Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line.

abstract：:Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...

journal_title：Oncology letters

authors： Li M,Zhao Y,Liu X,Zhang S,Jiang Y,Yang Z

更新日期：2020-04-01 00:00:00

abstract：:Receptor of activated C Kinase 1 (RACK1) is an essential scaffold and anchoring protein, which serves an important role in multiple tumorigenesis signaling pathways. The present study aimed to investigate the expression of RACK1 in gastric cancer (GC), and its association with the occurrence and development of GC. In ...

journal_title：Oncology letters

authors： Liu C,Ren L,Wang Y,Liu Y,Xiao J

更新日期：2017-10-01 00:00:00

abstract：:Peritoneal metastasis is an important prognostic factor for pancreatic cancer. The present study evaluated the possibility of diagnosing peritoneal metastasis by a photodynamic diagnosis using 5-aminolevulinic acid (5-ALA-PDD). In vitro, protoporphyrin IX (PpIX) accumulation was examined in the AsPC-1-GFP cell line fo...

journal_title：Oncology letters

authors： Harada K,Murayama Y,Kubo H,Matsuo H,Morimura R,Ikoma H,Fujiwara H,Okamoto K,Tanaka T,Otsuji E

更新日期：2018-07-01 00:00:00

abstract：:Peroxiredoxin 1 (Prx1) is important in the protection of cells from oxidative damage and the regulation of cell proliferation and apoptosis. Prx1 is overexpressed in oral precancerous lesions of oral leukoplakia (OLK) and oral cancer; however, the association between Prx1 expression and OLK pathogenesis remains unknow...

journal_title：Oncology letters

authors： Zhang J,Jing X,Niu W,Zhang M,Ge L,Miao C,Tang X

更新日期：2016-07-01 00:00:00

abstract：:Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and exhibits an organ-dependent expression pattern in cancer. PSCA is upregulated in prostate cancer and downregulated in gastric cancer. PSCA is expressed in a variety of human organs. Although certain studies prev...

journal_title：Oncology letters

authors： Ono H,Sakamoto H,Yoshida T,Saeki N

更新日期：2018-03-01 00:00:00

abstract：:The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...

journal_title：Oncology letters

authors： Takuwa H,Tsuji W,Yamamoto Y,Shintaku M,Yotsumoto F

更新日期：2018-05-01 00:00:00

abstract：:Thyroid cancer is the most common malignant endocrine tumor, with significant morbidity and mortality. Bovine myeloid antimicrobial peptide 28 (BMAP-28) is a cathelicidin that is found in bovine neutrophils. In the present study, the effect and relative mechanism of BMAP-28 on the human thyroid cancer TT cell line in ...

journal_title：Oncology letters

authors： Zhang D,Wan L,Zhang J,Liu C,Sun H

更新日期：2015-10-01 00:00:00

abstract：:The purpose of the present study was to evaluate the recent trend of diagnosing appendiceal diseases through the analysis of appendectomy materials, stressing the importance of their pathological examination. A clinicopathological assessment of patients undergoing an appendectomy was conducted, based on the pathologic...

journal_title：Oncology letters

authors： Tajima T,Tajiri T,Mukai M,Sugiyama T,Hasegawa S,Yamamoto S,Sadahiro S,Shimada H,Makuuchi H

更新日期：2018-05-01 00:00:00

abstract：:Metastasis negatively affects the prognosis of hepatocellular carcinoma (HCC). In the present study, niclosamide, which is known to suppress the proliferation of HCC cells, was investigated for possible suppressant effects on the migration of HCC cells. HLF and PLC/PRF/5 HCC cells were cultured in the presence of nicl...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Ishige N

更新日期：2015-12-01 00:00:00

abstract：:Liver kinase B1 (LKB1) encodes a serine/threonine kinase and functions as a tumor suppressor. LKB1 loss-of-function somatic mutations are frequently observed in sporadic types of cancer, particularly in lung cancer. Ectopic LKB1 induces growth arrest by upregulating p21/cyclin dependent kinase inhibitor 1A (WAF1) in L...

journal_title：Oncology letters

authors： Ma Q,Xiao P,Sun L,Wang J,Zhong D

更新日期：2018-07-01 00:00:00

abstract：:Ulcerative colitis (UC) is thought to be associated with precancerous lesions that can ultimately lead to colon cancer. Therefore, diagnostic markers for colorectal dysplasia and cancer are urgently needed for patients with UC. Stathmin 1 (STMN1) is a novel cancer biomarker that is also a novel target for treatment in...

journal_title：Oncology letters

authors： Osone K,Yokobori T,Katayama C,Takahashi R,Kato R,Tatsuski H,Takada T,Yajima R,Motegi Y,Ogawa H,Fujii T,Ojima H,Nakamura J,Yao T,Shirabe K,Kuwano H

更新日期：2019-11-01 00:00:00

abstract：:The ATP-binding cassette subfamily B member 1 (ABCB1) is a transporter that mediates multidrug resistance (MDR) against chemotherapy, which leads to decreased patient survival. To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) P...

journal_title：Oncology letters

authors： Wei S,Chen W,Hu L,Pan J,Wang X

更新日期：2018-11-01 00:00:00

abstract：:An individual with a twin who has developed leukemia or non-Hodgkin lymphoma (NHL) has an increased risk of developing the same disease, particularly with monozygotic twins. The few reported pairs of twins who developed NHL had similar primary sites and pathological subtypes. Here, we present the first reported cases ...

journal_title：Oncology letters

authors： Ishibashi N,Sugaya S,Takahashi H,Nishimaki H,Nakanishi Y,Chinen Y,Maebayashi T

更新日期：2019-01-01 00:00:00

abstract：:Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...

journal_title：Oncology letters

authors： He J,Li Y,Wang Y,Zhang H,Ge S,Fan X

更新日期：2018-05-01 00:00:00

abstract：:C-X-C motif chemokine ligand 5 (CXCL5) is a CXC-type chemokine that is a crucial inflammatory mediator and a powerful attractant for granulocytic immune cells. Increasing evidence has indicated that CXCL5 is involved in the tumorigenesis of various malignancies. The present investigation demonstrated that CXCL5 was ex...

journal_title：Oncology letters

authors： Yang Y,Hou J,Shao M,Zhang W,Qi Y,E S,Wang S,Sui H,Meng D,Wang B,Wang M,Han Y,Cao Y,Huang X,Li Y,Zhang P,Wang W

更新日期：2017-12-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is rare in the adult population and even rarer with jaw involvement. The current study presents the case of a 39-year-old male who complained of recurrent pain, swelling of the gingiva and an occasional pus-like discharge in the right mandible for one year. The patient was previousl...

journal_title：Oncology letters

authors： Shi S,Liu Y,Fu T,Li X,Zhao S

更新日期：2014-09-01 00:00:00

abstract：:Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the...

journal_title：Oncology letters

authors： Emam H,Refaat A,Jawaid P,Ur Rehman M,Li P,Zhao QL,Kondo T

更新日期：2017-07-01 00:00:00

abstract：:Induction of apoptosis in human cancer cells by Sasa quelpaertensis Nakai has been considered to be a potential therapeutic target for cancer treatment; however, the underlying mechanisms of action are not well understood. The present study investigated the role of nitric oxide (NO•) and inhibitors of apoptosis (IAPs)...

journal_title：Oncology letters

authors： Kim MY

更新日期：2020-04-01 00:00:00

abstract：:The aim of the present study was to investigate the function of microRNA-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway was a direct target of microRNA-543. When compared with para...

journal_title：Oncology letters

authors： Xiu D,Wang D,Wang J,Ji F,Zhang W

更新日期：2019-02-01 00:00:00

abstract：:The mechanisms underlying the pathogenesis of papillary thyroid carcinoma (PTC) have not yet been elucidated. The aim of the current study was to identify potential pathogenic biomarkers in PTC by comprehensively analyzing gene expression and methylation profiles, and to increase the understanding of PTC pathogenesis....

journal_title：Oncology letters

authors： Wei S,Yun X,Ruan X,Wei X,Zheng X,Gao M

更新日期：2019-12-01 00:00:00

abstract：:Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...

journal_title：Oncology letters

authors： Liu B,Li LJ,Gong X,Zhang W,Zhang H,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:S100A11, a member of S100 calcium-binding protein family, is associated with the numerous processes of tumorigenesis and metastasis. In the present study, the role of S100A11, and its possible underlying mechanisms in cell proliferation, apoptosis and cell cycle distribution in human pancreatic cancer were explored. I...

journal_title：Oncology letters

authors： Xiao M,Li T,Ji Y,Jiang F,Ni W,Zhu J,Bao B,Lu C,Ni R

更新日期：2018-01-01 00:00:00

abstract：:Focal adhesion kinase (FAK) has long been considered to be a key regulator of growth factor receptor- and integrin-mediated signals, with pivotal roles in tumor cells through its kinase activity and scaffolding function. Increased FAK expression and activity has been observed in tumors of various origins and is often ...

journal_title：Oncology letters

authors： Li M,Hou F,Zhao J,Zhang T,Li D,Wu W,Liu X,Xu L

更新日期：2018-03-01 00:00:00

abstract：:Lung cancer negatively impacts global health, and the incidence of non-small cell lung cancer (NSCLC) is highest among all forms of lung cancer. Chemotherapy failure mainly occurs due to drug resistance; however, the associated molecular mechanism remains unclear. Casein kinase II (CK2), which plays important roles in...

journal_title：Oncology letters

authors： Jin C,Song P,Pang J

更新日期：2019-10-01 00:00:00

abstract：:Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR...

journal_title：Oncology letters

authors： Zhang X,Li H,Mao M,Wang X,Zheng J,Yang S

更新日期：2019-12-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for patients with advanced cancer. The aim of the present study was to investigate the prognostic value of somatic mutations in mismatch repair (MMR) genes in metastatic cancers after ICI treatment, as well as their assoc...

journal_title：Oncology letters

authors： Liu Y,Chen L,Zhang S,Shu Y,Qi Q,Zhu M,Peng Y,Ling Y

更新日期：2020-10-01 00:00:00

abstract：:Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of ...

journal_title：Oncology letters

authors： Futamura N,Urakawa H,Tsukushi S,Arai E,Kozawa E,Ishiguro N,Nishida Y

更新日期：2016-04-01 00:00:00

abstract：:The present study aimed to conduct a prognosis analysis of Taiwanese patients with metastatic gastrointestinal stromal tumors (GISTs), who are resistant to or were unable to tolerate imatinib or sunitinib, and were subsequently treated with regorafenib. The study considered the survival, potential prognostic factors a...

journal_title：Oncology letters

authors： Hu CH,Yeh CN,Chen JS,Tsai CY,Wang SY,Cheng CT,Yeh TS

更新日期：2020-09-01 00:00:00

abstract：:Few studies on cervical intraepithelial neoplasia (CIN) keratinocyte cultures are available due to the numerous technical and methodological problems associated with the in vitro cultivation of these cells. The present study investigated an applicable and effective method for the in vitro cultivation of high-grade CIN...

journal_title：Oncology letters

authors： Liu YZ,Wang TT,Zhang YZ

更新日期：2016-02-01 00:00:00

abstract：:Liver cancer, particularly hepatocellular carcinoma (HCC), is one of leading causes of cancer-related mortality worldwide. Upregulation of the evolutionary conserved Hippo signaling pathway has been observed in HCC patients, and Yes-associated protein 1 (YAP1) has been reported to play a key role in HCC tumorigenesis....

journal_title：Oncology letters

authors： Ruan T,He X,Yu J,Hang Z

更新日期：2016-04-01 00:00:00