Abstract:
:Melanomas affect the foot and ankle region and are associated with a poor prognosis. The aim of the current study was to evaluate the functional and oncological outcomes of salvage surgery using cutaneous flaps for soft tissue reconstruction of the foot and ankle following the extended resection of a melanoma. A retrospective review was conducted to evaluate patients who presented with foot melanoma and underwent salvage surgery and defect reconstruction using three types of cutaneous flap (group S) or amputation (group A) between January 1999 and December 2010 at the First Hospital of Jilin University (Changchun, China). The postoperative mortality, surgical complications, functional outcomes and oncological outcomes were evaluated. Of the 21 patients, 11 were enrolled into group S and 10 were enrolled into group A. The median follow-up time of the patients was 58 months (range, 6-92 months). In group S, a reverse sural neurocutaneous island flap was used in six patients to perform the foot reconstruction, medial plantar flaps were used in four patients and lateral malleolus flaps were used in one patient. All 11 cutaneous flaps survived and provided satisfactory coverage. Only one cutaneous flap showed partial necrosis and required treatment comprising of debridement and regular changes to the wound dressing. The overall survival rate of patients was 65.0% and patients in the two groups experienced similar oncological outcomes. Salvage surgery with cutaneous flap reconstruction was found to be a reliable option for patients presenting with malignant melanoma of the foot and ankle.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Liu JF,Zhao LR,Lu LJ,Chen L,Liu ZG,Gong X,Liu Bdoi
10.3892/ol.2014.2440subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1966-1972issue
5eissn
1792-1074issn
1792-1082pii
ol-08-05-1966journal_volume
8pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Radiofrequency ablation (RFA) and cryoablation are alternative forms of therapy used widely in various pathological states, including treatment of carcinogenesis. The reason is that ablation techniques have ability of modulating the immune system. Furthermore, recent studies have applied this form of therapy on tumor ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4997
更新日期:2016-10-01 00:00:00
abstract::The purpose of the present study was to evaluate the newest status of patients diagnosed Burkitt lymphoma (BL), an aggressive lymphoma subset with a high cure rate. Furthermore, the study aimed to create prognostic nomograms to consider various prognostic factors and estimate patient survival, paving the way for clini...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11155
更新日期:2020-01-01 00:00:00
abstract::Multiple myeloma is a type of malignancy, which affects the plasma cells of the bone marrow. Recent studies have found that malignant plasma cells may express urokinase plasminogen activator (uPA) and uPA receptor (uPAR), and that initiation of proteolytic events by this system contributes to the process of invasion a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3613
更新日期:2015-10-01 00:00:00
abstract::Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia te...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5832
更新日期:2017-05-01 00:00:00
abstract::The aim of the present study was to identify genes that may serve as markers for breast cancer prognosis by constructing a gene co-expression network and mining modules associated with survival. Two gene expression datasets of breast cancer were downloaded from ArrayExpress and genes from these datasets with a coeffic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6779
更新日期:2017-10-01 00:00:00
abstract::The aim of this study was to investigate the effect of dexmedetomidine (Dex) on the respiratory function during anesthesia induction in pediatric patients undergoing retinoblastoma (RB) resection. A total of 87 pediatric patients who underwent RB resection in Yidu Central Hospital of Weifang were recruited into this s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9893
更新日期:2019-03-01 00:00:00
abstract::Oncostatin M (OSM) induces the differentiation of liver cancer stem cells (LCSCs) and increases sensitivity to the chemotherapeutic agent 5-fluorouracil, whereas salinomycin (Sal) induces apoptosis in cancer stem cells and inhibits the proliferation of liver cancer cells. However, there have been no studies investigat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9796
更新日期:2019-02-01 00:00:00
abstract::Pro-angiogenic factors [vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)] and anti-angiogenic factors (endostatin) play important roles in the progression of pancreatic cancer. The purpose of the present study was to investigate the knockdown effect by either VEGF or bFGF siRNA on th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1102
更新日期:2013-03-01 00:00:00
abstract::Although cisplatin (DDP) has been reported to be a promising antitumor therapy for non-small cell lung cancer (NSCLC), the effectiveness of the treatment remains limited due to an inherent tumor resistance to DDP. Genistein (GEN) is an abundant, naturally occurring isoflavonoid found in soy products that has been demo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2597
更新日期:2014-12-01 00:00:00
abstract::The molecule DRO1 (down‑regulated by oncogenes 1) is a potential tumor suppressor protein that is frequently down‑regulated in primary colorectal cancers and colorectal cancer cell lines. Although the mechanism of DRO1 action has yet to be elucidated, previous data have suggested that DRO1 interferes with tumor growth...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.356
更新日期:2011-09-01 00:00:00
abstract::Ewing sarcoma (ES) is a highly malignant pediatric tumor with a low survival rate and a high rate of metastasis. However, there have been limited reports on the exploration of new biomarkers of ES. Therefore, the aim of the present study was to identify the potential hub genes associated with overall vital survival (O...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10681
更新日期:2019-10-01 00:00:00
abstract::Breast cancer is the second leading cause of cancer-associated mortality in females in the USA. Hsa-miR-599 was demonstrated to function as a tumour suppressor during cancer progression. However, the function and mechanism of the hsa-miR-599 in human breast cancer remain elusive. Thus, the aim of the present study was...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6651
更新日期:2017-09-01 00:00:00
abstract::The medicinal mushroom Ganoderma lucidum (G. lucidum) has been used for the treatment of various diseases, and is known for the immune-enhancing activity of its polysaccharide. However, little is known about another of its major constituents, triterpene. This study investigated the anticancer mechanism of a triterpene...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.275
更新日期:2011-05-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1983
更新日期:2014-06-01 00:00:00
abstract::Docetaxel is the current first-line treatment for castration-resistant prostate cancer (CRPC), following failure to respond to maximal androgen blockade (MAB). Patients who fail to respond to docetaxel may receive cabazitaxel or abiraterone; however, there are no recommendations on which of these two agents should be ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1275
更新日期:2013-06-01 00:00:00
abstract::In the present study, the incidence of surgical wound complications in patients with large and deep high-grade soft tissue sarcoma (STS) was investigated. In addition, the disease-specific and event-free survival rates were examined in these patients. In total, 30 adult patients with primary high-grade deep STS with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3289
更新日期:2015-08-01 00:00:00
abstract::Aquaporin 1 (AQP1), which functions as a water transporter, is associated with cancer cell proliferation, invasion, metastasis and angiogenesis in numerous types of solid cancer, including colorectal cancer (CRC). The focus of the present study was to address the potential clinical use of AQP1 expression in CRC as a p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8170
更新日期:2018-05-01 00:00:00
abstract::Human papilloma virus (HPV) infection has previously been reported to be associated with TP53 and TP16 expression in Japanese and Taiwanese patients with lung cancer, but data for advanced non-small cell lung cancer (NSCLC) patients is limited. The present study examined the association between HPV infection and TP53 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5087
更新日期:2016-11-01 00:00:00
abstract::HER2 amplification occurs in ~20% of gastric cancer (GC) cases; however, in gastric and gastroesophageal junction cancer with HER2 gene amplification, trastuzumab in combination with cisplatin (DDP)-based chemotherapy has been reported to improve the oncological outcome. The aim of the present study was to evaluate th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2793
更新日期:2015-02-01 00:00:00
abstract::The aim of the present study was to investigate the relationship between the expression of transcription factor forkhead box C2 (FOXC2) and the clinical features of cervical cancer. A total of 66 patients with cervical cancer, 42 patients with cervical intraepithelial neoplasia (CIN) and 25 patients with cervical infl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7004
更新日期:2017-12-01 00:00:00
abstract::C-X-C motif chemokine ligand 5 (CXCL5) is a CXC-type chemokine that is a crucial inflammatory mediator and a powerful attractant for granulocytic immune cells. Increasing evidence has indicated that CXCL5 is involved in the tumorigenesis of various malignancies. The present investigation demonstrated that CXCL5 was ex...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7236
更新日期:2017-12-01 00:00:00
abstract::Colorectal cancer (CRC) is the third leading cause of cancer-associated mortalities. Long non-coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different ty...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10737
更新日期:2019-10-01 00:00:00
abstract::Primary testicular non-Hodgkin's lymphoma (TNHL) was first described as a clinical entity in 1866. It is a rare disease which accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. Hemophagocytic syndrome (HPS) is a rare but distinct condition caused by inappr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.701
更新日期:2012-07-01 00:00:00
abstract::Glioma is one of the most prevalent types of malignancy in the central nervous system worldwide, and the prognosis of patients with late stage glioma remains poor. Thus, the development of promising therapeutic strategies against glioma is essential. Long non-coding RNAs (lncRNAs) are functional RNA molecules involved...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11847
更新日期:2020-09-01 00:00:00
abstract::The aim of the present study was to investigate the significance and values of 3.0T diffusion weighted imaging (DWI) to differentially diagnose benign and malignant space-occupying liver lesions. A total of 91 patients with liver space-occupying lesions (145 lesions) were admitted into Zhongnan Hospital of Wuhan Unive...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7565
更新日期:2018-02-01 00:00:00
abstract::The transfer and development of chronic hepatitis B virus (HBV) infection is associated with the T cell immune response, therefore investigating the key regulators of cell immune response is needed to improve chronic HBV treatment. Blood samples from patients with chronic HBV infection were used to confirm the correla...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11534
更新日期:2020-07-01 00:00:00
abstract::The present study aims to quantitatively measure adiposity-related image features and to test the feasibility of applying multivariate statistical data analysis-based prediction models to generate a novel clinical marker and predict the benefit of epithelial ovarian cancer (EOC) patients with and without maintenance b...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4648
更新日期:2016-07-01 00:00:00
abstract::Hypoxia is a critical aspect of tumor biology and has been associated with poor prognosis and resistance to traditional therapy. In the present study, differentially expressed genes and microRNAs (miRNAs/miRs) were screened for in the hepatocellular carcinoma (HCC) cell line Huh7 under hypoxic conditions. On the basis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7349
更新日期:2018-01-01 00:00:00
abstract::Radiofrequency ablation has become an increasingly common therapeutic technique for patients with hepatocellular carcinoma or metastatic liver tumors. However, reports on the effect of percutaneous radiofrequency ablation (PRFA) on circulating tumor cells (CTCs) are limited. The present study aimed to further investig...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9019
更新日期:2018-09-01 00:00:00
abstract::Hepatocellular carcinoma is a serious public health problem in China. The mortality rate associated with the majority of cancer types has decreased as a result of targeted therapy. However, the mortality rates associated with hepatocellular carcinoma have not improved; therefore, the identification of new molecular ta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12245
更新日期:2020-12-01 00:00:00