Abstract:
:To aim of the present study was to investigate the association between special AT-rich DNA-binding protein-1 (SATB1) expression and liver cancer metastasis. SATB1 mRNA and protein expression in hepatocellular carcinoma tissues was analyzed by immunohistochemistry, and in two hepatocellular cancer cell lines, MHCC-97H (high metastatic potential) and HepG2 (low metastatic potential), by reverse transcription-polymerase chain reaction and western blot analysis. Transwell migration and wound-healing assays were also performed to investigate the metastasis of liver cancer following upregulation or silencing of SATB1 expression. The results revealed that SATB1 expression was significantly higher in hepatocellular carcinoma tissues compared with carcinoma-adjacent tissues. Furthermore, SATB1 expression was correlated with tumor size, differentiation degree, hemorrhage and/or necrosis, invasion and/or metastases and TNM stage. Both the mRNA and protein expression of SATB1 was higher in MHCC-97H cells than HepG2 cells. In addition, the migration capability of MHCC-97H cells was decreased after SATB1 silencing, whereas the migration capability of HepG2 cells was increased after SATB1 upregulation. SATB1 expression was demonstrated to be positively correlated with liver cancer metastasis. These results indicate that liver cancer metastasis is regulated by SATB1 expression. Thus, immunohistochemical SATB1 expression may present an independent risk factor for the metastasis of liver cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wu D,Zeng L,Liu F,Zhong Q,Zhang D,Cai C,Zhang W,Wu L,Chen Hdoi
10.3892/ol.2016.5281subject
Has Abstractpub_date
2016-12-01 00:00:00pages
4377-4384issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-5281journal_volume
12pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Extra-abdominal desmoid tumour is a rare type of tumour which is conventionally treated with wide local excision. However, wide local excision usually causes irreparable damage to the limbs. Nevertheless, few patients have been subjected to wide local excision and reconstructive surgery in a single procedure. A 52-yea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.766
更新日期:2012-09-01 00:00:00
abstract::1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane (DPD), a diamantane derivative, was previously noted as an anticancer compound through anticancer drug screening with NCI-60 human tumor cells. Irinotecan (CPT-11), a semisynthetic derivative of camptothecin, is clinically active in the treatment of colorectal can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4430
更新日期:2016-05-01 00:00:00
abstract::Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder. It is characterized by the presence of the Philadelphia (Ph) chromosome, t(9;22)(q34.1;q11.2), which carries the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have markedly changed the treatment approach of CML and have become the f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9497
更新日期:2018-11-01 00:00:00
abstract::The present study aimed to explore the clinical efficacy and safety of hydromorphone combined with sufentanil in patient-controlled intravenous analgesia (PCIA) for patients with hepatocellular carcinoma (HCC) and its effect on serum immune factors in serum. Data from 385 patients with HCC, admitted to the Hunan Provi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12159
更新日期:2020-12-01 00:00:00
abstract::Peroxiredoxin 1 (Prx1) is important in the protection of cells from oxidative damage and the regulation of cell proliferation and apoptosis. Prx1 is overexpressed in oral precancerous lesions of oral leukoplakia (OLK) and oral cancer; however, the association between Prx1 expression and OLK pathogenesis remains unknow...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4659
更新日期:2016-07-01 00:00:00
abstract::Plant secondary metabolites including alkaloids, demonstrate a complex diversity in their molecular scaffolds and exhibit tremendous pharmacological potential as anti-cancerous therapeutics. The present study aimed to evaluate the anticancer activity of a natural alkaloid, mecambridine, against human oral squamous cel...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7321
更新日期:2018-01-01 00:00:00
abstract::Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the m...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2018.9854
更新日期:2019-02-01 00:00:00
abstract::The aim of the present study was to perform a retrospective analysis to investigate the outcome and toxicity of radiation (RT) and chemoradiation (CRT) in elderly, inoperable patients >70 years old. Between 2003 and 2012, 1,024 patients with squamous cell carcinoma (SCC) of the esophagus were treated at the Department...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1694
更新日期:2014-01-01 00:00:00
abstract::Primary testicular non-Hodgkin's lymphoma (TNHL) was first described as a clinical entity in 1866. It is a rare disease which accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. Hemophagocytic syndrome (HPS) is a rare but distinct condition caused by inappr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.701
更新日期:2012-07-01 00:00:00
abstract::Askin tumors are rare malignant neoplasms that are localized in the thoracopulmonary region and mainly occur in children and adolescents. Further investigation with regard to the effective treatment of this disease is required, since the disease has a low incidence and limited knowledge is available on the biological ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1488
更新日期:2013-10-01 00:00:00
abstract::Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4424
更新日期:2016-05-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fr...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10349
更新日期:2019-07-01 00:00:00
abstract::The warning statement issued by the United States Food and Drug Administration against the use of laparoscopic power morcellators prompted a discussion about the methods of preoperative diagnosis of uterine myometrial lesions. Since 1994, transcervical needle biopsies have been performed to differentiate between uteri...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8425
更新日期:2018-06-01 00:00:00
abstract::Pulmonary sequestration (PS) is an uncommon lung disease. Carcinoid tumorlets in pulmonary sequestration are extremely rare. This case report presents a rare clinical case of carcinoid tumorlet in pulmonary sequestration with bronchiectasis after breast cancer. A 64-year-old female was diagnosed with infiltrating duct...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1210
更新日期:2013-05-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) accounts for 30% of all pediatric cancers. Currently available treatments exhibit toxicity and certain patients may develop resistance. Thus, less toxic and chemoresistance-reversal agents are required. In the present study, the potential effect of curcumin, a component of Curcuma lo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5217
更新日期:2016-11-01 00:00:00
abstract::Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.799
更新日期:2012-10-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical value of magnetic resonance imaging (MRI) in the preoperative T staging of gastric cancer and in the postoperative pathological diagnosis. In total, 30 patients with gastric cancer were investigated, including 19 males and 11 females (age, 50-69 years; mean age...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2135
更新日期:2014-07-01 00:00:00
abstract::Zinc finger E-box binding homeobox 1 (ZEB1) has been shown to promote invasion and metastasis in several types of human cancer and to have a prognostic role in certain cancers. However, the clinical significance of ZEB1 in colorectal cancer (CRC) has not been sufficiently investigated. This study aimed to address this...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1026
更新日期:2013-02-01 00:00:00
abstract::The aim of this study was to investigate the predictive impact of polymorphisms in the HIF-1α gene on the response to chemoradiotherapy (CRT) in rectal cancer. This study included two cohorts of patients with locally advanced rectal cancer receiving long-course CRT. The HIF-1α C1772T (rs11549465), G1790A (rs11549467) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.837
更新日期:2012-11-01 00:00:00
abstract::Expression of claudin-6 (CLDN6) in the tissues of gastric cancer patients and its association with clinical pathology and prognosis were investigated. A retrospective analysis was performed on 213 gastric cancer patients diagnosed and surgically treated in the Central Hospital of Zibo from January 2010 to January 2013...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10129
更新日期:2019-05-01 00:00:00
abstract::The DNA methyltransferase 3A (DNMT3A) -448A>G polymorphism is a novel functional single nucleotide polymorphism (SNP) that contributes to the genetic susceptibility to gastric cancer. In this study, we aimed to assess the genotype frequencies of DNMT3A -448A>G in colorectal cancer (CRC) patients and healthy control su...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.488
更新日期:2012-02-01 00:00:00
abstract::This study investigated the inhibitory effect of vitamin D-binding protein-derived macrophage-activating factor (GcMAF) on carcinogenesis and tumor growth, using a 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster cheek pouch carcinogenesis model, as well as the cytocidal effect of activated macrophages against ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.306
更新日期:2011-07-01 00:00:00
abstract::Connexins (Cxs), a conserved family of trans-membrane proteins, function in the organization of cell-cell communicatin via gap junctions in multicellular organisms. However, the role of Cxs in acute myeloid leukemia (AML) is poorly understood. In this study, we investigated the relationship between cell proliferation ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.884
更新日期:2012-11-01 00:00:00
abstract::Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8007
更新日期:2018-04-01 00:00:00
abstract::The aim of the present study was to investigate the expression of transactivation response RNA-binding protein (TARBP)1 and its clinical significance in human non-small-cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8202
更新日期:2018-05-01 00:00:00
abstract::A 77-year-old female, with proptosis, reduced eye motility and diplopia which had developed over two to three months and a 69-year-old female with proptosis, oedema of the eyelid, reduced motility and ptosis, which had developed over three weeks, are presented in the present study. Computed tomography scans revealed i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3282
更新日期:2015-08-01 00:00:00
abstract::Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4563
更新日期:2016-07-01 00:00:00
abstract::A total of 76 blood samples from patients without malignant disease and 107 blood samples from patients with malignant disease were investigated for the presence of circulating tumor cells (CTCs). To detect CTCs, hematopoietic cells were removed from the blood samples and different RNA extraction methods were used to ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6226
更新日期:2017-07-01 00:00:00
abstract::Patients with longstanding ulcerative colitis have an increased risk of colorectal cancer. Mouse models for colitis-associated tumors are indispensable for the development of novel strategies for prevention and intervention, as well as an improved understanding of the mechanisms underlying tumor formation. The present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6645
更新日期:2017-09-01 00:00:00
abstract::Survivin is expressed in the nucleus and/or cytoplasm of various malignant cells. Nuclear survivin is critical for the completion of mitosis, while cytoplasmic survivin functions as an inhibitor of apoptosis. The expression of survivin has been reported to be associated with the aggressiveness of certain types of canc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3374
更新日期:2015-09-01 00:00:00