Abstract:
:Cancer stem cells (CSCs), defined by CD133 expression, harbor heterogeneous subpopulations of cells, including endothelial progenitor cells (EPCs). This study aimed to investigate whether a subpopulation of CSCs could affect the radiographic characteristics of glioblastoma. Tissue samples from 10 patients newly diagnosed with glioblastoma were selected according to the radiographic characteristics of their tumors. The patients were divided into two groups based on preoperative magnetic resonance imaging demonstrating contrast enhancement, necrosis and infiltrative patterns: the enhancement/necrosis group (E/N, n=5) and the non-enhancement/infiltration group (NE/I, n=5). Flow cytometry was used to assess the CSCs while immunohistochemistry was used to study microvessel density and the proliferation index. The EPC (CD34+/CD133+) fraction in CSCs (CD133+) was larger in the NE/I group. However, there was little difference in the angiogenic activity assessed using microvessel density between the two groups. The proliferation index (assessed using the antibody Ki-67) was higher in the E/N group and was negatively correlated with the EPC fraction. The non-EPC (CD34-/CD133+) fraction is a major factor responsible for radiographic characteristics of contrast enhancement, thus establishing an association between a subpopulation fraction of CSCs and radiographic characteristics in glioblastoma. Therefore, the simple non-invasive assessment of studying contrast enhancement lesions in glioblastomas may be used to estimate CSC subpopulations.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Kim JE,Kim SK,Shin J,Se YB,Choi SH,Park SH,Choi SA,Lee JY,Phi JH,Wang KC,Park CK,Kim SKdoi
10.3892/ol.2016.5548subject
Has Abstractpub_date
2017-03-01 00:00:00pages
1175-1182issue
3eissn
1792-1074issn
1792-1082pii
OL-0-0-5548journal_volume
13pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Long non-coding RNAs (lncRNAs) have been reported to participate in multiple biological processes, including tumorigenesis. In the current study, the function of a novel lncRNA LINC00887 was investigated in lung carcinoma. For this purpose, LINC00887 expression was assessed by reverse-transcription quantitative PCR. C...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12348
更新日期:2021-02-01 00:00:00
abstract::Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5785
更新日期:2017-04-01 00:00:00
abstract::Resistance to oxaliplatin (L-OHP) is a major obstacle to successful chemotherapy in colorectal cancer (CRC). In the present study, the ability of gambogic acid (GA) to reverse L-OHP resistance in CRC LoVo cells was investigated. L-OHP-resistant LoVo/L-OHP cells were established by exposing them to increasing concentra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8916
更新日期:2018-08-01 00:00:00
abstract::The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the gene expression profiles of Luminal A breast cancer patients were downloaded from The Cancer Genome Atlas database. The differen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7940
更新日期:2018-04-01 00:00:00
abstract::Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3',5'-monophosphate- determined signaling pathway intercessors, which are associated with the pathogenesis of neurological disorders and numerous human diseases. To the best of our knowledge, the role of EPAC2 signaling via matrix metall...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10200
更新日期:2019-06-01 00:00:00
abstract::Primary hepatic lymphoma (PHL) is an uncommon lymphoid tumor with varied clinical features and treatment outcome. In the present study, the case of a 56-year-old patient with PHL and no clinical presentation was reported. During a routine physical examination, multiple hypodense nodules were incidentally detected in r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2920
更新日期:2015-04-01 00:00:00
abstract::Canonical WNT signaling promotes breast cancer progression. Although APC downregulated 1 (APCDD1) may inhibit canonical WNT signaling, its role in breast cancer remains to be fully understood. The present study demonstrated that APCDD1 suppressed in vitro breast cancer growth and metastasis by inhibiting canonical WNT...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6801
更新日期:2017-10-01 00:00:00
abstract::Ewing sarcoma (ES) is a highly malignant pediatric tumor with a low survival rate and a high rate of metastasis. However, there have been limited reports on the exploration of new biomarkers of ES. Therefore, the aim of the present study was to identify the potential hub genes associated with overall vital survival (O...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10681
更新日期:2019-10-01 00:00:00
abstract::Distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is upregulated in various solid tumors and serves a critical role in the tumorigenesis of cancer. However, to the best of our knowledge, the expression of circulating DLX6-AS1 and its role in the diagnosis of non-small cell lung cancer (NSCLC) have not been previously ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10892
更新日期:2019-11-01 00:00:00
abstract::N-myc downstream-regulated gene 1 (NDRG1) is a multifunctional protein associated with carcinogenesis and tumor progression. The function of NDRG1 in hepatocellular carcinoma (HCC) cells remains controversial. The present study investigated the role of NDRG1 in HCC as well as its molecular mechanism using a range of t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5924
更新日期:2017-05-01 00:00:00
abstract::Gastric cancer is one of the most common malignancies with high cancer-associated mortality rate globally. Hepcidin is the peptide hormone, which is critically important in the regulation of systemic iron homeostasis. Cumulating evidence has reported that the disturbed local expression of hepcidin may serve as a predi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7574
更新日期:2018-02-01 00:00:00
abstract::MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6809
更新日期:2017-10-01 00:00:00
abstract::Xeroderma pigmentosum variant (XP-V) is a subtype of xeroderma pigmentosum (XP) disease with typical pigmentation and types of cancer in the oral maxillofacial and other sun-exposed regions. Few factors of tumor proneness in XP-V have been completely elucidated with the exception of the POLH [which encodes DNA polymer...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1604
更新日期:2013-12-01 00:00:00
abstract::Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1454
更新日期:2013-09-01 00:00:00
abstract::Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia te...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5832
更新日期:2017-05-01 00:00:00
abstract::The present study aimed to investigate the impact of overexpression of long noncoding RNA PEG10 (lncRNA PEG10) on the proliferation, invasion and metastasis of hypopharyngeal squamous cell carcinoma (HSCC). Quantitative reverse transcription polymerase chain reaction was used to quantify lncRNA PEG10 expression levels...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6498
更新日期:2017-09-01 00:00:00
abstract::[This retracts the article DOI: 10.3892/ol.2016.4607.]. ...
journal_title:Oncology letters
pub_type: 杂志文章,撤回出版物
doi:10.3892/ol.2019.10108
更新日期:2019-05-01 00:00:00
abstract::The present study aimed to investigate the role of homeobox B4 (HOXB4) in breast cancer. Analysis of The Cancer Genome Atlas data revealed that HOXB4 expression was positively associated with expression of the StAR-related lipid transfer domain protein 13 (STARD13), and the overall survival of patients with breast can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6825
更新日期:2017-10-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are recently identified regulators in tumorigenesis and tumour progression. BRAF-activated lncRNA (BANCR) is overexpressed in melanoma and has a potential functional role in melanoma cell migration. However, little is known concerning the role of BANCR in the development of colorectal ca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2154
更新日期:2014-08-01 00:00:00
abstract::The aim of this study was to investigate the correlation between H-ras mutation and primary hepatocellular carcinoma (HCC) and to describe the role of H-ras mutation in carcinogenesis. Clinical samples of 69 patients were collected and the expression levels of H-ras in HCC and the surrounding normal tissues were exami...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.832
更新日期:2012-10-01 00:00:00
abstract::The present study aimed to investigate the effects of Na+/H+ exchanger regulatory factor 1 (NHERF1) gene knockdown, using short-hairpin RNA (shRNA), on the malignant behaviors of prostate cancer cells. A pSuper.puro NHERF1 shRNA vector was transfected into PC-3M prostate cancer cells using Lipofectamine 2000. Stable c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4007
更新日期:2016-02-01 00:00:00
abstract::Invasive breast carcinoma (BRCA) is a serious disease that threatens the survival time of those affected. Alternative splicing (AS) involved in BRCA pathogenesis may be a potential therapeutic target. However, to the best of our knowledge, a systematic analysis of survival-related alternative splicing events (SREs) ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11695
更新日期:2020-08-01 00:00:00
abstract::Serine/threonine kinase 39 (STK39) is associated with hypertension, autism, Parkinson's disease and various types of cancer in recent years. This study investigated STK39 expression and possible roles in osteosarcoma using qPCR and western blot analysis. Compared to normal bone tissues, the mRNA and protein expression...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6728
更新日期:2017-10-01 00:00:00
abstract::Taxanes, including paclitaxel (PTX) and docetaxel (DOC), are poorly soluble in water due to their hydrophobic properties and thus, require solvents. However, use of these solvents has been associated with toxic responses, including a hypersensitivity reaction (HSR). Nanoparticle albumin-bound paclitaxel (nab-PTX) is a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1471
更新日期:2013-10-01 00:00:00
abstract::The mechanisms underlying the pathogenesis of papillary thyroid carcinoma (PTC) have not yet been elucidated. The aim of the current study was to identify potential pathogenic biomarkers in PTC by comprehensively analyzing gene expression and methylation profiles, and to increase the understanding of PTC pathogenesis....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11059
更新日期:2019-12-01 00:00:00
abstract::Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions, increasing evidenc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1555
更新日期:2013-11-01 00:00:00
abstract::The aim of the present study was to investigate the underlying molecular mechanisms of the potent cell cycle inhibition and apoptotic effect of luteolin on LoVo human colon cancer cells. In the present study, Cell Counting kit-8 assay revealed that luteolin exerted notable cytotoxicity on LoVo cells in a dose- and tim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7475
更新日期:2018-02-01 00:00:00
abstract::In recent years, the use of statins has been reported to be associated with a reduced risk of prostate cancer (PCa), particularly metastatic PCa. The mechanisms underlying these epidemiological observations are poorly understood. Epithelial-mesenchymal transition (EMT) is a critical initial step and a hallmark for can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4404
更新日期:2016-05-01 00:00:00
abstract::The incidence of gastric cancer is high, especially in China. The present study aims to provide a novel therapeutic target for gastric cancer. Peripheral blood, cancerous and paracancerous tissues were collected from patients with gastric cancer. T-cell immunoglobulin mucin domain-3 (Tim-3) expression in T-cells was m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9743
更新日期:2019-02-01 00:00:00
abstract::Breast cancer has a major impact on the health of women worldwide. In the Kingdom of Saudi Arabia (KSA), breast cancer incidence is on the increase and is characterized by early onset and aggressiveness. Owing to the importance of the TP53 gene in breast carcinogenesis, we analyzed the possible link between TP53 singl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.581
更新日期:2012-04-01 00:00:00