α-smooth muscle actin-positive fibroblasts correlate with poor survival in hepatocellular carcinoma.

abstract：:The integrality of low molecular weight protein (LMP)2/LMP7 function plays an important role in the processing of GC cell antigens. The purpose of the present hospital-based case-control study was to estimate the effect of polymorphisms in the LMP2 and LMP7 genes on the risk of GC. Polymerase chain reaction-restrictio...

journal_title：Oncology letters

authors： Ma X,Yang C,Tang R,Xu Z,Zhang Z,Wang Y,Zhang J,Yang LI

更新日期：2015-07-01 00:00:00

abstract：:The incidence of breast cancer is increasing throughout the world. Although significant progress has been made in diagnostic techniques and targeted therapies, the prognosis of breast cancer remains poor. Regulator of differentiation 1 (ROD1) may inhibit the development of several types of cancer. However, the role of...

journal_title：Oncology letters

authors： Zhou Y,Zou H,Wu E,Huang L,Yin R,Mei Y,Zhu X

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present study was to compare intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in irradiation of lung cancer. Plans of 14 patients were compared. The results demonstrated that in peripheral lung cancer, V5 (%) of the lung in partial-arc (PA)-VMAT was decreased comp...

journal_title：Oncology letters

authors： Li Y,Wang J,Tan L,Hui B,Ma X,Yan Y,Xue C,Shi X,Drokow EK,Ren J

更新日期：2018-03-01 00:00:00

abstract：:Previous studies have demonstrated a significant difference in clinical characteristics between patients with non-small cell lung cancer (NSCLC) harboring exon 19 deletion (19-del) and an exon point mutation (21-L858R) in EGFR. The present retrospective study aimed to investigate the differential prognosis in patients...

journal_title：Oncology letters

authors： Hong W,Wu Q,Zhang J,Zhou Y

更新日期：2019-10-01 00:00:00

abstract：:Scalp angiosarcoma is a rare, extremely aggressive cutaneous malignancy with poor patient prognosis. The present study reviewed the cases of 42 patients who presented scalp angiosarcoma and were treated at the Zhongshan Hospital of Fudan University between January 2002 and December 2013. The clinical characteristics, ...

journal_title：Oncology letters

authors： Zhang Y,Yan Y,Zhu M,Chen C,Lu N,Qi F,Liu J

更新日期：2019-11-01 00:00:00

abstract：:Extra-abdominal desmoid tumour is a rare type of tumour which is conventionally treated with wide local excision. However, wide local excision usually causes irreparable damage to the limbs. Nevertheless, few patients have been subjected to wide local excision and reconstructive surgery in a single procedure. A 52-yea...

journal_title：Oncology letters

authors： Cao C,Zou J,Wu C,Bao Z,Yang H

更新日期：2012-09-01 00:00:00

abstract：:Pancreatic cancer has a low survival rate globally. Anillin (ANLN) is involved in the pathogenesis of pancreatic cancer (PC). The present study used databases and reverse transcription-quantitative PCR to investigate the association between ANLN expression, clinical variables and the survival rate of patients with pan...

journal_title：Oncology letters

authors： Nie Y,Zhao Z,Chen M,Ma F,Fan Y,Kang Y,Kang B,Wang C

更新日期：2021-02-01 00:00:00

abstract：:Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the ubiquitin-conjugating E2 family in the ubiquitin-proteasome pathway, has been reported to be overexpressed in certain tumor types and to have an important role in the Fanconi anemia pathway. In the present study, the expression of UBE2T and its association with...

journal_title：Oncology letters

authors： Gong YQ,Peng D,Ning XH,Yang XY,Li XS,Zhou LQ,Guo YL

更新日期：2016-12-01 00:00:00

abstract：:Laparoscopic partial nephrectomy has recently emerged as a minimally invasive treatment for small- to moderate-sized renal tumors. Renal artery pseudoaneurysms (RAPs) have been well-reported in patients with renal trauma or who have undergone percutaneous urological procedures, including biopsy, nephrostomy and percut...

journal_title：Oncology letters

authors： Pan H,Xia D,Wang S,Wang Z,Zhong B,Zhou X,Peng Z

更新日期：2014-06-01 00:00:00

abstract：:Tanshinone IIA exhibits natural antioxidative and antineoplastic activity. However, to the best of our knowledge, the effects of tanshinone IIA on human nasopharyngeal carcinoma cells remains unknown. The present study aimed to investigate whether tanshinone IIA inhibits proliferation and induces apoptosis of human na...

journal_title：Oncology letters

authors： Liu B,Liu L,Zang A,Song Z,Yang H,Wang Z,Shang Y,Ma T,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:The traditional Chinese medicine Jinfukang (JFK) has been shown as a valuable drug to treat non-small cell lung cancer (NSCLC). Previously, it was reported that JFK-induced epigenetic alteration is involved in anti-lung cancer activity. In the present study, the effect of JFK on lung cancer cell lines was examined wit...

journal_title：Oncology letters

authors： Lu J,Chen J,Kang Y,Wu J,Shi H,Fu Y,Jiao L,Dong C,Li X,Jin Y,Zhao W,Xu L,Zhao X

更新日期：2018-10-01 00:00:00

abstract：:Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ-H2AX is induced by DNA double-st...

journal_title：Oncology letters

authors： Kawashima S,Kawaguchi N,Taniguchi K,Tashiro K,Komura K,Tanaka T,Inomata Y,Imai Y,Tanaka R,Yamamoto M,Inoue Y,Lee SW,Kawai M,Tanaka K,Okuda J,Uchiyama K

更新日期：2020-09-01 00:00:00

abstract：:Intracranial chondrosarcoma is a rare malignant cartilage-forming tumor, with only a small number of cases in the posterior cranial fossa reported previously. The present study reports the case of a 40-year-old male patient who was admitted to Tianjin Huanhu Hospital with a progressive headache and dizziness that had ...

journal_title：Oncology letters

authors： Chi J,Zhang M,Kang J

更新日期：2016-11-01 00:00:00

abstract：:There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcriptio...

journal_title：Oncology letters

authors： Jiang X,Wang Z

更新日期：2018-09-01 00:00:00

abstract：:Virosecurinine, a primary alkaloid from Securinega suffruticosa plant is known as a potent differentiation-inducing agent in acute leukemia cells. The present study aimed to investigate the effects and underlying mechanisms of virosecurinine on human leukemia THP-1 cells in vitro. The effects of virosecurinine on cell...

journal_title：Oncology letters

authors： Zhang G,Gao X,Zeng H,Li Y,Guo X

更新日期：2018-01-01 00:00:00

abstract：:Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...

journal_title：Oncology letters

authors： Zhao J,Wang M,Li Z,Chen J,Yin Z,Chang J,Gao D,Wang S

更新日期：2014-03-01 00:00:00

abstract：:Malignant mesothelioma in the mediastinum is rare and the majority of known cases have been reported as 'localized mesothelioma'. The present study reports a case of an upper mediastinal tumor, which was diagnosed through thoracoscopic surgery and surgical biopsies of the mass. A computed tomography scan revealed a gi...

journal_title：Oncology letters

authors： Zhang S,Song P,Zhang B

更新日期：2013-07-01 00:00:00

abstract：:The Notch signaling pathway has been shown to be involved in the progression of chronic myeloid leukemia (CML). The aim of this study was to investigate the effects of exogenous Notch2 overexpression on cell proliferation and possible mechanisms in the human CML cell line K562. When exogenous intracellular fragment of...

journal_title：Oncology letters

authors： Yang Z,Yang C,Zhang S,Li Y,Chen J

更新日期：2013-04-01 00:00:00

abstract：:We previously reported the case of a 56-year-old male who underwent surgical treatment for gastric hepatoid adenocarcinoma and splenic metastasis. The present study reports the case of the same patient who underwent successful ex vivo hepatectomy and partial liver autotransplantation. Computed tomography scans demonst...

journal_title：Oncology letters

authors： Wang FQ,Lu Q,Yan J,Peng YY,Xie CR,Su YJ,Zhou JY,Wang BL,Zhao WX,Wang XM,Bie P,Yin ZY

更新日期：2015-05-01 00:00:00

abstract：:Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribut...

journal_title：Oncology letters

authors： Li D,Wang X,Lu S,Wang P,Wang X,Yin W,Zhu W,Li S

更新日期：2020-08-01 00:00:00

abstract：:Several previous studies have shown that mutations in B-Raf proto-oncogene (BRAF) and telomerase reverse transcriptase (TERT) can be used for the diagnosis and prognosis of papillary thyroid carcinoma (PTC). However, whether mutations in BRAF and the TERT promoter may improve the accurate identification and risk strat...

journal_title：Oncology letters

authors： Liu R,Li Y,Chen W,Cong J,Zhang Z,Ma L,Chu L,Xiao H,Zhang Y,Liu Y,Xu Y,Yu Q,Yang X,Sun C

更新日期：2020-10-01 00:00:00

abstract：:Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. The aim of the present study is to analyze the incidence of HER2 gene amplification in selected tumors with adverse features...

journal_title：Oncology letters

authors： Petroni S,Caldarola L,Scamarcio R,Giotta F,Latorre A,Mangia A,Simone G

更新日期：2016-11-01 00:00:00

abstract：:The present study aimed to assess the B rapidly accelerated fibrosarcoma (BRAFV600E) status in plasma from Chinese patients with melanoma, and evaluated its prognostic value following treatment with BRAF inhibitors. Mutation-specific 3D digital polymerase chain reaction (dPCR) was used to quantify BRAFV600E in circula...

journal_title：Oncology letters

authors： Tang H,Kong Y,Si L,Cui C,Sheng X,Chi Z,Dai J,Yu S,Ma M,Wu X,Yu J,Xu T,Yu H,Yan J,Guo J

更新日期：2018-02-01 00:00:00

abstract：:The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor surv...

journal_title：Oncology letters

authors： Yerushalmi R,Raiter A,Nalbandyan K,Hardy B

更新日期：2015-10-01 00:00:00

abstract：:FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effe...

journal_title：Oncology letters

authors： Jin K,Lan H,Cao F,Xu Z,Han N,Li G,He K,Teng L

更新日期：2012-05-01 00:00:00

abstract：:The autosomal dominant hereditary disorder von Hippel-Lindau (VHL) disease is caused by a germline mutation in the VHL gene. The symptoms of VHL include hemangioblastoma of the central nervous system, retinal angiomas, visceral tumors and multiple visceral cysts. However, advanced renal cell carcinoma (RCC) occurs in ...

journal_title：Oncology letters

authors： Zhang L,Xu B,Wang Y,Liu C,Lu K,Huang Y,Liu N,Zhang X,Chen S,Chen M

更新日期：2015-08-01 00:00:00

abstract：:MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...

journal_title：Oncology letters

authors： Hou L,Luo P,Ma Y,Jia C,Yu F,Lv Z,Wu C,Fu D

更新日期：2017-10-01 00:00:00

abstract：:Breast tissue is very sensitive to ionizing radiation due to the presence of reproductive hormones, including estrogen. In the present pilot study, the efficiency of mammography X-rays to induce DNA double strand breaks (DSB) in mammary epithelial cells was investigated. For this, freshly resected healthy breast tissu...

journal_title：Oncology letters

authors： Depuydt J,Viaene T,Blondeel P,Roche N,Van den Broecke R,Thierens H,Vral A

更新日期：2018-09-01 00:00:00

abstract：:Epithelial ovarian cancer has the highest mortality of all gynecological cancers, and its progression is often without symptoms. Clinical outcome and survival may be improved if the disease is identified in the early stages. The objective of the study was to evaluate the utility of the serum biomarkers human epididymi...

journal_title：Oncology letters

authors： Fritz-Rdzanek A,Grzybowski W,Beta J,Durczyński A,Jakimiuk A

更新日期：2012-09-01 00:00:00

abstract：:To define the correlation between BCR promoter DNA methylation and response to imatinib in chronic myeloid leukemia (CML), we investigated BCR promoter DNA methylation in three groups of subjects. The first group included chronic phase patients enrolled in an imatinib dose escalation trial. In the trial, patients who ...

journal_title：Oncology letters

authors： Koh Y,Kim DY,Park SH,Byun HM,Kim I,Yoon SS,Kim BK,Park E,Yang AS,Park S

更新日期：2011-01-01 00:00:00