MicroRNA-205 is downregulated in hepatocellular carcinoma and inhibits cell growth and metastasis via directly targeting vascular endothelial growth factor A.

abstract：:Sirtuin 3 (Sirt3) is an important member of the sirtuin protein family. It is a deacetylase that was previously reported to modulate the level of reactive oxygen species (ROS) production and limit the extent of oxidative damage in cellular components. As an important member of the class III type of histone deacetylase...

journal_title：Oncology letters

authors： Shi Y,He R,Yang Y,He Y,Zhan L,Wei B

更新日期：2020-11-01 00:00:00

abstract：:The present study was performed to quantify tumor neo-vessels, macrophages and fibroblasts in the tumor microenvironment of hepatocellular carcinoma (HCC) and explore the prognostic factors of HCC. The distribution of tumor neo-vessels, macrophages and fibroblasts was quantified by immunohistochemistry and inverted mi...

journal_title：Oncology letters

authors： Fang M,Yuan J,Chen M,Sun Z,Liu L,Cheng G,Ying H,Yang S,Chen M

更新日期：2018-04-01 00:00:00

abstract：:Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 ...

journal_title：Oncology letters

authors： Yuan H,Xin S,Huang Y,Bao Y,Jiang H,Zhou L,Ren X,Li L,Wang Q,Zhang J

更新日期：2017-09-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical process in the promotion of epithelial tumor progression and metastasis. The present study aimed to investigate the role of Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) in transforming growth factor (TGF)-β1 induced EMT. EMT occurred i...

journal_title：Oncology letters

authors： He X,Qian Y,Cai H,Yang S,Cai J,Wang Z

更新日期：2015-08-01 00:00:00

abstract：:Terrein is a bioactive fungal metabolite isolated from Aspergillus terreus. Besides being a melanogenesis inhibitor, previous studies have revealed that terrein has antiproliferative effects on a number of types of cancer tumors. In the present study, the inhibitory effect of terrein on esophageal cancer was evaluated...

journal_title：Oncology letters

authors： Wu Y,Zhu Y,Li S,Zeng M,Chu J,Hu P,Li J,Guo Q,Lv XB,Huang G

更新日期：2017-04-01 00:00:00

abstract：:The present study investigated the correlations of the Tspan-1 gene expression with the clinical characteristics and survival prognoses of patients with advanced gastric cancer. A total of 150 patients with advanced gastric cancer were enrolled in the present study, of whom 84 were at stage II and 66 were at stage III...

journal_title：Oncology letters

authors： Cai Y,Zheng M,Zhao Z,Huang H,Fu W,Xu X

更新日期：2017-09-01 00:00:00

abstract：:Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expr...

journal_title：Oncology letters

authors： Schcolnik-Cabrera A,Dominguez-Gómez G,Chávez-Blanco A,Ramírez-Yautentzi M,Morales-Bárcenas R,Chávez-Díaz J,Taja-Chayeb L,Dueáas-González A

更新日期：2019-12-01 00:00:00

abstract：:The aim of the present study was to investigate the long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA regulatory network in gastric cancer (GC) using bioinformatics analysis. Two mRNA gene expression profiles, GSE79973 and GSE54129, and two miRNA expression profiles, GSE93415 and GSE78091, were downloaded from the Ge...

journal_title：Oncology letters

authors： Ma XY,Ma Y,Zhou H,Zhang HJ,Sun MJ

更新日期：2019-12-01 00:00:00

abstract：:K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...

journal_title：Oncology letters

authors： Peng N,Zhao X

更新日期：2014-08-01 00:00:00

abstract：:The major aim of the present study was to develop an integrin receptor-targeted liposomal paclitaxel (PTX) to enhance the targeting specificity and therapeutic effect of PTX on hepatocellular carcinoma (HCC) cells. The specific Arg-Gly-Asp (RGD) ligand was conjugated to 1,2-distearoylphosphatidylethanolamine-polyethyl...

journal_title：Oncology letters

authors： Chen L,Liu Y,Wang W,Liu K

更新日期：2015-07-01 00:00:00

abstract：:Sigma-1 receptor (sigma-1R), a 25-kDa integral membrane protein, is expressed at a high density in various tumor cell lines and its ligands mediate tumor cell proliferation. However, the effect of this receptor on proliferation and the associated intracellular molecules in tumors remains unclear. The present study aim...

journal_title：Oncology letters

authors： Wu Y,Bai X,Li X,Zhu C,Wu ZP

更新日期：2018-11-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) show great promise as novel cancer biomarkers. Several studies have revealed an association between abnormal miRNA expression and the risk of various cancer types. However, the diagnostic accuracy and reliability of miRNAs remains unclear. The present meta-analysis was performed to summarize th...

journal_title：Oncology letters

authors： Liu B,Liu Y,Luo X,Pan Y,Yang L,Li F,Gao R,Chen W,He J

更新日期：2018-11-01 00:00:00

abstract：:Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrupted and cell cycle ...

journal_title：Oncology letters

authors： Nakamura Y,Ishigaki Y

更新日期：2014-12-01 00:00:00

abstract：:Zinc finger E-box binding homeobox 1 (ZEB1) has been shown to promote invasion and metastasis in several types of human cancer and to have a prognostic role in certain cancers. However, the clinical significance of ZEB1 in colorectal cancer (CRC) has not been sufficiently investigated. This study aimed to address this...

journal_title：Oncology letters

authors： Zhang GJ,Zhou T,Tian HP,Liu ZL,Xia SS

更新日期：2013-02-01 00:00:00

abstract：:Esophageal cancer staging is important for the treatment of esophageal cancer. Endoscopic ultrasonography (EUS) is a common diagnostic tool for esophageal cancer prior to surgery. However, EUS is unable to accurately discriminate the N-staging of lymph nodes. In order to distinguish an optimized standard for malignant...

journal_title：Oncology letters

authors： Zhang Y,He S,Dou L,Liu Y,Ke Y,Yu X,Wang Z,Wang G

更新日期：2019-01-01 00:00:00

abstract：:Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, the suitability and optimal settings of ICG fluorescence imaging for SN biopsy in early gastric cancer were determined. Patients wi...

journal_title：Oncology letters

authors： Kinami S,Oonishi T,Fujita J,Tomita Y,Funaki H,Fujita H,Nakano Y,Ueda N,Kosaka T

更新日期：2016-06-01 00:00:00

abstract：:The present study aimed to retrospectively review the contribution of 18F-fluorodeoxygluose-positron emission tomography/computed tomography (18F-FDG PET/CT) in the assessment of biochemical recurrence in patients with a diagnosis of local-stage prostate cancer (PCa) who underwent radical prostatectomy (RP) or receive...

journal_title：Oncology letters

authors： Öztürk H,Karapolat I

更新日期：2016-01-01 00:00:00

abstract：:Ductal adenocarcinoma of the prostate (DAP) is a rare variant of prostate cancer, and has poorly-identified clinical characteristics. Few cases have been previously reported in Chinese males and DAP is more commonly reported in Caucasian males over 70-years of age. In the present study, a 55-year-old Chinese male pati...

journal_title：Oncology letters

authors： Ji C,Zhou M,Gan W,Zheng J,Yan X,Guo H

更新日期：2016-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 base pairs that regulate the expression of genes by targeting messenger RNA with complementarity with the miRNA base sequence. Regulation of gene expression by miRNAs is crucial in cellular development and differentiation, and recent studies suggest a re...

journal_title：Oncology letters

authors： Yanokura M,Banno K,Kobayashi Y,Kisu I,Ueki A,Ono A,Masuda K,Nomura H,Hirasawa A,Susumu N,Aoki D

更新日期：2010-11-01 00:00:00

abstract：:A standard therapeutic approach for advanced malignant thymoma has yet to be defined given the rarity of this condition. We present a patient with advanced thymoma, evaluated as inoperable at diagnosis due to multiple serosal metastases. The strong constitution and determination of the patient allowed treatment with s...

journal_title：Oncology letters

authors： Bergonzi M,Orlandoni G,Corbella F,Gobbi PG

更新日期：2011-05-01 00:00:00

abstract：:The ATP-binding cassette subfamily B member 1 (ABCB1) is a transporter that mediates multidrug resistance (MDR) against chemotherapy, which leads to decreased patient survival. To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) P...

journal_title：Oncology letters

authors： Wei S,Chen W,Hu L,Pan J,Wang X

更新日期：2018-11-01 00:00:00

abstract：:Knowledge of potential tumor markers may improve chemotherapeutic efficacy. Interleukin-6 (IL-6) expression in local tumor tissues is associated with cancer progression and poor prognosis in variety of cancer types. The aim of the present study was to investigate the role and potential application of IL-6 in determini...

journal_title：Oncology letters

authors： Zhao ZF,Li JX,Ye R,Wu X,Gao LL,Niu BL

更新日期：2016-02-01 00:00:00

abstract：:The purpose of this study was to confirm the correlation between serum levels of cystatin C (Cys-C) and those of creatinine (Cre), the most widely used index of renal function in clinical practice, and to evaluate serum levels of Cys-C, with a particular focus on the effects of aging, body mass index (BMI), C-reactive...

journal_title：Oncology letters

authors： Ohara G,Miyazaki K,Kurishima K,Kagohashi K,Ishikawa H,Satoh H,Hizawa N

更新日期：2012-02-01 00:00:00

abstract：:The purpose of the present study was to characterize uncommon portosystemic collateral circulation in hepatic cirrhosis. Portosystemic uncommon collateral circulation (UCC) was detected, characterized and evaluated by a combination of spiral computed tomography angiography, three-dimensional imaging angiography and el...

journal_title：Oncology letters

authors： Wu Q,Shen L,Chu J,Ma X,Jin B,Meng F,Chen J,Wang Y,Wu L,Han J,Zhang W,Ma W,Wang H,Li H

更新日期：2015-01-01 00:00:00

abstract：:The present study aimed to screen the regulatory mechanism of microRNA (miR/miRNA) typing on gastric cancer cells in gastric cancer tissues. In total, 46 patients who underwent gastric resection in Xiangya Hospital of Central-South University (Changsha, Hunan, China) between January and December 2012 were selected. Ga...

journal_title：Oncology letters

authors： Yang O,Huang J,Lin S

更新日期：2014-08-01 00:00:00

abstract：:Expression of mineral dust-induced gene (mdig) in lung cancer NCI-H1650 cells was detected to investigate the effects of mdig on proliferation and apoptosis of NCI-H1650 cells. NCI-H1650 lung cancer cells were cultured in vitro. The expression of mdig in NCI-H1650 cells was lowered using ribonucleic acid interference ...

journal_title：Oncology letters

authors： Xu X,Cao L,Zhang Y,Lian H,Sun Z,Cui Y

更新日期：2018-12-01 00:00:00

abstract：:The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...

journal_title：Oncology letters

authors： Takuwa H,Tsuji W,Yamamoto Y,Shintaku M,Yotsumoto F

更新日期：2018-05-01 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the most common female malignancies, and there is an urgent requirement to explore new therapeutic strategies. In the present study, Ishikawa H cells were treated with Momordica charantia protein (MCP30). The cell morphology, growth inhibition rate, cell cycle distribution, and exp...

journal_title：Oncology letters

authors： Gu HZ,Lin RR,Wang HC,Zhu XJ,Hu Y,Zheng FY

更新日期：2017-05-01 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through the direct targeting of oncogenes or tumor suppressors. It has been previously suggested that miR-126 may be associated with endometrial cancer (EC). However, the exact role of miR-126...

journal_title：Oncology letters

authors： Zhao X,Zhu D,Lu C,Yan D,Li L,Chen Z

更新日期：2016-02-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the clinicopathological and demographic factors, and the survival time of patients with triple-negative breast cancer (TNBC) in China. The patients had received adjuvant chemotherapy consisting of 5-fluorouracil, epirubicin and cyclophosphamide (F...

journal_title：Oncology letters

authors： Sun W,Li C,Liu M,Liu W,Yang C,Cai LI

更新日期：2016-03-01 00:00:00