Abstract:
:The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28-year old man presented at our hospital with a large mass in his right shank which had a hard texture and an obscure boundary. The histopathological diagnosis of excisional biopsy specimens was synovial sarcoma with low differentiation. Theprubicin/Cisplatin (THP/CDDP) neoadjuvant chemotherapy was selected based on the results obtained from the CD-DST. After three courses, a computed tomography (CT) scan was performed which indicated that the volume of the tumor had decreased significantly. Additionally, tumor necrosis, as well as the clinical response, showed complete response. The histopathological diagnosis of wide excision specimens indicated a grade III chemotherapy response. The patient was alive and without recurrence after a follow-up of 16 months. Our results indicated that the CD-DST is a useful tool for selecting neoadjuvant chemotherapeutic drugs for patients with synovial sarcoma.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Gu F,Ma Y,Fan Y,Lang R,Ding T,Hao X,Gong Y,Kobayahsi H,Fang Z,Fu Ldoi
10.3892/ol_00000157subject
Has Abstractpub_date
2010-09-01 00:00:00pages
885-888issue
5eissn
1792-1074issn
1792-1082pii
ol-01-05-0885journal_volume
1pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Effects of Rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT) signaling pathway were studied. The retinoblastoma Y79 cells were selected and divided into negative control group (NC group), 0.2 µM Rapamycin group and 0.4 µ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11363
更新日期:2020-04-01 00:00:00
abstract::Osteosarcoma (OS) is the most common form of bone malignancy in children and adolescents. A class of molecules known as microRNAs (miRNAs) have been routinely associated in the development and progression of OS. The present study was centered on the less well-known miRNA, miRNA (miR)-150, and its role in OS was invest...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5709
更新日期:2017-04-01 00:00:00
abstract::Curcumin is a non-nutritive yellow pigment found in the spice turmeric, which is derived from the rhizome of the plant Curcuma longa Linn. Six cyclohexanone analogues of curcumin (A(1)-A(6)) were investigated for their effects on growth and apoptosis in PC-3 human prostate cancer cells. The ability of these compounds ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.710
更新日期:2012-08-01 00:00:00
abstract::The role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is a disease with not only a genetic, but also an immunological basis. Additionally, immune cell infiltration is an important feature of oral cancer. C-X-C motif chemokine ligand 12 (CXCL12) serves an important role in immune suppression in the tum...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10415
更新日期:2019-08-01 00:00:00
abstract::DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.522
更新日期:2012-03-01 00:00:00
abstract::Expression of the transcription factor hypoxiainducible factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia, particularly in relation to tumour angiogenesis. Expression of the HIF-1α subunit is responsive to changes in oxygen levels. Overexpression of HIF-1α has been reported to be associated with a po...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1185
更新日期:2013-04-01 00:00:00
abstract::Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11653
更新日期:2020-08-01 00:00:00
abstract::Endotracheal intubation (ETI) and laryngeal mask airway (LMA) in terms of hemodynamics and reaction were compared. A total of 54 general anesthesia patients were randomized into two groups with 27 cases in each group. Acceleration index (ACI), cardiac index (CI), cardiac output (CO), left cardiac work (LCW), systemic ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9813
更新日期:2019-02-01 00:00:00
abstract::Although it is the most widely used biomarker for prostate cancer, the use of prostate specific antigen (PSA) is controversial due to its limitations in specificity and sensitivity. The proteasome is a complex associated with cell proliferation and apoptosis, and the abnormity of these processes may lead to tumor occu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7936
更新日期:2018-04-01 00:00:00
abstract::MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6809
更新日期:2017-10-01 00:00:00
abstract::The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1407
更新日期:2013-08-01 00:00:00
abstract::Gastric cancer is one of the most common malignancies with high cancer-associated mortality rate globally. Hepcidin is the peptide hormone, which is critically important in the regulation of systemic iron homeostasis. Cumulating evidence has reported that the disturbed local expression of hepcidin may serve as a predi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7574
更新日期:2018-02-01 00:00:00
abstract::Central nervous system-based cancers have a much higher mortality rate with the 2016 estimates at 6.4 for incidence and 4.3 for deaths per 100,000 individuals. Grade IV astrocytomas, known as glioblastomas are highly aggressive and show a high proliferation index, diffused infiltration, angiogenesis, microvascular pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4952
更新日期:2016-10-01 00:00:00
abstract::Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6049
更新日期:2017-06-01 00:00:00
abstract::K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2205
更新日期:2014-08-01 00:00:00
abstract::We compared the clinical effects and prognosis of patients receiving lymph node dissection after surgical removal of the thyroid tissues and those not receiving it after the removal. A total of 80 patients diagnosed with differentiated thyroid carcinoma (DTC) by our hospital from March 2012 to March 2014 were successi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5450
更新日期:2017-01-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical importance of melanoma-associated antigen D4 (MAGE-D4) expression in glioma, and to identify it as a valuable prognostic biomarker and therapeutic target. To achieve this, the expression of MAGE-D4 protein in 124 tumor tissues from patients with glioma was meas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7884
更新日期:2018-04-01 00:00:00
abstract::The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcription factor 1 (RUNX...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6151
更新日期:2017-07-01 00:00:00
abstract::Effect of microRNA-27b (miR-27b) on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma (OSCC) was investigated to provide a reference for clinical prevention of OSCC cell resistance. The clinical tissues of 34 patients with OSCC-resistant cancer and 28 patients with cisplatin-sensitive OSCC in Nanjing ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10347
更新日期:2019-07-01 00:00:00
abstract::Pulmonary inflammatory myofibroblastic tumors (PIMTs) are extremely rare in adults. If occurring in patients >40 years old, PIMT should be rapidly distinguished from lung cancer. The present study aimed to characterize the imaging features of PIMT in patients >40 years old in order to improve the diagnosis of PIMT. Th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2923
更新日期:2015-04-01 00:00:00
abstract::The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2177
更新日期:2014-08-01 00:00:00
abstract::Osteosarcoma (OS) is the third most frequent type of cancer in adolescents and represents >56% of all bone tumors. In addition, metastatic OS frequently demonstrates resistance to conventional chemotherapy; thus, the development of novel therapeutic agents for the treatment of patients with metastatic OS is warranted....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5953
更新日期:2017-06-01 00:00:00
abstract::Morphological response is considered an improved surrogate to the Response Evaluation Criteria in Solid Tumors (RECIST) model with regard to predicting the prognosis for patients with colorectal liver metastases. However, its use as a decision-making tool for surgical intervention has not been examined. The present st...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6338
更新日期:2017-08-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1983
更新日期:2014-06-01 00:00:00
abstract::The aim of the present study was to develop a procedure for the isolation of circulating tumor cells (CTCs), and to evaluate its application in the detection of epidermal growth factor receptor (EGFR) mutations, and potential heterogeneity in patients with non-small-cell lung cancer (NSCLC). Peripheral blood samples w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10016
更新日期:2019-04-01 00:00:00
abstract::Cancer is a histologically and genetically heterogeneous population of tumor cells that exhibits distinct molecular profiles determined by epigenetic alterations. P-element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) have been previously demonstrated to be involved in epigenetic r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5932
更新日期:2017-05-01 00:00:00
abstract::Extra-abdominal desmoid tumour is a rare type of tumour which is conventionally treated with wide local excision. However, wide local excision usually causes irreparable damage to the limbs. Nevertheless, few patients have been subjected to wide local excision and reconstructive surgery in a single procedure. A 52-yea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.766
更新日期:2012-09-01 00:00:00
abstract::The value of interventional ultrasound in the diagnosis and treatment of submucous myoma of the uterus was assessed to study the ultrasonographic features of modified sonohysterography for submucous polyp of uterus. A total of 25 patients diagnosed preliminarily as submucous myoma of the uterus via conventional ultras...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8122
更新日期:2018-05-01 00:00:00
abstract::Gastric cancer is a common malignancy in China, with the second highest mortality rate worldwide. Advanced gastric cancer usually exhibits a poor prognosis with a low 5-year survival rate. Therefore, developing novel drugs for the treatment of this cancer will be beneficial for patients. Demethylzeylasteral, an extrac...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12310
更新日期:2021-01-01 00:00:00
abstract::Patients with non-platinum-sensitive recurrent ovarian cancer have a poor prognosis. Non-pegylated liposomal doxorubicin (Myocet®) is a promising drug that may be able to improve treatment for such patients. In the current study, patients with recurrent ovarian cancer relapsing within 12 months after primary treatment...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4740
更新日期:2016-08-01 00:00:00