RNA interference-mediated silencing of VEGF and bFGF suppresses endostatin secretion in pancreatic carcinoma cells.

abstract：:Lung cancer is the most common cause of cancer-related mortality in men and women. Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, >50% of patients are >65 years old. Through an improved understanding of the molecular mechanisms involved in lung oncogenesis, molecular-ta...

journal_title：Oncology letters

authors： Antonelli G,Libra M,Panebianco V,Russo AE,Vitale FV,Colina P,D'Angelo A,Rossello R,Ferraù F

更新日期：2016-01-01 00:00:00

abstract：:T-box 3 (Tbx3), a member of the T-box transcription factor family, serves a crucial role in embryonic development and cancer progression. Previous studies have demonstrated the clinical significance of Tbx3 in numerous types of cancer. However, the expression level and pathological function of Tbx3 in non-small cell l...

journal_title：Oncology letters

authors： Wu Y,Feng J,Hu W,Zhang Y

更新日期：2017-05-01 00:00:00

abstract：:Plumbagin, a naphthoquinone constituent of Plumbago zeylanica L. (Plumbaginaceae) is widely used in traditional Chinese medicine as an antifungal, antibacterial and anti-inflammatory agent. Plumbagin is known to exhibit proapoptotic, antiangiogenic and antimetastatic effects in cancer cells. The transcriptional co-fac...

journal_title：Oncology letters

authors： Xue YL,Meng XQ,Ma LJ,Yuan Z

更新日期：2016-08-01 00:00:00

abstract：:The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...

journal_title：Oncology letters

authors： Dai S,Xu C,Tian Y,Cheng W,Li B

更新日期：2014-10-01 00:00:00

abstract：:Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...

journal_title：Oncology letters

authors： Wang J,Hua L,Guo M,Yang L,Liu X,Li Y,Shang X,Luo J

更新日期：2017-06-01 00:00:00

abstract：:Increasing evidence has indicated that the dysregulation of microRNA (miRNA) occur in the pathogenesis of retinoblastoma (RB). Aim of the present study was to investigate the possible role of miR-494 (miR-494-3p) in RB. It was demonstrated that miR-494 expression was increased in RB tissue samples and cell lines. Also...

journal_title：Oncology letters

authors： Xu F,Liu G,Wang L,Wang X,Jin X,Bo W

更新日期：2020-08-01 00:00:00

abstract：:Newcastle disease virus (NDV) has been reported to selectively duplicate in and then destroy tumor cells, whilst sparing normal cells. However, the effect of NDV on lung cancer has yet to be elucidated. In the present study, recombinant NDV (rl-RVG) was applied to lung adenocarcinoma A549 cell tumor-bearing mice to ex...

journal_title：Oncology letters

authors： Yan Y,Jia L,Zhang J,Liu Y,Bu X

更新日期：2014-12-01 00:00:00

abstract：:Ovarian carcinoma (OV) is one of the most lethal gynecological malignancies globally, and the overall 5-year survival rate of OV was 47% in 2018 according to American data. To increase the survival rate of patients with OV, many researchers have sought to identify biomarkers that act as both prognosis-predictive marke...

journal_title：Oncology letters

authors： Lin H,Wang J,Wen X,Wen Q,Huang S,Mai Z,Lu L,Liang X,Pan H,Li S,He Y,Ma H

更新日期：2020-11-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...

journal_title：Oncology letters

authors： Jiang Y,Luan Y,Chang H,Chen G

更新日期：2018-09-01 00:00:00

abstract：:Glutathione (GSH) is the keystone of the cellular response toward oxidative stress. Elevated GSH content correlates with increased resistance to chemotherapy and radiotherapy of head and neck (HN) tumors. The purpose of the present cross-sectional study was to evaluate whether the expression of glutamate-cysteine liga...

journal_title：Oncology letters

authors： Dequanter D,VAN DE Velde M,Bar I,Nuyens V,Rousseau A,Nagy N,Vanhamme L,Vanhaeverbeek M,Brohée D,Delrée P,Boudjeltia K,Lothaire P,Uzureau P

更新日期：2016-06-01 00:00:00

abstract：:The aim of the present study was to perform a retrospective analysis to investigate the outcome and toxicity of radiation (RT) and chemoradiation (CRT) in elderly, inoperable patients >70 years old. Between 2003 and 2012, 1,024 patients with squamous cell carcinoma (SCC) of the esophagus were treated at the Department...

journal_title：Oncology letters

authors： Xu HY,DU ZD,Zhou L,Yu M,Ding ZY,Lu Y

更新日期：2014-01-01 00:00:00

abstract：:Fibroadenoma (FA) is the most common type of breast lesion in young female individuals. Although malignant transformation in FA is rare, there is evidence of an association with breast carcinoma, particularly in middle-aged females with associated risk factors, such as a strong family history and/or BRCA-1/2 mutations...

journal_title：Oncology letters

authors： Hua B,Xu JY,Jiang L,Wang Z

更新日期：2015-09-01 00:00:00

abstract：:Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by a genome-wide search for differentially expressed genes in human colon cancer tissues, metastases and normal tissues. MACC1 exerts an important role in colon cancer metastasis through upregulation of the c-Met proto-oncogene. T...

journal_title：Oncology letters

authors： Li H,Zhang H,Zhao S,Shi Y,Yao J,Zhang Y,Guo H,Liu X

更新日期：2015-05-01 00:00:00

abstract：:Cancer stem cell (CSC) properties have been recently proposed to explain tumor carcinogenesis and multidrug resistance in several human cancers, including non-small cell lung cancer (NSCLC). The present study examined the protein expression of three CSC-associated markers, namely ATP binding cassette subfamily B membe...

journal_title：Oncology letters

authors： Zou F,Seike M,Noro R,Kunugi S,Kubota K,Gemma A

更新日期：2017-07-01 00:00:00

abstract：:Polydatin, extracted from Polygonum cuspidatum, is known for its anti-platelet aggregation and anti-inflammatory effects. However, studies on the association of polydatin with cancer are limited, particularly with regards to epithelial-mesenchymal transition (EMT)-associated migration and invasion of cancer cells. The...

journal_title：Oncology letters

authors： Jiang J,Chen Y,Dong T,Yue M,Zhang Y,An T,Zhang J,Liu P,Yang X

更新日期：2019-05-01 00:00:00

abstract：:The present study aimed to analyze the characteristics of polyethylene glycol (PEG)ylated carboplatin liposomes (PL-CBPs), including size, stability, their release, entrapping and loading efficiencies, and their antitumor and antimetastatic effects on the lymph nodes. The PL-CBPs were prepared using PEG-2000 with the ...

journal_title：Oncology letters

authors： Zhang J,Huang C,Huang H

更新日期：2014-11-01 00:00:00

abstract：:MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...

journal_title：Oncology letters

authors： Lin MH,Chen YZ,Lee MY,Weng KP,Chang HT,Yu SY,Dong BJ,Kuo FR,Hung LT,Liu LF,Chen WS,Tsai KW

更新日期：2018-06-01 00:00:00

abstract：:Penile cancer is an extremely rare form of urological cancer that usually originates in the epithelium of the inner preputium or glans. Major etiological factors include phimosis, poor penile hygiene and smoking. Nearly 95% of penile cancers are squamous cell carcinomas and usually occur in the sixth decade of life. T...

journal_title：Oncology letters

authors： Öztürk H

更新日期：2015-03-01 00:00:00

abstract：:Breast cancer is the most common malignant disease occurring in women. Conservative breast cancer surgery followed by radiation therapy is currently the standard treatment for this type of cancer. The majority of metastases occur within the scar, which initiated a series of studies. As a result, clinical trials aimed ...

journal_title：Oncology letters

authors： Zaleska K,Przybyła A,Kulcenty K,Wichtowski M,Mackiewicz A,Suchorska W,Murawa D

更新日期：2017-10-01 00:00:00

abstract：:Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...

journal_title：Oncology letters

authors： Ma J,Liang L,Liu H

更新日期：2012-09-01 00:00:00

abstract：:The correlation between the expression levels of p65 and TNF-α in patients with acute myelocytic leukemia (AML) and AML cell lines were investigated. The bone marrow samples of 30 AML patients and 10 non-leukemia controls were studied. The mRNA expression levels of p65 and TNF-α were detected by reverse transcription-...

journal_title：Oncology letters

authors： Dong QM,Ling C,Zhu JF,Chen X,Tang Y,Zhao LI

更新日期：2015-11-01 00:00:00

abstract：:Osteosarcoma is known as a malignant tumour with a high mortality rate in orthopaedic settings; however, the factors associated with its degree of malignancy and the biological response remains to be elucidated. Although the essential role of the long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been recen...

journal_title：Oncology letters

authors： Shi Y,Lv C,Shi L,Tu G

更新日期：2018-02-01 00:00:00

abstract：:Central nervous system-based cancers have a much higher mortality rate with the 2016 estimates at 6.4 for incidence and 4.3 for deaths per 100,000 individuals. Grade IV astrocytomas, known as glioblastomas are highly aggressive and show a high proliferation index, diffused infiltration, angiogenesis, microvascular pro...

journal_title：Oncology letters

authors： Huang WJ,Chen WW,Zhang X

更新日期：2016-10-01 00:00:00

abstract：:The present study evaluated the use of saliva surface-enhanced Raman spectroscopy (SERS) for the detection of non-invasive nasopharyngeal carcinoma (NPC). SERS measurements were taken from 62 saliva samples, of which 32 were from NPC patients and 30 from healthy volunteers. Notable biochemical Raman bands in the SERS ...

journal_title：Oncology letters

authors： Qiu S,Xu Y,Huang L,Zheng W,Huang C,Huang S,Lin J,Lin D,Feng S,Chen R,Pan J

更新日期：2016-01-01 00:00:00

abstract：:Hypermethylated in cancer 1 (HIC1) is a putative suppressor gene, cooperating with TP53 in the regulation of apoptosis. The promoter site of this gene contains CpG islands susceptible to methylation. Altered methylation leads to the silencing of HIC1. Persistent loss of HIC1 function reflects the attenuation of proapo...

journal_title：Oncology letters

authors： Markowski J,Sieroń AL,Kasperczyk K,Ciupińska-Kajor M,Auguściak-Duma A,Likus W

更新日期：2015-05-01 00:00:00

abstract：:Radiofrequency ablation (RFA) and cryoablation are alternative forms of therapy used widely in various pathological states, including treatment of carcinogenesis. The reason is that ablation techniques have ability of modulating the immune system. Furthermore, recent studies have applied this form of therapy on tumor ...

journal_title：Oncology letters

authors： Liu Y,Cao CS,Yu Y,Si YM

更新日期：2016-10-01 00:00:00

abstract：:Bone metastasis resulting from breast cancer in pregnancy is rare. In the literature there are few reports regarding osteolytic lesions in pregnancy and no data on the treatment of such femoral fractures. The present study reports a case of a 29-week primigravida presenting with severe lumbosciatica in the left side, ...

journal_title：Oncology letters

authors： Ciavattini A,Mancioli F,Paci E,Politano R

更新日期：2016-01-01 00:00:00

abstract：:Parathyroid carcinoma (PTCA) is a rare disease, and ectopic PTCA is particularly rare. Parathyroid hormone-related protein (PTHrP) expression in PTCA has not been previously described in the relevant literature to the best of our knowledge. The present study reports a unique case with a mediastinal parathyroid carcino...

journal_title：Oncology letters

authors： Cao C,Dou C,Chen F,Wang Y,Zhang X,Lai H

更新日期：2016-06-01 00:00:00

abstract：:Primary testicular non-Hodgkin's lymphoma (TNHL) was first described as a clinical entity in 1866. It is a rare disease which accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. Hemophagocytic syndrome (HPS) is a rare but distinct condition caused by inappr...

journal_title：Oncology letters

authors： Ren W,Zhong Z,Zhao X,Yang J,Zhang L,Xu R,Li S,Zhu X,Lu C,Chin JL

更新日期：2012-07-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the m...

journal_title：Oncology letters

authors： Meng L,Liu B,Ji R,Jiang X,Yan X,Xin Y

更新日期：2019-02-01 00:00:00