Abstract:
:Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, cancer immunotherapies have received considerable attention as a viable therapeutic option for GC. Specifically, the immune checkpoint inhibitors, chimeric antigen rector (CAR)-T cells and tumor vaccines, represent immunotherapies that have exhibited promising effects in the treatment of GC. A number of clinical trials have employed either immuno-oncology monotherapies or combination therapies to improve the overall survival time (OS) and objective response rate (ORR) of patients with GC. The current review presents a summary of the clinical effects of checkpoint inhibitors, including CAR-T and tumor vaccines, in the treatment of GC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Yang L,Wang Y,Wang Hdoi
10.3892/ol.2019.10935subject
Has Abstractpub_date
2019-12-01 00:00:00pages
5681-5690issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-10935journal_volume
18pub_type
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