Abstract:
:The aim of the present study was to investigate the expression of transactivation response RNA-binding protein (TARBP)1 and its clinical significance in human non-small-cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in 10 NSCLC tissues and paired adjacent normal tissues. TARBP1 protein expression was analyzed in 90 paraffin-embedded NSCLC tissue samples and paired adjacent normal tissues by immunohistochemistry. Statistical analyses were performed to assess the clinicopathological significance of TARBP1 expression. The expression of TARBP1 mRNA was higher in the 10 NSCLC samples than in the paired adjacent non-tumor tissues (P=0.0017). In the paraffin-embedded tissue samples, the expression level of TARBP1 was higher in the cancer tissues than in the adjacent non-cancerous tissues. TARBP1 expression was detected in 76.67% (69/90) of the NSCLC samples and in 22.22% (20/90) of the adjacent normal lung tissues (P<0.001). The expression of TARBP1 was significantly associated with histological grade (P<0.001), clinical stage (P=0.024) and pathological type (P<0.001), along with a decreased overall survival (OS) rate (P<0.001). On multivariate analysis, the expression of TARBP1 was an independent prognostic factor for hazard ratio (OS, 2.729; 95% confidence interval, 1.471-5.061; P=0.003). TARBP1 is overexpressed in NSCLC, and the expression of TARBP1 is associated with pathological grade, clinical stage and pathological type. Thus, TARBP1 may be an independent prognostic marker in patients with NSCLC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Ye J,Wang J,Zhang N,Liu Y,Tan L,Xu Ldoi
10.3892/ol.2018.8202subject
Has Abstractpub_date
2018-05-01 00:00:00pages
7182-7190issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-8202journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. T...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.955
更新日期:2013-01-01 00:00:00
abstract::Effect of crizotinib on apoptosis of lung cancer cells was investigated. Human non-small cell lung adenocarcinoma H2228 cells were cultured in the presence of 0, 20, 40, 80, 160 and 320 nmol/l of crizotinib for 3 days, respectively. The inhibition rate of cell proliferation was measured by MTT assay, and half maximal ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9387
更新日期:2018-11-01 00:00:00
abstract::Glutathione transferase Mu 1 (GSTM1) induces cancer drug resistance by hydrolyzing cancer chemotherapeutics or activating the anti-apoptosis pathway. However, the chemoresistance-inducing mechanism of GSTM1 in hepatocellular carcinoma (HCC) remains unknown. In the present study, the expression of GSTM1 was examined in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8667
更新日期:2018-07-01 00:00:00
abstract::Bone metastasis resulting from breast cancer in pregnancy is rare. In the literature there are few reports regarding osteolytic lesions in pregnancy and no data on the treatment of such femoral fractures. The present study reports a case of a 29-week primigravida presenting with severe lumbosciatica in the left side, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3900
更新日期:2016-01-01 00:00:00
abstract::Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5702
更新日期:2017-04-01 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1954
更新日期:2014-05-01 00:00:00
abstract::Lung adenocarcinoma (LUAD) is a common malignancy; however, the majority of its underlying molecular mechanisms remain unknown. In the present study, weighted gene co-expression network analysis was applied to construct gene co-expression networks for the GSE19804 dataset, in order to screen hub genes associated with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11193
更新日期:2020-02-01 00:00:00
abstract::Krüppel-like factor 5 (KLF5) is frequently deleted and inactivated in prostate cancer, and exerts tumor-suppressing function in prostate cancer cells. However, the function of KLF5 in the apoptosis of prostate cancer cells remains unclear. In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PM...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6293
更新日期:2017-08-01 00:00:00
abstract::The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12265
更新日期:2021-01-01 00:00:00
abstract::Breast cancer is a common malignant tumor among females, with triple-negative breast cancer being an important type accounting for 15-20% of all breast cancer cases. Triple-negative breast cancer is one of the most aggressive types of cancer without standard adjuvant chemotherapy. Ganoderic acid A (GA-A) is one of the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9475
更新日期:2018-11-01 00:00:00
abstract::In the present study, Frizzled-2 (Fz2), a receptor of the Wnt ligand, was investigated as a potential target of molecular therapy for hepatocellular carcinoma (HCC). Quantitative polymerase chain reaction (PCR) was performed to determine the expression levels of Fz2. A surgical specimen of HCC was immunostained with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2408
更新日期:2014-10-01 00:00:00
abstract::Clear cell myoepithelial carcinoma is a very rare disease which develops primarily in the parotid gland. To date, only 17 cases of clear cell myoepithelial carcinoma have been reported worldwide. Among them, only three cases developed in the minor salivary gland in the oral cavity. No cases developed in the base of th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.900
更新日期:2012-12-01 00:00:00
abstract::No evidence currently exists to demonstrate the prognostic value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with unresectable colorectal cancer liver metastases (CRLM). Therefore, we retrospectively investigated the correlation between serum CEA and CA19-9 levels and ove...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.574
更新日期:2012-04-01 00:00:00
abstract::The present study investigated the effects of N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine, on the growth of gliomas. To analyze the effects of ketamine treatment, rat C6 glioma cells arising from astrocytes, and RNB cells representing non-malignant astrocytes, were examined. In ketamine-treated C6 cells,...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6806
更新日期:2017-10-01 00:00:00
abstract::Ovarian endometrioid borderline tumors (EBTs) are extremely rare, and are thought to be precursors of endometrioid carcinoma, beginning as adenofibroma or endometriosis and progressing in a slow, stepwise manner. In endometrioid carcinomas, a high frequency of activating mutations in phosphatase and tensin homolog (PT...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8626
更新日期:2018-07-01 00:00:00
abstract::The aim of the present study was to compare intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in irradiation of lung cancer. Plans of 14 patients were compared. The results demonstrated that in peripheral lung cancer, V5 (%) of the lung in partial-arc (PA)-VMAT was decreased comp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7732
更新日期:2018-03-01 00:00:00
abstract::TACC3, a member of the transforming acidic coiled-coil protein (TACC) family, is a multifunctional protein that is involved in various biological functions, including proliferation and differentiation of tumor cells, cancer progression and metastasis. The aims of the present study were to examine whether TACC3 express...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8262
更新日期:2018-05-01 00:00:00
abstract::Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, che...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6685
更新日期:2017-10-01 00:00:00
abstract::The present study aimed to examine the impact of sarcopenia, defined as low muscle mass on computed tomography (CT), prior to sorafenib therapy on the clinical outcomes of patients with hepatocellular carcinoma (HCC) receiving sorafenib therapy. In total, 232 patients with unresectable HCC (median age, 72 years) were ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6287
更新日期:2017-08-01 00:00:00
abstract::Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and its expression in chronic hepatitis B, liver cirrhosis and liver cancer were investigated to evaluated the significance of APOBEC3G. Fifty-eight patients with chronic hepatitis B were selected, including 20 cases of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11257
更新日期:2020-03-01 00:00:00
abstract::The aim of the present study was to investigate the significance and values of 3.0T diffusion weighted imaging (DWI) to differentially diagnose benign and malignant space-occupying liver lesions. A total of 91 patients with liver space-occupying lesions (145 lesions) were admitted into Zhongnan Hospital of Wuhan Unive...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7565
更新日期:2018-02-01 00:00:00
abstract::Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10905
更新日期:2019-11-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC). Covalently closed circular DNA (cccDNA) is an intermediate in the life cycle of HBV. HBV-encoded X protein (HBx), a key viral oncoprotein, can be specifically ubiquitylated by male specific lethal 2 (MSL2), which causes upregulatio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10833
更新日期:2019-11-01 00:00:00
abstract::Previous studies have reported that basic fibroblast growth factor (bFGF) is associated with tumor genesis, growth and prognosis. The present study was conducted to detect the levels of bFGF expression in women with non-small cell lung cancer (NSCLC), colon cancer, breast cancer and melanoma, and analyze its associati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6335
更新日期:2017-08-01 00:00:00
abstract::The present study examined the association between squamous cell carcinoma antigen (SCCA) expression and the response of patients with cervical cancer to docetaxel-carboplatin (DC) combination chemotherapy, in order to determine the prognostic potential of SCCA expression. A total of 21 patients were enrolled with sta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5560
更新日期:2017-03-01 00:00:00
abstract::Patients with longstanding ulcerative colitis have an increased risk of colorectal cancer. Mouse models for colitis-associated tumors are indispensable for the development of novel strategies for prevention and intervention, as well as an improved understanding of the mechanisms underlying tumor formation. The present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6645
更新日期:2017-09-01 00:00:00
abstract::Clinical effects of FOLFOX4 and TPF chemotherapy regimen on postoperative gastric cancer patients were investigated. A total of 60 patients admitted to the First People's Hospital of Changzhou receiving gastric cancer operation were selected and they were divided into two groups at random. Thirty patients in the FOLFO...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9695
更新日期:2019-01-01 00:00:00
abstract::The aim of the present study was to investigate the effects of the heat shock protein (HSP)90 inhibitor AUY922 on the proliferation and migratory ability of renal cell carcinoma (RCC) cells. The expression of HSP90 was measured in vitro using western blotting and quantitative polymerase chain reaction in the ACHN and ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3299
更新日期:2015-08-01 00:00:00
abstract::Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8007
更新日期:2018-04-01 00:00:00
abstract::5-fluorouracil (5-FU) is one of the standard chemoradiotherapy regimens for hepatocellular carcinoma (HCC) treatment. B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) has been demonstrated to regulate proliferation. Additionally, Bmi-1 overexpression has been identified in HCC cell lines and corr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.805
更新日期:2012-10-01 00:00:00