Expression of p53, epidermal growth factor receptor, Ki-67 and O6-methylguanine-DNA methyltransferase in human gliomas.

abstract：:Melanoma is the most severe type of skin cancer and its incidence has increased in the last decades. In the United States, it is the 6th most common cancer in both men and women. Prognosis for patients with melanoma depends on the stage of the disease at the time of diagnosis and it can be influenced by the immunologi...

journal_title：Oncology letters

authors： Antohe M,Nedelcu RI,Nichita L,Popp CG,Cioplea M,Brinzea A,Hodorogea A,Calinescu A,Balaban M,Ion DA,Diaconu C,Bleotu C,Pirici D,Zurac SA,Turcu G

更新日期：2019-05-01 00:00:00

abstract：:MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...

journal_title：Oncology letters

authors： Hou L,Luo P,Ma Y,Jia C,Yu F,Lv Z,Wu C,Fu D

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present study was to investigate the expression and role of microRNA-26a (miR-26a) in lung cancer, and to verify whether differentially expressed in adenocarcinoma of the lung (DAL-1) is the target protein of miR-26a. mRNA expression levels of miR-26a and DAL-1 were detected using reverse transcription-...

journal_title：Oncology letters

authors： Cai T,Guan X,Wang H,Fang Y,Long J,Xie X,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to investigate the effects of the WW domain-containing oxidoreductase (WWOX) gene on the stem cell properties of human ovarian cancer stem cells. A eukaryotic expression vector containing the WWOX gene was transfected into human ovarian cancer stem cells and Western blotting was used to assess ...

journal_title：Oncology letters

authors： Yan HC,Xu J,Fang LS,Qiu YY,Lin XM,Huang HX,Han QY

更新日期：2015-04-01 00:00:00

abstract：:Gefitinib is a selective inhibitor of the tyrosine kinase epidermal growth factor receptor, which inhibits tumor pathogenesis, metastasis and angiogenesis, as well as promoting apoptosis. Therefore, gefitinib presents an effective drug for the targeted therapy of lung cancer. However, the underlying mechanisms by whic...

journal_title：Oncology letters

authors： Zhao ZQ,Yu ZY,Li J,Ouyang XN

更新日期：2016-07-01 00:00:00

abstract：:Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atl...

journal_title：Oncology letters

authors： Zhang ZH,Luan ZY,Han F,Chen HQ,Liu WB,Liu JY,Cao J

更新日期：2019-11-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) govern gene expression by competitively binding to microRNA response elements (MREs). Although they were initially considered as transcriptional noise, lncRNAs have attracted increased attention in oncology. Dysregulation of lncRNAs occurs in various types of human tumor, including esoph...

journal_title：Oncology letters

authors： Yu Y,Chen X,Cang S

更新日期：2019-11-01 00:00:00

abstract：:The present study aimed to analyze the characteristics of polyethylene glycol (PEG)ylated carboplatin liposomes (PL-CBPs), including size, stability, their release, entrapping and loading efficiencies, and their antitumor and antimetastatic effects on the lymph nodes. The PL-CBPs were prepared using PEG-2000 with the ...

journal_title：Oncology letters

authors： Zhang J,Huang C,Huang H

更新日期：2014-11-01 00:00:00

abstract：:Delisheng is a widely used antineoplastic agent in China. Although previous studies revealed that Delisheng exhibits numerous pharmacological effects including the inhibition of cancer cell differentiation and enhancement of immune function with the lowest toxicity, the precise anticancer mechanisms of Delisheng in hu...

journal_title：Oncology letters

authors： Sun HF,Jing L,Wu T,Li M,Guo YH,Guo H,Zhao Z,Wang MC,Wang SH,Nan KJ

更新日期：2017-12-01 00:00:00

abstract：:Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...

journal_title：Oncology letters

authors： Xu Y,Wang Z,Bi Y,Duan Z,Yue X

更新日期：2018-08-01 00:00:00

abstract：:Esophageal cancer is one of the most prevalent forms of cancer and has a particularly high mortality rate due to early metastasis; however, the underlying mechanisms of its formation and progression remain unclear. The present study performed immunohistochemical analysis and observed that the expression of activating ...

journal_title：Oncology letters

authors： Li J,Yang Z,Chen Z,Bao Y,Zhang H,Fang X,Yang W

更新日期：2016-09-01 00:00:00

abstract：:In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells, leaving only the nuclear localization signal (NLS)...

journal_title：Oncology letters

authors： Wang H,Yang R,Zhong L,Zhu XY,Ma PP,Yang XQ,Jiang KL,Liu BZ

更新日期：2017-04-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-associated mortality worldwide and its prognosis is poor. Few effective biomarkers for non-small cell lung cancer (NSCLC) have been translated into the clinical practice aiming to assist in the treatment plan design and prognosis evaluation. The aim of the present study was t...

journal_title：Oncology letters

authors： Hao L,Du B,Xi X

更新日期：2017-08-01 00:00:00

abstract：:Leiomyosarcomas account for ~24% of all adult sarcomas, and develop predominantly either in the uterus [uterine leiomyosarcoma (ULMS)] or in deep soft tissue or the retroperitoneum [non-uterine leiomyosarcoma (NULMS)]. Leiomyosarcomas are relatively chemoresistant tumors, and the prognosis of patients with leiomyosarc...

journal_title：Oncology letters

authors： Iura K,Kohashi K,Yasutake N,Ishii T,Maekawa A,Bekki H,Otsuka H,Yamada Y,Yamamoto H,Ohishi Y,Matsumoto Y,Iwamoto Y,Oda Y

更新日期：2018-01-01 00:00:00

abstract：:Adenocarcinoma is one of the most serious diseases that threaten human health. Numerous studies have investigated adenocarcinoma and have obtained a considerable amount of data regarding genes and microRNA (miRNA) in adenocarcinoma. However, studies have only focused on one or a small number of genes and miRNAs, and t...

journal_title：Oncology letters

authors： Ning J,Guo X,Wang N,Xue L

更新日期：2015-11-01 00:00:00

abstract：:The present study aimed to examine whether monoclonal immunoglobulin heavy chain (IGH) or T-cell receptor (TCR) gene rearrangement in cell-free DNA (cfDNA) may be used for minimal residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML). Monoclonal IGH and TCR rearrangement in cfDNA were monitor...

journal_title：Oncology letters

authors： Zhong L,Chen J,Huang X,Li Y,Jiang T

更新日期：2018-08-01 00:00:00

abstract：:Silent information regulator 6 (SIRT6) is broadly considered as a tumor suppressor due to its function in the suppression of oncogene expression. However, the role of SIRT6 in colorectal cancer stem cells (CSCs) remains uncharacterized. In the present study, it was demonstrated that SIRT6 expression was reduced in col...

journal_title：Oncology letters

authors： Liu W,Wu M,Du H,Shi X,Zhang T,Li J

更新日期：2018-04-01 00:00:00

abstract：:Bladder cancer is one of the most common forms of malignancies involving the urinary system and multiple risk factors have been associated with its etiology. The most common of which include cigarette smoking and various occupational or chemical exposures. It is usually diagnosed in older individuals with an average a...

journal_title：Oncology letters

authors： Khan R,Ibrahim H,Tulpule S,Iroka N

更新日期：2016-05-01 00:00:00

abstract：:Rare types of cancer are often not effectively treated by approaches such as chemotherapy and radio-therapy, although their side-effects persist. Immunotherapy has been gaining attention worldwide with growing examples of its anticancer activity demonstrated in vivo. This case report describes a 35-year-old male who s...

journal_title：Oncology letters

authors： Ratnavelu K,Subramani B,Pullai CR,Krishnan K,Sugadan SD,Rao MS,Veerakumarasivam A,Deng X,Hiroshi T

更新日期：2013-05-01 00:00:00

abstract：:Wiskott-Aldrich syndrome protein family member 3 (WASF3) is required for invasion and metastasis in different cancer cell types, and has been demonstrated to possess prognostic value in various types of human cancer. However, to the best of our knowledge, the expression profile of WASF3 and its correlations with the c...

journal_title：Oncology letters

authors： Wu J,Wang GC,Chen XJ,Xue ZR

更新日期：2014-09-01 00:00:00

abstract：:Docking protein 2 (Dok2) and Ras p21 protein activator 1 (RASA1) are tumor suppressors which have been identified in numerous solid tumors; however, the association between their expression in breast cancer and patient prognosis remains unclear. A total of 285 consecutive patients diagnosed histopathologically with br...

journal_title：Oncology letters

authors： Huang J,Peng X,Zhang K,Li C,Su B,Zhang Y,Yu W

更新日期：2017-11-01 00:00:00

abstract：:Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...

journal_title：Oncology letters

authors： Xu T,Li D,He Y,Zhang F,Qiao M,Chen Y

更新日期：2018-10-01 00:00:00

abstract：:Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...

journal_title：Oncology letters

authors： Xie C,Yang Z,Hu Y,Cao X,Chen J,Zhu Y,Lu N

更新日期：2017-11-01 00:00:00

abstract：:Renal oncocytoma is one of the most unusual benign lesion, which are usually diagnosed postoperatively, since their differentiation from renal cell carcinoma is challenging. The present study reports two cases of renal oncocytoma in a 60-year-old woman and a 46-year-old man. Relevant clinical and pathological data on ...

journal_title：Oncology letters

authors： Wang Y,Hu YU,Zhai X,Wang W,Dong B,Zhou H

更新日期：2016-07-01 00:00:00

abstract：:Radical cystectomy, as the most common surgical treatment for patients with invasive bladder cancer (IBC) complicated by peritoneal metastasis, is usually accompanied by a urinary diversion procedure. In this study, we evaluated the improved tubeless cutaneous ureterostomy technique by comparing the resulting clinical...

journal_title：Oncology letters

authors： Liu Z,Tian Q,Xia S,Yin H,Yao D,Xiu Y

更新日期：2016-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transc...

journal_title：Oncology letters

authors： Wang Z,Fu H,Li W

更新日期：2018-09-01 00:00:00

abstract：:It has been demonstrated that numerous types of metastatic cancer overexpress vacuolar-type H+ (V)-ATPases. It may be possible to inhibit the growth and metastasis of human cancer cells by inhibiting V-ATPases. It was previously reported that diphyllin, a novel V-ATPase inhibitor, can inhibit the migration and invasio...

journal_title：Oncology letters

authors： Pan S,Cai H,Gu L,Cao S

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to compare intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in irradiation of lung cancer. Plans of 14 patients were compared. The results demonstrated that in peripheral lung cancer, V5 (%) of the lung in partial-arc (PA)-VMAT was decreased comp...

journal_title：Oncology letters

authors： Li Y,Wang J,Tan L,Hui B,Ma X,Yan Y,Xue C,Shi X,Drokow EK,Ren J

更新日期：2018-03-01 00:00:00

abstract：:HRas proto-oncogene (HRAS) is one of the most commonly mutated genes in thyroid cancer, with mutations frequently occurring in the follicular and Hurthle cell subtypes. However, the contribution of mutations in HRAS to papillary thyroid carcinoma (PTC) progression and the tall-cell variant (TCV) is poorly understood. ...

journal_title：Oncology letters

authors： Dou R,Zhang L,Lu T,Liu D,Mei F,Huang J,Qian L

更新日期：2018-04-01 00:00:00

abstract：:Poly(ADP-Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma and prostate cancer. The expression and function of PARP9 in human breast cancer remains unknown. In the present study, it was demonstrated that PARP9 is frequently overexpressed in human br...

journal_title：Oncology letters

authors： Tang X,Zhang H,Long Y,Hua H,Jiang Y,Jing J

更新日期：2018-09-01 00:00:00