Abstract:
:Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thyroid receptor (TR), retinoid X receptor (RXR), peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) in malignant breast tumour tissue samples. Patients diagnosed and treated for breast cancer between 1990 and 2000 were included. Receptor expression was detected by immunohistochemical staining. Correlation analyses for the expression of the receptors were performed for the clinical and histopathological data. The paraffin-embedded tissue from 82 breast cancer patients was available. The different steroid receptors showed varying results when correlated with known histopathological markers. TRα2 demonstrated the most significant correlations with steroid hormone receptors. Significant correlations between the major isoforms of TR, and between RXR, PPAR and VDR, were demonstrated in the patient sample. The immunohistochemical association of these receptors may provide the first proof of an interaction on the molecular level. This assumption awaits confirmation in studies with larger cohorts.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Ditsch N,Mayr D,Lenhard M,Strauss C,Vodermaier A,Gallwas J,Stoeckl D,Graeser M,Weissenbacher T,Friese K,Jeschke Udoi
10.3892/ol.2012.799subject
Has Abstractpub_date
2012-10-01 00:00:00pages
665-671issue
4eissn
1792-1074issn
1792-1082pii
ol-04-04-0665journal_volume
4pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::First-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the treatment of non-small cell lung cancer (non-SCLC) with EGFR-sensitive mutations. However, acquired resistance to these drugs was inevitable. The transformation of lung adenocarcinoma to SCLC following ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6229
更新日期:2017-07-01 00:00:00
abstract::Preeclampsia (PE) is characterized by gestational hypertension and proteinuria, and is a leading cause of maternal death and perinatal morbidity globally. Although the exact cause of PE remains unclear, several studies have suggested a role for abnormal expression of multiple genes. The aim of the present study was to...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11721
更新日期:2020-08-01 00:00:00
abstract::Primary hepatic lymphoma (PHL) is an uncommon lymphoid tumor with varied clinical features and treatment outcome. In the present study, the case of a 56-year-old patient with PHL and no clinical presentation was reported. During a routine physical examination, multiple hypodense nodules were incidentally detected in r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2920
更新日期:2015-04-01 00:00:00
abstract::Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNA that have gained attention from researchers for their involvement in multiple biological processes. circRNAs are ubiquitously expressed in eukaryotic cells and regulate gene expression at the transcriptional or post-transcriptional level by interac...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7118
更新日期:2017-12-01 00:00:00
abstract::Circulating tumor cells (CTCs), isolated as a 'liquid biopsy', may provide important diagnostic and prognostic information. Therefore, rapid, reliable and unbiased detection of CTCs are required for routine clinical analyses. It was demonstrated that negative enrichment, an epithelial marker-independent technique for ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6046
更新日期:2017-06-01 00:00:00
abstract::Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide. The usual treatment of GC consists of surgery with additional adjuvant chemotherapy. In the present study, the feasibility and safety of adjuvant S-1 plus oxaliplatin (SOX) chemotherapy for patients with GC and the optimal dosage of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2821
更新日期:2015-03-01 00:00:00
abstract::MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through the direct targeting of oncogenes or tumor suppressors. It has been previously suggested that miR-126 may be associated with endometrial cancer (EC). However, the exact role of miR-126...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4001
更新日期:2016-02-01 00:00:00
abstract::Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various malignant tumors. However, the function of circulating VEGF-C is unclear and it ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9358
更新日期:2018-11-01 00:00:00
abstract::Exophthalmos, myxedema and osteoarthropathy (EMO) comprise the triad known as EMO syndrome, which is rarely observed in patients with autoimmune thyroid disease. The present study reports the case of a patient with EMO, including the response of this rare combination to radiotherapy. A 48-year-old patient with EMO syn...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2990
更新日期:2015-05-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment remains a challenge. Effective control of cell survival and proliferation is critical in the prevention of oncogenesis and successful treatment of cancer. Long non-coding RNAs (lncRNAs) have emerged as primary regulators of carcinogene...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5841
更新日期:2017-05-01 00:00:00
abstract::HRas proto-oncogene (HRAS) is one of the most commonly mutated genes in thyroid cancer, with mutations frequently occurring in the follicular and Hurthle cell subtypes. However, the contribution of mutations in HRAS to papillary thyroid carcinoma (PTC) progression and the tall-cell variant (TCV) is poorly understood. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7818
更新日期:2018-04-01 00:00:00
abstract::The present study aimed to investigate the clinical significance of paired-box 8 (PAX8) in primary epithelial ovarian cancer (PEOC). Using immunohistochemical (IHC) staining, the expression of PAX8 in 60 patients with PEOC, 20 patients with ovarian benign lesions and 10 patients with metastatic ovarian cancer (MOC), w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6949
更新日期:2017-11-01 00:00:00
abstract::A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11336
更新日期:2020-03-01 00:00:00
abstract::Gene therapy with adenoviral early region gene (E1A) may enhance the susceptibility of neoplastic cells to chemotherapy-induced cell death. Our previous study developed a urothelium-specific oncolytic serotype 5 adenovirus (Ad5) with the uroplakin II (UPII) promoter controlling E1A expression. The present study invest...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6416
更新日期:2017-08-01 00:00:00
abstract::Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrupted and cell cycle ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2549
更新日期:2014-12-01 00:00:00
abstract::Although bulk high-throughput genomic profiling studies have led to a significant increase in the understanding of cancer biology, there is increasing awareness that bulk profiling approaches do not completely elucidate tumor heterogeneity. Single-cell genomic profiling enables the distinction of tumor heterogeneity, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5669
更新日期:2017-03-01 00:00:00
abstract::The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12044
更新日期:2020-11-01 00:00:00
abstract::Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduce...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11614
更新日期:2020-07-01 00:00:00
abstract::The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4764
更新日期:2016-08-01 00:00:00
abstract::In the present study, Frizzled-2 (Fz2), a receptor of the Wnt ligand, was investigated as a potential target of molecular therapy for hepatocellular carcinoma (HCC). Quantitative polymerase chain reaction (PCR) was performed to determine the expression levels of Fz2. A surgical specimen of HCC was immunostained with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2408
更新日期:2014-10-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-associated mortality worldwide and its prognosis is poor. Few effective biomarkers for non-small cell lung cancer (NSCLC) have been translated into the clinical practice aiming to assist in the treatment plan design and prognosis evaluation. The aim of the present study was t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6467
更新日期:2017-08-01 00:00:00
abstract::A gallbladder neuroendocrine neoplasm (GB-NEN) is a unique heterogeneous neoplasm, originating from neuroendocrine cells and able to secrete peptides as its neurotransmitter. Among all the neuroendocrine tumors (NETs), the GB-NEN prevalence is 0.5%, which accounts for ~2.1% of all gallbladder tumors. The current study...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11461
更新日期:2020-05-01 00:00:00
abstract::Ovarian metastasis from non-small cell lung cancer (NSCLC) is a rare condition. The current study presents the cases of 2 female patients aged 38 and 47 years old, respectively, who were initially diagnosed with NSCLC adenocarcinoma on histology. Both patients initially presented with chest pain and a cough, and subse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5292
更新日期:2016-12-01 00:00:00
abstract::The present study aimed to investigate the imaging characteristics of primary malignant bone tumors in children. The imaging results of 34 children with primary malignant bone tumors confirmed by histopathological diagnosis between March 2008 and January 2014 were retrospectively analyzed. In total, 25 patients had os...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6939
更新日期:2017-11-01 00:00:00
abstract::Alcohol consumption is a risk factor for the development of hepatocellular carcinoma (HCC); however, the association between alcohol and HCC remains unknown. The present study aimed to identify key genes related to alcohol-associated HCC to improve the current understanding of the pathology of this disease. Alcohol-as...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9757
更新日期:2019-02-01 00:00:00
abstract::The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8772
更新日期:2018-08-01 00:00:00
abstract::A 56-year-old male patient with locally advanced mucinous rectal cancer underwent neoadjuvant chemoradiotherapy. Follow-up imaging with positron emission tomography-computed tomography (PET-CT) revealed a local response to chemoradiotherapy, whereas diffusion-weighted magnetic resonance imaging (DW-MRI) showed newly p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.663
更新日期:2012-06-01 00:00:00
abstract::Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. The aim of the present study is to analyze the incidence of HER2 gene amplification in selected tumors with adverse features...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5125
更新日期:2016-11-01 00:00:00
abstract::Pro-angiogenic factors [vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)] and anti-angiogenic factors (endostatin) play important roles in the progression of pancreatic cancer. The purpose of the present study was to investigate the knockdown effect by either VEGF or bFGF siRNA on th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1102
更新日期:2013-03-01 00:00:00
abstract::Radiofrequency ablation (RFA) and cryoablation are alternative forms of therapy used widely in various pathological states, including treatment of carcinogenesis. The reason is that ablation techniques have ability of modulating the immune system. Furthermore, recent studies have applied this form of therapy on tumor ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4997
更新日期:2016-10-01 00:00:00