Abstract:
:Epithelial ovarian cancer has the highest mortality of all gynecological cancers, and its progression is often without symptoms. Clinical outcome and survival may be improved if the disease is identified in the early stages. The objective of the study was to evaluate the utility of the serum biomarkers human epididymis protein 4 (HE4), soluble mesothelin-related protein (SMRP) and CA125 in the detection of ovarian cancer. In this retrospective study, the serum concentrations of CA125, HE4 protein and SMRP were measured in a cohort of 70 patients with epithelial ovarian cancer (EOC) compared with 78 healthy controls. Median serum levels of CA125 for ovarian cancer cases were 503.55±560.7 U/ml vs. 9.28±14.47 U/ml in the control group (p<0.001); for SMRP 5.13±7.64 nM vs. 1.02±0.89 nM (p<0.01); and for HE4 597.95±934.59 pM vs. 56.75±43.79 pM (p<0.001), respectively. Positive correlations between the clinical stage of EOC and CA125, HE4 and SMRP serum concentrations were found [(R=0.83; p<0.001); (R=0.64; p<0.001); (R=0.45; p<0.001), respectively]. Data analysis for the whole study group also revealed a significant correlation between plasma concentrations of CA125 and HE4 (R=0.45; p<0.001), between CA125 and SMRP (R=0.38; p<0.001) as well as HE4 and SMRP (R=0.51; p<0.001). Similar significant correlations between serum biomarker concentrations were also found in the ovarian cancer group [CA125 and HE4 (R=0.31; p<0.01); CA125 and SMRP (R=0.25; p<0.05); HE4 and SMRP (R=0.44, p<0.001), respectively]. A significant correlation was observed between the serous histological type of EOC and serum concentration of HE4 in the study group compared with other non-serous types of ovarian cancer (p<0.01). In conclusion, measuring CA125 in combination with new biomarkers such as SMRP and HE4 may improve the accuracy of ovarian cancer diagnosis, particularly in early detection of the disease.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Fritz-Rdzanek A,Grzybowski W,Beta J,Durczyński A,Jakimiuk Adoi
10.3892/ol.2012.757subject
Has Abstractpub_date
2012-09-01 00:00:00pages
385-389issue
3eissn
1792-1074issn
1792-1082pii
ol-04-03-0385journal_volume
4pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Metastatic spread of gastric carcinoma to the breast is rare. In previous decades, reports on this subject were minimal and primarily limited to case reports. At present, little is known on the clinicopathological features and prognosis of this condition, and breast metastasis remains a challenging clinical problem. A...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9383
更新日期:2018-11-01 00:00:00
abstract::Glioblastomas are the most common primary and malignant brain tumors. The standard therapy includes surgery and radiotherapy plus chemotherapy, with additional bevacizumab to block the angiogenesis in tumors. However, the ever-growing tolerance of glioblastomas to chemotherapeutic drugs impairs the clinical outputs of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7446
更新日期:2018-02-01 00:00:00
abstract::Studies conducted in our lab have indicated that thalidomide cytotoxicity in the KG-1a human acute myelogenous leukemia (AML) cell line was enhanced by combining it with arsenic trioxide. The current investigation was conducted in order to evaluate the effect of thalidomide either alone or in combination with arsenic ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000116
更新日期:2010-07-01 00:00:00
abstract::Heterogeneous radiological responses (HRRs) among tumor lesions are usually observed following chemotherapy or radiation treatment in cancer patients. When HRR is observed after chemotherapy or radiation treatment, a change in anticancer treatment is recommended due to the clinically high suspicion of resistance in th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3709
更新日期:2015-11-01 00:00:00
abstract::Activating transcription factor 2 (ATF2) is a member of the cAMP response element binding protein family that heterodimerizes and activates other transcription factors involved in stress and DNA damage responses, growth, differentiation and apoptosis. ATF2 has been investigated as a potential carcinogenic biomarker in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3922
更新日期:2016-01-01 00:00:00
abstract::5-fluorouracil (5-FU) is one of the standard chemoradiotherapy regimens for hepatocellular carcinoma (HCC) treatment. B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) has been demonstrated to regulate proliferation. Additionally, Bmi-1 overexpression has been identified in HCC cell lines and corr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.805
更新日期:2012-10-01 00:00:00
abstract::Docking protein 2 (Dok2) and Ras p21 protein activator 1 (RASA1) are tumor suppressors which have been identified in numerous solid tumors; however, the association between their expression in breast cancer and patient prognosis remains unclear. A total of 285 consecutive patients diagnosed histopathologically with br...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6844
更新日期:2017-11-01 00:00:00
abstract::The ubiquitin-proteasome pathway is an important protein degradation regulatory system in cells. This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. Ovarian tumor-associated proteases domain-containing...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10883
更新日期:2019-11-01 00:00:00
abstract::The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4764
更新日期:2016-08-01 00:00:00
abstract::The present study aimed to explore the clinical efficacy and safety of hydromorphone combined with sufentanil in patient-controlled intravenous analgesia (PCIA) for patients with hepatocellular carcinoma (HCC) and its effect on serum immune factors in serum. Data from 385 patients with HCC, admitted to the Hunan Provi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12159
更新日期:2020-12-01 00:00:00
abstract::The aim of the present study was to identify a specific biological marker for the diagnosis of colorectal adenomas through the analysis of variations in serum protein profiling in colorectal adenoma patients. The study was conducted at the Renmin Hospital of Wuhan University (Wuhan, China) between September 2011 and M...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1304
更新日期:2013-06-01 00:00:00
abstract::The present study aimed to identify the regulatory mechanisms associated with the metastasis of prostate cancer (PC). The microRNA (miRNA/miR) microarray dataset GSE21036 and gene transcript dataset GSE21034 were downloaded from the Gene Expression Omnibus database. Following pre-processing, differentially expressed m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6969
更新日期:2017-11-01 00:00:00
abstract::A 77-year-old female, with proptosis, reduced eye motility and diplopia which had developed over two to three months and a 69-year-old female with proptosis, oedema of the eyelid, reduced motility and ptosis, which had developed over three weeks, are presented in the present study. Computed tomography scans revealed i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3282
更新日期:2015-08-01 00:00:00
abstract::MicroRNAs (miRs) can function as tumor suppressors or oncogenes in different types of human malignancy, and may provide an effective therapy for cancer. The expression and functions of miR-592 have previously been studied in relation to cancer. However, the expression and potential functions of miR-592 in hepatocellul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5902
更新日期:2017-05-01 00:00:00
abstract::Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold atmospheric plasma (CAP) has been regarded as a promising anti-oncogenic therapy. Previous experimental studies have demonstrated that CAP treatment results in significant growth inhibition of human sarcoma and is able to induce a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11115
更新日期:2020-01-01 00:00:00
abstract::The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distingu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2880
更新日期:2015-03-01 00:00:00
abstract::Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon cancer-related complication characterized by intimal proliferation in pulmonary small arteries and arterioles with or without tumor emboli. In the majority of cases, the causative lesion is gastric poorly differentiated adenocarcinoma. In the present stu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.270
更新日期:2011-05-01 00:00:00
abstract::The current case-control study was conducted to assess the value of activated fibroblasts with high α-smooth muscle actin (α-SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Cent...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1720
更新日期:2014-02-01 00:00:00
abstract::Studies investigating the effects of microRNA (miR)-155 on the behavior of tumor cells have concentrated primarily on proliferation and apoptosis. The aim of the present study was to investigate the effect of miR-155 inhibitor on the metastatic and invasive ability of gastric carcinoma cells and whether this effect is...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9152
更新日期:2018-10-01 00:00:00
abstract::Cisplatin-resistant ovarian cancer occurs in patients with ovarian cancer treated with cisplatin-based chemotherapy, which results in tumor progression during treatment, or recurrence of the tumor within 6 months of the treatment. It is vital that a novel biomarker for diagnosis, or an efficient therapeutic target of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8433
更新日期:2018-06-01 00:00:00
abstract::Gliomas are the most common type of primary brain tumor in adults, where more than half of the cases are malignant, and the prognosis is poor. The early viral 1A (E1A) protein has been widely recognized to be essential for adenoviral replication and production of progeny virions in human cells, a process that is regul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7684
更新日期:2018-03-01 00:00:00
abstract::Expression of claudin-6 (CLDN6) in the tissues of gastric cancer patients and its association with clinical pathology and prognosis were investigated. A retrospective analysis was performed on 213 gastric cancer patients diagnosed and surgically treated in the Central Hospital of Zibo from January 2010 to January 2013...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10129
更新日期:2019-05-01 00:00:00
abstract::Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic mar...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10982
更新日期:2019-12-01 00:00:00
abstract::The aim of the present study was to investigate the immunohistochemical expression of cluster of differentiation (CD) 34 and vascular endothelial growth factor (VEGF) in breast cancer tissue, and their prognostic significance. High CD34 expression levels (microvessel density, >15/HPF) were identified in 27.3% (12/44) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3348
更新日期:2015-08-01 00:00:00
abstract::Substantial evidence implicates that low-abundance cancer stem cells (CSCs) are responsible for tumor metastasis and recurrence in hepatocellular carcinoma (HCC). Side population (SP) cells possess typical CSCs-like features, and are frequently considered as a special subpopulation in which CSCs are enriched and in st...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4343
更新日期:2016-05-01 00:00:00
abstract::Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1204
更新日期:2013-05-01 00:00:00
abstract::Extraosseous osteosarcoma originating from paratesticular soft tissue is an extremely rare type of malignant tumor. With the exception of the present study, only one other case of osteosarcoma originating from paratesticular soft tissue has previously been reported. A 52-year-old man presented with a painless scrotal ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.518
更新日期:2012-03-01 00:00:00
abstract::Secretory breast carcinoma is a very rare and distinct subtype of breast cancer, characterized by the presence of intracellular and extracellular secretory material. Secretory breast carcinoma has a good clinical outcome and systemic involvement is rare. The majority of studies of this tumor have been case reports or ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2213
更新日期:2014-08-01 00:00:00
abstract::Damnacanthal, an anthraquinone compound, is isolated from the roots of Morinda citrifolia L. (noni), which has been used for traditional therapy in several chronic diseases, including cancer. Although noni has long been consumed in Asian and Polynesian countries, the molecular mechanisms by which it exerts several ben...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1898
更新日期:2014-05-01 00:00:00
abstract::The aim of the present study was to investigate the optimal strategy and dosimetric measurement of thoracic radiotherapy based on three-dimensional (3D) modeling of mediastinal lymph nodes (MLNs). A 3D model of MLNs was constructed from a Chinese Visible Human female dataset. Image registration and fusion between reco...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8084
更新日期:2018-04-01 00:00:00