Abstract:
:Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fruits and vegetables have a significantly reduced incidence rate of CRC. This chemo-preventive effect is primarily associated with the presence of phytochemicals in the dietary components. Plant-derived chemical agents act as a prominent source of novel compounds for drug discovery. Phytochemicals have been the focus of an increasing number of studies due to their ability to modulate carcinogenic processes through the alteration of multiple cancer cell survival pathways. Despite promising results from experimental studies, only a limited number of phytochemicals have entered into clinical trials. The purpose of the current review is to compile previously published pre-clinical and clinical evidence of phytochemicals in cases of CRC. A PubMed, Google Scholar and Science Direct search was performed for relevant articles published between 2008-2018 using the following key terms: 'Phytochemicals with colorectal cancers', 'apoptosis', 'cell cycle', 'reactive oxygen species' and 'clinical anticancer activities'. The present review may aid in identifying the most investigated phytochemicals in CRC cells, and due to the limited number of studies that make it from the laboratory bench to clinical trial stage, may provide a novel foundation for future research.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Ahmed K,Zaidi SF,Cui ZG,Zhou D,Saeed SA,Inadera Hdoi
10.3892/ol.2019.10349subject
Has Abstractpub_date
2019-07-01 00:00:00pages
487-498issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-10349journal_volume
18pub_type
杂志文章,评审相关文献
Oncology Letters文献大全abstract::Ovarian carcinoma (OV) is one of the most lethal gynecological malignancies globally, and the overall 5-year survival rate of OV was 47% in 2018 according to American data. To increase the survival rate of patients with OV, many researchers have sought to identify biomarkers that act as both prognosis-predictive marke...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12067
更新日期:2020-11-01 00:00:00
abstract::The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The result...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.527
更新日期:2012-03-01 00:00:00
abstract::Notch-regulated ankyrin-repeat protein (NRARP) has recently been reported to be involved in a number of malignant cancers; however, its role in non-small lung cancer (NSCLC) remains unclear. The present study aimed to identify whether NRARP could be applied as a novel prognostic marker for NSCLC. A total of 108 NSCLC ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8826
更新日期:2018-08-01 00:00:00
abstract::In the present study, the incidence of surgical wound complications in patients with large and deep high-grade soft tissue sarcoma (STS) was investigated. In addition, the disease-specific and event-free survival rates were examined in these patients. In total, 30 adult patients with primary high-grade deep STS with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3289
更新日期:2015-08-01 00:00:00
abstract::Distant metastases from colorectal cancer (CRC) most frequently spread to the liver and lungs. CRC metastasis to the kidney is extremely rare and may be generally associated with an unfavorable prognosis. Thus, patients with metastatic CRC and kidney metastasis are a diagnostic and therapeutic challenge. The present s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3290
更新日期:2015-08-01 00:00:00
abstract::Linked color imaging (LCI) is a novel endoscopic system used to increase color contrast. As LCI does not decrease luminal brightness, it may improve the detection of colonic neoplasms. However, the extent to which LCI improves the visibility of colonic polyps has not yet been determined. Between December 2016 and May ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10917
更新日期:2019-11-01 00:00:00
abstract::Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS-TICs) were isolated and enriched from the osteosarcoma U2OS and MG-63 cell lines using sphere formation ass...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6132
更新日期:2017-07-01 00:00:00
abstract::The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). The viability of T24 cells was estimated using a sulforhodamine B assay. Cell morphological changes were examin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6159
更新日期:2017-07-01 00:00:00
abstract::In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells, leaving only the nuclear localization signal (NLS)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5706
更新日期:2017-04-01 00:00:00
abstract::Radiotherapy is the primary treatment for nasopharyngeal carcinoma (NPC), but radioresistance often remains an obstacle to successful treatment. In our previous study, it was demonstrated that Annexin A1 (ANXA1) was involved in the p53-mediated radioresponse in NPC cells, which suggested that it may be associated with...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5324
更新日期:2016-12-01 00:00:00
abstract::The aim of the present study was to identify monitoring and prevention measures as well as predictive factors for early detection of renal toxicity associated with long-term administration of adefovir dipivoxil in order to avoid progression to Fanconi syndrome. Clinical data of 28 patients with Fanconi syndrome caused...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5393
更新日期:2017-01-01 00:00:00
abstract::Gastric cancer and cholangiocarcinoma are problematic throughout the world due to their destructive malignancy. In attempts to treat cholangiocarcinoma and gastric cancer, researchers often explore the effects of transforming growth factor-β1 (TGF-β1). TGF-β1 plays a crucial role in causing cell cycle arrest and fibro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1024
更新日期:2013-02-01 00:00:00
abstract::Vestibular schwannoma (VS) is a benign, slow-growing cranial tumor that originates from the hypertrophy of Schwann cells. The majority of sporadic VS are unilateral, and the mechanisms underlying VS tumorigenesis are not fully understood. The human neurofibromin 2 (NF2) gene encodes the tumor suppressor protein merlin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4685
更新日期:2016-08-01 00:00:00
abstract::Breast cancer affects ~10% of women worldwide and is responsible for ~12% of all cancer-associated mortalities. Breast cancer is more prone to metastasis compared with other types of cancer. Up to 5% of patients with breast cancer present with incurable metastasis and an additional 10-15% of patients develop metastase...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8726
更新日期:2018-07-01 00:00:00
abstract::Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10499
更新日期:2019-08-01 00:00:00
abstract::The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory exa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3051
更新日期:2015-05-01 00:00:00
abstract::The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcription factor 1 (RUNX...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6151
更新日期:2017-07-01 00:00:00
abstract::Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by modulating histone methylation and has been associated with numerous high-risk cancers. Previously, our group and others identified LSD1 as an upregulated gene in ovarian cancer, and reported that the upregulation of LSD1 was associated...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8511
更新日期:2018-06-01 00:00:00
abstract::Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8252
更新日期:2018-05-01 00:00:00
abstract::Non-Hodgkin lymphoma of the bone is rare and typically causes an extensive bone lesion. The present study describes a case of diffuse large B-cell primary non-Hodgkin lymphoma of the bone, which occurred in the right femur, and was initially treated with surgery and chemotherapy. Following a 7-year period of complete ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7895
更新日期:2018-04-01 00:00:00
abstract::Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were ret...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5552
更新日期:2017-03-01 00:00:00
abstract::Point mutation of the BRAF gene is a genetic event that occurs in a subset of lung adenocarcinoma cases. For example, BRAF V600E is a driver mutation that can be effectively targeted using selective BRAF and/or MEK inhibitors. The present study hypothesized that an increase in BRAF copy number may be correlated with c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2719
更新日期:2015-02-01 00:00:00
abstract::Telomeres are located at the ends of chromosomes and protect them from degradation. Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining short telomeres is a protective mechanism against cancer in humans. In most human somatic cells, the expression of telomerase reverse transcriptase...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11659
更新日期:2020-08-01 00:00:00
abstract::Early mitotic inhibitor-1 (Emi1), as a key cell cycle regulatory gene, induces S phase and mitotic entry by controlling anaphase-promoting complex substrates. Emi1 overexpression may be a prognostic factor for patients with invasive breast cancer. However, its expression and clinical significance in esophageal squamou...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4611
更新日期:2016-07-01 00:00:00
abstract::Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4264
更新日期:2016-04-01 00:00:00
abstract::The aim of the present study was to investigate the inhibitory effects of dihydroartemisinin (DHA) on the primary tumor growth and metastasis of the human breast cancer cell line, MDA-MB-231, in vitro. The expression levels of urokinase-type plasminogen activator (uPA) were detected by immunocytochemistry in two cell ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1918
更新日期:2014-05-01 00:00:00
abstract::Lichen sclerosus is a chronic and inflammatory disease. Extensive studies have focused on the epidermis, with the dermis or epidermis-dermis receiving less attention. To investigate the role of galectin-7, a keratinocyte protein, in vulvar lichen sclerosus (VLS) and its potential effects on dermal fibroblasts, immunoh...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8897
更新日期:2018-08-01 00:00:00
abstract::The aim of this study was to investigate the correlation between H-ras mutation and primary hepatocellular carcinoma (HCC) and to describe the role of H-ras mutation in carcinogenesis. Clinical samples of 69 patients were collected and the expression levels of H-ras in HCC and the surrounding normal tissues were exami...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.832
更新日期:2012-10-01 00:00:00
abstract::The warning statement issued by the United States Food and Drug Administration against the use of laparoscopic power morcellators prompted a discussion about the methods of preoperative diagnosis of uterine myometrial lesions. Since 1994, transcervical needle biopsies have been performed to differentiate between uteri...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8425
更新日期:2018-06-01 00:00:00
abstract::microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9011
更新日期:2018-09-01 00:00:00