Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer.

abstract：:Ovarian cancer is the most fatal gynecological cancer, with a 5-year survival rate of only 30%. Lysophosphatidic acid (LPA), which possesses growth factor-like functions, is a major regulatory factor in the peritoneal metastasis of ovarian cancer. LPA stimulates the expression of numerous genes that are associated wit...

journal_title：Oncology letters

authors： Wang H,Liu W,Wei D,Hu K,Wu X,Yao Y

更新日期：2014-05-01 00:00:00

abstract：:The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, th...

journal_title：Oncology letters

authors： Shan XY,Xu TT,Liu ZL,Hu XF,Zhang YD,Guo SZ,Wang B

更新日期：2017-08-01 00:00:00

abstract：:Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...

journal_title：Oncology letters

authors： Li M,Zhao Y,Liu X,Zhang S,Jiang Y,Yang Z

更新日期：2020-04-01 00:00:00

abstract：:CD133+ tumor cells have a greater potential ability for tumorigenesis, proliferation, invasion and metastasis compared with CD133- tumor cells. Ki-67 is associated with cell proliferation in various tumors and has a markedly positive correlation with the prognosis of patients. However, there are a limited number of st...

journal_title：Oncology letters

authors： Lu C,Liu L,Wu X,Xu W

更新日期：2013-11-01 00:00:00

abstract：:microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...

journal_title：Oncology letters

authors： Li L,Jia L,Ding Y

更新日期：2018-09-01 00:00:00

abstract：:Breast cancer is the most common malignant disease occurring in women. Conservative breast cancer surgery followed by radiation therapy is currently the standard treatment for this type of cancer. The majority of metastases occur within the scar, which initiated a series of studies. As a result, clinical trials aimed ...

journal_title：Oncology letters

authors： Zaleska K,Przybyła A,Kulcenty K,Wichtowski M,Mackiewicz A,Suchorska W,Murawa D

更新日期：2017-10-01 00:00:00

abstract：:Acute myeloid leukemia associated with t(8;21)(q22;q22)/runt related transcription factor (RUNX)1-RUNX1 translocation partner 1 has been reported to exhibit a favorable outcome. The quantitative polymerase chain reaction is a reliable method for assessing minimal residual disease persistence, and peripheral blood (PB)...

journal_title：Oncology letters

authors： Tian X,Wang Y,Liu Y,Yin J,Chen D,Ke X,Ma W

更新日期：2018-10-01 00:00:00

abstract：:The aim of the present study was to investigate the treatment options for patients with tuberous sclerosis complex (TSC)-associated renal angiomyolipomas (AMLs). A total of 17 patients who were consecutively diagnosed with TSC-associated renal AMLs at the Department of Urology of Zhongshan Hospital between 1998 and 20...

journal_title：Oncology letters

authors： Wang H,Long Q,Wang Y,Liu L,Zhou L,Guo J

更新日期：2016-08-01 00:00:00

abstract：:Imiquimod is an imidazoquinoline immune response modifier that is used in antiviral and antiallergic creams. Combination therapy using transcutaneous imiquimod and oral sorafenib was previously demonstrated to reduce the tumor burden of renal cell carcinoma growing cutaneously in a mouse model. In the present study, a...

journal_title：Oncology letters

authors： Karashima T,Udaka K,Niimura M,Suzuki K,Osakabe H,Shimamoto T,Fukata S,Inoue K,Kuroda N,Seiki M,Shuin T

更新日期：2017-07-01 00:00:00

abstract：:In the present study, a low molecular weight polysaccharide, ABP-AW1, isolated from Agaricus blazei Murill was assessed for its potential adjuvant activity. ABP-AW1 is considered to create a 'depot' of antigen at a subcutaneous injection site. ICR mice were immunized with 100 μg ovalbumin (OVA) alone or with 100 μg OV...

journal_title：Oncology letters

authors： Cui L,Sun Y,Xu H,Xu H,Cong H,Liu J

更新日期：2013-10-01 00:00:00

abstract：:Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painles...

journal_title：Oncology letters

authors： Gong Z,Zhang Y,Chu H,Lian P,Zhang L,Sun P,Chen J

更新日期：2014-11-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...

journal_title：Oncology letters

authors： Dong Y,Yuan H,Jin G

更新日期：2018-08-01 00:00:00

abstract：:Brain-specific metastasis is one of the primary causes of recurrence following complete resection of non-small cell lung cancer (NSCLC) and the underlying mechanism remains unclear. The present study was designed to investigate the correlation between C-X-C chemokine receptor type 4 (CXCR4) expression and brain-specif...

journal_title：Oncology letters

authors： Wang L,Wang Z,Liu X,Liu F

更新日期：2014-06-01 00:00:00

abstract：:N-myc downstream-regulated gene 1 (NDRG1) is a multifunctional protein associated with carcinogenesis and tumor progression. The function of NDRG1 in hepatocellular carcinoma (HCC) cells remains controversial. The present study investigated the role of NDRG1 in HCC as well as its molecular mechanism using a range of t...

journal_title：Oncology letters

authors： Song Y,Wu G,Zhang M,Kong Q,Du J,Zheng Y,Yue L,Cao L

更新日期：2017-05-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a rare acquired form of hypophosphatemia commonly associated with phosphaturic mesenchymal tumors (PMTs) located in the bone or soft tissue. Resection of the tumor can cure osteomalacia. Fibroblast growth factor 23 has been identified as a major pathophysiological factor responsible...

journal_title：Oncology letters

authors： Morimoto T,Takenaka S,Hashimoto N,Araki N,Myoui A,Yoshikawa H

更新日期：2014-07-01 00:00:00

abstract：:The involvement of the female genital tract in transitional cell carcinoma (TCC) has not been fully elucidated in women, although involvement is usually associated with a poor prognosis. The vagina, in particular, is considered to be the most commonly affected gynecological organ, with an incidence of 4% of total TCC ...

journal_title：Oncology letters

authors： Aoun F,Kourie HR,El Rassy E,van Velthoven R

更新日期：2016-09-01 00:00:00

abstract：:Increasing evidence has indicated that the dysregulation of microRNA (miRNA) occur in the pathogenesis of retinoblastoma (RB). Aim of the present study was to investigate the possible role of miR-494 (miR-494-3p) in RB. It was demonstrated that miR-494 expression was increased in RB tissue samples and cell lines. Also...

journal_title：Oncology letters

authors： Xu F,Liu G,Wang L,Wang X,Jin X,Bo W

更新日期：2020-08-01 00:00:00

abstract：:With the growing requirement for novel prognostic biomarkers for pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although many studies have been performed, carbohydrate antigen 19-9 is the only biomarker in clinical use. Therefore, the present study examined whether γ-secretase genes...

journal_title：Oncology letters

authors： Jeon YH,Ha M,Kim SW,Kim MJ,Lee CS,Oh CK,Han ME,Oh SO,Kim YH

更新日期：2019-05-01 00:00:00

abstract：:Over the latest decade, the role of microRNAs (miRNAs/miRs) has received more attention. miRNAs are small non-coding RNAs that may serve a role as oncogenes or tumor suppressor genes. Certain miRNAs regulate the apoptosis pathway by influencing pro- or anti-apoptotic genes. We hypothesized that increases in the expres...

journal_title：Oncology letters

authors： Ostadrahimi S,Fayaz S,Parvizhamidi M,Abedi-Valugerdi M,Hassan M,Kadivar M,Teimoori-Toolabi L,Asgari M,Shahrokh H,Abolhasani M,Mahdian R,Fard-Esfahani P

更新日期：2018-05-01 00:00:00

abstract：:Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...

journal_title：Oncology letters

authors： Liu B,Li LJ,Gong X,Zhang W,Zhang H,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:Poly(ADP-Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma and prostate cancer. The expression and function of PARP9 in human breast cancer remains unknown. In the present study, it was demonstrated that PARP9 is frequently overexpressed in human br...

journal_title：Oncology letters

authors： Tang X,Zhang H,Long Y,Hua H,Jiang Y,Jing J

更新日期：2018-09-01 00:00:00

abstract：:Ulcerative colitis (UC) is thought to be associated with precancerous lesions that can ultimately lead to colon cancer. Therefore, diagnostic markers for colorectal dysplasia and cancer are urgently needed for patients with UC. Stathmin 1 (STMN1) is a novel cancer biomarker that is also a novel target for treatment in...

journal_title：Oncology letters

authors： Osone K,Yokobori T,Katayama C,Takahashi R,Kato R,Tatsuski H,Takada T,Yajima R,Motegi Y,Ogawa H,Fujii T,Ojima H,Nakamura J,Yao T,Shirabe K,Kuwano H

更新日期：2019-11-01 00:00:00

abstract：:The novel synthesis of dibenzofluorene has been achieved by a cyclodehydration method. Several derivatives have also been prepared using this hydrocarbon. These compounds have been tested against a number of cancer cell lines in vitro, and useful selectivity has been observed. ...

journal_title：Oncology letters

authors： Banik BK,Mukhopadhyay C,Becker FF

更新日期：2010-03-01 00:00:00

abstract：:The aim of the present study was to investigate the expression and role of microRNA-26a (miR-26a) in lung cancer, and to verify whether differentially expressed in adenocarcinoma of the lung (DAL-1) is the target protein of miR-26a. mRNA expression levels of miR-26a and DAL-1 were detected using reverse transcription-...

journal_title：Oncology letters

authors： Cai T,Guan X,Wang H,Fang Y,Long J,Xie X,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to examine the effectiveness of immunostaining of cytological specimens in discerning squamous from non-squamous cell carcinoma. Various combinations of six antibodies were examined in order to determine the optimal combination for use in differential diagnosis. Immunostaining was performed usi...

journal_title：Oncology letters

authors： Ikeda S,Naruse K,Nagata C,Kuramochi M,Onuki T,Inagaki M,Suzuki K

更新日期：2015-05-01 00:00:00

abstract：:Local adjuvant treatment of giant cell tumours (GCTs) of the bone with phenol has led to a significant reduction in recurrence rates. In the current study, the optimal phenol concentration and duration of intralesional exposure were evaluated. Specimens of GCTs were exposed to various concentrations of phenol solution...

journal_title：Oncology letters

authors： Mittag F,Leichtle C,Kieckbusch I,Wolburg H,Rudert M,Kluba T,Leichtle U

更新日期：2013-05-01 00:00:00

abstract：:The putative oncogenic role of ATP/GTP binding protein like 2 (AGBL2) in catalyzing α-tubulin detyrosination has recently been characterized in cancer. However, the status of AGBL2 expression in ovarian cancer and its potential clinical and prognostic significance remain unclear. In the present study, immunohistochemi...

journal_title：Oncology letters

authors： He WP,Wang LL

更新日期：2019-11-01 00:00:00

abstract：:Voltage-dependent anion channels (VDACs) are situated in the outer membrane of the mitochondria and serve as gatekeepers that control metabolite and ion exchange between the cytosol and mitochondria. VDAC1 is one of the most studied members of the VDAC protein family and is overexpressed in multiple types of cancer. H...

journal_title：Oncology letters

authors： Yang G,Zhou D,Li J,Wang W,Zhong W,Fan W,Yu M,Cheng H

更新日期：2019-09-01 00:00:00

abstract：:Discovering the underlying signalling pathways that control cancer cells is crucial for understanding their biology and to develop therapeutic regimens. Thus, the aim of the present study was to determine the effect of Cripto-1 on pathways controlling glioblastoma (GBM) cell function. To this end, changes in protein p...

journal_title：Oncology letters

authors： Alowaidi F,Hashimi SM,Alqurashi N,Wood SA,Wei MQ

更新日期：2019-09-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) accounts for 30% of all pediatric cancers. Currently available treatments exhibit toxicity and certain patients may develop resistance. Thus, less toxic and chemoresistance-reversal agents are required. In the present study, the potential effect of curcumin, a component of Curcuma lo...

journal_title：Oncology letters

authors： Pimentel-Gutiérrez HJ,Bobadilla-Morales L,Barba-Barba CC,Ortega-De-La-Torre C,Sánchez-Zubieta FA,Corona-Rivera JR,González-Quezada BA,Armendáriz-Borunda JS,Silva-Cruz R,Corona-Rivera A

更新日期：2016-11-01 00:00:00