate the recent trend of diagnosing appendiceal diseases through the analysis of appendectomy materials, stressing the importance of their pathological examination. A clinicopathological assessment of patients undergoing an appendectomy was conducted, based on the pathologic...

journal_title：Oncology letters

authors： Tajima T,Tajiri T,Mukai M,Sugiyama T,Hasegawa S,Yamamoto S,Sadahiro S,Shimada H,Makuuchi H

更新日期：2018-05-01 00:00:00

abstract：:It is estimated that breast cancer will be the second leading cause of cancer-associated mortality in women in 2018. Previous research has demonstrated that the atypical protein kinase C-ζ (PKC-ζ) is a component of numerous dysregulated pathways in breast cancer, including cellular proliferation, survival, and cell cy...

journal_title：Oncology letters

authors： Smalley T,Islam SMA,Apostolatos C,Apostolatos A,Acevedo-Duncan M

更新日期：2019-02-01 00:00:00

abstract：:Protease-activated receptor 4 (PAR4), a member of the G-protein-coupled receptor family, was previously identified to be involved in the progression of cancer. Previous study revealed that the expression of PAR4 was increased in colorectal cancer tissues compared with the associated normal tissues, particularly in pos...

journal_title：Oncology letters

authors： Zhang H,Jiang P,Zhang C,Lee S,Wang W,Zou H

更新日期：2018-11-01 00:00:00

abstract：:A 54-year-old female presented with a large pancreatic tumor of the tail during a regular physical examination. The patient underwent surgical intervention and the surgeon identified that the tumor originated from the retroperitoneal region. Markedly severe hemodynamic fluctuations occurred during the manipulation of ...

journal_title：Oncology letters

authors： Huang YH,Liaw WJ,Kuo CP,Wu ZF,Cherng CH,Yu JC,Horng HC,Huang ST

更新日期：2013-09-01 00:00:00

abstract：:Individuals >65 years old account for a large proportion of cancer patients, and usually have poor prognoses due to relative weaker physiological function and lower drug tolerance. To characterize the efficacy and safety of dendritic cell (DC)-activated cytokine-induced killer cell (CIK)-mediated treatment, and develo...

journal_title：Oncology letters

authors： Liu Y,Liu H,Liu H,He P,Li J,Liu X,Chen L,Wang M,Xi J,Wang H,Zhang H,Zhu Y,Zhu W,Ning J,Guo C,Sun C,Zhang M

更新日期：2016-12-01 00:00:00

abstract：:Arteriosclerosis poses a significant risk to human health and involves the thickening and hardening of the walls of arteries. Accumulated evidence demonstrates that aberrant proliferation of vascular smooth muscle cells (VSMCs) accounts for the onset and progression of arteriosclerosis. Suppression of their proliferat...

journal_title：Oncology letters

authors： Han D,Zhang X,Zhang J,Guo X,Zheng Y,Sui S,Zheng J

更新日期：2016-11-01 00:00:00

abstract：:Previously, the preoperative neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a beneficial prognostic marker in patients with upper tract urothelial carcinoma (UTUC). However, to the best of our knowledge, the postoperative NLR has rarely been investigated. Therefore, the present study evaluated the pr...

journal_title：Oncology letters

authors： Nishihara K,Suekane S,Ueda K,Nakiri M,Matsuo M,Igawa T

更新日期：2019-06-01 00:00:00

abstract：:Survivin is expressed in the nucleus and/or cytoplasm of various malignant cells. Nuclear survivin is critical for the completion of mitosis, while cytoplasmic survivin functions as an inhibitor of apoptosis. The expression of survivin has been reported to be associated with the aggressiveness of certain types of canc...

journal_title：Oncology letters

authors： Hirano H,Maeda H,Yamaguchi T,Yokota S,Mori M,Sakoda S

更新日期：2015-09-01 00:00:00

abstract：:Few reports have explored laparoscopic adnexal tumorectomy as a treatment for large and symptomatic ovarian leiomyomas during pregnancy. The current study presents the case of a patient with a large and symptomatic ovarian leiomyoma at 14 weeks of pregnancy. A laparoscopic adnexal tumorectomy was performed without com...

journal_title：Oncology letters

authors： Zhao X,Chen L,Zeng W,Jin B,DU W

更新日期：2014-12-01 00:00:00

abstract：:Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity ...

journal_title：Oncology letters

authors： Heubner M,Kimmig R,Aktas B,Siffert W,Frey UH

更新日期：2014-06-01 00:00:00

abstract：:Metastasis negatively affects the prognosis of hepatocellular carcinoma (HCC). In the present study, niclosamide, which is known to suppress the proliferation of HCC cells, was investigated for possible suppressant effects on the migration of HCC cells. HLF and PLC/PRF/5 HCC cells were cultured in the presence of nicl...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Ishige N

更新日期：2015-12-01 00:00:00

abstract：:The CyberKnife® is expected to be a novel local treatment for hepatocellular carcinoma (HCC), however, a long-term follow-up using dynamic computed tomography and magnetic resonance imaging is required to determine the effect of treatment in a number of the affected patients. Therefore, there is a requirement to evalu...

journal_title：Oncology letters

authors： Shiozawa K,Watanabe M,Ikehara T,Kobayashi K,Ochi Y,Suzuki Y,Fuchinoue K,Yoneda M,Kenmochi T,Okubo Y,Mori T,Makino H,Tsukamoto N,Igarashi Y,Sumino Y

更新日期：2016-01-01 00:00:00

abstract：:Previous studies have demonstrated that the chronic administration of valproic acid (VPA) suppresses angiogenesis in vivo; however, the mechanisms implicated in VPA-induced autophagy remain unclear. The current study aimed to assess VPA-induced autophagy in three prostate cancer cell lines (PC3, DU145 and LNCaP), in a...

journal_title：Oncology letters

authors： Xia Q,Zheng Y,Jiang W,Huang Z,Wang M,Rodriguez R,Jin X

更新日期：2016-09-01 00:00:00

abstract：:The soluble urokinase-type plasminogen activator receptor (suPAR) and the urokinase-type plasminogen activator receptor (uPAR) have been proposed as useful biomarkers of tumor progression. Recently, suPAR was associated with chemoresistance in lung cancer. However, its clinical significance in leukemia has not previou...

journal_title：Oncology letters

authors： Guo H,Zhou LX,Ma H,Liu B,Cheng J,Ma YY,Zhao L

更新日期：2017-07-01 00:00:00

abstract：:Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were ret...

journal_title：Oncology letters

authors： Shi Y,Li X,Chen X,Xu Y,Bo G,Zhou H,Liu Y,Zhou G,Wang Z

更新日期：2017-03-01 00:00:00

abstract：:The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the ...

journal_title：Oncology letters

authors： Scapulatempo-Neto C,Veo C,Fregnani JHTG,Lorenzi A,Mafra A,Melani AGF,Loaiza EAA,Rosa LAR,de Oliveira CM,Levi JE,Longatto-Filho A

更新日期：2017-03-01 00:00:00

abstract：:The expression of human transfer ribonucleic acid (tRNA) methyltransferase 9-like (KIAA1456) protein in lung cancer tissue and its effects on certain genes involved in the proliferation, migration and invasion of lung cancer cells were investigated. Immunohistochemistry was applied to stain lung cancer tissue and adja...

journal_title：Oncology letters

authors： Wang S,Liu X,Huang J,Zhang Y,Sang C,Li T,Yuan J

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to investigate the association between methylation of cyclin-dependent kinase inhibitor 2B (CDKN2B) CpG islands and telomerase activity in children with acute lymphoblastic leukemia (ALL). A total of 72 children with ALL and 12 children with immune thrombocytopenia (ITP) were subjected...

journal_title：Oncology letters

authors： Hu Q,Chen X,Liu S,Wen R,Yuan X,Xu D,Liu G,Wen F

更新日期：2017-04-01 00:00:00

abstract：:Expression of mineral dust-induced gene (mdig) in lung cancer NCI-H1650 cells was detected to investigate the effects of mdig on proliferation and apoptosis of NCI-H1650 cells. NCI-H1650 lung cancer cells were cultured in vitro. The expression of mdig in NCI-H1650 cells was lowered using ribonucleic acid interference ...

journal_title：Oncology letters

authors： Xu X,Cao L,Zhang Y,Lian H,Sun Z,Cui Y

更新日期：2018-12-01 00:00:00

abstract：:Breast metastasis is a rare pattern of distant metastasis from nasopharyngeal carcinoma (NPC) following curative treatment. The present study reported two patients with breast metastasis from NPC and reviewed four such patients reported in the literature, including the analysis of clinical profiles, pathological diagn...

journal_title：Oncology letters

authors： Xiao W,He Z,Xing C,Zhen W,Wang S,Lin H

更新日期：2015-12-01 00:00:00