Abstract:
:Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells were treated with cisplatin and/or IFN-α. Apoptosis and autophagy were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, Hoechst 33258 staining, flow cytometry assay, acridine orange staining, green fluorescent protein-LC3 dot assay and transmission electron microscopy. Further analysis revealed that the efficacy of cisplatin was enhanced by the addition of the cytokine, IFN-α. These results indicate that the combination therapy of chemotherapeutics and IFN-α is a new approach for osteosarcoma, which requires validation by experiments in vivo.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhao J,Wang M,Li Z,Chen J,Yin Z,Chang J,Gao D,Wang Sdoi
10.3892/ol.2013.1762subject
Has Abstractpub_date
2014-03-01 00:00:00pages
827-833issue
3eissn
1792-1074issn
1792-1082pii
ol-07-03-0827journal_volume
7pub_type
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