Abstract:
:The aim of the present study was to investigate the expression of transactivation response RNA-binding protein (TARBP)1 and its clinical significance in human non-small-cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in 10 NSCLC tissues and paired adjacent normal tissues. TARBP1 protein expression was analyzed in 90 paraffin-embedded NSCLC tissue samples and paired adjacent normal tissues by immunohistochemistry. Statistical analyses were performed to assess the clinicopathological significance of TARBP1 expression. The expression of TARBP1 mRNA was higher in the 10 NSCLC samples than in the paired adjacent non-tumor tissues (P=0.0017). In the paraffin-embedded tissue samples, the expression level of TARBP1 was higher in the cancer tissues than in the adjacent non-cancerous tissues. TARBP1 expression was detected in 76.67% (69/90) of the NSCLC samples and in 22.22% (20/90) of the adjacent normal lung tissues (P<0.001). The expression of TARBP1 was significantly associated with histological grade (P<0.001), clinical stage (P=0.024) and pathological type (P<0.001), along with a decreased overall survival (OS) rate (P<0.001). On multivariate analysis, the expression of TARBP1 was an independent prognostic factor for hazard ratio (OS, 2.729; 95% confidence interval, 1.471-5.061; P=0.003). TARBP1 is overexpressed in NSCLC, and the expression of TARBP1 is associated with pathological grade, clinical stage and pathological type. Thus, TARBP1 may be an independent prognostic marker in patients with NSCLC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Ye J,Wang J,Zhang N,Liu Y,Tan L,Xu Ldoi
10.3892/ol.2018.8202subject
Has Abstractpub_date
2018-05-01 00:00:00pages
7182-7190issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-8202journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The aim of the present study was to investigate the underlying molecular mechanisms of the potent cell cycle inhibition and apoptotic effect of luteolin on LoVo human colon cancer cells. In the present study, Cell Counting kit-8 assay revealed that luteolin exerted notable cytotoxicity on LoVo cells in a dose- and tim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7475
更新日期:2018-02-01 00:00:00
abstract::The aim of the present study was to perform a retrospective analysis to investigate the outcome and toxicity of radiation (RT) and chemoradiation (CRT) in elderly, inoperable patients >70 years old. Between 2003 and 2012, 1,024 patients with squamous cell carcinoma (SCC) of the esophagus were treated at the Department...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1694
更新日期:2014-01-01 00:00:00
abstract::Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1204
更新日期:2013-05-01 00:00:00
abstract::Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide; therefore, there is an emerging need for novel experimental models that allow for the identification and validation of biomarkers for CRC-specific progression. In the present study, a repeated sphere-forming assay was used as a strate...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11829
更新日期:2020-09-01 00:00:00
abstract::Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia. Colorectal cancer (CRC) is the third most common type ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10528
更新日期:2019-09-01 00:00:00
abstract::Osteosarcoma (OS) is the most common form of bone malignancy in children and adolescents. A class of molecules known as microRNAs (miRNAs) have been routinely associated in the development and progression of OS. The present study was centered on the less well-known miRNA, miRNA (miR)-150, and its role in OS was invest...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5709
更新日期:2017-04-01 00:00:00
abstract::Regenerating islet-derived family, member 4 (REG4, which encodes Reg IV) is a marker for cancer and inflammatory bowel disease. This study aimed to investigate the diagnostic utility of Reg IV measurement in sera from esophageal cancer patients. Reg IV expression was examined in 269 esophageal cancer samples by immuno...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.239
更新日期:2011-03-01 00:00:00
abstract::Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7812
更新日期:2018-03-01 00:00:00
abstract::Although tumor thrombus (TT) infringement of the inferior vena cava (IVC) and right atrium (RA) is rarely observed in hepatocellular carcinoma (HCC), the prognosis for this condition is extremely poor, with a median survival time of several months, given that the condition is often diagnosed at an advanced tumor stage...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11962
更新日期:2020-10-01 00:00:00
abstract::Previous studies have shown that the activation of the β2 adrenergic receptor (ADRB2) can stimulate several signaling pathways that promote tumor growth and metastasis. β-adrenergic antagonism may have a beneficial role in cancer treatment; however, little is known about the effect of ADRB2 inhibition on the growth of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8847
更新日期:2018-08-01 00:00:00
abstract::Sarcomatoid carcinomas exhibit features that are common to epithelial and mesenchymal tumors. These carcinomas are rare, particularly in the small intestine. In the current case report, we describe a case of an intestinal sarcomatoid carcinoma in a 70-year-old Chinese female. Sarcomatoid carcinoma was confirmed based ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1378
更新日期:2013-08-01 00:00:00
abstract::Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11423
更新日期:2020-04-01 00:00:00
abstract::The present study aimed to clarify the association between kinesin family member 11 (KIF11) and human breast cancer, and the effect of KIF11 on breast cancer cell progression. Western blot analysis, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis, retroviral infection, immunohistochemis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7053
更新日期:2017-12-01 00:00:00
abstract::Osteosarcoma is a malignant tumor derived from the skeletal system, often occurring in bone tissues, and it is the most common malignant tumor in the skeletal system, with more than 90% of cases being highly malignant. The present study was designed to explore the regulatory effects of microRNA (miR)-19a on the prolif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12033
更新日期:2020-11-01 00:00:00
abstract::K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2205
更新日期:2014-08-01 00:00:00
abstract::Voltage-dependent anion channels (VDACs) are situated in the outer membrane of the mitochondria and serve as gatekeepers that control metabolite and ion exchange between the cytosol and mitochondria. VDAC1 is one of the most studied members of the VDAC protein family and is overexpressed in multiple types of cancer. H...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10534
更新日期:2019-09-01 00:00:00
abstract::Vestibular schwannoma (VS) is a benign, slow-growing cranial tumor that originates from the hypertrophy of Schwann cells. The majority of sporadic VS are unilateral, and the mechanisms underlying VS tumorigenesis are not fully understood. The human neurofibromin 2 (NF2) gene encodes the tumor suppressor protein merlin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4685
更新日期:2016-08-01 00:00:00
abstract::Studies conducted in our lab have indicated that thalidomide cytotoxicity in the KG-1a human acute myelogenous leukemia (AML) cell line was enhanced by combining it with arsenic trioxide. The current investigation was conducted in order to evaluate the effect of thalidomide either alone or in combination with arsenic ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000116
更新日期:2010-07-01 00:00:00
abstract::Studies have shown that homeobox D10 (HOXD10) is the target gene of microRNA-10b (miR-10b) and is closely associated with the inhibition of cell migration and invasion. Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. The effect of miR-10b on colorectal cance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4628
更新日期:2016-07-01 00:00:00
abstract::Delisheng is a widely used antineoplastic agent in China. Although previous studies revealed that Delisheng exhibits numerous pharmacological effects including the inhibition of cancer cell differentiation and enhancement of immune function with the lowest toxicity, the precise anticancer mechanisms of Delisheng in hu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7074
更新日期:2017-12-01 00:00:00
abstract::Parathyroid carcinoma (PTCA) is a rare disease, and ectopic PTCA is particularly rare. Parathyroid hormone-related protein (PTHrP) expression in PTCA has not been previously described in the relevant literature to the best of our knowledge. The present study reports a unique case with a mediastinal parathyroid carcino...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4548
更新日期:2016-06-01 00:00:00
abstract::Ovarian cancer (OC) has the worst prognosis among all malignancy types in females worldwide according to epidemiological studies in 2017. Although radiotherapy, chemotherapy and surgical treatment are the most common treatment methods, their curative effects are not satisfactory. The present study aimed to examine the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10306
更新日期:2019-07-01 00:00:00
abstract::The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5248
更新日期:2016-12-01 00:00:00
abstract::The aim of the present study was to assess the expression of microRNA-146a (miR-146a) in human lung adenocarcinoma cells, its effect on cellular behaviors, and the underlying molecular mechanisms. Reverse transcription-quantitative PCR (RT-qPCR) was used to measure miR-146a expression in the human normal lung epitheli...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11474
更新日期:2020-06-01 00:00:00
abstract::Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1762
更新日期:2014-03-01 00:00:00
abstract::Effects of Rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT) signaling pathway were studied. The retinoblastoma Y79 cells were selected and divided into negative control group (NC group), 0.2 µM Rapamycin group and 0.4 µ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11363
更新日期:2020-04-01 00:00:00
abstract::Epithelioid angiosarcoma (EA) is an extremely rare subtype of angiosarcoma, which is characterized by large cells with an epithelioid morphology. EA typically arises in deep soft tissues, including the adrenal gland, skin and thyroid, however, EA rarely arises in the spine. The current study presents a case of osteoly...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2055
更新日期:2014-06-01 00:00:00
abstract::Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27-year-old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient receiv...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5555
更新日期:2017-03-01 00:00:00
abstract::The present study examined the expression of podocalyxin (PODX) in surgically-resected astrocytomas, associated the levels of PODX expression with the clinicopathological characteristics and survival outcomes of astrocytoma and assessed how PODX affected the viability of astrocytoma cells following the administration ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1556
更新日期:2013-11-01 00:00:00
abstract::The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA fro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6038
更新日期:2017-06-01 00:00:00