Abstract:
:Gene markers are crucial for cancer prognosis and treatment. Previous studies have placed greater emphasis on individual diagnostic genes, thereby ignoring systemic-level attributes across diseases. Female-specific cells namely, breast, endometrium, cervical, ovarian and vulvar cells are highly susceptible to cancer. To date, a limited number of molecular studies have been performed that evaluate common biological processes across gynecological types of cancer. Differentially expressed genes in breast, cervical, endometrial, vulvar and ovarian cancer were utilized to construct protein-protein interaction networks, and to identify a common module across the five cancer types. A single common module with 8 nodes and 26 edges was mined among the five cancer systems. In total, four hub genes were present across the five cancer gene sets. Genes in the common module were enriched for the common pathways and associated diseases. The aurora kinase pathway was revealed to be conserved across the five cancer types surveyed. The present study, therefore, revealed that the aurora kinase pathway has a crucial function in the pathogenesis of the five aforementioned gynecological types of cancer through cross-tumor conservation.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Suman S,Mishra Adoi
10.3892/ol.2017.7368subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1125-1132issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-7368journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-β (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8441
更新日期:2018-06-01 00:00:00
abstract::Glutathione (GSH) is the keystone of the cellular response toward oxidative stress. Elevated GSH content correlates with increased resistance to chemotherapy and radiotherapy of head and neck (HN) tumors. The purpose of the present cross-sectional study was to evaluate whether the expression of glutamate-cysteine liga...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4458
更新日期:2016-06-01 00:00:00
abstract::As a member of the tripartite motif family, tripartite motif-containing protein 59 (TRIM59) serves as an E3 ubiquitin ligase in various cellular processes, including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy and carcinogenesis. The present study aimed to inves...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11199
更新日期:2020-02-01 00:00:00
abstract::Pituitary tumor transforming gene 1 (PTTG11) is abundantly expressed in glioma. Our previous study demonstrated that the downregulation of PTTG11 gene expression significantly inhibited the proliferation, migration and invasion ability, and increased the apoptosis of SHG44 glioma cells. However, the molecular mechanis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11867
更新日期:2020-10-01 00:00:00
abstract::Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6049
更新日期:2017-06-01 00:00:00
abstract::Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1215
更新日期:2013-05-01 00:00:00
abstract::Osteosarcoma is known as a malignant tumour with a high mortality rate in orthopaedic settings; however, the factors associated with its degree of malignancy and the biological response remains to be elucidated. Although the essential role of the long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been recen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7463
更新日期:2018-02-01 00:00:00
abstract::Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11897
更新日期:2020-10-01 00:00:00
abstract::Distant metastases from colorectal cancer (CRC) most frequently spread to the liver and lungs. CRC metastasis to the kidney is extremely rare and may be generally associated with an unfavorable prognosis. Thus, patients with metastatic CRC and kidney metastasis are a diagnostic and therapeutic challenge. The present s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3290
更新日期:2015-08-01 00:00:00
abstract::The concentrations required for curcumin to exert its anticancer activity (IC50, 20 µM) are difficult to achieve in the blood plasma of patients, due to the low bioavailability of the compound. Therefore, much effort has been devoted to the development of curcumin analogues that exhibit stronger anticancer activity an...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4536
更新日期:2016-06-01 00:00:00
abstract::Hepatocyte growth factor (HGF) expression is a poor prognostic factor in various types of cancer. Expression levels of HGF have been reported to be regulated by shorter poly(dA) sequences in the promoter region. In the present study, the poly(dA) mononucleotide tract in various types of human cancer cell lines was exa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2702
更新日期:2015-01-01 00:00:00
abstract::Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11465
更新日期:2020-05-01 00:00:00
abstract::The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11799
更新日期:2020-09-01 00:00:00
abstract::A 72-year-old man initially presented with lumbar and right chest pain, but was later found out to also have an elevated prostate-specific antigen (PSA) level at 2,000.0 ng/ml. Further evaluation disclosed metastatic prostate cancer involving the bones and lymph nodes. The patient was initially treated with combined a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7628
更新日期:2018-02-01 00:00:00
abstract::Circulating tumor cells (CTCs), isolated as a 'liquid biopsy', may provide important diagnostic and prognostic information. Therefore, rapid, reliable and unbiased detection of CTCs are required for routine clinical analyses. It was demonstrated that negative enrichment, an epithelial marker-independent technique for ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6046
更新日期:2017-06-01 00:00:00
abstract::Ovarian cancer is the most common gynecological malignant cancer in female genitalia. Dysregulation or dysfunction of microRNAs (miRs) contribute to cancer development. The role of miR-520b in ovarian cancer remains unclear. The present study investigated the role of miR-520b in ovarian cancer and determined that the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6552
更新日期:2017-09-01 00:00:00
abstract::The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in numerous diseases, and aberrant lncRNA PVT1 expression has been associated with the development of cancer. However, the underlying mechanism by which lncRNA PVT1 affects cell invasion in esophageal cancer...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5026
更新日期:2016-10-01 00:00:00
abstract::Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6050
更新日期:2017-06-01 00:00:00
abstract::Giant osteomas of the ethmoid and frontal sinuses ary very rare, with only a few dozen cases reported in the literature. Given their rarity, the clinical characteristics and treatment of this disease remain controversial. In this study, the clinical presentation and surgical methods used to treat three patients with g...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1239
更新日期:2013-05-01 00:00:00
abstract::Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also uncommon, representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases ar...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5783
更新日期:2017-04-01 00:00:00
abstract::Integrin signaling may modulate several different functions involved in cell migration, invasion, proliferation and motility, and is a potential candidate biomarker for oral cancer. In the present study, a total of four integrin genes were evaluated as potential biomarkers of oral squamous cell carcinoma (OSCC). Gene ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9168
更新日期:2018-10-01 00:00:00
abstract::While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11663
更新日期:2020-08-01 00:00:00
abstract::Pyropia yezoensis Sookwawon 104 is a newly cultivated strain of red marine algae. The present study aimed to investigate the in vitro antiproliferative activity of sulfated polysaccharide extracted from P. yezoensis Sookwawon 104 (PYSP), as well as that of its low molecular weight (Mw) derivatives. PYSP is a heterogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11952
更新日期:2020-10-01 00:00:00
abstract::The purpose of the present study was to evaluate the newest status of patients diagnosed Burkitt lymphoma (BL), an aggressive lymphoma subset with a high cure rate. Furthermore, the study aimed to create prognostic nomograms to consider various prognostic factors and estimate patient survival, paving the way for clini...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11155
更新日期:2020-01-01 00:00:00
abstract::Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the m...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2018.9854
更新日期:2019-02-01 00:00:00
abstract::In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9616
更新日期:2019-01-01 00:00:00
abstract::The aim of the present study was to explore the therapeutic effect of 20 kHz ultrasound (US) and microbubbles (MBs) on rabbit VX2 liver tumors by spiral computed tomography (CT) scanning. A total of 16 New Zealand rabbits with hepatic VX2 tumors were divided into four groups: Control, MB, low-frequency US and US + MB....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6557
更新日期:2017-09-01 00:00:00
abstract::Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by a genome-wide search for differentially expressed genes in human colon cancer tissues, metastases and normal tissues. MACC1 exerts an important role in colon cancer metastasis through upregulation of the c-Met proto-oncogene. T...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2984
更新日期:2015-05-01 00:00:00
abstract::Zinc finger E-box binding homeobox 1 (ZEB1) has been shown to promote invasion and metastasis in several types of human cancer and to have a prognostic role in certain cancers. However, the clinical significance of ZEB1 in colorectal cancer (CRC) has not been sufficiently investigated. This study aimed to address this...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1026
更新日期:2013-02-01 00:00:00
abstract::The aim of the study was to determine whether interleukin-8 (IL-8) affects human SKOV3 ovarian cancer cell migration and invasion by targeting silencing of IL-8 expression. Silencing small-interfering RNA (siRNA) targeting IL-8 gene was constructed to infect SKOV3 cells by lentiviral vector. The expression of IL-8 and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5511
更新日期:2017-02-01 00:00:00