Abstract:
:Heterogeneous radiological responses (HRRs) among tumor lesions are usually observed following chemotherapy or radiation treatment in cancer patients. When HRR is observed after chemotherapy or radiation treatment, a change in anticancer treatment is recommended due to the clinically high suspicion of resistance in the majority of cases. The present study reports the case report of a patient with limited-stage small cell lung cancer, diagnosed by bronchoscopy, who received concurrent chemoradiation therapy. Upon response evaluation, the majority of lesions irradiated had nearly completely disappeared following treatment, but one lesion had apparently increased in size. For histological confirmation, a percutaneous needle biopsy for the lesion was performed, however, non-specific necrosis was found and the results were inconclusive for the differentiation of other causes from tumor necrosis. Several acid-fast bacilli were identified on Ziehl-Neelsen staining for the differential diagnosis. This case suggests that a non-tumor diagnosis should be considered when HRR presents after treatment that is expected to result in a higher response rate, particularly in tuberculosis endemic areas.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Ryu JS,Kim L,Kim WC,Kim JS,Memon A,Yi BR,Kim HJdoi
10.3892/ol.2015.3709subject
Has Abstractpub_date
2015-11-01 00:00:00pages
2953-2956issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-3709journal_volume
10pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory exa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3051
更新日期:2015-05-01 00:00:00
abstract::Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in numerous types of cancer, and is implicated in various cellular processes associated with cancer progression. However, the underlying molecular mechanisms by which MALAT1 regulates metastasis remain unclear. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11914
更新日期:2020-10-01 00:00:00
abstract::The present study aims to quantitatively measure adiposity-related image features and to test the feasibility of applying multivariate statistical data analysis-based prediction models to generate a novel clinical marker and predict the benefit of epithelial ovarian cancer (EOC) patients with and without maintenance b...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4648
更新日期:2016-07-01 00:00:00
abstract::Lung cancer is a major cause of death worldwide, and non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The aim of this study was to investigate whether miR-96 mediated the invasion and metastasis of NSCLC by targeting glypican-3 (GPC3). Reverse transcription-quantitative PCR (RT-qPCR) was empl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8507
更新日期:2018-06-01 00:00:00
abstract::In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2387
更新日期:2014-10-01 00:00:00
abstract::The Klotho (KL) gene was first identified as a potent aging suppressor. The KL family currently comprises of three proteins: α-Klotho (KLA), β-Klotho (KLB), and γ-Klotho (KLG). Many studies have shown that KLA and KLB participate in tumor progression or suppression, depending on the type of cancer; however, the relati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11308
更新日期:2020-03-01 00:00:00
abstract::Glucagonoma is an extremely rare pancreatic α-islet cell tumor and is often accompanied by certain clinical symptoms including necrotizing migratory erythema (NME), diabetes, weight loss and anemia. The objectives of the current review were to discern the clinical features, diagnosis, treatment and prognosis of glucag...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7703
更新日期:2018-03-01 00:00:00
abstract::The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1608
更新日期:2013-12-01 00:00:00
abstract::Platinum-compound chemotherapy is known to have ototoxic side-effects. However, there is a paucity of literature examining hearing function prospectively and longitudinally in cohorts containing paediatric and adult patients treated within the same cisplatin- or carboplatin-containing treatment trial protocols. In Ger...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.997
更新日期:2013-01-01 00:00:00
abstract::Imiquimod is an imidazoquinoline immune response modifier that is used in antiviral and antiallergic creams. Combination therapy using transcutaneous imiquimod and oral sorafenib was previously demonstrated to reduce the tumor burden of renal cell carcinoma growing cutaneously in a mouse model. In the present study, a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6235
更新日期:2017-07-01 00:00:00
abstract::This study aims to comparatively analyze the impact of laparoscopic myomectomy (LM) and transcervical resection of myoma (TCRM) on ovarian function, immune function and quality of sexual life of patients with hysteromyoma. Two hundred and forty patients with hysteromyoma admitted into the Second Affiliated Hospital of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7631
更新日期:2018-03-01 00:00:00
abstract::It is crucial to classify cervical lesions into high-grade squamous intraepithelial lesions (HSILs) and low-grade SILs (LSILs), as LSILs are conservatively treated by observation, based on an expectation of natural regression, whereas HSILs usually require electrosurgical excision. In the present study, peripheral blo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11779
更新日期:2020-09-01 00:00:00
abstract::Ulcerative colitis (UC) is thought to be associated with precancerous lesions that can ultimately lead to colon cancer. Therefore, diagnostic markers for colorectal dysplasia and cancer are urgently needed for patients with UC. Stathmin 1 (STMN1) is a novel cancer biomarker that is also a novel target for treatment in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10814
更新日期:2019-11-01 00:00:00
abstract::Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and as a potential target for cancer therapy. In this study, F§FJ-5, a characterized naphthoquinone modifier of mollugin, was synthesized in order to investigate its anticancer activity and the potential mechanisms. It was observed...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5522
更新日期:2017-02-01 00:00:00
abstract::Connexins (Cxs), a conserved family of trans-membrane proteins, function in the organization of cell-cell communicatin via gap junctions in multicellular organisms. However, the role of Cxs in acute myeloid leukemia (AML) is poorly understood. In this study, we investigated the relationship between cell proliferation ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.884
更新日期:2012-11-01 00:00:00
abstract::MicroRNAs (miRs) are an emerging class of non-coding, endogenous and small RNA molecules that serve important functions in tumorigenesis and development. The present study investigated the expression, functions and molecular mechanism underlying miR-205 in hepatocellular carcinoma. miR-205 was downregulated in hepatoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8933
更新日期:2018-08-01 00:00:00
abstract::Aberrant expression of Ras homolog enriched in brain (RHEB) has been observed in a variety of cancer tissues and is closely associated with clinicopathological features. However, the expression profile of RHEB in patients with hepatocellular carcinoma (HCC) and its clinical signature with underlying mechanisms have no...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7759
更新日期:2018-03-01 00:00:00
abstract::Interleukin (IL)-37, a new IL-1 family member, has received increasing attention in recent years. In the past decade, it has been determined that IL-37 is expressed in various normal cells and tissues and is regulated by inflammatory stimuli and pro-cytokines via different signal transduction pathways. Recently, it ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7982
更新日期:2018-04-01 00:00:00
abstract::The current study presents the case of a 68-year-old female patient who received biological intensity-modulated radiotherapy (BIMRT) and neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer. The International Federation of Gynecology and Obstetrics disease stage was IIIc. In addition, the pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2820
更新日期:2015-03-01 00:00:00
abstract::Small cell lung cancer (SCLC) is a type of lung cancer characterized by a rapid disease progression and poor prognosis. Its diagnosis is often accompanied by distant metastasis. A literature review revealed that metastases to the stomach from breast, lung and esophageal cancer are frequently reported. While SCLC is a ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10484
更新日期:2019-08-01 00:00:00
abstract::Evaluation of carcinogenic substances from the environment is a challenge for scientists. Recently, a novel approach based on 10 key characteristics of human carcinogens classified by the International Agency for Research on Cancer (IARC) has emerged. Carcinogenesis depends on different mechanisms and factors, includi...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11566
更新日期:2020-07-01 00:00:00
abstract::Small cell carcinoma of the rectum is extremely rare. The present study aimed to improve the recognition of computed tomography (CT) and magnetic resonance imaging (MRI) features observed in patients with small cell carcinoma of the rectum. A total of 4 cases of patients with histologically confirmed small cell carcin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4136
更新日期:2016-03-01 00:00:00
abstract::Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and its expression in chronic hepatitis B, liver cirrhosis and liver cancer were investigated to evaluated the significance of APOBEC3G. Fifty-eight patients with chronic hepatitis B were selected, including 20 cases of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11257
更新日期:2020-03-01 00:00:00
abstract::The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5650
更新日期:2017-03-01 00:00:00
abstract::Breast cancer has a major impact on the health of women worldwide. In the Kingdom of Saudi Arabia (KSA), breast cancer incidence is on the increase and is characterized by early onset and aggressiveness. Owing to the importance of the TP53 gene in breast carcinogenesis, we analyzed the possible link between TP53 singl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.581
更新日期:2012-04-01 00:00:00
abstract::Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, che...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6685
更新日期:2017-10-01 00:00:00
abstract::Induction of apoptosis in human cancer cells by Sasa quelpaertensis Nakai has been considered to be a potential therapeutic target for cancer treatment; however, the underlying mechanisms of action are not well understood. The present study investigated the role of nitric oxide (NO•) and inhibitors of apoptosis (IAPs)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11379
更新日期:2020-04-01 00:00:00
abstract::Primary smooth muscle tumors of the thyroid gland are extremely rare neoplasms. Due to their rarity, clinical case studies concerning management are lacking. According to a literature review, only 19 cases of primary thyroid leiomyosarcomas (TLs) have been reported. In the majority of patients, the prognosis is poor s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1853
更新日期:2014-04-01 00:00:00
abstract::Andrographolide (Andro), a natural compound isolated from Andrographis paniculata, has been demonstrated to have anticancer efficacy in several types of tumors. In the present study, the anticancer effects and mechanism of Andro in human malignant melanoma were investigated. Cell viability analysis was performed using...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7941
更新日期:2018-04-01 00:00:00
abstract::The present study aimed to identify the underlying molecular mechanisms associated with spinal metastases. Gene expression profiles in cancellous bone samples from the spines of five patients with spinal metastases, with different primary cancers, and three normal control patients were measured using microarray analys...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7267
更新日期:2018-01-01 00:00:00