Abstract:
:The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory examinations were compared, and a literature review was conducted. According to the French-American-British classification system, patient 1 was M4, patient 2 was M1 and patient 3 was M2. The cytogenetic aberrations were 46, XY, t(16;21)(p11;q22)/47, idem, +21 for patient 1 and 46, XX, t(16;21)(p11;q22) for patients 2 and 3. Cytophagocytosis and cluster of differentiation 56 antigen expression were found in all three cases. The prognosis was poor in all the cases. AML with t(16;21)(p11;q22) is a specific subtype of AML that exhibits unique characteristics of morphology, immunology, cytogenetics and clinical features, as well as a poor prognosis. Stem cell transplantation may be the first and only choice for treatment.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhang Z,Zou J,Li Y,Liu Z,Xu R,Tian W,Zhao Z,Sun H,Han J,Wang J,Zhang B,Ju Ydoi
10.3892/ol.2015.3051subject
Has Abstractpub_date
2015-05-01 00:00:00pages
2244-2248issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-3051journal_volume
9pub_type
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