Abstract:
:Previous studies have shown that the activation of the β2 adrenergic receptor (ADRB2) can stimulate several signaling pathways that promote tumor growth and metastasis. β-adrenergic antagonism may have a beneficial role in cancer treatment; however, little is known about the effect of ADRB2 inhibition on the growth of human hepatocellular carcinoma (HCC) cells. The present study revealed that ADRB2 was highly expressed in HCC cell lines compared with that in a normal liver cell line. Treatment with the ADRB2 antagonists ICI118,551 and metoprolol significantly inhibited the growth of human HCC cells. Annexin V/propidium iodide apoptosis and Hoechst staining assays revealed that treatment with ADRB2 antagonists induced apoptosis in HCC cells. Additionally, cell cycle analysis using propidium iodide staining demonstrated that growth suppression was associated with G2/M phase cell cycle arrest by ADRB2 antagonism in HCC cells. Treatment with the ADRB2 antagonists suppressed HCC growth, possibly through inhibiting expression of B-cell lymphoma-2 (Bcl-2) and upregulating that of caspase-9 and Bcl-2-associated X, as well as downregulating the expression levels of the G2/M phase-associated proteins cyclin B1 and cyclin-dependent kinase 1. Therefore, the observations of the present study indicate that ADRB2 blockade inhibited HCC growth, potentially mediated by inducing apoptosis and G2/M phase cell cycle arrest. ADRB2 antagonists may therefore be a promising therapeutic strategy for HCC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Dang D,Zhang J,Yang Jdoi
10.3892/ol.2018.8847subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1425-1430issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-8847journal_volume
16pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Selective amino acid restriction targets mitochondria to induce apoptosis of DU145 and PC3 prostate cancer cells. Biochemical assays and flow cytometry were uitilized to analyze the glucose consumption, lactate production, pyruvate dehydrogenase (PDH), nicotinamide adenine dinucleotide (NAD)/NADH and nicotinamide aden...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.237
更新日期:2011-01-18 00:00:00
abstract::Recent studies have shown that a small subpopulation of stem-like cancer cells within most solid tumors are responsible for the malignancy of aggressive cancer cells, including tumorigenicity and relapse of solid tumors. These tumor cells may be enriched and maintained in vitro in the presence of growth factors (GFs),...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.531
更新日期:2012-03-01 00:00:00
abstract::The present study aimed to clarify the association between kinesin family member 11 (KIF11) and human breast cancer, and the effect of KIF11 on breast cancer cell progression. Western blot analysis, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis, retroviral infection, immunohistochemis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7053
更新日期:2017-12-01 00:00:00
abstract::Ameloblastoma is the most common and clinically relevant type of odontogenic tumor. Clear cell odontogenic carcinoma is histologically characterized by solid sheets and nests of clear cells, whereas clear cell ameloblastoma (CCAM) is histologically characterized by an ameloblastomatous component intermixed with an ext...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7116
更新日期:2017-12-01 00:00:00
abstract::Effective therapies are limited for pancreatic cancer, particularly for those with distant tumour metastases. Therefore, more individualised drug screening is urgently required. Next-generation sequencing (NGS) is a powerful tool to investigate the genomic landscape of patients and the mechanism of drug response, whic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9876
更新日期:2019-02-01 00:00:00
abstract::Krüppel-like factor 5 (KLF5) is frequently deleted and inactivated in prostate cancer, and exerts tumor-suppressing function in prostate cancer cells. However, the function of KLF5 in the apoptosis of prostate cancer cells remains unclear. In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PM...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6293
更新日期:2017-08-01 00:00:00
abstract::The aim of this study was to evaluate the efficacy of multi-detector row helical computed tomography (MDCT) angiography in the detection of feeding arteries prior to multi-arterial infusion for lung cancer. A total of 59 consecutive patients (44 males and 15 females; age range, 27-86 years; median age, 62 years) with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1000
更新日期:2013-01-01 00:00:00
abstract::Renal oncocytoma is one of the most unusual benign lesion, which are usually diagnosed postoperatively, since their differentiation from renal cell carcinoma is challenging. The present study reports two cases of renal oncocytoma in a 60-year-old woman and a 46-year-old man. Relevant clinical and pathological data on ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4594
更新日期:2016-07-01 00:00:00
abstract::Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.767
更新日期:2012-09-01 00:00:00
abstract::Gene therapy with adenoviral early region gene (E1A) may enhance the susceptibility of neoplastic cells to chemotherapy-induced cell death. Our previous study developed a urothelium-specific oncolytic serotype 5 adenovirus (Ad5) with the uroplakin II (UPII) promoter controlling E1A expression. The present study invest...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6416
更新日期:2017-08-01 00:00:00
abstract::Lung cancer is a major cause of death worldwide, and non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The aim of this study was to investigate whether miR-96 mediated the invasion and metastasis of NSCLC by targeting glypican-3 (GPC3). Reverse transcription-quantitative PCR (RT-qPCR) was empl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8507
更新日期:2018-06-01 00:00:00
abstract::Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10905
更新日期:2019-11-01 00:00:00
abstract::Cancer stem cells (CSCs), defined by CD133 expression, harbor heterogeneous subpopulations of cells, including endothelial progenitor cells (EPCs). This study aimed to investigate whether a subpopulation of CSCs could affect the radiographic characteristics of glioblastoma. Tissue samples from 10 patients newly diagno...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5548
更新日期:2017-03-01 00:00:00
abstract::The monolocular cystic formation associated with gallbladder carcinoma is an extremely rare condition. A 79-year-old female suffering from upper abdominal pain and distention was admitted to our hospital. Ultrasonography and computed tomography revealed a monolocular cyst with an irregular wall thickness of 15 cm in d...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2010.182
更新日期:2010-11-01 00:00:00
abstract::Extranodal natural killer/T-cell lymphoma (ENKL) is marked by a profound cellular immune deficiency that may influence the capacity of T cells to extract an efficient antitumor immune response. It has been confirmed that the B7-CD28 pathway may promote tumor immune evasion by providing a negative regulatory signal. Th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2356
更新日期:2014-10-01 00:00:00
abstract::Carbonyl reductase 1 (CBR1) is theorized to participate in various cellular processes, such as signal transduction, apoptosis, carcinogenesis and drug resistance, and is highly expressed in certain malignancies, including lung tumors. Several studies have provided evidence that gene polymorphisms may affect susceptibi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6926
更新日期:2017-11-01 00:00:00
abstract::Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully under...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12235
更新日期:2020-12-01 00:00:00
abstract::Melanomas affect the foot and ankle region and are associated with a poor prognosis. The aim of the current study was to evaluate the functional and oncological outcomes of salvage surgery using cutaneous flaps for soft tissue reconstruction of the foot and ankle following the extended resection of a melanoma. A retro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2440
更新日期:2014-11-01 00:00:00
abstract::Primary testicular non-Hodgkin's lymphoma (TNHL) was first described as a clinical entity in 1866. It is a rare disease which accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. Hemophagocytic syndrome (HPS) is a rare but distinct condition caused by inappr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.701
更新日期:2012-07-01 00:00:00
abstract::Patients diagnosed preoperatively with ductal carcinoma in situ (DCIS) breast cancer have the potential to develop invasive ductal carcinoma (IDC). The present study investigated the usefulness of exosome-encapsulated microRNA-223-3p (miR-223-3p) as a biomarker for detecting IDC in patients initially diagnosed with DC...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8457
更新日期:2018-06-01 00:00:00
abstract::Giant cell tumor (GCT) of the bone is a relatively common primary bone tumor. Treatment with simple curettage often results in a high local recurrence rate. Tumor resection and reconstruction with prosthesis or an allograft has a low rate of local recurrence; however, the patient's native joint function becomes signif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1036
更新日期:2013-02-01 00:00:00
abstract::The histological boundary between benign and malignant vascular tumors is not clear. Thus, the discrepancies between clinical judgement and pathological diagnosis often lead to a difficult clinical decision, and may result in misdiagnosis. In order to develop more effective treatment methods, the clinical and patholog...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1025
更新日期:2013-02-01 00:00:00
abstract::Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.799
更新日期:2012-10-01 00:00:00
abstract::Numerous studies have shown that marital status may be a prognostic factor in various malignancies, but little is known about its effect on duodenal adenocarcinoma. The aim of the present study was to determine the association between marital status and survival in patients with duodenal adenocarcinoma. The Surveillan...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10475
更新日期:2019-08-01 00:00:00
abstract::Extra-adrenal pheochromocytomas are rare tumors that originate from the chromaffin tissue of the sympathetic nervous system. Ovarian extra-adrenal pheochromocytoma is even more rare. The present study reports a rare case of an extra-adrenal pheochromocytoma that was localized to the right ovary, but was gynecologicall...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2718
更新日期:2015-02-01 00:00:00
abstract::Malignant melanoma can be successfully treated when it is identified in its early stages, but the disease is associated with a poor prognosis when it is detected in an advanced stage. Papillary thyroid carcinoma is a thyroid cancer that has a good prognosis. The present study reports a rare case of malignant melanoma ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2642
更新日期:2015-01-01 00:00:00
abstract::The present study aimed to investigate the effect of gastrin-releasing peptide (GRP) on the proliferation and invasion of ovarian cancer ES2 cells. The ovarian cancer ES2 cells were transfected with small interfering RNA against GRP. Cell proliferation was assessed using the Trypan blue assay, apoptosis was determined...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3240
更新日期:2015-07-01 00:00:00
abstract::The liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5631
更新日期:2017-03-01 00:00:00
abstract::This study investigated the inhibitory effect of vitamin D-binding protein-derived macrophage-activating factor (GcMAF) on carcinogenesis and tumor growth, using a 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster cheek pouch carcinogenesis model, as well as the cytocidal effect of activated macrophages against ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.306
更新日期:2011-07-01 00:00:00
abstract::MicroRNA (miR)-29a has been associated with carcinogenesis in humans; however, its functional significance in esophageal squamous cell carcinoma (ESCC) is yet to be determined. In the present study, the expression of miR-29a was markedly downregulated in ESCC tissue and the ESCC TE-1 cell line, compared with normal es...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2678
更新日期:2015-01-01 00:00:00