Abstract:
:Epithelial-mesenchymal transition (EMT) is a critical process in the promotion of epithelial tumor progression and metastasis. The present study aimed to investigate the role of Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) in transforming growth factor (TGF)-β1 induced EMT. EMT occurred in human cervical carcinoma SiHa cells following TGF-β1 stimulation for 4 days, as demonstrated by the appearance of mesenchymal morphology, reorganization of the actin cytoskeleton, reduced E-cadherin expression and increased Vimentin expression, which was associated with increased RhoC expression and activity. However, EMT was not observed in cells that were pretreated with RhoC siRNA prior to TGF-β1 stimulation. Downregulation of RhoC 4 days following TGF-β1 stimulation was not able to reverse the existing EMT. In addition, TGF-β1 promoted the invasion of the control SiHa cells but not that of the cells in which RhoC was downregulated. In conclusion, RhoC expression is activated by TGF-β1, and sufficient RhoC expression levels are essential for TGF-β1-induced EMT.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
He X,Qian Y,Cai H,Yang S,Cai J,Wang Zdoi
10.3892/ol.2015.3287subject
Has Abstractpub_date
2015-08-01 00:00:00pages
985-989issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-3287journal_volume
10pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in regulating glycolysis, angiogenesis and apoptosis. Recently, ARNT has been reported to a play role in pancreatic-islet function in type 2 diabetes. However, the role of ARNT in kidney cancer h...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11917
更新日期:2020-10-01 00:00:00
abstract::Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7928
更新日期:2018-04-01 00:00:00
abstract::The present study aimed to investigate the expression levels of microRNA (miR)-23a and miR-23b in the tumor tissues of patients with ovarian cancer. The study also explored the correlation of miR-23a and miR-23b expression levels in the tumor tissues with the clinic-pathological parameters and prognosis of the patient...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8669
更新日期:2018-07-01 00:00:00
abstract::Elevated expression of the retinoic acid-metabolizing enzyme cytochrome P450 26A1 (CYP26A1) has been demonstrated to have an oncogenic function in carcinogenesis. In order to address the oncogenic capacity of CYP26A1 in vivo, transgenic mice that ubiquitously overexpressed CYP26A1 driven by the cytomegalovirus promote...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8599
更新日期:2018-06-01 00:00:00
abstract::To aim of the present study was to investigate the association between special AT-rich DNA-binding protein-1 (SATB1) expression and liver cancer metastasis. SATB1 mRNA and protein expression in hepatocellular carcinoma tissues was analyzed by immunohistochemistry, and in two hepatocellular cancer cell lines, MHCC-97H ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5281
更新日期:2016-12-01 00:00:00
abstract::Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, che...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6685
更新日期:2017-10-01 00:00:00
abstract::Activating mutations in the cytosolic serine/threonine kinase, BRAF, have been reported in a variety of neoplasms. BRAF activation may contribute to tumor growth via activation of the MAP/ERK kinase pathway, and BRAF represents a possible therapeutic target. Activating BRAF mutations were recently reported in approxim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000127
更新日期:2010-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chond...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5466
更新日期:2017-02-01 00:00:00
abstract::Glutathione S-transferases (GSTs) participate in the detoxification and elimination of electrophilic carcinogens by conjugating them to glutathione. Previous studies have reported a potential association between GSTM1 polymorphism and the risk of developing nasopharyngeal cancer (NPC). However, those findings remain c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3848
更新日期:2016-01-01 00:00:00
abstract::The present study investigated the anticancer functions of ursolic acid (UA) and its novel derivatives, with a nitrogen-containing heterocyclic scaffold and the privileged fragment at the C-28 position on apoptosis induction, cell proliferation and cell cycle in human BC lines. UA was chemically modified in the presen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7578
更新日期:2018-02-01 00:00:00
abstract::Urothelial cancer is the most frequently diagnosed type of malignant tumor in the bladder, of which primary adenocarcinoma accounts for a small percentage. Secondary malignancies, in particular metastatic adenocarcinoma from the lung, are exceedingly rare, with only six cases previously reported in the literature. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3445
更新日期:2015-09-01 00:00:00
abstract::The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12044
更新日期:2020-11-01 00:00:00
abstract::Gefitinib is a selective inhibitor of the tyrosine kinase epidermal growth factor receptor, which inhibits tumor pathogenesis, metastasis and angiogenesis, as well as promoting apoptosis. Therefore, gefitinib presents an effective drug for the targeted therapy of lung cancer. However, the underlying mechanisms by whic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4606
更新日期:2016-07-01 00:00:00
abstract::This study aimed to investigate the correlation between the expression of CD24 and B7-H3 in breast cancer tissues and the clinical significance. Expression of CD24 and B7-H3 in breast cancer and adjacent tissues were detected by immunohistochemistry. Quantitative PCR was used to detect the expression of CD24 and B7-H3...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7142
更新日期:2017-12-01 00:00:00
abstract::The present study aimed to investigate the impact of overexpression of long noncoding RNA PEG10 (lncRNA PEG10) on the proliferation, invasion and metastasis of hypopharyngeal squamous cell carcinoma (HSCC). Quantitative reverse transcription polymerase chain reaction was used to quantify lncRNA PEG10 expression levels...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6498
更新日期:2017-09-01 00:00:00
abstract::MicroRNAs (miRs) are often located in genomic breakpoint regions and are hypothesized to be important regulators involved in the regulation of critical cell processes, including cell apoptosis, proliferation and differentiation. miR-299 has been reported to be upregulated in acute promyelocytic leukemia (APL); however...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4621
更新日期:2016-07-01 00:00:00
abstract::Diagnostic value of magnetic resonance imaging (MRI) and multi-slice spiral CT (MSCT) for different pathological stages of prostate cancer was compared. A total of 112 patients with prostate cancer who underwent surgical pathology in The Affiliated Yantai Yuhuangding Hospital of Qingdao University from February 2014 t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10272
更新日期:2019-06-01 00:00:00
abstract::MicroRNA (miR)-29a has been associated with carcinogenesis in humans; however, its functional significance in esophageal squamous cell carcinoma (ESCC) is yet to be determined. In the present study, the expression of miR-29a was markedly downregulated in ESCC tissue and the ESCC TE-1 cell line, compared with normal es...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2678
更新日期:2015-01-01 00:00:00
abstract::The present study aimed to evaluate the expression of p53, Ki-67, epidermal growth factor receptor (EGFR) and O6-methylguanine-DNA methyltransferase (MGMT), and to analyze the correlation between their expression and the histological grade of the tumors in 152 patients with gliomas. The tumors were classified accordin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1317
更新日期:2013-07-01 00:00:00
abstract::Epidemiological data has demonstrated that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 µm (PM2.5) is associated with cancer incidence. However, the precise mechanisms underlying PM2.5-mediated hepatocellular carcinoma cancer (HCC) migration and invasion remain unclear. The aim of the present study was t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5947
更新日期:2017-05-01 00:00:00
abstract::Hypoxia occurs in a wide range of solid tumors, and is strongly associated with radio-resistance of malignant tumors. The aim of the present study was to investigate the effect of endostatin combined with ionizing radiation (IR) on hypoxic conditions. A total of 24 mice bearing SKOV3 ovarian carcinoma were divided int...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5559
更新日期:2017-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) metastases in the mediastinum are rare, particularly under the arch of the aorta. The present study describes the case of a 30-year-old male patient who presented with back pain and hoarseness for 2 months due to lymph node metastasis of HCC. The patient had undergone right hepatic lobec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4687
更新日期:2016-08-01 00:00:00
abstract::Carbonyl reductase 1 (CBR1) is theorized to participate in various cellular processes, such as signal transduction, apoptosis, carcinogenesis and drug resistance, and is highly expressed in certain malignancies, including lung tumors. Several studies have provided evidence that gene polymorphisms may affect susceptibi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6926
更新日期:2017-11-01 00:00:00
abstract::Radical cystectomy, as the most common surgical treatment for patients with invasive bladder cancer (IBC) complicated by peritoneal metastasis, is usually accompanied by a urinary diversion procedure. In this study, we evaluated the improved tubeless cutaneous ureterostomy technique by comparing the resulting clinical...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4045
更新日期:2016-02-01 00:00:00
abstract::Studies have shown that homeobox D10 (HOXD10) is the target gene of microRNA-10b (miR-10b) and is closely associated with the inhibition of cell migration and invasion. Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. The effect of miR-10b on colorectal cance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4628
更新日期:2016-07-01 00:00:00
abstract::The danger of overexposure to solar ultraviolet radiation has been widely reviewed since the 1980s due to the depletion of the ozone layer. However, the benefits of mild exposure of the skin to ultraviolet (UV) light have not been widely investigated. Numerous reports have demonstrated that an association exists betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3519
更新日期:2015-10-01 00:00:00
abstract::A total of 76 blood samples from patients without malignant disease and 107 blood samples from patients with malignant disease were investigated for the presence of circulating tumor cells (CTCs). To detect CTCs, hematopoietic cells were removed from the blood samples and different RNA extraction methods were used to ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6226
更新日期:2017-07-01 00:00:00
abstract::Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7812
更新日期:2018-03-01 00:00:00
abstract::Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10935
更新日期:2019-12-01 00:00:00
abstract::MicroRNA-1470 (miR-1470) is overexpressed in esophageal squamous cell carcinoma (ESCC); however, its role and underlying molecular mechanism remain unknown. The aim of the present study was to explore the tumorigenic role and mechanism of miR-1470 overexpression in ESCC. The expression of miR-1470 in ESCC tissues and ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7190
更新日期:2017-12-01 00:00:00