Abstract:
:The present study aimed to investigate the effect of gastrin-releasing peptide (GRP) on the proliferation and invasion of ovarian cancer ES2 cells. The ovarian cancer ES2 cells were transfected with small interfering RNA against GRP. Cell proliferation was assessed using the Trypan blue assay, apoptosis was determined using propidium iodide/fluorescein isothiocyanate and flow cytometry, and the invasion ability was detected using the Transwell assay. The results revealed that the expression of GRP significantly decreased following transfection with GRP-short hairpin RNA. Furthermore, the silencing of GRP resulted in increased apoptosis and a reduced invasive ability of the ES2 cells. It was concluded that GRP may regulate the proliferation and migration of human ovarian cancer cells, which indicates that GRP may be a potential novel target for the treatment of ovarian cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Jia Y,Shi H,Fan Ddoi
10.3892/ol.2015.3240subject
Has Abstractpub_date
2015-07-01 00:00:00pages
359-363issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-3240journal_volume
10pub_type
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