Abstract:
:Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR)-122a was downregulated HCC and was inversely correlated with MANCR only in cancer tissues. MANCR overexpression resulted in downregulation of miR-122a, while miR-122a overexpression showed no obvious effects on MANCR expression. MANCR overexpression showed no significant effects on HCC cell proliferation but led to promoted cell migration and invasion. miR-122a overexpression led to inhibited migration and invasion of HCC cells and attenuated the effects of MANCR overexpression. Therefore, lncRNA MANCR may promote cancer cell proliferation in HCC by downregulating miR-122a.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhang X,Li H,Mao M,Wang X,Zheng J,Yang Sdoi
10.3892/ol.2019.10947subject
Has Abstractpub_date
2019-12-01 00:00:00pages
6237-6242issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-10947journal_volume
18pub_type
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