Distinct expression and prognostic value of OTU domain-containing proteins in non-small-cell lung cancer.

abstract：:The present study aimed to investigate the expression and roles of deleted in pancreatic carcinoma locus 4 (DPC4) and vascular endothelial growth factor (VEGF) in the development of cervical carcinoma. A total of 115 patients aged between 25 and 60 years were involved, including 19 cervical inflammation, 35 cervical i...

journal_title：Oncology letters

authors： A Y,Li Y,Zhao S

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to determine the impact of obesity on radiation-induced gastrointestinal (GI) and genitourinary (GU) toxicity. The cases of 54 patients with prostate cancer, treated with three-dimensional conformal radiation therapy (RT), were reviewed. For each patient, the body mass index (BMI), dis...

journal_title：Oncology letters

authors： Doi H,Ishimaru F,Tanooka M,Inoue H,Odawara S,Takada Y,Niwa Y,Fujiwara M,Kamikonya N,Yamamoto S,Hirota S

更新日期：2014-01-01 00:00:00

abstract：:The poor outcome of patients with recurrent ovarian cancer constitutes a continuous challenge for decision-making in clinical practice. In this setting, molecular targets have recently been identified, and novel compounds are now available. Bevacizumab has been introduced for the treatment of patients with ovarian can...

journal_title：Oncology letters

authors： Selle F,Emile G,Pautier P,Asmane I,Soares DG,Khalil A,Alexandre J,Lhommé C,Ray-Coquard I,Lotz JP,Goldwasser F,Tazi Y,Heudel P,Pujade-Lauraine E,Gouy S,Tredan O,Barbaza MO,Ady-Vago N,Dubot C

更新日期：2016-03-01 00:00:00

abstract：:The aim of the present study is to investigate if rapamycin is a radiosensitizer of nasopharyngeal carcinoma (NPC), and to identify which pathways are involved in radiation sensitization. In vitro, using untreated cells as the control, NPC cells were treated with rapamycin, ionizing radiation (IR) or both. Differences...

journal_title：Oncology letters

authors： Wang D,Gao L,Liu X,Yuan C,Wang G

更新日期：2017-07-01 00:00:00

abstract：:The aim of this study was to investigate the characteristics of serum secreted frizzled-related protein 5 (SFRP5), an inhibitor of Wnt signaling, in hepatitis B virus (HBV)-associated infections and hepatocellular carcinoma (HCC) patients. Serum SFRP5 levels were detected in 147 patients with HBV-associated chronic in...

journal_title：Oncology letters

authors： Peng C,Xiao X,Kang B,He S,Li J

更新日期：2014-09-01 00:00:00

abstract：:Lung cancer negatively impacts global health, and the incidence of non-small cell lung cancer (NSCLC) is highest among all forms of lung cancer. Chemotherapy failure mainly occurs due to drug resistance; however, the associated molecular mechanism remains unclear. Casein kinase II (CK2), which plays important roles in...

journal_title：Oncology letters

authors： Jin C,Song P,Pang J

更新日期：2019-10-01 00:00:00

abstract：:A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...

journal_title：Oncology letters

authors： Mantas D,Kostakis ID,Machairas N,Markopoulos C

更新日期：2016-08-01 00:00:00

abstract：:Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) database data, and ass...

journal_title：Oncology letters

authors： Lu G,Fu D,Jia C,Chai L,Han Y,Liu J,Wu T,Xie R,Chang Z,Yang H,Luo P,Lv Z,Yu F,Zhong X,Ma Y

更新日期：2017-12-01 00:00:00

abstract：:Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...

journal_title：Oncology letters

authors： He J,Li Y,Wang Y,Zhang H,Ge S,Fan X

更新日期：2018-05-01 00:00:00

abstract：:Effective therapies are limited for pancreatic cancer, particularly for those with distant tumour metastases. Therefore, more individualised drug screening is urgently required. Next-generation sequencing (NGS) is a powerful tool to investigate the genomic landscape of patients and the mechanism of drug response, whic...

journal_title：Oncology letters

authors： Guan Z,Lan H,Sun D,Wang X,Jin K

更新日期：2019-02-01 00:00:00

abstract：:The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28...

journal_title：Oncology letters

authors： Gu F,Ma Y,Fan Y,Lang R,Ding T,Hao X,Gong Y,Kobayahsi H,Fang Z,Fu L

更新日期：2010-09-01 00:00:00

abstract：:High-fat diet induced obesity was associated with more aggressive prostate cancer. Recent research has demonstrated that integrin-linked kinase (ILK), β-parvin and downstream cofilin 1 jointly affected cancer progression. Meanwhile, these proteins were also involved in energy metabolism. Therefore, the present study w...

journal_title：Oncology letters

authors： Hu MB,Hu JM,Jiang LR,Yang T,Zhu WH,Hu Y,Wu XB,Jiang HW,Ding Q

更新日期：2018-10-01 00:00:00

abstract：:An alteration in the mitochondrial DNA (mtDNA) copy number has been detected in numerous human cancers. However, certain changes in the mtDNA copy number that occur during the initiation and progression of gastric cancer remain undetected. In the present study, using quantitative PCR analysis, the quantitative changes...

journal_title：Oncology letters

authors： Wen SL,Zhang F,Feng S

更新日期：2013-10-01 00:00:00

abstract：:The current case-control study was conducted to assess the value of activated fibroblasts with high α-smooth muscle actin (α-SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Cent...

journal_title：Oncology letters

authors： Parikh JG,Kulkarni A,Johns C

更新日期：2014-02-01 00:00:00

abstract：:Breast cancer is the most common malignant disease occurring in women. Conservative breast cancer surgery followed by radiation therapy is currently the standard treatment for this type of cancer. The majority of metastases occur within the scar, which initiated a series of studies. As a result, clinical trials aimed ...

journal_title：Oncology letters

authors： Zaleska K,Przybyła A,Kulcenty K,Wichtowski M,Mackiewicz A,Suchorska W,Murawa D

更新日期：2017-10-01 00:00:00

abstract：:The ATP-binding cassette subfamily B member 1 (ABCB1) is a transporter that mediates multidrug resistance (MDR) against chemotherapy, which leads to decreased patient survival. To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) P...

journal_title：Oncology letters

authors： Wei S,Chen W,Hu L,Pan J,Wang X

更新日期：2018-11-01 00:00:00

abstract：:The correlation between the expression levels of p65 and TNF-α in patients with acute myelocytic leukemia (AML) and AML cell lines were investigated. The bone marrow samples of 30 AML patients and 10 non-leukemia controls were studied. The mRNA expression levels of p65 and TNF-α were detected by reverse transcription-...

journal_title：Oncology letters

authors： Dong QM,Ling C,Zhu JF,Chen X,Tang Y,Zhao LI

更新日期：2015-11-01 00:00:00

abstract：:Current therapy for rheumatoid arthritis (RA) relies on global suppression of the immune response or specific blockade of inflammatory cytokines. However, it is unclear how immunosuppressants affect patients with cancer. Therefore, in the present study, the effect of three biological agents, tofacitinib, anti-mouse IL...

journal_title：Oncology letters

authors： Shimaoka H,Takeno S,Maki K,Sasaki T,Hasegawa S,Yamashita Y

更新日期：2017-09-01 00:00:00

abstract：:The current report presents the case of a 43-year-old male suffering from a penile cutaneous horn. A surgical excision of the lesion was performed and histopathology demonstrated hyperkeratosis, dyskeratosis and epithelial hyperplasia. The cutaneous horn progressed to squamous cell carcinoma <1.5 months following surg...

journal_title：Oncology letters

authors： Zhou Y,Tang Y,Tang J,Xia B,Dai Y

更新日期：2014-09-01 00:00:00

abstract：:The purpose of the present study was to characterize uncommon portosystemic collateral circulation in hepatic cirrhosis. Portosystemic uncommon collateral circulation (UCC) was detected, characterized and evaluated by a combination of spiral computed tomography angiography, three-dimensional imaging angiography and el...

journal_title：Oncology letters

authors： Wu Q,Shen L,Chu J,Ma X,Jin B,Meng F,Chen J,Wang Y,Wu L,Han J,Zhang W,Ma W,Wang H,Li H

更新日期：2015-01-01 00:00:00

abstract：:Zinc finger E-box binding homeobox 1 (ZEB1) has been shown to promote invasion and metastasis in several types of human cancer and to have a prognostic role in certain cancers. However, the clinical significance of ZEB1 in colorectal cancer (CRC) has not been sufficiently investigated. This study aimed to address this...

journal_title：Oncology letters

authors： Zhang GJ,Zhou T,Tian HP,Liu ZL,Xia SS

更新日期：2013-02-01 00:00:00

abstract：:The epithelial cell adhesion molecule (EpCAM) is overexpressed in the majority of human epithelial carcinomas, and its overexpression is associated with proliferation and neoplastic transformation. However, the precise molecular mechanism involved in EpCAM-related proliferation and metastasis in hypopharyngeal carcino...

journal_title：Oncology letters

authors： Mu Y,Sa N,Yu L,Lu S,Wang H,Xu W

更新日期：2014-07-01 00:00:00

abstract：:Connexins (Cxs), a conserved family of trans-membrane proteins, function in the organization of cell-cell communicatin via gap junctions in multicellular organisms. However, the role of Cxs in acute myeloid leukemia (AML) is poorly understood. In this study, we investigated the relationship between cell proliferation ...

journal_title：Oncology letters

authors： Yi S,Chen Y,Wen L,Yang L,Cui G

更新日期：2012-11-01 00:00:00

abstract：:Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, ...

journal_title：Oncology letters

authors： Toshiyama R,Konno M,Eguchi H,Asai A,Noda T,Koseki J,Asukai K,Ohashi T,Matsushita K,Iwagami Y,Yamada D,Asaoka T,Wada H,Kawamoto K,Gotoh K,Kudo T,Satoh T,Doki Y,Mori M,Ishii H

更新日期：2018-05-01 00:00:00

abstract：:In patients with bladder cancer (BC), the association between ST3 β-galactoside α-2,3-sialyltransferase 5 (ST3GAL5) expression and clinical outcomes, particularly regarding muscle-invasive disease, high tumor grade and prognosis, remain unknown. In the present study, the expression of ST3GAL5 and its association with ...

journal_title：Oncology letters

authors： Ouyang S,Liu JH,Ni Z,Ding GF,Wang QZ

更新日期：2020-07-01 00:00:00

abstract：:The present study investigated the effects of N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine, on the growth of gliomas. To analyze the effects of ketamine treatment, rat C6 glioma cells arising from astrocytes, and RNB cells representing non-malignant astrocytes, were examined. In ketamine-treated C6 cells,...

journal_title：Oncology letters

authors： Niwa H,Furukawa KI,Seya K,Hirota K

更新日期：2017-10-01 00:00:00

abstract：:Selective amino acid restriction targets mitochondria to induce apoptosis of DU145 and PC3 prostate cancer cells. Biochemical assays and flow cytometry were uitilized to analyze the glucose consumption, lactate production, pyruvate dehydrogenase (PDH), nicotinamide adenine dinucleotide (NAD)/NADH and nicotinamide aden...

journal_title：Oncology letters

authors： Liu X,Fu YM,Meadows GG

更新日期：2011-01-18 00:00:00

abstract：:Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also uncommon, representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases ar...

journal_title：Oncology letters

authors： Panelli Santos KCP,Matsuzaki H,Unetsubo T,Tsuyoshi S,Nagatsuka H,Asaumi JI

更新日期：2017-04-01 00:00:00

abstract：:Metaplastic carcinoma of the breast (MBC) is a rare and heterogeneous type of neoplasm. Knowledge about its clinical characteristics, prognostic significance and optimal treatment modalities is fragmentary and controversial. The present retrospective study aimed to investigate the prognostic value of the clinicopathol...

journal_title：Oncology letters

authors： Xiao M,Yang Z,Tang X,Mu L,Cao X,Wang X

更新日期：2017-08-01 00:00:00

abstract：:Primary testicular non-Hodgkin's lymphoma (TNHL) was first described as a clinical entity in 1866. It is a rare disease which accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. Hemophagocytic syndrome (HPS) is a rare but distinct condition caused by inappr...

journal_title：Oncology letters

authors： Ren W,Zhong Z,Zhao X,Yang J,Zhang L,Xu R,Li S,Zhu X,Lu C,Chin JL

更新日期：2012-07-01 00:00:00