Abstract:
:The aim of the present study was to investigate the function of microRNA-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway was a direct target of microRNA-543. When compared with paracarcinoma tissue, microRNA-543 expression in tissue samples from patients with liver cancer was identified to be decreased. Furthermore, overall survival of patients with high microRNA-543 expression was increased compared with patients with low microRNA-543 expression. Inhibition of microRNA-543 expression increased cell proliferation and decreased apoptosis of liver cancer cells. It also activated the protein expression of phosphorylated JAK2, phosphorylated STAT3, c-Myc and B-cell lymphoma 2 (Bcl-2) in liver cancer cells. However, activation of microRNA-543 expression in turn decreased cell proliferation and increased apoptosis of liver cancer cells. The results of the present study highlight the pivotal function of microRNA-543 as an inhibitor in liver cancer cell proliferation by observing JAK2/STAT3/c-Myc/Bcl-2 in liver cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Xiu D,Wang D,Wang J,Ji F,Zhang Wdoi
10.3892/ol.2018.9838subject
Has Abstractpub_date
2019-02-01 00:00:00pages
2451-2456issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-9838journal_volume
17pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::MicroRNAs (miRNAs/miRs) are identified to serve key functions in the progression of various tumors. miR-214 is aberrantly expressed in various types of cancer. In the present study, the function of miR-214 and its feasibility as a potential non-invasive biomarker for patients with prostate cancer (PCa) in a hyperplasi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9522
更新日期:2019-01-01 00:00:00
abstract::The aim of the present study was to identify a specific biological marker for the diagnosis of colorectal adenomas through the analysis of variations in serum protein profiling in colorectal adenoma patients. The study was conducted at the Renmin Hospital of Wuhan University (Wuhan, China) between September 2011 and M...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1304
更新日期:2013-06-01 00:00:00
abstract::Expression of claudin-6 (CLDN6) in the tissues of gastric cancer patients and its association with clinical pathology and prognosis were investigated. A retrospective analysis was performed on 213 gastric cancer patients diagnosed and surgically treated in the Central Hospital of Zibo from January 2010 to January 2013...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10129
更新日期:2019-05-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment remains a challenge. Effective control of cell survival and proliferation is critical in the prevention of oncogenesis and successful treatment of cancer. Long non-coding RNAs (lncRNAs) have emerged as primary regulators of carcinogene...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5841
更新日期:2017-05-01 00:00:00
abstract::Retroperitoneal primary mucinous adenocarcinoma (RPMA) is extremely rare and the histogenesis of this tumor remains unclear. There is no consensus on the appropriate treatment for RPMA. Surgical resection is standard for the treatment of RPMA, whereas the benefits of chemotherapy with regard to this tumor remain to be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.319
更新日期:2011-07-01 00:00:00
abstract::The CDw75 epitope is an α(2,6) sialylated antigen overexpressed in colorectal cancer (CRC), where its expression correlates with the progression of the disease. The CDw75 epitope is located mainly in N-glycoproteins, whose identity remains unknown. The aim of the present study was to identify proteins with the CDw75 e...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7336
更新日期:2018-01-01 00:00:00
abstract::Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11653
更新日期:2020-08-01 00:00:00
abstract::Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9195
更新日期:2018-10-01 00:00:00
abstract::The Mantle Cell Lymphoma International Prognostic Index (MIPI) combines four factors to differentiate low-, intermediate- and high-risk prognostic groups in advanced mantle cell lymphoma using data from patients treated in clinical trials. To evaluate its use in routine practice, we applied the simplified index retros...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000034
更新日期:2010-01-01 00:00:00
abstract::KRAS mutation is frequently identified in advanced colorectal carcinoma (CRC); however, its prognostic significance and the associated histological features have remained to be clarified. In the present study, the precise histological results and prognostic value of KRAS-mutated CRCs were investigated in patients from...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11606
更新日期:2020-07-01 00:00:00
abstract::The predominant characteristic of malignant glioma is the presence of invading tumor cells in the peritumoral zone. Distinguishing between tumor cells and normal cells in a peritumoral lesion is challenging. Therefore, the aim of the present study was to investigate the cell-cycle phase measurements of fixed paraffin-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4205
更新日期:2016-03-01 00:00:00
abstract::Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8863
更新日期:2018-08-01 00:00:00
abstract::Interleukin-8 (IL-8), an important inflammatory factor, is induced by Helicobacter pylori infection and is clearly associated with gastric cancer. IL-8 levels have been revealed to correlate significantly with the adhesion, migration and invasion of gastric cancer cells. However, whether IL-8 influences cell prolifera...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2531
更新日期:2014-12-01 00:00:00
abstract::We previously reported the case of a 56-year-old male who underwent surgical treatment for gastric hepatoid adenocarcinoma and splenic metastasis. The present study reports the case of the same patient who underwent successful ex vivo hepatectomy and partial liver autotransplantation. Computed tomography scans demonst...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3041
更新日期:2015-05-01 00:00:00
abstract::Adenocarcinoma is one of the most serious diseases that threaten human health. Numerous studies have investigated adenocarcinoma and have obtained a considerable amount of data regarding genes and microRNA (miRNA) in adenocarcinoma. However, studies have only focused on one or a small number of genes and miRNAs, and t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3676
更新日期:2015-11-01 00:00:00
abstract::Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6256
更新日期:2017-07-01 00:00:00
abstract::The aim of the present study was to perform a retrospective analysis to investigate the outcome and toxicity of radiation (RT) and chemoradiation (CRT) in elderly, inoperable patients >70 years old. Between 2003 and 2012, 1,024 patients with squamous cell carcinoma (SCC) of the esophagus were treated at the Department...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1694
更新日期:2014-01-01 00:00:00
abstract::The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11310
更新日期:2020-03-01 00:00:00
abstract::Laparoscopic partial nephrectomy has recently emerged as a minimally invasive treatment for small- to moderate-sized renal tumors. Renal artery pseudoaneurysms (RAPs) have been well-reported in patients with renal trauma or who have undergone percutaneous urological procedures, including biopsy, nephrostomy and percut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2045
更新日期:2014-06-01 00:00:00
abstract::Induction of apoptosis in human cancer cells by Sasa quelpaertensis Nakai has been considered to be a potential therapeutic target for cancer treatment; however, the underlying mechanisms of action are not well understood. The present study investigated the role of nitric oxide (NO•) and inhibitors of apoptosis (IAPs)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11379
更新日期:2020-04-01 00:00:00
abstract::Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS-TICs) were isolated and enriched from the osteosarcoma U2OS and MG-63 cell lines using sphere formation ass...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6132
更新日期:2017-07-01 00:00:00
abstract::The present study describes the case of a 48-year-old man who was diagnosed with lung adenocarcinoma with an epidermal growth factor receptor (EGFR) 21 L858R mutation. The patient received surgery and adjuvant chemotherapy. When multiple lung metastases appeared, icotinib was administered. Following resistance to icot...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8040
更新日期:2018-04-01 00:00:00
abstract::The aim of the present study was to evaluate the utility of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis of common renal tumors. Conventional magnetic resonance imaging and DWI were performed on 85 patients with renal lesions (54 renal carcinoma and 31 renal angiomyolipoma cases). The apparent ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3605
更新日期:2015-10-01 00:00:00
abstract::A 39-year-old female presented to The First Affiliated Hospital of Jishou University (Jishou, Hunan) with a fever of unknown origin and progressive abdominal distension. Physical examination revealed generalized lymphadenopathy, multiple non-tender cutaneous nodules, hepatomegaly, splenomegaly and abdominal edema. An ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3010
更新日期:2015-05-01 00:00:00
abstract::This study aimed to determine whether manipulation of the microRNA-200 (miR-200) family could influence colon adenocarcinoma cell behavior. The miR-200 family has a significant role in tumor suppression and functions as an oncogene. In vitro studies on gain and loss of function with small interfering RNA demonstrated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10753
更新日期:2019-10-01 00:00:00
abstract::Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. The aim of the present study is to analyze the incidence of HER2 gene amplification in selected tumors with adverse features...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5125
更新日期:2016-11-01 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1954
更新日期:2014-05-01 00:00:00
abstract::MicroRNA (miR)-29a has been associated with carcinogenesis in humans; however, its functional significance in esophageal squamous cell carcinoma (ESCC) is yet to be determined. In the present study, the expression of miR-29a was markedly downregulated in ESCC tissue and the ESCC TE-1 cell line, compared with normal es...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2678
更新日期:2015-01-01 00:00:00
abstract::Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painles...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2488
更新日期:2014-11-01 00:00:00
abstract::Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research. The increase is associated with UV irradiation-i...
journal_title:Oncology letters
pub_type: 杂志文章,收录出版
doi:10.3892/ol.2016.5093
更新日期:2016-11-01 00:00:00