Significance of gastrin-releasing peptide in ovarian cancer ES2 cells.

Abstract:

:The present study aimed to investigate the effect of gastrin-releasing peptide (GRP) on the proliferation and invasion of ovarian cancer ES2 cells. The ovarian cancer ES2 cells were transfected with small interfering RNA against GRP. Cell proliferation was assessed using the Trypan blue assay, apoptosis was determined using propidium iodide/fluorescein isothiocyanate and flow cytometry, and the invasion ability was detected using the Transwell assay. The results revealed that the expression of GRP significantly decreased following transfection with GRP-short hairpin RNA. Furthermore, the silencing of GRP resulted in increased apoptosis and a reduced invasive ability of the ES2 cells. It was concluded that GRP may regulate the proliferation and migration of human ovarian cancer cells, which indicates that GRP may be a potential novel target for the treatment of ovarian cancer.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Jia Y,Shi H,Fan D

doi

10.3892/ol.2015.3240

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

359-363

issue

1

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-3240

journal_volume

10

pub_type

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